{"id":"https://openalex.org/W7225797387","doi":"https://doi.org/10.1111/1744-1633.70116","title":"Effect of Melatonin on Interleukin\u20106 and C\u2010Reactive Protein in Neonates Undergoing Surgery","display_name":"Effect of Melatonin on Interleukin\u20106 and C\u2010Reactive Protein in Neonates Undergoing Surgery","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225797387","doi":"https://doi.org/10.1111/1744-1633.70116"},"language":"en","primary_location":{"id":"doi:10.1111/1744-1633.70116","doi":"https://doi.org/10.1111/1744-1633.70116","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1744-1633.70116","pdf_url":null,"source":{"id":"https://openalex.org/S101670428","display_name":"Surgical Practice","issn_l":"1744-1625","issn":["1744-1625","1744-1633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046369032","display_name":"Reza Saeidi","orcid":"https://orcid.org/0000-0002-9033-3321","observed_orcids":["https://orcid.org/0000-0002-9033-3321"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Reza Saeidi","raw_affiliation_strings":["Neonatal Health Research Center Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences  Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-9033-3321","affiliations":[{"raw_affiliation_string":"Neonatal Health Research Center Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences  Tehran Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002966185","display_name":"Abdollah Karimi","orcid":"https://orcid.org/0000-0003-4599-1496","observed_orcids":["https://orcid.org/0000-0003-4599-1496","https://orcid.org/0000-0002-4225-0097"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abdollah Karimi","raw_affiliation_strings":["Pediatric Infections Research Center Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences  Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-4225-0097","affiliations":[{"raw_affiliation_string":"Pediatric Infections Research Center Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences  Tehran Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161495166","display_name":"Elnaz Nobakht","orcid":"https://orcid.org/0000-0002-9092-7672","observed_orcids":["https://orcid.org/0000-0002-9092-7672"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Elnaz Nobakht","raw_affiliation_strings":["Neonatal Health Research Center Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences  Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-9092-7672","affiliations":[{"raw_affiliation_string":"Neonatal Health Research Center Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences  Tehran Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094242225","display_name":"Mohammad Kordkatouli","orcid":"https://orcid.org/0009-0006-3008-6820","observed_orcids":["https://orcid.org/0009-0006-3008-6820"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I41775361","display_name":"Islamic Azad University Central Tehran Branch","ror":"https://ror.org/03a11m818","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I41775361"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Kordkatouli","raw_affiliation_strings":["Applied Biotechnology Research Center, TeMS.C Islamic Azad University  Tehran Iran","Department of Genetics, Faculty of Advanced Sciences and Technology, TeMS.C Islamic Azad University  Tehran Iran"],"raw_orcid":"https://orcid.org/0009-0006-3008-6820","affiliations":[{"raw_affiliation_string":"Applied Biotechnology Research Center, TeMS.C Islamic Azad University  Tehran Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I41775361"]},{"raw_affiliation_string":"Department of Genetics, Faculty of Advanced Sciences and Technology, TeMS.C Islamic Azad University  Tehran Iran","institution_ids":["https://openalex.org/I110525433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161432282","display_name":"Farnoosh Keshavarzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farnoosh Keshavarzi","raw_affiliation_strings":["Mofid Children's Hospital  Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mofid Children's Hospital  Tehran Iran","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161472304","display_name":"Zari Gholinezhad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zari Gholinezhad","raw_affiliation_strings":["Mofid Children's Hospital  Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mofid Children's Hospital  Tehran Iran","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5094242225","https://openalex.org/A5161495166"],"corresponding_institution_ids":["https://openalex.org/I110525433","https://openalex.org/I41775361","https://openalex.org/I48379061","https://openalex.org/I58048189"],"apc_list":{"value":2760,"currency":"USD","value_usd":2760},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.974399983882904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9309999942779541},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.739799976348877},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.70660001039505},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5949000120162964},{"id":"https://openalex.org/C3017583242","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Placebo