{"id":"https://openalex.org/W7225795722","doi":"https://doi.org/10.20944/preprints202611.1088.v1","title":"When Two Genomes Go to War\u2014New Perspectives for Bovine TB Research and Control","display_name":"When Two Genomes Go to War\u2014New Perspectives for Bovine TB Research and Control","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225795722","doi":"https://doi.org/10.20944/preprints202611.1088.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202611.1088.v1","doi":"https://doi.org/10.20944/preprints202611.1088.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.1088.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202611.1088.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035416120","display_name":"Adrian R. Allen","orcid":"https://orcid.org/0000-0002-9077-8662","observed_orcids":["https://orcid.org/0000-0002-9077-8662"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adrian Allen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9077-8662","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067576037","display_name":"Andrea Doeschl\u2010Wilson","orcid":"https://orcid.org/0000-0002-2658-6973","observed_orcids":["https://orcid.org/0000-0002-2658-6973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Doeschl-Wilson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2658-6973","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030835975","display_name":"Robin Skuce","orcid":"https://orcid.org/0000-0001-5177-9198","observed_orcids":["https://orcid.org/0000-0001-5177-9198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin Skuce","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5177-9198","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004152149","display_name":"Tom Ford","orcid":"https://orcid.org/0000-0002-1131-8335","observed_orcids":["https://orcid.org/0000-0002-1131-8335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Ford","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1131-8335","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035416120"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7581999897956848},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6086999773979187},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6032999753952026},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5619000196456909},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5401999950408936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4894999861717224},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.48510000109672546},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4505999982357025},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4212000072002411},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41440001130104065},{"id":"https://openalex.org/C2778497218","wikidata":"https://www.wikidata.org/wiki/Q133447","display_name":"Mycobacterium bovis","level":4,"score":0.40369999408721924},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4018000066280365},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.3799999952316284},{"id":"https://openalex.org/C16683452","wikidata":"https://www.wikidata.org/wiki/Q7834601","display_name":"Transmissibility (structural dynamics)","level":4,"score":0.36649999022483826},{"id":"https://openalex.org/C172777353","wikidata":"https://www.wikidata.org/wiki/Q1374271","display_name":"Genetic variability","level":4,"score":0.35440000891685486},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34470000863075256},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C97669555","wikidata":"https://www.wikidata.org/wiki/Q4118435","display_name":"Molecular epidemiology","level":4,"score":0.3292999863624573},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.3156000077724457},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.2838999927043915},{"id":"https://openalex.org/C2776914050","wikidata":"https://www.wikidata.org/wiki/Q19597524","display_name":"Host adaptation","level":4,"score":0.28060001134872437},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.2773999869823456},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.27730000019073486},{"id":"https://openalex.org/C177860879","wikidata":"https://www.wikidata.org/wiki/Q5532897","display_name":"Genetic epidemiology","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C2778375072","wikidata":"https://www.wikidata.org/wiki/Q5909198","display_name":"Host\u2013pathogen interaction","level":4,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202611.1088.v1","doi":"https://doi.org/10.20944/preprints202611.1088.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.1088.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202611.1088.v1","doi":"https://doi.org/10.20944/preprints202611.1088.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.1088.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Advances":[0],"in":[1,56,72,81,97,142,160,179,213,226,261],"pathogen":[2,34,155,184,190,229,265],"genomics":[3,35],"have":[4],"enabled":[5],"exploration":[6],"of":[7,12,131,196,200,255],"the":[8,13,49,84,95,181,197,214,282],"evolution":[9],"and":[10,44,63,79,92,99,111,156,176,186,189,192,210,216,228,232,240,258,264,286],"diversity":[11,267],"Mycobacterium":[14],"tuberculosis":[15,53],"complex":[16],"(MTBC)":[17],"at":[18,281],"unprecedented":[19],"resolution.":[20],"These":[21],"bacilli":[22],"were":[23],"thought":[24],"to":[25,90,120,127,134,243,274],"be":[26],"genetically":[27],"homogeneous":[28],"with":[29,94,218],"limited":[30],"phenotypic":[31,45],"diversity.":[32,46],"However,":[33,167],"provides":[36],"a":[37,208,288],"more":[38],"nuanced":[39],"picture,":[40],"revealing":[41,104],"significant":[42],"genotypic":[43],"For":[47],"example,":[48],"human-adapted":[50],"pathogen,":[51],"M.":[52,73],"exhibits":[54],"heterogeneity":[55,71],"epidemiologically":[57],"relevant":[58,294],"traits,":[59],"such":[60],"as":[61],"virulence":[62,185],"transmissibility.":[64],"Less":[65],"is":[66,108,170,207,238],"known":[67],"about":[68],"how":[69,154,174,262],"genetic":[70,85,125,140,158,198,235,266,284],"bovis":[74],"may":[75,241],"affect":[76,163,269],"disease":[77,168,270],"outcomes":[78,245,271],"epidemiology":[80],"livestock.":[82],"Concurrently,":[83],"architecture":[86],"influencing":[87],"host":[88,106,143,157,187,193,227,263],"response":[89],"exposure":[91,273],"infection":[93],"MTBC":[96],"humans":[98],"animals":[100],"has":[101,117,146],"been":[102,118,147],"investigated,":[103],"that":[105,291],"susceptibility":[107,130,188],"moderately":[109],"heritable":[110],"polygenic.":[112],"In":[113],"cattle,":[114],"this":[115],"knowledge":[116,224,259],"exploited":[119],"develop":[121],"breeding":[122],"indices":[123],"for":[124],"selection":[126],"cumulatively":[128],"reduce":[129],"cattle":[132],"populations":[133],"bovine":[135],"TB":[136,275],"(bTB).":[137],"Additionally,":[138],"exploitable":[139,244],"variation":[141],"bTB":[144,164,206,298],"infectivity":[145],"demonstrated.":[148],"There":[149],"is,":[150,203],"therefore,":[151],"evidence":[152],"on":[153],"variation,":[159],"isolation,":[161],"can":[162,268],"epidemiological":[165],"processes.":[166],"outcome":[169],"largely":[171],"determined":[172],"by":[173],"pathogens":[175],"hosts":[177],"interact,":[178],"particular":[180],"interplay":[182],"between":[183],"transmissibility":[191],"infectivity.":[194],"Understanding":[195],"basis":[199],"these":[201,234],"interactions":[202],"however,":[204],"limited.":[205],"persistent":[209],"costly":[211],"problem":[212],"UK":[215],"Ireland,":[217],"eradication":[219,248],"proving":[220],"elusive.":[221],"Filling":[222],"existing":[223],"gaps":[225,260],"genetics":[230],"research":[231,289],"uniting":[233],"data":[236],"sources":[237],"timely":[239],"translate":[242],"which":[246],"enhance":[247],"efforts.":[249],"Here,":[250],"we":[251],"provide":[252,293],"an":[253],"overview":[254],"current":[256],"insights":[257,296],"following":[272],"bacteria.":[276],"We":[277],"explore":[278],"tentative":[279],"work":[280],"host-pathogen":[283],"interface":[285],"describe":[287],"strategy":[290],"could":[292],"novel":[295],"into":[297],"epidemiology.":[299]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
