{"id":"https://openalex.org/W7225796060","doi":"https://doi.org/10.3389/fphar.2026.1988640","title":"Fructus mume total flavonoids exert neuroprotective effects involving miR-143-3p and CaMKK\u03b2/AMPK/mTOR signaling in experimental models of Parkinson\u2019s disease","display_name":"Fructus mume total flavonoids exert neuroprotective effects involving miR-143-3p and CaMKK\u03b2/AMPK/mTOR signaling in experimental models of Parkinson\u2019s disease","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225796060","doi":"https://doi.org/10.3389/fphar.2026.1988640"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1988640","doi":"https://doi.org/10.3389/fphar.2026.1988640","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1988640","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2026.1988640","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123365591","display_name":"Xiaodong Wen","orcid":"https://orcid.org/0009-0005-6848-7454","observed_orcids":["https://orcid.org/0009-0005-6848-7454"]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Wen","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071634770","display_name":"Lian Gu","orcid":"https://orcid.org/0000-0002-5865-7940","observed_orcids":["https://orcid.org/0000-0002-5865-7940"]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian Gu","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137077795","display_name":"Xinmei Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinmei Zhou","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058356853","display_name":"Wenyong Feng","orcid":"https://orcid.org/0009-0003-1646-2306","observed_orcids":["https://orcid.org/0009-0003-1646-2306"]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyong Feng","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101333016","display_name":"Liting Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liting Huang","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161420451","display_name":"Chunling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunling Wang","raw_affiliation_strings":["College of Pharmacy, Guangxi University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Guangxi University of Chinese Medicine","institution_ids":["https://openalex.org/I4210113348"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161420451"],"corresponding_institution_ids":["https://openalex.org/I4210113348"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9090999960899353},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.741599977016449},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.6833999752998352},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.5881999731063843},{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.5748000144958496},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5738999843597412},{"id":"https://openalex.org/C37753355","wikidata":"https://www.wikidata.org/wiki/Q911877","display_name":"Nissl body","level":3,"score":0.539900004863739},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45899999141693115},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.45320001244544983},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4528000056743622},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.4325000047683716},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4180999994277954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3635999858379364},{"id":"https://openalex.org/C2911016594","wikidata":"https://www.wikidata.org/wiki/Q15946111","display_name":"Hydroxydopamine","level":4,"score":0.35899999737739563},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3181999921798706},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3061999976634979},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25690001249313354},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fphar.2026.1988640","doi":"https://doi.org/10.3389/fphar.2026.1988640","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1988640","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1988640","doi":"https://doi.org/10.3389/fphar.2026.1988640","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1988640","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1505937405","https://openalex.org/W1964619935","https://openalex.org/W1972589158","https://openalex.org/W1976561247","https://openalex.org/W2067979493","https://openalex.org/W2088359248","https://openalex.org/W2103230459","https://openalex.org/W2210032257","https://openalex.org/W2276621711","https://openalex.org/W2295947083","https://openalex.org/W2787688191","https://openalex.org/W2964855767","https://openalex.org/W3014945289","https://openalex.org/W3046284969","https://openalex.org/W3078860289","https://openalex.org/W3085991453","https://openalex.org/W3131403912","https://openalex.org/W3183174924","https://openalex.org/W3186641632","https://openalex.org/W4200569725","https://openalex.org/W4206109804","https://openalex.org/W4213104388","https://openalex.org/W4213453505","https://openalex.org/W4224700161