{"id":"https://openalex.org/W7225798049","doi":"https://doi.org/10.1002/poh2.70074","title":"Real\u2010World Distribution and Mortality Assessment of MDF and MELD Scores in Hospitalized Patients With Alcohol\u2010Associated Cirrhosis and Clinically Diagnosed Alcohol\u2010Associated Hepatitis","display_name":"Real\u2010World Distribution and Mortality Assessment of MDF and MELD Scores in Hospitalized Patients With Alcohol\u2010Associated Cirrhosis and Clinically Diagnosed Alcohol\u2010Associated Hepatitis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225798049","doi":"https://doi.org/10.1002/poh2.70074"},"language":"en","primary_location":{"id":"doi:10.1002/poh2.70074","doi":"https://doi.org/10.1002/poh2.70074","is_oa":true,"landing_page_url":"https://doi.org/10.1002/poh2.70074","pdf_url":null,"source":{"id":"https://openalex.org/S4393919537","display_name":"Portal hypertension & cirrhosis","issn_l":"2770-5838","issn":["2770-5838","2770-5846"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","oarl"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Portal Hypertension &amp; Cirrhosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1002/poh2.70074","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037964506","display_name":"\u82cf\u5a05","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya Su","raw_affiliation_strings":["Department of Gastroenterology Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123714081","display_name":"Xinyu Hu","orcid":"https://orcid.org/0009-0007-5477-5740","observed_orcids":["https://orcid.org/0009-0007-5477-5740"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Hu","raw_affiliation_strings":["Department of Infectious Diseases Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161429692","display_name":"Yin Long","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yin Long","raw_affiliation_strings":["Department of Infectious Diseases Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161480243","display_name":"Xigu Rigan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xigu Rigan","raw_affiliation_strings":["Baogedayingaole Sumu Central Health Center Xianghuang Banner, Xilin Gol League Inner Mongolia China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baogedayingaole Sumu Central Health Center Xianghuang Banner, Xilin Gol League Inner Mongolia China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161449962","display_name":"Rina Na","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rina Na","raw_affiliation_strings":["Department of Gastroenterology Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161422823","display_name":"Han Baiyila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Han Baiyila","raw_affiliation_strings":["Department of Infectious Diseases Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Affiliated Hospital of Inner Mongolia Minzu University Tongliao Inner Mongolia China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428322","display_name":"Jie Li","orcid":"https://orcid.org/0000-0003-0973-8645","observed_orcids":["https://orcid.org/0000-0003-0973-8645"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Li","raw_affiliation_strings":["Department of Infectious Diseases Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0003-0973-8645","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011249716","display_name":"\u738b\u70b3\u5143","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bingyuan Wang","raw_affiliation_strings":["Department of Gastroenterology The First Hospital of China Medical University Shenyang Liaoning China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology The First Hospital of China Medical University Shenyang Liaoning China","institution_ids":["https://openalex.org/I4210140515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011249716","https://openalex.org/A5100428322"],"corresponding_institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210140515","https://openalex.org/I881766915"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9333000183105469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7402999997138977},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.671500027179718},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.51419997215271},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5055000185966492},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4625000059604645},{"id":"https://openalex.org/C3019983190","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis a virus","level":3,"score":0.4325000047683716},{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.4291999936103821},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4221999943256378},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.41499999165534973},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.40070000290870667},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C163864269","wikidata":"https://www.wikidata.org/wiki/Q1107106","display_name":"Cohen's kappa","level":2,"score":0.366100013256073},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.3653999865055084},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C2780931562","wikidata":"https://www.wikidata.org/wiki/Q7331102","display_name":"Alcohol abuse","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C41771347","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Discriminant function analysis","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.289000004529953},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.26089999079704285}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/poh2.70074","doi":"https://doi.org/10.1002/poh2.70074","is_oa":true,"landing_page_url":"https://doi.org/10.1002/poh2.70074","pdf_url":null,"source":{"id":"https://openalex.org/S4393919537","display_name":"Portal hypertension & cirrhosis","issn_l":"2770-5838","issn":["2770-5838","2770-5846"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","oarl"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Portal Hypertension &amp; Cirrhosis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/poh2.70074","doi":"https://doi.org/10.1002/poh2.70074","is_oa":true,"landing_page_url":"https://doi.org/10.1002/poh2.70074","pdf_url":null,"source":{"id":"https://openalex.org/S4393919537","display_name":"Portal hypertension & cirrhosis","issn_l":"2770-5838","issn":["2770-5838","2770-5846"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","oarl"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Portal Hypertension &amp; Cirrhosis","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1889183644","https://openalex.org/W2066193523","https://openalex.org/W2069243984","https://openalex.org/W2073048831","https://openalex.org/W2124490091","https://openalex.org/W2136041389","https://openalex.org/W2142873961","https://openalex.org/W2286042547","https://openalex.org/W2403143385","https://openalex.org/W2474441668","https://openalex.org/W2768403718","https://openalex.org/W2795611455","https://openalex.org/W2910169101","https://openalex.org/W2954328737","https://openalex.org/W2961821163","https://openalex.org/W2999991362","https://openalex.org/W3133895088","https://openalex.org/W3175639850","https://openalex.org/W4200252274","https://openalex.org/W4229007354","https://openalex.org/W4387597577","https://openalex.org/W4391540982","https://openalex.org/W4392454119","https://openalex.org/W4408845592"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Aims":[1],"The":[2,185],"Maddrey":[3],"Discriminant":[4],"Function":[5],"(MDF)":[6],"and":[7,22,41,58,82,92,101,104,121,129,137,166,177,206,240,246,264,286,302,308,319,345],"Model":[8],"for":[9,87],"End\u2010Stage":[10],"Liver":[11],"Disease":[12],"(MELD)":[13],"scores":[14],"are":[15],"widely":[16],"used":[17],"to":[18,33],"evaluate":[19],"disease":[20,278],"severity":[21,35,143,212,258,282,293,322],"prognosis":[23],"in":[24,52,106,142,255,270],"patients":[25,54,70,158,180,231,271],"with":[26,50,55,71,118,192,232,338],"alcohol\u2010associated":[27,56,72],"hepatitis":[28],"(AH).":[29],"This":[30,63],"study":[31,66],"aimed":[32],"compare":[34],"classification":[36,144,307],"derived":[37],"from":[38],"MDF,":[39,99,262],"MELD,":[40,100,263],"etiology\u2010adjusted":[42,186],"MELD":[43,138,172,195,287],"(MELD[A]),":[44],"as":[45,47,160,164,169,222,273],"well":[46],"their":[48,116,296],"associations":[49,117],"mortality":[51,123,235,309,349],"hospitalized":[53,69],"cirrhosis":[57,73],"clinically":[59],"diagnosed":[60],"AH.":[61],"Methods":[62],"single\u2010center":[64,342],"retrospective":[65,343],"included":[67],"92":[68],"who":[74],"met":[75],"the":[76,229,315,341],"National":[77],"Institute":[78],"on":[79,291,328],"Alcohol":[80],"Abuse":[81],"Alcoholism":[83],"(NIAAA)":[84],"clinical":[85],"criteria":[86],"AH":[88,292,318],"between":[89],"April":[90,93],"2015":[91],"2023.":[94],"Severity":[95],"was":[96,109],"classified":[97,156,173,272],"using":[98,111,126],"MELD(A)":[102,187],"scores,":[103],"agreement":[105,141,191,217],"category":[107],"assignment":[108],"evaluated":[110,125],"weighted":[112],"kappa":[113],"statistics.":[114],"Meanwhile,":[115],"1\u2010,":[119],"3\u2010,":[120],"12\u2010month":[122],"were":[124,243],"survival":[127,256],"analysis":[128],"receiver":[130],"operating":[131],"characteristic":[132],"curve":[133],"analysis.":[134],"Results":[135],"MDF":[136,155,193,285],"showed":[139,189],"limited":[140,346],"(":[145,196],"\u03ba":[146,197],"=":[147,198],"0.37,":[148],"95%":[149,200],"CI:":[150,201],"0.28\u20130.47,":[151],"p":[152,203],"<":[153,204],"0.001).":[154],"44":[157],"(47.8%)":[159],"mild,":[161],"17":[162],"(18.5%)":[163],"moderate,":[165],"31":[167],"(33.7%)":[168],"severe,":[170],"whereas":[171],"0,":[174],"59":[175],"(64.1%),":[176],"33":[178],"(35.9%)":[179],"into":[181],"these":[182,280],"categories,":[183,213],"respectively.":[184,248],"score":[188],"higher":[190],"than":[194],"0.54,":[199],"0.42\u20130.66,":[202],"0.001),":[205],"produced":[207],"substantial":[208],"redistribution":[209],"of":[210,224,295,299,317,348],"patient":[211],"although":[214],"this":[215],"greater":[216],"should":[218,324,335],"not":[219,325],"be":[220,336],"interpreted":[221,337],"evidence":[223],"superior":[225],"prognostic":[226],"performance.":[227],"Among":[228],"86":[230],"available":[233],"follow\u2010up,":[234],"rates":[236],"at":[237],"1,":[238],"3,":[239],"12":[241],"months":[242],"5.8%,":[244],"10.5%,":[245],"18.6%,":[247],"Kaplan\u2013Meier":[249],"analyses":[250],"demonstrated":[251],"statistically":[252],"significant":[253],"differences":[254],"across":[257],"categories":[259,313],"defined":[260],"by":[261,279],"MELD(A).":[265],"Mortality":[266],"events":[267,310],"occurred":[268],"even":[269],"having":[274],"mild":[275],"or":[276],"moderate":[277],"conventional":[281],"stratifications.":[283],"Conclusions":[284],"provide":[288],"different":[289],"perspectives":[290],"because":[294],"distinct":[297],"weighting":[298],"bilirubin,":[300],"coagulation,":[301],"renal":[303],"function.":[304],"Their":[305],"discordant":[306],"among":[311],"lower\u2010severity":[312],"highlight":[314],"heterogeneity":[316],"suggest":[320],"that":[321],"assessment":[323],"rely":[326],"solely":[327],"a":[329],"single":[330],"scoring":[331],"system.":[332],"These":[333],"findings":[334],"caution":[339],"given":[340],"design":[344],"number":[347],"events.":[350]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}