{"id":"https://openalex.org/W7225797107","doi":"https://doi.org/10.3389/fcvm.2026.1979659","title":"Atherogenic lipoprotein particles and premature coronary artery disease: from molecular mechanisms to precision prevention","display_name":"Atherogenic lipoprotein particles and premature coronary artery disease: from molecular mechanisms to precision prevention","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225797107","doi":"https://doi.org/10.3389/fcvm.2026.1979659"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2026.1979659","doi":"https://doi.org/10.3389/fcvm.2026.1979659","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1979659","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcvm.2026.1979659","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137009666","display_name":"GuangRong Zhang","orcid":"https://orcid.org/0009-0001-7843-5683","observed_orcids":["https://orcid.org/0009-0001-7843-5683"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangrong Zhang","raw_affiliation_strings":["Department of Cardiology, Suining Central Hospital","Department of Clinical Medicine, North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Suining Central Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Clinical Medicine, North Sichuan Medical College","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040403775","display_name":"Longzhou Chen","orcid":"https://orcid.org/0009-0000-8719-2487","observed_orcids":["https://orcid.org/0009-0000-8719-2487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Longzhou Chen","raw_affiliation_strings":["Department of Cardiology, Suining Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Suining Central Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033732617","display_name":"\u5434\u5b66\u78a7","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuebi Wu","raw_affiliation_strings":["Department of Clinical Medicine, North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, North Sichuan Medical College","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137232479","display_name":"Yongxin Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongxin Ma","raw_affiliation_strings":["Department of Clinical Medicine, North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, North Sichuan Medical College","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124334666","display_name":"Wencai Jiang","orcid":"https://orcid.org/0000-0001-5017-2837","observed_orcids":["https://orcid.org/0000-0001-5017-2837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wencai Jiang","raw_affiliation_strings":["Department of Cardiology, Suining Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Suining Central Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161454631","display_name":"Gang Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang Huang","raw_affiliation_strings":["Department of Cardiology, Suining Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Suining Central Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043340788","display_name":"Xuejun Deng","orcid":"https://orcid.org/0000-0001-5414-0007","observed_orcids":["https://orcid.org/0000-0001-5414-0007"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xuejun Deng","raw_affiliation_strings":["Department of Cardiology, Suining Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Suining Central Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043340788"],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C11772777","wikidata":"https://www.wikidata.org/wiki/Q423126","display_name":"Chylomicron","level":5,"score":0.7250000238418579},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7074999809265137},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6912000179290771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5784000158309937},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5527999997138977},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.4982999861240387},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43970000743865967},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.43700000643730164},{"id":"https://openalex.org/C2778402494","wikidata":"https://www.wikidata.org/wiki/Q599756","display_name":"National Cholesterol Education Program","level":4,"score":0.413100004196167},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.4072999954223633},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38519999384880066},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.3440999984741211},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3384000062942505},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C2993857929","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Primary