{"id":"https://openalex.org/W7225797992","doi":"https://doi.org/10.3389/fphar.2026.1969983","title":"Potential therapeutic strategies targeting ferroptosis in chronic diabetic wounds","display_name":"Potential therapeutic strategies targeting ferroptosis in chronic diabetic wounds","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225797992","doi":"https://doi.org/10.3389/fphar.2026.1969983"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1969983","doi":"https://doi.org/10.3389/fphar.2026.1969983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1969983","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2026.1969983","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153575904","display_name":"Yongkang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongkang Yang","raw_affiliation_strings":["Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114911027","display_name":"Tianjiao Li","orcid":"https://orcid.org/0000-0002-7912-5281","observed_orcids":["https://orcid.org/0000-0002-7912-5281"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianjiao Li","raw_affiliation_strings":["Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161445817","display_name":"Yuzhe Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhe Wei","raw_affiliation_strings":["Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161442952","display_name":"Jingyi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Wang","raw_affiliation_strings":["Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161438106","display_name":"Xujin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xujin Liu","raw_affiliation_strings":["Department of Hepatology, Qilu Hospital of Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Qilu Hospital of Shandong University","institution_ids":["https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161487959","display_name":"Tianyi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyi Liu","raw_affiliation_strings":["Department of Oncology, The Fourth Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Fourth Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4392738115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058574894","display_name":"Cheng Qiu","orcid":"https://orcid.org/0000-0002-8766-5499","observed_orcids":["https://orcid.org/0000-0002-8766-5499"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Qiu","raw_affiliation_strings":["Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161490218","display_name":"Fan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn, Plastic Surgery and Beauty, Qilu Hospital of Shandong University","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5161490218"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8747000098228455},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7124000191688538},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.5281000137329102},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5084999799728394},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.508400022983551},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48249998688697815},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4733999967575073},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.430400013923645},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3862000107765198},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C2781051411","wikidata":"https://www.wikidata.org/wiki/Q2078852","display_name":"Chronic wound","level":3,"score":0.3495999872684479},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.3149000108242035},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C3018696855","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Multisystem disease","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C2778144972","wikidata":"https://www.wikidata.org/wiki/Q52859","display_name":"Diabetic foot ulcer","level":4,"score":0.26649999618530273},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26019999384880066},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C2777660278","wikidata":"https://www.wikidata.org/wiki/Q489997","display_name":"Diabetic