{"id":"https://openalex.org/W7225796131","doi":"https://doi.org/10.3390/biomedicines14112604","title":"Within- and Between-Episode Association Between C-Reactive Protein and D-Dimer Across Ordered Assessments in Adults with Clinically Recorded Sepsis: A Secondary Exploratory Single-Center Analysis","display_name":"Within- and Between-Episode Association Between C-Reactive Protein and D-Dimer Across Ordered Assessments in Adults with Clinically Recorded Sepsis: A Secondary Exploratory Single-Center Analysis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225796131","doi":"https://doi.org/10.3390/biomedicines14112604"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines14112604","doi":"https://doi.org/10.3390/biomedicines14112604","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112604","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines14112604","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123466465","display_name":"Andra Rotea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Andra Rotea","raw_affiliation_strings":["Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123511299","display_name":"Bogdan Rotea","orcid":"https://orcid.org/0009-0009-3398-9090","observed_orcids":["https://orcid.org/0009-0009-3398-9090"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Bogdan Rotea","raw_affiliation_strings":["Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"],"raw_orcid":"https://orcid.org/0009-0009-3398-9090","affiliations":[{"raw_affiliation_string":"Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","institution_ids":[]},{"raw_affiliation_string":"Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093027549","display_name":"Madalina-Ianca Suba","orcid":"https://orcid.org/0009-0008-8387-7700","observed_orcids":["https://orcid.org/0009-0008-8387-7700"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]},{"id":"https://openalex.org/I4210134468","display_name":"Spitalul Clinic Dr. Victor Babes","ror":"https://ror.org/03j3q6b81","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210134468"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"M\u0103d\u0103lina-Ianca \u0218uba","raw_affiliation_strings":["Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","Dr. Victor Babe\u0219 Clinical Hospital of Infectious Diseases and Pneumophthisiology, 300310 Timi\u0219oara, Romania","Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"],"raw_orcid":"https://orcid.org/0009-0008-8387-7700","affiliations":[{"raw_affiliation_string":"Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Dr. Victor Babe\u0219 Clinical Hospital of Infectious Diseases and Pneumophthisiology, 300310 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210134468"]},{"raw_affiliation_string":"Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052624670","display_name":"Ovidiu Ro\u0219ca","orcid":"https://orcid.org/0000-0001-8236-2205","observed_orcids":["https://orcid.org/0000-0001-8236-2205"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ovidiu Rosca","raw_affiliation_strings":["Department XIII, Discipline of Infectious Diseases, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania","Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"],"raw_orcid":"https://orcid.org/0000-0001-8236-2205","affiliations":[{"raw_affiliation_string":"Department XIII, Discipline of Infectious Diseases, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015686691","display_name":"Bianca Cerbu","orcid":"https://orcid.org/0009-0007-5362-1133","observed_orcids":["https://orcid.org/0009-0007-5362-1133"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Bogdan Cerbu","raw_affiliation_strings":["Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","institution_ids":[]},{"raw_affiliation_string":"Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Doctoral School, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090878032","display_name":"Ileana En\u0103tescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ileana Enatescu","raw_affiliation_strings":["Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","institution_ids":[]},{"raw_affiliation_string":"Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112103711","display_name":"Mirabela Adina Dima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mirabela Adina Dima","raw_affiliation_strings":["Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","institution_ids":[]},{"raw_affiliation_string":"Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018248283","display_name":"Emil Radu Iacob","orcid":"https://orcid.org/0000-0002-5863-6613","observed_orcids":["https://orcid.org/0000-0002-5863-6613"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Emil Radu Iacob","raw_affiliation_strings":["Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","Department of Pediatric Surgery and Orthopedics, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"],"raw_orcid":"https://orcid.org/0000-0002-5863-6613","affiliations":[{"raw_affiliation_string":"Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Surgery and Orthopedics, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042874302","display_name":"Adrian Gluhovschi","orcid":"https://orcid.org/0000-0001-8354-9928","observed_orcids":["https://orcid.org/0000-0001-8354-9928"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Adrian Gluhovschi","raw_affiliation_strings":["Department XII, Discipline of Obstetrics and Gynecology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"],"raw_orcid":"https://orcid.org/0000-0001-8354-9928","affiliations":[{"raw_affiliation_string":"Department XII, Discipline of Obstetrics and Gynecology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031192559","display_name":"Daniela Iacob","orcid":"https://orcid.org/0000-0003-2468-6003","observed_orcids":["https://orcid.org/0000-0003-2468-6003"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Daniela