prevention","level":3,"score":0.3273000121116638},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31279999017715454},{"id":"https://openalex.org/C2776104379","wikidata":"https://www.wikidata.org/wiki/Q21112670","display_name":"Lipoprotein(a)","level":4,"score":0.2996000051498413},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.257099986076355},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcvm.2026.1979659","doi":"https://doi.org/10.3389/fcvm.2026.1979659","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1979659","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2026.1979659","doi":"https://doi.org/10.3389/fcvm.2026.1979659","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1979659","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":152,"referenced_works":["https://openalex.org/W72392028","https://openalex.org/W171081901","https://openalex.org/W1520609538","https://openalex.org/W1940197145","https://openalex.org/W1968171440","https://openalex.org/W1970055375","https://openalex.org/W1972483153","https://openalex.org/W1984970871","https://openalex.org/W1990204315","https://openalex.org/W1990679071","https://openalex.org/W1993751949","https://openalex.org/W1996810831","https://openalex.org/W2002146594","https://openalex.org/W2009013500","https://openalex.org/W2011523747","https://openalex.org/W2012344261","https://openalex.org/W2040612932","https://openalex.org/W2040770080","https://openalex.org/W2048908649","https://openalex.org/W2049054110","https://openalex.org/W2066568926","https://openalex.org/W2067539811","https://openalex.org/W2088832735","https://openalex.org/W2098230963","https://openalex.org/W2098518124","https://openalex.org/W2104355263","https://openalex.org/W2107004670","https://openalex.org/W2107134698","https://openalex.org/W2150100875","https://openalex.org/W2152086330","https://openalex.org/W2152354184","https://openalex.org/W2155121555","https://openalex.org/W2163437618","https://openalex.org/W2164089346","https://openalex.org/W2170009139","https://openalex.org/W2235916715","https://openalex.org/W2247997571","https://openalex.org/W2249128185","https://openalex.org/W2286999219","https://openalex.org/W2336656712","https://openalex.org/W2339876638","https://openalex.org/W2485128303","https://openalex.org/W2530844910","https://openalex.org/W2549881333","https://openalex.org/W2557654447","https://openalex.org/W2581493570","https://openalex.org/W2586930478","https://openalex.org/W2587693305","https://openalex.org/W2596179513","https://openalex.org/W2604768034","https://openalex.org/W2617605538","https://openalex.org/W2734430340","https://openalex.org/W2736457837","https://openalex.org/W2748400555","https://openalex.org/W2750646243","https://openalex.org/W2782889826","https://openalex.org/W2809135070","https://openalex.org/W2894645224","https://openalex.org/W2899669642","https://openalex.org/W2899997727","https://openalex.org/W2901728784","https://openalex.org/W2903621130","https://openalex.org/W2909345647","https://openalex.org/W2913667911","https://openalex.org/W2940327706","https://openalex.org/W2945278503","https://openalex.org/W2963459076","https://openalex.org/W2981767898","https://openalex.org/W2985476501","https://openalex.org/W2986908456","https://openalex.org/W2997944188","https://openalex.org/W3013214255","https://openalex.org/W3094352449","https://openalex.org/W3099468740","https://openalex.org/W3107163014","https://openalex.org/W3139122744","https://openalex.org/W3155824129","https://openalex.org/W3160421219","https://openalex.org/W3163123861","https://openalex.org/W3179782779","https://openalex.org/W3189301043","https://openalex.org/W3197326839","https://openalex.org/W3198763602","https://openalex.org/W4205190794","https://openalex.org/W4206591430","https://openalex.org/W4283695295","https://openalex.org/W4283711740","https://openalex.org/W4293462875","https://openalex.org/W4294707281","https://openalex.org/W4308367139","https://openalex.org/W4308373292","https://openalex.org/W4310766578","https://openalex.org/W4311457512","https://openalex.org/W4313554841","https://openalex.org/W4318052546","https://openalex.org/W4323075797","https://openalex.org/W4365446484","https://openalex.org/W4366144743","https://openalex.org/W4367042627","https://openalex.org/W4376107247","https://openalex.org/W4376604812","https://openalex.org/W4381888526","https://openalex.org/W4386046149","https://openalex.org/W4387856887","https://openalex.org/W4389372257","https://openalex.org/W4389767312","https://openalex.org/W4391824096","https://openalex.org/W4393318145","https://openalex.org/W4393386912","https://openalex.org/W4394062100","https://openalex.org/W4394063777","https://openalex.org/W4396514135","https://openalex.org/W4396624888","https://openalex.org/W4399140511","https://openalex.org/W4399703935","https://openalex.org/W4400033798","https://openalex.org/W4400849169","https://openalex.org/W4400932334","