{"id":"https://openalex.org/W7225798591","doi":"https://doi.org/10.1038/s43856-026-01971-2","title":"Dysfunction of hepatic lipid metabolism in mice haploinsufficient for the histone methyltransferase Kmt2c","display_name":"Dysfunction of hepatic lipid metabolism in mice haploinsufficient for the histone methyltransferase Kmt2c","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225798591","doi":"https://doi.org/10.1038/s43856-026-01971-2"},"language":"en","primary_location":{"id":"doi:10.1038/s43856-026-01971-2","doi":"https://doi.org/10.1038/s43856-026-01971-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43856-026-01971-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210167893","display_name":"Communications Medicine","issn_l":"2730-664X","issn":["2730-664X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s43856-026-01971-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091039652","display_name":"Kazuki Harada","orcid":"https://orcid.org/0000-0002-0793-6851","observed_orcids":["https://orcid.org/0000-0002-0793-6851"]},"institutions":[{"id":"https://openalex.org/I200202764","display_name":"National Institute for Environmental Studies","ror":"https://ror.org/02hw5fp67","country_code":"JP","type":"education","lineage":["https://openalex.org/I200202764"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Harada","raw_affiliation_strings":["Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan","Health and Environmental Risk Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba-shi, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Health and Environmental Risk Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba-shi, Ibaraki, Japan","institution_ids":["https://openalex.org/I200202764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161441066","display_name":"Takumi Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Nakamura","raw_affiliation_strings":["Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012904292","display_name":"Kurara Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kurara Honda","raw_affiliation_strings":["Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018431076","display_name":"Takashi Takaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Takaki","raw_affiliation_strings":["Center for Electron microscopy, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Electron microscopy, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158735488","display_name":"Yuri Osuga\u2010Yoshiike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuri Osuga-Yoshiike","raw_affiliation_strings":["Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005693637","display_name":"Mie Kubota\u2010Sakashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mie Kubota-Sakashita","raw_affiliation_strings":["Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161471890","display_name":"Shogo Haraguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Haraguchi","raw_affiliation_strings":["Department of Biochemistry, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631067","display_name":"Tadafumi Kato","orcid":"https://orcid.org/0000-0001-7856-3952","observed_orcids":["https://orcid.org/0000-0001-7856-3952"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadafumi Kato","raw_affiliation_strings":["Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7856-3952","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071402049","display_name":"Atsushi Takata","orcid":"https://orcid.org/0000-0002-0928-4586","observed_orcids":["https://orcid.org/0000-0002-0928-4586"]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Takata","raw_affiliation_strings":["Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan","Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080968511","display_name":"Takashi Tsuboi","orcid":"https://orcid.org/0000-0001-8290-2021","observed_orcids":["https://orcid.org/0000-0001-8290-2021"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Tsuboi","raw_affiliation_strings":["Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8290-2021","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080968511"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.18520000576972961,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.15559999644756317,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.7735999822616577},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6373000144958496},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5909000039100647},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.552299976348877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5401999950408936},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5209000110626221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5012000203132629},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.47760000824928284},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.4318999946117401},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.42489999532699585},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.3921000063419342},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3853999972343445},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3833000063896179},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3799000084400177},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3327000141143799},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C2909799055","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid Metabolism Disorder","level":4,"score":0.3303000032901764},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.32919999957084656},{"id":"https://openalex.org/C2777735490","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disorder","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3192000091075897},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C2778087339","wikidata":"https://www.wikidata.org/wiki/Q18029587","display_name":"MTRR","level":5,"score":0.2831000089645386},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.28209999203681946},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.27309998869895935},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C2993790521","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxide","level":4,"score":0.26910001039505005},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.26030001044273376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.25110000371932983},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.2508000135421753},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s43856-026-01971-2","doi":"https://doi.org/10.1038/s43856-026-01971-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43856-026-01971-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210167893","display_name":"Communications