{"id":"https://openalex.org/W7225797437","doi":"https://doi.org/10.3390/ijms272210094","title":"Integrated Comparative Analysis Reveals Structural Diversification and Functional Associations of Arabidopsis DEAD-Box RNA Helicases","display_name":"Integrated Comparative Analysis Reveals Structural Diversification and Functional Associations of Arabidopsis DEAD-Box RNA Helicases","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225797437","doi":"https://doi.org/10.3390/ijms272210094"},"language":"en","primary_location":{"id":"doi:10.3390/ijms272210094","doi":"https://doi.org/10.3390/ijms272210094","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210094","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms272210094","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004176037","display_name":"Sara Fontcuberta-Cervera","orcid":"https://orcid.org/0000-0001-9410-6946","observed_orcids":["https://orcid.org/0000-0001-9410-6946"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sara Fontcuberta-Cervera","raw_affiliation_strings":["Instituto de Bioingenier\u00eda, Universidad Miguel Hern\u00e1ndez, Campus de Elche, 03202 Elche, Alicante, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9410-6946","affiliations":[{"raw_affiliation_string":"Instituto de Bioingenier\u00eda, Universidad Miguel Hern\u00e1ndez, Campus de Elche, 03202 Elche, Alicante, Spain","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020598101","display_name":"Mar\u00eda Rosa Ponce","orcid":"https://orcid.org/0000-0003-0770-4230","observed_orcids":["https://orcid.org/0000-0003-0770-4230"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Rosa Ponce","raw_affiliation_strings":["Instituto de Bioingenier\u00eda, Universidad Miguel Hern\u00e1ndez, Campus de Elche, 03202 Elche, Alicante, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0770-4230","affiliations":[{"raw_affiliation_string":"Instituto de Bioingenier\u00eda, Universidad Miguel Hern\u00e1ndez, Campus de Elche, 03202 Elche, Alicante, Spain","institution_ids":["https://openalex.org/I111262870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020598101"],"corresponding_institution_ids":["https://openalex.org/I111262870"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"22","first_page":"10094","last_page":"10094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.4255000054836273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8899999856948853},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.7193999886512756},{"id":"https://openalex.org/C34957205","wikidata":"https://www.wikidata.org/wiki/Q277338","display_name":"Pseudogene","level":4,"score":0.6572999954223633},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6531999707221985},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5958999991416931},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.5512999892234802},{"id":"https://openalex.org/C68592252","wikidata":"https://www.wikidata.org/wiki/Q17913854","display_name":"RNA Helicase A","level":5,"score":0.5422999858856201},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5259000062942505},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5170999765396118},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.462799996137619},{"id":"https://openalex.org/C188880781","wikidata":"https://www.wikidata.org/wiki/Q2430501","display_name":"Three-domain system","level":4,"score":0.45829999446868896},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43320000171661377},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.4235000014305115},{"id":"https://openalex.org/C2777938546","wikidata":"https://www.wikidata.org/wiki/Q5","display_name":"Homo sapiens","level":2,"score":0.4147999882698059},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.3720000088214874},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3709000051021576},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.3630000054836273},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.3366999924182892},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.33219999074935913},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.3296000063419342},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.32749998569488525},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.30489999055862427},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.304500013589859},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.2824999988079071},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.2712000012397766}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms272210094","doi":"https://doi.org/10.3390/ijms272210094","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210094","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms272210094","doi":"https://doi.org/10.3390/ijms272210094","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210094","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":137,"referenced_works":["https://openalex.org/W102715436","https://openalex.org/W1867346435","https://openalex.org/W1965962521","https://openalex.org/W1967222028","https://openalex.org/W1969123603","https://openalex.org/W1978547782","https://openalex.org/W1978847462","https://openalex.org/W1994125590","https://openalex.org/W1994717822","https://openalex.org/W1995100160","https://openalex.org/W1996690481","https://openalex.org/W2009395178","https://openalex.org/W2011383767","https://openalex.org/W2014825330","https://openalex.org/W2025479911","https://openalex.org/W2028007077","https://openalex.org/W2033744628","https://openalex.org/W2035336413","https://openalex.org/W2036650968","https://openalex.org/W2037456549","https://openalex.org/W2037978116","https://openalex.org/W2041595366","https://openalex.org/W2042537644","https://openalex.org/W2047179560","https://openalex.org/W2047624476","https://openalex.org/W2049252087","https://openalex.org/W2051848082","https://openalex.org/W2055957092","https://openalex.org/W2056746971","https://openalex.org/W2061685498","https://openalex.org/W2061967064","https://openalex.org/W2069460765","https://openalex.org/W2087195619","https://openalex.org/W2094750367","https://openalex.org/W2097681319","https://openalex.org/W2098489135","https://openalex.org/W2101617498","https://openalex.org/W2109147807","https://openalex.org/W2110335151","https://openalex.org/W2114850508","https://openalex.org/W2115025826","https://openalex.org/W2117260329","https://openalex.org/W2117381795","https://openalex.org/W2118115270","https://openalex.org/W2123957786","https://openalex.org/W2124815451","https://openalex.org/W2128456221","https://openalex.org/W2132888497","https://openalex.org/W2132926880","https://openalex.org/W2135834023","https://openalex.org/W2138098955","https://openalex.org/W2138347882","https://openalex.org/W2141292707","https://openalex.org/W2144636061","https://openalex.org/W2147159495","https://openalex.org/W2148016800","https://openalex.org/W2155239677","https://openalex.org/W2155471967","https://openalex.org/W2155704264","https://openalex.org/W2156773881","https://openalex.org/W2162001612","https://openalex.org/W2166663904","https://openalex.org/W2167905787","https://openalex.org/W2268617882","https://openalex.org/W2279082649","https://openalex.org/W2280364009","https://openalex.org/W2336535279","https://openalex.org/W2341861303","https://openalex.org/W2342979098","https://openalex.org/W2468838547","https://openalex.org/W2473595169","https://openalex.org/W2517720692","https://openalex.org/W2557794320","https://openalex.org/W2604750784","https://openalex.org/W2614227967","https://openalex.org/W2766795794","https://openalex.org/W2768603262","https://openalex.org/W2789922055","https://openalex.org/W2789938322","https://openalex.org/W2792861625","https://openalex.org/W2792918872","https://openalex.org/W2810876945","https://openalex.org/W2816930172","https://openalex.org/W2903281649","https://openalex.org/W2913625143","https://openalex.org/W2924491056","https://openalex.org/W2940443859","https://openalex.org/W2942759699","https://openalex.org/W2946921443","https://openalex.org/W2976346201","https://openalex.org/W3000639767","https://openalex.org/W3003695200","https://openalex.org/W3008645643","https://openalex.org/W3012068569","https://openalex.org/W3015467071","https://openalex.org/W3016960651","https://openalex.org/W3017259446","https://openalex.org/W3029953567","https://openalex.org/W3036789314","https://openalex.org/W3121956420","https://openalex.org/W3129539500","https://openalex.org/W3132769338","https://openalex.org/W3175699012","https://openalex.org/W3196623616","https://openalex.org/W3212441795","https://openalex.org/W4200263380","https://openalex.org/W4200428158","https://openalex.org/W4206875024","https://openalex.org/W4220966290","https://openalex.org/W4289711454","https://openalex.org/W4308634992","https://openalex.org/W4309828928","https://openalex.org/W4317931724","https://openalex.org/W4380574528","https://openalex.org/W4383483284","https://openalex.org/W4383497886","https://openalex.org/W4386468736","https://openalex.org/W4392348350","https://openalex.org/W4392600686","https://openalex.org/W4394694796","https://openalex.org/W4399385519","https://openalex.org/W4399701695","https://openalex.org/W4400345361","https://openalex.org/W4400391966","https://openalex.org/W4401725080","https://openalex.org/W4403146478","https://openalex.org/W4403479110","https://openalex.org/W4404276311","https://openalex.org/W4404458588","https://openalex.org/W4404511434","https://openalex.org/W4407930754","https://openalex.org/W4409875822","https://openalex.org/W4411516105","https://openalex.org/W4416608069","https://openalex.org/W7139073441","https://openalex.org/W7166553713","https://openalex.org/W7171440502"],"related_works":[],"abstract_inverted_index":{"DEAD-box":[0,42,153,247,299],"RNA":[1,14],"helicases":[2],"(RHs)":[3],"constitute":[4],"one":[5],"of":[6,13,25,37,53,59,72,126,138,143,149,215,234,242,267,271,296],"the":[7,20,38,91,139,144,150,156,179,195,225,265,283,291,297],"largest":[8],"and":[9,23,56,76,83,100,108,112,120,147,166,206,224,236,249,280,293],"most":[10],"conserved":[11,105],"families":[12],"metabolism":[15],"factors":[16],"in":[17,136,190,210,264],"eukaryotes,":[18],"yet":[19],"evolutionary":[21],"relationships":[22],"functions":[24],"many":[26],"plant":[27],"members":[28],"remain":[29],"unresolved.":[30],"We":[31],"present":[32],"an":[33,286],"integrated":[34,287],"comparative":[35,51],"analysis":[36],"Arabidopsis":[39,246,298],"thaliana":[40],"(Arabidopsis)":[41],"RH":[43,300],"family":[44],"by":[45,178],"combining":[46],"structural":[47,292],"curation,":[48],"orthology":[49],"inference,":[50],"analyses":[52,125,241],"protein":[54,127],"features,":[55],"cross-species":[57],"comparisons":[58,115],"biological":[60],"pathway":[61,239],"enrichment":[62,240],"among":[63],"co-expressed":[64,244],"genes.":[65],"Structural":[66],"curation":[67],"established":[68],"a":[69,212,253],"reference":[70],"set":[71],"53":[73],"intact":[74],"genes":[75,243],"four":[77],"putative":[78,109],"pseudogenes":[79],"(RH43,":[80],"RH44,":[81],"RH45,":[82],"RH55)":[84],"for":[85,255,259,289],"subsequent":[86],"analyses.":[87],"Orthology":[88],"inference":[89],"using":[90],"DRSC":[92],"Integrative":[93],"Ortholog":[94],"Prediction":[95],"Tool":[96],"(DIOPT)":[97],"identified":[98,209],"high-":[99],"moderate-confidence":[101],"orthologous":[102],"relationships,":[103],"revealed":[104,129],"helicase":[106,226],"lineages":[107],"lineage-specific":[110],"expansions,":[111],"enabled":[113],"systematic":[114],"with":[116,186,245],"Saccharomyces":[117],"cerevisiae":[118],"(yeast)":[119],"Homo":[121],"sapiens":[122],"(humans).":[123],"Comparative":[124],"features":[128],"that":[130,194],"non-canonical":[131],"DExD-box":[132],"motif":[133],"variants":[134,170],"occur":[135],"10":[137],"57":[140],"Arabidopsis,":[141],"three":[142],"26":[145],"yeast,":[146],"five":[148],"38":[151],"human":[152],"RHs.":[154],"Although":[155,274],"DECD":[157],"variant":[158],"appears":[159],"to":[160,308],"be":[161,306],"shared":[162],"across":[163],"plant,":[164],"fungal,":[165],"metazoan":[167],"lineages,":[168,192],"other":[169,309],"show":[171],"restricted":[172],"or":[173],"patchy":[174],"distributions,":[175],"as":[176],"exemplified":[177],"DEVD":[180],"variant,":[181],"whose":[182],"distribution":[183],"is":[184,199],"consistent":[185],"its":[187],"independent":[188],"emergence":[189],"several":[191],"indicating":[193],"canonical":[196],"DEAD":[197],"sequence":[198],"not":[200],"universally":[201],"conserved.":[202,231],"Annotated":[203],"accessory":[204],"motifs":[205],"domains":[207],"were":[208],"only":[211],"small":[213],"subset":[214],"proteins,":[216,262],"although":[217],"annotation-based":[218],"counts":[219],"probably":[220],"underestimate":[221],"their":[222,250],"frequency,":[223],"core":[227],"architecture":[228],"was":[229],"broadly":[230],"Kyoto":[232],"Encyclopedia":[233],"Genes":[235],"Genomes":[237],"(KEGG)":[238],"RHs":[248],"orthologs":[251],"provided":[252],"basis":[254],"generating":[256],"functional":[257,294],"hypotheses":[258,276],"previously":[260],"uncharacterized":[261],"even":[263],"absence":[266],"prior":[268],"experimental":[269,281],"evidence":[270],"ortholog":[272],"function.":[273],"these":[275],"require":[277],"further":[278],"investigation":[279],"validation,":[282],"findings":[284],"provide":[285],"framework":[288],"investigating":[290],"diversification":[295],"family.":[301],"This":[302],"approach":[303],"may":[304],"also":[305],"extended":[307],"poorly":[310],"characterized":[311],"multigene":[312],"families.":[313]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}