https://openalex.org/W4401135905","https://openalex.org/W4401536042","https://openalex.org/W4402280397","https://openalex.org/W4403499392","https://openalex.org/W4404379091","https://openalex.org/W4404470222","https://openalex.org/W4404470236","https://openalex.org/W4405632020","https://openalex.org/W4405971160","https://openalex.org/W4406463747","https://openalex.org/W4407150135","https://openalex.org/W4407592310","https://openalex.org/W4408037068","https://openalex.org/W4408318984","https://openalex.org/W4408977126","https://openalex.org/W4409133212","https://openalex.org/W4409338088","https://openalex.org/W4409606641","https://openalex.org/W4409963252","https://openalex.org/W4410007493","https://openalex.org/W4410083737","https://openalex.org/W4411025562","https://openalex.org/W4412039920","https://openalex.org/W4412138177","https://openalex.org/W4413106150","https://openalex.org/W4414654822","https://openalex.org/W4415017452","https://openalex.org/W4415420506","https://openalex.org/W7128592435","https://openalex.org/W7131776315","https://openalex.org/W7132823284","https://openalex.org/W7171569938","https://openalex.org/W7172397866","https://openalex.org/W7202205663"],"related_works":[],"abstract_inverted_index":{"Premature":[0],"coronary":[1,8],"artery":[2],"disease":[3,9],"(PCAD),":[4],"commonly":[5],"defined":[6],"as":[7,43,234],"before":[10],"age":[11],"55":[12],"in":[13,17,48,70,159],"men":[14],"and":[15,28,66,75,85,92,103,109,124,142,187,210,213,224],"65":[16],"women,":[18],"reflects":[19],"interactions":[20],"among":[21],"inherited":[22,101,223],"susceptibility,":[23],"metabolic":[24,209,225],"dysfunction,":[25],"environmental":[26],"exposures,":[27],"vascular":[29],"inflammation.":[30],"This":[31],"narrative":[32],"review":[33],"examines":[34],"cumulative":[35],"exposure":[36,102],"to":[37,118],"atherogenic":[38],"apolipoprotein":[39],"B":[40],"(apoB)-containing":[41],"particles":[42],"one":[44],"major,":[45],"modifiable":[46],"pathway":[47],"atherosclerotic":[49],"PCAD.":[50],"Low-density":[51],"lipoprotein":[52,79,82],"cholesterol":[53,56,120],"(LDL-C)":[54],"measures":[55],"mass,":[57],"whereas":[58],"apoB":[59,204],"provides":[60],"an":[61,250],"estimate":[62],"of":[63,183,222],"particle":[64],"burden":[65],"may":[67,219],"reveal":[68],"discordance":[69],"insulin":[71],"resistance,":[72],"diabetes,":[73],"obesity,":[74],"hypertriglyceridemia.":[76],"Hepatic":[77],"very-low-density":[78],"(VLDL),":[80],"intermediate-density":[81],"(IDL),":[83],"LDL,":[84],"lipoprotein(a)":[86],"[Lp(a)]":[87],"contain":[88,95],"apoB-100;":[89],"intestinal":[90],"chylomicrons":[91],"their":[93,131],"remnants":[94,113],"apoB-48.":[96],"Lp(a)":[97,207],"adds":[98],"a":[99,135,178,235],"predominantly":[100],"carries":[104],"oxidized":[105],"phospholipids":[106],"with":[107],"inflammatory":[108],"calcific":[110],"effects.":[111],"Triglyceride-rich":[112],"connect":[114],"impaired":[115],"lipid":[116],"metabolism":[117],"arterial":[119],"delivery.":[121],"Epidemiological,":[122],"genetic,":[123],"mechanistic":[125],"evidence":[126],"supports":[127],"these":[128],"pathways,":[129],"but":[130,227],"clinical":[132],"interpretation":[133,174],"requires":[134],"distinction":[136],"between":[137],"association,":[138],"lifelong":[139],"genetic":[140,215],"exposure,":[141],"treatment":[143],"benefit.":[144],"LDL-lowering":[145],"therapies":[146,189],"have":[147],"established":[148,247],"cardiovascular":[149,172],"outcome":[150],"efficacy.":[151],"By":[152],"contrast,":[153],"company-reported":[154],"topline":[155],"results":[156],"from":[157],"Lp(a)HORIZON":[158],"September":[160],"2026":[161],"indicated":[162],"that":[163],"pelacarsen":[164],"did":[165],"not":[166,231],"meet":[167],"its":[168],"prespecified":[169],"primary":[170],"composite":[171],"endpoint;":[173],"remains":[175,249],"provisional":[176],"pending":[177],"peer-reviewed":[179],"report.":[180],"Outcome":[181],"benefits":[182],"other":[184],"selective":[185],"Lp(a)-":[186],"remnant-directed":[188],"remain":[190],"under":[191],"investigation.":[192],"A":[193],"proposed":[194],"conceptual":[195],"framework":[196,229],"for":[197],"prevention":[198,248],"combines":[199],"conventional":[200],"risk-factor":[201],"control,":[202],"complementary":[203],"assessment,":[205,212],"once-in-adulthood":[206],"testing,":[208],"family":[211],"selected":[214],"evaluation.":[216],"These":[217],"elements":[218],"improve":[220,244],"recognition":[221],"risk,":[226],"the":[228],"has":[230],"been":[232],"validated":[233],"treatment-selection":[236],"algorithm.":[237],"Whether":[238],"apoB-guided":[239],"care":[240],"or":[241],"mechanism-specific":[242],"interventions":[243],"outcomes":[245],"beyond":[246],"important":[251],"research":[252],"question.":[253]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