group","level":4,"score":0.5647000074386597},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5372999906539917},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4325999915599823},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42260000109672546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4034000039100647},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3675999939441681},{"id":"https://openalex.org/C2780120127","wikidata":"https://www.wikidata.org/wiki/Q743664","display_name":"Abdominal surgery","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/1744-1633.70116","doi":"https://doi.org/10.1111/1744-1633.70116","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1744-1633.70116","pdf_url":null,"source":{"id":"https://openalex.org/S101670428","display_name":"Surgical Practice","issn_l":"1744-1625","issn":["1744-1625","1744-1633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Practice","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2089758120","https://openalex.org/W2156233785","https://openalex.org/W2169986008","https://openalex.org/W2789394686","https://openalex.org/W2996262831","https://openalex.org/W3030413681","https://openalex.org/W3104170506","https://openalex.org/W3122803921","https://openalex.org/W3135528850","https://openalex.org/W3183286355","https://openalex.org/W4293276053","https://openalex.org/W4319455609","https://openalex.org/W4387744829","https://openalex.org/W4389100660","https://openalex.org/W4400927757","https://openalex.org/W4413006586","https://openalex.org/W7131405401","https://openalex.org/W7161277268","https://openalex.org/W7167665825"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Neonatal":[2],"surgery":[3,69,80],"induces":[4],"a":[5,256],"significant":[6,177,185,211,275],"systemic":[7],"inflammatory":[8],"response":[9],"mediated":[10],"by":[11],"cytokines":[12],"such":[13],"as":[14],"IL\u20106":[15,44,138,157,248,279],"and":[16,22,45,105,111,143,206,249],"CRP.":[17],"Melatonin":[18],"has":[19],"well\u2010established":[20],"antioxidant":[21],"anti\u2010inflammatory":[23],"properties,":[24],"but":[25,194],"data":[26],"in":[27,48,160,171,186,196,218,266,278,280],"neonates":[28,49,60],"remain":[29],"limited.":[30],"This":[31,53],"study":[32],"aimed":[33],"to":[34,151,253,289],"evaluate":[35],"the":[36,115,132,161,169,172,187,197,221,227,267,270,274,281],"effect":[37],"of":[38,64,220,226,269],"adjunctive":[39],"oral":[40,87],"melatonin":[41,88,133,173,188,228,241],"on":[42],"serum":[43],"CRP":[46,104,144,182,250],"levels":[47,149,251],"undergoing":[50,66],"surgery.":[51,125],"Methods":[52],"randomized,":[54],"double\u2010blind,":[55],"placebo\u2010controlled":[56],"trial":[57],"included":[58],"40":[59],"under":[61],"1":[62],"month":[63],"age":[65],"major":[67],"abdominal":[68],"at":[70,109],"Mofid":[71],"Children's":[72],"Hospital,":[73],"Tehran":[74],"(2023\u20132024).":[75],"Positive":[76],"blood":[77,215],"culture":[78],"before":[79],"was":[81,175,184,242],"an":[82],"exclusion":[83],"criterion.":[84],"Neonates":[85],"received":[86],"(0.1":[89],"mg/kg/day,":[90],"n":[91,97],"=":[92,98,141,147,166,180,192,202,232],"20)":[93,99],"or":[94],"placebo":[95,162,198,222,282],"(":[96,139,145,164,178,190,200,230],"for":[100],"3":[101],"days.":[102],"IL\u20106,":[103],"WBC":[106,204],"were":[107,120,129,237],"measured":[108],"baseline":[110],"72":[112,122],"h":[113,123],"after":[114,124],"last":[116],"dose.":[117],"Blood":[118],"cultures":[119,216],"repeated":[121],"Results":[126],"Baseline":[127],"characteristics":[128],"comparable.":[130],"Post\u2010intervention,":[131],"group":[134,163,174,189,199,223,229],"showed":[135,209],"significantly":[136,159,245],"lower":[137,246],"p":[140,146,165,179,191,201,231],"0.0102)":[142],"0.0156)":[148],"compared":[150,252],"placebo.":[152],"Within\u2010group":[153],"analysis":[154],"revealed":[155],"that":[156],"increased":[158],"0.003),":[167],"whereas":[168],"decrease":[170],"not":[176,195],"0.09).":[181],"reduction":[183],"0.01)":[193],"0.65).":[203],"counts":[205],"hospital":[207],"stay":[208],"no":[210],"differences.":[212],"Postoperative":[213],"positive":[214],"occurred":[217],"35%":[219],"versus":[224],"10%":[225],"0.118).":[233],"No":[234],"adverse":[235],"events":[236],"reported.":[238],"Conclusion":[239],"Perioperative":[240],"associated":[243],"with":[244,255],"postoperative":[247,276],"placebo,":[254],"favourable":[257],"safety":[258],"profile.":[259],"These":[260],"between\u2010group":[261],"differences":[262],"should":[263],"be":[264],"interpreted":[265],"context":[268],"within\u2010group":[271],"findings,":[272],"including":[273],"rise":[277],"group.":[283],"Larger":[284],"multicenter":[285],"trials":[286],"are":[287],"needed":[288],"confirm":[290],"these":[291],"findings.":[292]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}