{"id":"https://openalex.org/W7225798268","doi":"https://doi.org/10.1097/wnp.0000000000001314","title":"Artificial Intelligence-Based Neonatal Seizure Detection: A Pragmatic Evaluation of Clinical Performance Tradeoffs in Clinical EEG","display_name":"Artificial Intelligence-Based Neonatal Seizure Detection: A Pragmatic Evaluation of Clinical Performance Tradeoffs in Clinical EEG","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225798268","doi":"https://doi.org/10.1097/wnp.0000000000001314"},"language":"en","primary_location":{"id":"doi:10.1097/wnp.0000000000001314","doi":"https://doi.org/10.1097/wnp.0000000000001314","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnp.0000000000001314","pdf_url":null,"source":{"id":"https://openalex.org/S116127033","display_name":"Journal of Clinical Neurophysiology","issn_l":"0736-0258","issn":["0736-0258","1537-1603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029163115","display_name":"Jennifer C. Keene","orcid":"https://orcid.org/0000-0002-3104-6533","observed_orcids":["https://orcid.org/0000-0002-3104-6533"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer C. Keene","raw_affiliation_strings":["Department of Pediatrics, Division of Child Neurology, University of Utah, Salt Lake City, Utah, U.S.A.;"],"raw_orcid":"https://orcid.org/0000-0002-3104-6533","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Child Neurology, University of Utah, Salt Lake City, Utah, U.S.A.;","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024218932","display_name":"Nicholas Scott Abend","orcid":"https://orcid.org/0000-0001-6166-2663","observed_orcids":["https://orcid.org/0000-0001-6166-2663"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas S. Abend","raw_affiliation_strings":["Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.;","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055196790","display_name":"Giulia M. Benedetti","orcid":"https://orcid.org/0000-0002-2917-4026","observed_orcids":["https://orcid.org/0000-0002-2917-4026"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulia M. Benedetti","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Neurology, University of Michigan Medical School, Michigan, U.S.A.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Neurology, University of Michigan Medical School, Michigan, U.S.A.;","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161446196","display_name":"Zach Fulmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zach Fulmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027353424","display_name":"Maire Keene","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maire Keene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161424534","display_name":"Saeed Montazeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Saeed Montazeri","raw_affiliation_strings":["BABA Center, Pediatric Research Center, Departments of Physiology and Clinical Neurophysiology, New Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BABA Center, Pediatric Research Center, Departments of Physiology and Clinical Neurophysiology, New Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; and","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210090554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091906480","display_name":"Craig A. Press","orcid":"https://orcid.org/0000-0003-4435-206X","observed_orcids":["https://orcid.org/0000-0003-4435-206X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Press","raw_affiliation_strings":["Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.;","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010111370","display_name":"Nathan J. Stevenson","orcid":"https://orcid.org/0000-0002-5146-8450","observed_orcids":["https://orcid.org/0000-0002-5146-8450"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nathan J. Stevenson","raw_affiliation_strings":["QIMR Berghofer, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032026142","display_name":"Sampsa Vanhatalo","orcid":"https://orcid.org/0000-0002-9771-7061","observed_orcids":["https://orcid.org/0000-0002-9771-7061"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sampsa Vanhatalo","raw_affiliation_strings":["BABA Center, Pediatric Research Center, Departments of Physiology and Clinical Neurophysiology, New Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BABA Center, Pediatric Research Center, Departments of Physiology and Clinical Neurophysiology, New Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; and","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210090554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027714809","display_name":"Amanda G. Sandoval Karamian","orcid":"https://orcid.org/0000-0002-0813-1334","observed_orcids":["https://orcid.org/0000-0002-0813-1334"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda G. Sandoval Karamian","raw_affiliation_strings":["Department of Pediatrics, Division of Child Neurology, University of Utah, Salt Lake City, Utah, U.S.A.