{"id":"https://openalex.org/W7225797281","doi":"https://doi.org/10.18502/acta.v64i10.23200","title":"Diagnostic Performance of a Salivary Extracellular-Vesicle microRNA Panel for Endometriosis: A Prospective Case-Control Development Study Without Diagnostic Imaging","display_name":"Diagnostic Performance of a Salivary Extracellular-Vesicle microRNA Panel for Endometriosis: A Prospective Case-Control Development Study Without Diagnostic Imaging","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225797281","doi":"https://doi.org/10.18502/acta.v64i10.23200"},"language":"en","primary_location":{"id":"doi:10.18502/acta.v64i10.23200","doi":"https://doi.org/10.18502/acta.v64i10.23200","is_oa":true,"landing_page_url":"https://doi.org/10.18502/acta.v64i10.23200","pdf_url":null,"source":{"id":"https://openalex.org/S2754060852","display_name":"ACTA MEDICA IRANICA","issn_l":"0044-6025","issn":["0044-6025","1735-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319141","host_organization_name":"Tehran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319141"],"host_organization_lineage_names":["Tehran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA MEDICA IRANICA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18502/acta.v64i10.23200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161455520","display_name":"Marwa Habeeb Nazza Eswad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202735123","display_name":"Thi Qar University","ror":"https://ror.org/02ypa8k59","country_code":"IQ","type":"education","lineage":["https://openalex.org/I202735123"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Marwa Habeeb Nazza Eswad","raw_affiliation_strings":["Department of Gynecology and Obstetrics, College of Medicine, University of Thi-Qar, Nasiriyah, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, College of Medicine, University of Thi-Qar, Nasiriyah, Iraq","institution_ids":["https://openalex.org/I202735123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077505427","display_name":"Aseel Mosa Jabber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202735123","display_name":"Thi Qar University","ror":"https://ror.org/02ypa8k59","country_code":"IQ","type":"education","lineage":["https://openalex.org/I202735123"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Aseel Mosa Jabber","raw_affiliation_strings":["Department of Gynecology and Obstetrics, College of Medicine, University of Thi-Qar, Nasiriyah, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, College of Medicine, University of Thi-Qar, Nasiriyah, Iraq","institution_ids":["https://openalex.org/I202735123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161420826","display_name":"Wassan Raheem Mubark Al khafajy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202735123","display_name":"Thi Qar University","ror":"https://ror.org/02ypa8k59","country_code":"IQ","type":"education","lineage":["https://openalex.org/I202735123"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Wassan Raheem Mubark Al khafajy","raw_affiliation_strings":["Department of Gynecology and Obstetrics, College of Medicine, University of Thi-Qar, Nasiriyah, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, College of Medicine, University of Thi-Qar, Nasiriyah, Iraq","institution_ids":["https://openalex.org/I202735123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I202735123"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9538999795913696},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.7160999774932861},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6687999963760376},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5730999708175659},{"id":"https://openalex.org/C170964787","wikidata":"https://www.wikidata.org/wiki/Q7611170","display_name":"Stepwise regression","level":2,"score":0.5254999995231628},{"id":"https://openalex.org/C2777120189","wikidata":"https://www.wikidata.org/wiki/Q780067","display_name":"Triage","level":2,"score":0.5080000162124634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49639999866485596},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.43050000071525574},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.36649999022483826},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.36559998989105225},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.3587000072002411},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3359000086784363},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.328000009059906},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.3199000060558319},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3149000108242035},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.30709999799728394},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18502/acta.v64i10.23200","doi":"https://doi.org/10.18502/acta.v64i10.23200","is_oa":true,"landing_page_url":"https://doi.org/10.18502/acta.v64i10.23200","pdf_url":null,"source":{"id":"https://openalex.org/S2754060852","display_name":"ACTA MEDICA IRANICA","issn_l":"0044-6025","issn":["0044-6025","1735-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319141","host_organization_name":"Tehran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319141"],"host_organization_lineage_names":["Tehran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA MEDICA IRANICA","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18502/acta.v64i10.23200","doi":"https://doi.org/10.18502/acta.v64i10.23200","is_oa":true,"landing_page_url":"https://doi.org/10.18502/acta.v64i10.23200","pdf_url":null,"source":{"id":"https://openalex.org/S2754060852","display_name":"ACTA MEDICA IRANICA","issn_l":"0044-6025","issn":["0044-6025","1735-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319141","host_organization_name":"Tehran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319141"],"host_organization_lineage_names":["Tehran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA MEDICA IRANICA","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Endometriosis":[0,167],"is":[1,9,23,323,340],"a":[2,147,248,257,281],"chronic":[3,72],"inflammatory":[4],"disease":[5],"for":[6,27,286,327],"which":[7],"diagnosis":[8],"often":[10],"delayed":[11],"and,":[12],"in":[13,69,233,333],"many":[14],"patients,":[15],"still":[16],"relies":[17],"on":[18],"invasive":[19],"confirmation.":[20],"Consequently,":[21],"there":[22],"an":[24,212,266],"urgent":[25],"need":[26],"non-invasive":[28],"biomarkers":[29],"to":[30,188,343],"support":[31],"triage":[32],"and":[33,49,105,116,131,144,162,177,179,185,192,205,229,265,314,336],"clinical":[34,67,77,245,329],"assessment.":[35],"This":[36],"developmental-phase":[37],"prospective":[38],"diagnostic":[39,284,345],"case-control":[40,236,297],"study":[41],"included":[42],"25":[43,50],"women":[44,70],"with":[45,211,292],"surgically":[46,307],"documented":[47],"endometriosis":[48],"gynecologic":[51],"control":[52],"participants.":[53],"Control":[54],"status":[55],"was":[56,88,138,153,209,227,231],"verified":[57,303],"by":[58,65,103,125,128],"prior":[59,342],"negative":[60,308],"laparoscopy":[61],"where":[62,119],"available,":[63],"or":[64,82],"structured":[66],"assessment":[68,118],"without":[71],"pelvic":[73],"pain,":[74],"moderate-to-severe":[75],"dysmenorrhea,":[76],"suspicion":[78],"of":[79,174,182,214,223,252,260,270,301,317],"deep":[80],"disease,":[81],"elevated":[83],"CA-125.":[84],"Unstimulated":[85],"whole":[86],"saliva":[87],"collected":[89],"under":[90],"standardized":[91,202],"conditions.":[92],"Salivary":[93],"extracellular":[94],"vesicles":[95],"(EVs)":[96],"were":[97,106,123],"isolated":[98],"using":[99,155,241],"size-exclusion":[100],"chromatography":[101],"followed":[102],"ultrafiltration,":[104],"characterized":[107],"via":[108],"protein":[109],"quantification,":[110],"CD63/CD81":[111],"ELISAs,":[112],"hemoglobin":[113],"absorbance":[114],"screening,":[115],"particle":[117],"available.":[120],"Candidate":[121],"miRNAs":[122],"measured":[124],"RT-qPCR,":[126],"normalized":[127,141],"global-mean":[129],"\u0394Ct,":[130],"log2-transformed.":[132],"A":[133],"LASSO":[134],"logistic":[135],"regression":[136],"model":[137,200],"developed":[139],"from":[140],"miRNA":[142,278],"expression":[143],"refitted":[145],"as":[146],"parsimonious":[148],"multivariable":[149],"model.":[150],"Model":[151],"performance":[152],"summarized":[154],"ROC":[156],"analysis,":[157,161],"calibration":[158,258],"assessment,":[159],"decision-curve":[160],"planned":[163],"bootstrap":[164,249],"internal":[165],"validation.":[166],"cases":[168],"exhibited":[169],"higher":[170],"salivary":[171,276],"EV":[172,277],"levels":[173,181],"miR-451a,":[175,203],"miR-21-5p,":[176,204],"miR-125b-5p,":[178],"lower":[180],"let-7a-5p,":[183],"let-7d-5p,":[184],"miR-200c-3p":[186],"compared":[187],"controls,":[189,309],"while":[190],"miR-16-5p":[191],"miR-191-5p":[193],"remained":[194],"relatively":[195],"stable.":[196],"The":[197,275],"final":[198],"three-miRNA":[199],"retained":[201],"miR-200c-3p.":[206],"Apparent":[207],"discrimination":[208],"high,":[210],"AUC":[213,251],"0.902":[215],"(95%":[216,254,262,272],"CI:":[217,255,263,273],"0.814\u20130.991).":[218],"At":[219],"the":[220,242,295,299,310,315],"Youden-index":[221],"threshold":[222],"0.502,":[224],"apparent":[225],"sensitivity":[226],"88%":[228],"specificity":[230],"96%":[232],"this":[234,321],"balanced":[235,296],"cohort.":[237],"Internal":[238],"validation":[239,332],"performed":[240],"observed":[243],"individual-level":[244],"dataset":[246],"yielded":[247],"optimism-corrected":[250,267],"0.847":[253],"0.739-0.938),":[256],"slope":[259],"0.78":[261],"0.42-1.16),":[264],"Brier":[268],"score":[269],"0.142":[271],"0.102-0.188).":[274],"panel":[279,322],"demonstrates":[280],"promising":[282],"developmental":[283],"signal":[285],"endometriosis,":[287],"alongside":[288],"biologically":[289],"coherent":[290],"associations":[291],"pain.":[293],"However,":[294],"design,":[298],"use":[300],"clinically":[302,337],"rather":[304],"than":[305],"uniformly":[306],"small":[311],"sample":[312],"size,":[313],"risk":[316],"overfitting":[318],"indicate":[319],"that":[320],"not":[324],"yet":[325],"ready":[326],"stand-alone":[328],"use.":[330],"External":[331],"larger,":[334],"multicenter,":[335],"representative":[338],"cohorts":[339],"required":[341],"routine":[344],"application.":[346]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}