angiopathy","level":3,"score":0.25540000200271606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fphar.2026.1969983","doi":"https://doi.org/10.3389/fphar.2026.1969983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1969983","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1969983","doi":"https://doi.org/10.3389/fphar.2026.1969983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1969983","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W323406638","https://openalex.org/W1589007430","https://openalex.org/W1608217646","https://openalex.org/W1975548302","https://openalex.org/W1997183854","https://openalex.org/W2015248217","https://openalex.org/W2035898183","https://openalex.org/W2067107606","https://openalex.org/W2096080244","https://openalex.org/W2120472250","https://openalex.org/W2146631283","https://openalex.org/W2157072884","https://openalex.org/W2157891776","https://openalex.org/W2163005196","https://openalex.org/W2265062179","https://openalex.org/W2345350059","https://openalex.org/W2408722709","https://openalex.org/W2508296626","https://openalex.org/W2513656923","https://openalex.org/W2549188196","https://openalex.org/W2550324626","https://openalex.org/W2755903659","https://openalex.org/W2762087180","https://openalex.org/W2778262854","https://openalex.org/W2893952489","https://openalex.org/W2906319220","https://openalex.org/W2914574872","https://openalex.org/W2943793201","https://openalex.org/W2980472864","https://openalex.org/W2981179816","https://openalex.org/W2997323331","https://openalex.org/W3015020891","https://openalex.org/W3084755902","https://openalex.org/W3101330565","https://openalex.org/W3123756955","https://openalex.org/W3123922203","https://openalex.org/W3143634367","https://openalex.org/W3157250170","https://openalex.org/W3158754692","https://openalex.org/W3162306949","https://openalex.org/W3163579061","https://openalex.org/W4200026682","https://openalex.org/W4221117858","https://openalex.org/W4281648955","https://openalex.org/W4281770536","https://openalex.org/W4281773857","https://openalex.org/W4283795391","https://openalex.org/W4284880560","https://openalex.org/W4289638016","https://openalex.org/W4307512598","https://openalex.org/W4308472098","https://openalex.org/W4310437249","https://openalex.org/W4312019718","https://openalex.org/W4312085095","https://openalex.org/W4367318602","https://openalex.org/W4378980763","https://openalex.org/W4381799391","https://openalex.org/W4382393918","https://openalex.org/W4382632603","https://openalex.org/W4382918816","https://openalex.org/W4383217259","https://openalex.org/W4386944597","https://openalex.org/W4387256971","https://openalex.org/W4389097378","https://openalex.org/W4390940567","https://openalex.org/W4390979659","https://openalex.org/W4391383725","https://openalex.org/W4391595218","https://openalex.org/W4392133511","https://openalex.org/W4392710902","https://openalex.org/W4392757422","https://openalex.org/W4392773060","https://openalex.org/W4393144087","https://openalex.org/W4396867908","https://openalex.org/W4397007740","https://openalex.org/W4400255096","https://openalex.org/W4400368753","https://openalex.org/W4401045394","https://openalex.org/W4401376459","https://openalex.org/W4401525599","https://openalex.org/W4402299039","https://openalex.org/W4402537884","https://openalex.org/W4402549795","https://openalex.org/W4402732453","https://openalex.org/W4402827811","https://openalex.org/W4402853246","https://openalex.org/W4403369705","https://openalex.org/W4404733480","https://openalex.org/W4405368190","https://openalex.org/W4406380112","https://openalex.org/W4407439102","https://openalex.org/W4407927815","https://openalex.org/W4409112481","https://openalex.org/W4409359766","https://openalex.org/W4409412590","https://openalex.org/W4409412632","https://openalex.org/W4409781726","https://openalex.org/W4409980433","https://openalex.org/W4410027902","https://openalex.org/W4410083443","https://openalex.org/W4410096406","https://openalex.org/W4410133420","https://openalex.org/W4410350900","https://openalex.org/W4411238441","https://openalex.org/W4411346552","https://openalex.org/W4413004043","https://openalex.org/W4413344633","https://openalex.org/W4414106285","https://openalex.org/W4414295131","https://openalex.org/W4414402154","https://openalex.org/W4414417708","https://openalex.org/W4414459673","https://openalex.org/W4414616265","https://openalex.org/W4415071837","https://openalex.org/W4415081074","https://openalex.org/W4415507537","https://openalex.org/W4415741355","https://openalex.org/W4415929050","https://openalex.org/W4415964301","https://openalex.org/W4415994575","https://openalex.org/W4416235305","https://openalex.org/W4416309232","https://openalex.org/W4416392922","https://openalex.org/W4416716777","https://openalex.org/W4416807094","https://openalex.org/W4416934138","https://openalex.org/W4417066145","https://openalex.org/W4417121382","https://openalex.org/W4417261691","https://openalex.org/W4417497903","https://openalex.org/W4417524110","https://openalex.org/W7118073265","https://openalex.org/W7119520477","https://openalex.org/W7123355258","https://openalex.org/W7125984442","https://openalex.org/W7128598212","https://openalex.org/W7128908174","https://openalex.org/W7130335508","https://openalex.org/W7130394411","https://openalex.org/W7130549407","https://openalex.org/W7131252388","https://openalex.org/W7131395569","https://openalex.org/W7131432207","https://openalex.org/W7132840593","https://openalex.org/W7134913433","https://openalex.org/W7138123742","https://openalex.org/W7138866011","https://openalex.org/W7140305800","https://openalex.org/W7143276371","https://openalex.org/W7153552234","https://openalex.org/W7156313586","https://openalex.org/W7163323865","https://openalex.org/W7165622571"],"related_works":[],"abstract_inverted_index":{"Chronic":[0],"diabetic":[1,7,27,98,153,193,230],"wounds,":[2,194],"most":[3,15],"commonly":[4],"presenting":[5],"as":[6,91],"foot":[8],"ulcers":[9],"(DFUs),":[10],"represent":[11],"one":[12],"of":[13,18,26,36,73,83,123,182,200,225],"the":[14,80,120,134,148,213,222],"devastating":[16],"complications":[17],"diabetes":[19],"mellitus.":[20],"They":[21],"affect":[22],"a":[23,60,92,126,197],"large":[24],"proportion":[25],"patients":[28,49],"worldwide":[29],"and":[30,43,110,172,204,215],"are":[31],"associated":[32],"with":[33,125],"elevated":[34],"risks":[35],"non-traumatic":[37],"lower":[38],"limb":[39],"amputation,":[40],"high":[41],"mortality,":[42],"substantial":[44],"socioeconomic":[45],"burden.":[46],"Many":[47],"affected":[48],"fail":[50],"to":[51,158,220],"achieve":[52],"complete":[53],"wound":[54,99,143,169],"closure":[55],"following":[56],"standard-of-care":[57],"treatment,":[58],"highlighting":[59],"critical":[61,198],"unmet":[62],"need":[63],"for":[64,167,192,228],"novel":[65],"mechanism-driven":[66],"therapeutic":[67,174,190],"targets.":[68],"Ferroptosis,":[69],"an":[70],"iron-dependent":[71],"form":[72],"regulated":[74],"cell":[75,138],"death":[76],"(RCD)":[77],"driven":[78],"by":[79,104,196],"lethal":[81],"accumulation":[82],"lipid":[84,112],"peroxides,":[85],"has":[86],"emerged":[87],"in":[88,141,151,212],"recent":[89],"years":[90],"key":[93],"pathogenic":[94],"mechanism":[95],"underlying":[96],"impaired":[97],"repair.":[100],"Ferroptosis":[101],"is":[102,185],"defined":[103],"glutathione":[105],"depletion,":[106],"intracellular":[107],"iron":[108],"overload,":[109],"unrestrained":[111],"peroxidation.":[113],"This":[114],"review":[115,184],"synthesizes":[116],"current":[117],"evidence":[118],"regarding":[119],"regulatory":[121],"mechanisms":[122],"ferroptosis,":[124],"particular":[127],"focus":[128],"on":[129,133,187],"its":[130],"detrimental":[131],"effects":[132],"four":[135],"major":[136],"wound-repair-associated":[137],"populations":[139],"involved":[140],"cutaneous":[142],"healing.":[144],"Furthermore,":[145],"we":[146,208],"delineate":[147],"pathological":[149],"alterations":[150],"chronic":[152,229],"wounds":[154],"that":[155,162],"sensitize":[156],"cells":[157],"ferroptosis.":[159],"Ferroptosis-related":[160],"biomarkers":[161],"may":[163],"have":[164],"clinical":[165,223],"utility":[166],"predicting":[168],"healing":[170],"prognosis":[171],"monitoring":[173],"responses":[175],"were":[176],"also":[177],"evaluated.":[178],"A":[179],"central":[180],"emphasis":[181],"this":[183],"placed":[186],"emerging":[188],"anti-ferroptotic":[189],"strategies":[191],"accompanied":[195],"appraisal":[199],"their":[201],"preclinical":[202],"efficacy":[203],"translational":[205],"potential.":[206],"Finally,":[207],"discuss":[209],"prevailing":[210],"challenges":[211],"field":[214],"propose":[216],"future":[217],"research":[218],"directions":[219],"accelerate":[221],"translation":[224],"ferroptosis-targeted":[226],"therapies":[227],"wounds.":[231]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}