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Child Neurology, University of Utah, Salt Lake City, Utah, U.S.A.;","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.6747999787330627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5983999967575073},{"id":"https://openalex.org/C2780208886","wikidata":"https://www.wikidata.org/wiki/Q18967838","display_name":"Neonatal seizure","level":3,"score":0.5683000087738037},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4478999972343445},{"id":"https://openalex.org/C2776836416","wikidata":"https://www.wikidata.org/wiki/Q1364844","display_name":"False alarm","level":2,"score":0.4041000008583069},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.388700008392334},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34610000252723694},{"id":"https://openalex.org/C2779119184","wikidata":"https://www.wikidata.org/wiki/Q294350","display_name":"ALARM","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C77052588","wikidata":"https://www.wikidata.org/wiki/Q644307","display_name":"Constant false alarm rate","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2565999925136566},{"id":"https://openalex.org/C2983449737","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Clinical diagnosis","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/wnp.0000000000001314","doi":"https://doi.org/10.1097/wnp.0000000000001314","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnp.0000000000001314","pdf_url":null,"source":{"id":"https://openalex.org/S116127033","display_name":"Journal of Clinical Neurophysiology","issn_l":"0736-0258","issn":["0736-0258","1537-1603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Neurophysiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1975879668","https://openalex.org/W2024313504","https://openalex.org/W2056393180","https://openalex.org/W2085526496","https://openalex.org/W2113182013","https://openalex.org/W2132575173","https://openalex.org/W2171776836","https://openalex.org/W2256628866","https://openalex.org/W2338386685","https://openalex.org/W2520685154","https://openalex.org/W2810030448","https://openalex.org/W2895359345","https://openalex.org/W2943148419","https://openalex.org/W2982580298","https://openalex.org/W2997409612","https://openalex.org/W3012189245","https://openalex.org/W3012983955","https://openalex.org/W3021808607","https://openalex.org/W3080952300","https://openalex.org/W3165230952","https://openalex.org/W3201878590","https://openalex.org/W3205543424","https://openalex.org/W4205514089","https://openalex.org/W4220962505","https://openalex.org/W4225597912","https://openalex.org/W4396214532","https://openalex.org/W4401577661","https://openalex.org/W4402005510","https://openalex.org/W4402547066","https://openalex.org/W4402597889","https://openalex.org/W4406155212"],"related_works":[],"abstract_inverted_index":{"Purpose:":[0],"The":[1,189],"aim":[2],"of":[3,40,128,144,165],"this":[4],"study":[5],"was":[6,58,196],"to":[7,29,192,249],"evaluate":[8],"how":[9,227],"three":[10,66],"artificial":[11],"intelligence":[12],"(AI)-based":[13],"neonatal":[14,54],"seizure":[15,32,111,238],"detectors":[16,100],"(NSDs)":[17],"perform":[18],"in":[19],"a":[20,37,76,80,90],"large,":[21],"clinically":[22,82],"acquired":[23],"data":[24],"set":[25],"and":[26,69,97,102,120,160,181,201,221,235,252],"their":[27],"potential":[28],"support":[30,92,236],"timely":[31],"identification.":[33],"Methods:":[34],"We":[35,124],"conducted":[36],"secondary":[38],"analysis":[39],"continuous":[41],"EEG":[42,233],"(cEEG)":[43],"recordings":[44],"from":[45],"169":[46],"neonates":[47,136,145],"born":[48],"at":[49],"\u226535":[50],"weeks":[51],"gestation":[52],"with":[53,146],"encephalopathy.":[55],"Seizure":[56],"presence":[57],"determined":[59],"by":[60,63,75],"independent":[61],"review":[62],"two":[64,98],"or":[65],"pediatric":[67],"encephalographers,":[68],"2,455":[70],"individual":[71],"seizures":[72],"were":[73,88],"annotated":[74],"single":[77],"expert":[78],"as":[79],"pragmatic,":[81],"representative":[83],"reference":[84],"standard.":[85],"Three":[86],"NSDs":[87,141,210],"evaluated:":[89],"feature-based":[91],"vector":[93],"machine":[94],"detector":[95],"(NSD1)":[96],"deep-learning":[99],"(NSD2":[101],"Persyst-15).":[103],"Using":[104],"an":[105],"any-overlap":[106],"approach,":[107],"outcomes":[108],"included":[109],"neonate-level":[110],"identification,":[112],"seizure-level":[113,219],"detection,":[114],"false":[115],"detections":[116],"per":[117,133],"day":[118],"(FD/day),":[119],"detection":[121,149,195,220],"latency.":[122],"Results:":[123],"analyzed":[125],"15,343":[126],"hours":[127,132],"cEEG":[129],"(median":[130],"98":[131],"neonate);":[134],"55":[135],"(33%)":[137],"had":[138],"seizures.":[139,147,166],"All":[140],"identified":[142],"\u226595%":[143],"Seizure-level":[148],"varied:":[150],"NSD2":[151,177],"detected":[152],"35%":[153],"(IQR":[154,158,163],"17\u201353%),":[155],"NSD1":[156,167,200],"63%":[157],"38\u201382%),":[159],"Persyst-15":[161,182],"60%":[162],"37\u201380%)":[164],"generated":[168],"significantly":[169],"more":[170],"FDs":[171],"(46":[172],"FD/day,":[173],"IQR":[174,179,184],"22\u201382)":[175],"than":[176],"(3.2":[178],"1.2\u20139.3)":[180],"(2.8":[183],"1.1\u20136.2;":[185],"P":[186],"<":[187],"0.0001).":[188],"median":[190],"time":[191],"first":[193],"true":[194],"<1":[197],"minute":[198],"for":[199,206,244],"Persyst-15,":[202],"versus":[203],"26":[204],"minutes":[205],"NSD2.":[207],"Conclusions:":[208],"AI-based":[209],"demonstrated":[211],"high":[212],"infant-level":[213],"sensitivity":[214],"but":[215],"different":[216],"tradeoffs":[217],"between":[218],"alarm":[222],"burden.":[223],"These":[224],"findings":[225],"highlight":[226],"AI":[228],"tools":[229],"may":[230],"augment":[231],"clinical":[232],"workflows":[234],"earlier":[237],"recognition,":[239],"while":[240],"underscoring":[241],"the":[242],"need":[243],"evaluation":[245],"under":[246],"real-world":[247],"conditions":[248],"guide":[250],"safe":[251],"effective":[253],"implementation.":[254]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