Medicine","issn_l":"2730-664X","issn":["2730-664X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s43856-026-01971-2","doi":"https://doi.org/10.1038/s43856-026-01971-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43856-026-01971-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210167893","display_name":"Communications Medicine","issn_l":"2730-664X","issn":["2730-664X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1503760388","https://openalex.org/W1559066998","https://openalex.org/W1998803081","https://openalex.org/W2008341411","https://openalex.org/W2011404755","https://openalex.org/W2019455536","https://openalex.org/W2027753197","https://openalex.org/W2030427461","https://openalex.org/W2039153962","https://openalex.org/W2043335839","https://openalex.org/W2045775732","https://openalex.org/W2059223607","https://openalex.org/W2101628996","https://openalex.org/W2120521980","https://openalex.org/W2138207763","https://openalex.org/W2162227712","https://openalex.org/W2167279371","https://openalex.org/W2168526937","https://openalex.org/W2169456326","https://openalex.org/W2169767637","https://openalex.org/W2179438025","https://openalex.org/W2551675827","https://openalex.org/W2766489743","https://openalex.org/W2780667489","https://openalex.org/W2888185150","https://openalex.org/W2889225561","https://openalex.org/W2899132188","https://openalex.org/W2936480486","https://openalex.org/W2948003108","https://openalex.org/W2952883732","https://openalex.org/W2966964832","https://openalex.org/W2979183639","https://openalex.org/W2995604272","https://openalex.org/W2999541689","https://openalex.org/W3000060865","https://openalex.org/W3037672594","https://openalex.org/W3095414032","https://openalex.org/W3169908914","https://openalex.org/W3174336210","https://openalex.org/W3175752499","https://openalex.org/W3203773879","https://openalex.org/W4214568609","https://openalex.org/W4220699785","https://openalex.org/W4285676530","https://openalex.org/W4293068820","https://openalex.org/W4311182072","https://openalex.org/W4313544485","https://openalex.org/W4321366315","https://openalex.org/W4322619006","https://openalex.org/W4378715009","https://openalex.org/W4390963726","https://openalex.org/W4393198871","https://openalex.org/W4394619766","https://openalex.org/W4396857124","https://openalex.org/W4400826502","https://openalex.org/W4402135883","https://openalex.org/W4402974600","https://openalex.org/W4403014803","https://openalex.org/W4403681202","https://openalex.org/W4405262761","https://openalex.org/W4410629960","https://openalex.org/W6912636611"],"related_works":[],"abstract_inverted_index":{"Metabolic":[0],"dysfunction":[1,21,221,324],"is":[2,235],"influenced":[3],"by":[4,204,280],"various":[5],"factors":[6],"including":[7],"environmental":[8],"effects":[9],"and":[10,13,22,76,80,87,93,111,129,136,154,163,175,208,212,225,243,250,262,268,293,308,327],"genetic":[11],"variants,":[12],"recent":[14],"evidence":[15],"reveals":[16,146],"close":[17],"associations":[18],"between":[19,31],"metabolic":[20,220,257,323],"neurodevelopmental":[23,224,326],"or":[24,285],"neuropsychiatric":[25,226,328],"disorders.":[26],"However,":[27],"the":[28,45,176,201,283,319],"mechanistic":[29],"link":[30],"them":[32],"remains":[33,229],"unclear.":[34,230],"To":[35],"clarify":[36],"these":[37,273],"relationships,":[38],"we":[39,58,119,288],"utilized":[40],"mice":[41,86,123,170,246,303],"with":[42,114,332],"haploinsufficiency":[43],"in":[44,56,83,197,200,223,282,291,325],"autism":[46,238],"spectrum":[47,239],"disorder-related":[48],"gene":[49],"lysine":[50],"methyltransferase":[51,232],"2c":[52,233],"(Kmt2c)":[53,234],"(Kmt2c+/fs":[54],"mice),":[55],"which":[57],"previously":[59],"confirmed":[60],"significantly":[61],"less":[62,214,251],"body":[63,67,126,130,215,252,265],"weight.":[64,216,253],"We":[65,254],"characterized":[66],"composition,":[68],"small":[69,134],"intestinal":[70],"transcriptome,":[71],"fecal":[72,137],"metagenome,":[73],"plasma":[74,143],"metabolome,":[75],"hepatic":[77,297],"mitochondrial":[78],"morphology":[79,162,292],"biochemical":[81,164,294],"activity":[82,295],"male":[84],"Kmt2c+/fs":[85,122,169,260,302],"wild-type":[88],"controls.":[89],"Hepatic":[90,158],"transcriptomic":[91],"changes":[92,281,290],"lipid":[94,173,182,198,306,311],"accumulation":[95,174,307],"were":[96,101,275],"also":[97],"assessed.":[98],"Group":[99],"comparisons":[100],"performed":[102],"using":[103],"two-sided":[104],"Mann-Whitney":[105],"U-tests,":[106],"two-way":[107],"repeated":[108],"measures":[109],"ANOVA,":[110],"enrichment":[112],"analyses":[113],"appropriate":[115],"multiple-testing":[116],"correction.":[117],"Here":[118],"show":[120,139],"that":[121,191],"have":[124],"decreased":[125,172,269,305],"mass":[127,266],"index":[128,267],"fat":[131,270],"mass.":[132,271],"The":[133,166,217,299],"intestine":[135,284],"metagenome":[138],"minimal":[140],"alterations,":[141],"while":[142],"metabolomic":[144],"analysis":[145],"an":[147],"increase":[148],"of":[149,168,178,206,219,237,259,296,301,310,322],"metabolites":[150],"related":[151,180],"to":[152,181,277],"glucose":[153,207],"amino":[155,209],"acid":[156,186,210],"metabolism.":[157],"mitochondria":[159],"display":[160],"altered":[161],"activity.":[165],"liver":[167,300],"exhibits":[171],"downregulation":[177,309],"genes":[179],"metabolism,":[183],"particularly":[184],"fatty":[185],"synthesis.":[187],"These":[188,314],"findings":[189],"indicate":[190],"KMT2C":[192],"deficiency":[193],"triggers":[194],"functional":[195],"defects":[196],"metabolism":[199,211],"liver,":[202],"accompanied":[203],"upregulation":[205],"consequently":[213],"mechanism":[218,321],"observed":[222],"disorders":[227],"largely":[228],"Lysine":[231],"one":[236],"disorder":[240],"(ASD)-related":[241],"genes,":[242],"Kmt2c":[244],"mutant":[245],"exhibit":[247],"ASD-like":[248],"phenotypes":[249,274],"precisely":[255],"analyzed":[256],"profiles":[258],"mice,":[261],"discovered":[263],"lower":[264],"While":[272],"unlikely":[276],"be":[278],"explained":[279],"gut":[286],"bacteria,":[287],"found":[289],"mitochondria.":[298],"showed":[304],"metabolism-related":[312],"genes.":[313],"results":[315],"provide":[316],"insight":[317],"into":[318],"onset":[320],"disorders,":[329],"especially":[330],"associated":[331],"epigenetic":[333],"regulations.":[334]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}