","https://openalex.org/W4236357753","https://openalex.org/W4283775096","https://openalex.org/W4286002175","https://openalex.org/W4292240714","https://openalex.org/W4296746220","https://openalex.org/W4297016881","https://openalex.org/W4297859554","https://openalex.org/W4313471849","https://openalex.org/W4317521285","https://openalex.org/W4318696266","https://openalex.org/W4319762866","https://openalex.org/W4328048490","https://openalex.org/W4362521820","https://openalex.org/W4367043224","https://openalex.org/W4378905161","https://openalex.org/W4380150275","https://openalex.org/W4388294944","https://openalex.org/W4388540810","https://openalex.org/W4392037749","https://openalex.org/W4392125637","https://openalex.org/W4392242690","https://openalex.org/W4402519734","https://openalex.org/W4402897602","https://openalex.org/W4402910388","https://openalex.org/W4403486225","https://openalex.org/W4403827644","https://openalex.org/W4404321435","https://openalex.org/W4406115413","https://openalex.org/W4406852061","https://openalex.org/W4409186597","https://openalex.org/W4410157046","https://openalex.org/W4417056788","https://openalex.org/W7118804791","https://openalex.org/W7124137530","https://openalex.org/W7124827487","https://openalex.org/W7135064131","https://openalex.org/W7169874589","https://openalex.org/W7214701141"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Parkinson\u2019s":[1],"disease":[2],"(PD)":[3],"is":[4],"a":[5,25,262],"common":[6],"neurodegenerative":[7],"disorder":[8],"in":[9,18,36,59,128,133,171,197,209,236,252,285,314,351],"the":[10,42,54,70,88,113,118,129,148,152,162,172,180,198,211,228,268,274,280,294,299,335,342],"elderly.":[11],"Dysregulated":[12],"mitophagy":[13,67,127],"contributes":[14],"to":[15,111,146],"neuronal":[16,124,169],"damage":[17],"PD.":[19,40,352],"Fructus":[20,30],"mume":[21],"total":[22],"flavonoids":[23,350],"(FMF),":[24],"flavonoid-enriched":[26],"extract":[27],"prepared":[28],"from":[29],"mume,":[31],"have":[32],"shown":[33],"neuroprotective":[34,55,153,312,336],"effects":[35,56,114,154,249,282,301,313,337],"experimental":[37,315],"models":[38,61,316],"of":[39,57,62,78,85,115,155,164,174,182,213,230,250,273,283,302,317,338,346],"However,":[41],"underlying":[43,72,151],"molecular":[44,149],"mechanisms":[45,150],"remain":[46],"incompletely":[47],"understood.":[48],"Therefore,":[49],"this":[50],"study":[51],"investigated":[52],"whether":[53],"FMF":[58,116,158,177,204,223,251,284,309,339],"rat":[60,76],"PD":[63,79,135,175,214],"were":[64,109],"associated":[65],"with":[66,143,293],"and":[68,94,106,117,126,167,191,216,227,233,267,291,324,340,348],"explored":[69],"potential":[71,263,343],"mechanisms.":[73],"Methods":[74],"A":[75],"model":[77,136],"was":[80,137],"established":[81,138],"by":[82,139],"stereotaxic":[83],"injection":[84],"6-OHDA":[86],"into":[87,334],"substantia":[89],"nigra":[90],"pars":[91],"compacta":[92],"(SNpc)":[93],"ventral":[95],"tegmental":[96],"area.":[97],"HE":[98],"staining,":[99,101,103],"Nissl":[100,165],"TUNEL":[102],"immunohistochemistry":[104],"staining":[105],"Western":[107],"blotting":[108],"used":[110],"evaluate":[112],"autophagy":[119],"inhibitor":[120,244,296],"3-methyladenine":[121],"(3-MA)":[122],"on":[123],"injury":[125],"SNpc.":[130,199],"Additionally,":[131,222],"an":[132],"vitro":[134],"treating":[140],"SH-SY5Y":[141,220,240,256,289],"cells":[142],"MPP":[144,217,237,253,286],"+":[145,218,238,254,287],"investigate":[147],"FMF.":[156,303],"Results":[157],"treatment":[159],"significantly":[160,205,245],"increased":[161,179],"number":[163],"bodies":[166],"reduced":[168,234],"apoptosis":[170,235],"SNpc":[173,212],"rats.":[176],"also":[178,278],"expression":[181,208,229],"tyrosine":[183],"hydroxylase,":[184],"LC3-II,":[185],"Beclin":[186],"1,":[187],"p62,":[188],"PINK1,":[189],"Parkin":[190],"TOM20,":[192],"while":[193],"reducing":[194],"\u03b1-synuclein":[195],"accumulation":[196],"RT-qPCR":[200],"analysis":[201],"showed":[202],"that":[203,308],"upregulated":[206],"miR-143-3p":[207,243,266,295],"both":[210],"rats":[215],"-treated":[219,239,255,288],"cells.":[221,257],"promoted":[224],"cell":[225],"proliferation":[226],"mitophagy-related":[231],"proteins":[232],"cells,":[241,290],"whereas":[242],"weakened":[246,279,298],"these":[247],"pharmacological":[248,281,300],"Dual-luciferase":[258],"reporter":[259],"assays":[260],"suggested":[261,307],"interaction":[264],"between":[265],"CaMKK\u03b2":[269],"3\u2032UTR.":[270],"Pharmacological":[271],"inhibition":[272],"CaMKK\u03b2/AMPK/mTOR":[275,322],"signaling":[276,323],"pathway":[277],"co-treatment":[292],"further":[297],"Conclusion":[304],"These":[305,327],"findings":[306,328],"may":[310],"exert":[311],"PD,":[318],"potentially":[319],"involving":[320],"miR-143-3p,":[321],"mitophagy-associated":[325],"processes.":[326],"would":[329],"provide":[330],"new":[331],"mechanistic":[332],"insights":[333],"support":[341],"therapeutic":[344],"application":[345],"FM":[347],"its":[349]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}