Iacob","raw_affiliation_strings":["Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"],"raw_orcid":"https://orcid.org/0000-0003-2468-6003","affiliations":[{"raw_affiliation_string":"Center for Multidisciplinary Research and Management in Pediatric Surgical Conditions, Iosif Nemoianu Street No. 2, 300011 Timi\u0219oara, Romania","institution_ids":[]},{"raw_affiliation_string":"Discipline of Neonatology, Victor Babe\u0219 University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5123511299"],"corresponding_institution_ids":["https://openalex.org/I4210088791"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"11","first_page":"2604","last_page":"2604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7878999710083008},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6959999799728394},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.679099977016449},{"id":"https://openalex.org/C2777357209","wikidata":"https://www.wikidata.org/wiki/Q3595842","display_name":"Phlebotomy","level":2,"score":0.5454000234603882},{"id":"https://openalex.org/C10936531","wikidata":"https://www.wikidata.org/wiki/Q786600","display_name":"Procalcitonin","level":3,"score":0.4814000129699707},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.46790000796318054},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.45080000162124634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.429500013589859},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C2781059462","wikidata":"https://www.wikidata.org/wiki/Q5158906","display_name":"Concordance correlation coefficient","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C27403532","wikidata":"https://www.wikidata.org/wiki/Q5532474","display_name":"Generalized estimating equation","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2540000081062317}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biomedicines14112604","doi":"https://doi.org/10.3390/biomedicines14112604","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112604","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines14112604","doi":"https://doi.org/10.3390/biomedicines14112604","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112604","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1989528047","https://openalex.org/W1993041144","https://openalex.org/W2006758816","https://openalex.org/W2031508708","https://openalex.org/W2042161439","https://openalex.org/W2129383046","https://openalex.org/W2280404143","https://openalex.org/W2322327936","https://openalex.org/W2599076725","https://openalex.org/W2608823051","https://openalex.org/W2745119542","https://openalex.org/W2963387556","https://openalex.org/W2965665569","https://openalex.org/W3006173042","https://openalex.org/W4318479024","https://openalex.org/W4372333096","https://openalex.org/W4377093577","https://openalex.org/W4386046299","https://openalex.org/W4402311046","https://openalex.org/W4413276983","https://openalex.org/W4413452925","https://openalex.org/W4414084661","https://openalex.org/W4417517038","https://openalex.org/W7119483052"],"related_works":[],"abstract_inverted_index":{"Background/Objectives:":[0],"C-reactive":[1],"protein":[2],"(CRP)":[3],"and":[4,38,65,72,101,171],"D-dimer":[5,39,138],"are":[6],"routinely":[7],"measured":[8],"in":[9,44,104,167],"sepsis,":[10],"but":[11,162],"it":[12],"is":[13],"uncertain":[14],"whether":[15],"their":[16],"repeated":[17],"values":[18],"covary":[19],"within":[20],"the":[21,33,189],"same":[22],"hospital":[23],"episode":[24],"independently":[25],"of":[26,195],"differences":[27],"between":[28,36],"episodes.":[29],"We":[30],"therefore":[31],"evaluated":[32],"same-assessment":[34,197],"association":[35],"CRP":[37,122,140],"across":[40,159],"ordered":[41],"clinical":[42,215],"assessments":[43],"adults":[45],"with":[46,88],"clinically":[47],"recorded":[48],"sepsis.":[49],"Methods:":[50],"This":[51],"secondary":[52,117,187],"exploratory":[53],"single-center":[54],"repeated-measures":[55],"analysis":[56],"used":[57],"100":[58],"admission":[59],"episodes":[60,90,176],"assessed":[61],"at":[62,92],"M0,":[63],"M2,":[64],"M3;":[66],"exact":[67,73],"elapsed":[68],"times":[69],"for":[70,109],"M2/M3":[71],"phlebotomy":[74],"timestamps":[75],"were":[76],"unavailable.":[77],"The":[78,120,142],"primary":[79],"model":[80,107],"included":[81],"190":[82],"CRP\u2013D-dimer":[83,180,198],"pairs":[84],"from":[85],"88":[86],"episodes,":[87],"64":[89],"contributing":[91],"least":[93],"two":[94],"pairs.":[95],"Log-CRP":[96],"was":[97,113,124,145],"decomposed":[98],"into":[99],"episode-centered":[100],"episode-mean":[102],"components":[103],"a":[105,114,204],"random-intercept":[106],"adjusted":[108],"assessment.":[110],"Procalcitonin":[111],"(PCT)":[112],"prespecified":[115,160],"gated":[116],"marker.":[118],"Results:":[119],"within-episode":[121],"coefficient":[123,144],"\u03b2":[125,146],"=":[126,132,147,153],"0.1731":[127],"(95%":[128,149],"CI":[129,150],"0.0259\u20130.3204;":[130],"p":[131,152],"0.0212),":[133],"corresponding":[134],"to":[135],"12.7%":[136],"higher":[137],"per":[139],"doubling.":[141],"PCT":[143],"0.0979":[148],"0.0037\u20130.1921;":[151],"0.0415).":[154],"Point":[155],"estimates":[156],"remained":[157],"positive":[158,196],"sensitivities,":[161],"confidence":[163],"intervals":[164],"crossed":[165],"zero":[166],"fixed-effects,":[168],"robust":[169],"GEE,":[170],"complete-case":[172],"analyses;":[173],"only":[174],"49/100":[175],"contributed":[177],"an":[178],"M3":[179],"pair.":[181],"Conclusions:":[182],"In":[183],"this":[184],"small,":[185],"incomplete":[186],"dataset,":[188],"findings":[190],"provide":[191],"limited,":[192],"model-dependent":[193],"evidence":[194],"covariation.":[199],"They":[200],"do":[201],"not":[202],"establish":[203],"definitive":[205],"association,":[206],"temporal":[207],"coupling,":[208],"causality,":[209],"SIC/DIC,":[210],"treatment":[211],"response,":[212],"prognosis,":[213],"or":[214],"thresholds.":[216]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
