{"id":"https://openalex.org/W7225794666","doi":"https://doi.org/10.1038/s41598-026-75999-8","title":"Green gradient RP-HPLC with variable flow rate for simultaneous analysis of paracetamol and ascorbic acid in pharmaceuticals","display_name":"Green gradient RP-HPLC with variable flow rate for simultaneous analysis of paracetamol and ascorbic acid in pharmaceuticals","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225794666","doi":"https://doi.org/10.1038/s41598-026-75999-8"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-75999-8","doi":"https://doi.org/10.1038/s41598-026-75999-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75999-8","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-026-75999-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161431669","display_name":"Hui Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Peng","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China","institution_ids":["https://openalex.org/I4210087969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101578055","display_name":"Tongxing Shi","orcid":"https://orcid.org/0000-0002-2528-9379","observed_orcids":["https://orcid.org/0000-0002-2528-9379"]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong-Xing Shi","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China","institution_ids":["https://openalex.org/I4210087969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027158234","display_name":"Jin\u2010Kui Ma","orcid":"https://orcid.org/0000-0001-9346-2076","observed_orcids":["https://orcid.org/0000-0001-9346-2076"]},"institutions":[{"id":"https://openalex.org/I183816158","display_name":"Zhaoqing University","ror":"https://ror.org/025n5kj18","country_code":"CN","type":"education","lineage":["https://openalex.org/I183816158"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin-Kui Ma","raw_affiliation_strings":["School of Food & Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, 526061, China"],"raw_orcid":"https://orcid.org/0000-0001-9346-2076","affiliations":[{"raw_affiliation_string":"School of Food & Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, 526061, China","institution_ids":["https://openalex.org/I183816158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004244805","display_name":"Ahmed Sobhy Darwish","orcid":"https://orcid.org/0009-0009-9000-3777","observed_orcids":["https://orcid.org/0009-0009-9000-3777"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ahmed Sobhy Darwish","raw_affiliation_strings":["Department of Chemistry, Science Faculty, Zagazig University, Zagazig, Egypt","Egyptian International Pharmaceutical Industries Company, EIPICO, 10th of Ramadan City, Egypt","Science Faculty, Zagazig University, Zagazig, Egypt"],"raw_orcid":"https://orcid.org/0009-0009-9000-3777","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Science Faculty, Zagazig University, Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]},{"raw_affiliation_string":"Egyptian International Pharmaceutical Industries Company, EIPICO, 10th of Ramadan City, Egypt","institution_ids":[]},{"raw_affiliation_string":"Science Faculty, Zagazig University, Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004244805","https://openalex.org/A5027158234"],"corresponding_institution_ids":["https://openalex.org/I183816158","https://openalex.org/I192398990"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.8657000064849854},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8363000154495239},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.76419997215271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7110000252723694},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.5756000280380249},{"id":"https://openalex.org/C179428855","wikidata":"https://www.wikidata.org/wiki/Q1069216","display_name":"Microscale chemistry","level":2,"score":0.5371000170707703},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.49810001254081726},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.476500004529953},{"id":"https://openalex.org/C3017686574","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"Gradient elution","level":3,"score":0.47380000352859497},{"id":"https://openalex.org/C2777682752","wikidata":"https://www.wikidata.org/wiki/Q8564473","display_name":"Forced degradation","level":4,"score":0.4571000039577484},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.429500013589859},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.42739999294281006},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C172120300","wikidata":"https://www.wikidata.org/wiki/Q1134348","display_name":"Volumetric flow rate","level":2,"score":0.4043000042438507},{"id":"https://openalex.org/C2781289165","wikidata":"https://www.wikidata.org/wiki/Q3381491","display_name":"Potassium phosphate","level":2,"score":0.3847000002861023},{"id":"https://openalex.org/C96616956","wikidata":"https://www.wikidata.org/wiki/Q285100","display_name":"Phosphate buffered saline","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C110084920","wikidata":"https://www.wikidata.org/wiki/Q381624","display_name":"Chromatography detector","level":3,"score":0.3456000089645386},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.3395000100135803},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.3089999854564667},{"id":"https://openalex.org/C45188465","wikidata":"https://www.wikidata.org/wiki/Q645497","display_name":"Reversed-phase chromatography","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C2779745421","wikidata":"https://www.wikidata.org/wiki/Q3080279","display_name":"Clofibric acid","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C2992520659","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatographic separation","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-75999-8","doi":"https://doi.org/10.1038/s41598-026-75999-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75999-8","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-75999-8","doi":"https://doi.org/10.1038/s41598-026-75999-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75999-8","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Paracetamol":[0],"and":[1,17,25,49,90,109,141,173,182],"ascorbic":[2,139],"acid":[3,140],"are":[4],"widely":[5],"incorporated":[6],"into":[7],"combination":[8],"pharmaceutical":[9,40],"formulations":[10,52],"for":[11,33,138,144],"the":[12,23,34,66,93,159,163],"symptomatic":[13],"treatment":[14],"of":[15,27,37,135,152,162,177],"cold":[16],"influenza.":[18],"The":[19,127],"present":[20],"study":[21],"reports":[22],"development":[24],"validation":[26,60],"a":[28,54,74,117],"green,":[29],"stability-indicating":[30,160],"RP-HPLC":[31],"method":[32,128],"simultaneous":[35],"quantification":[36],"these":[38],"active":[39],"ingredients":[41],"in":[42,63],"bulk":[43],"drug":[44],"materials,":[45],"intravenous":[46],"infusion":[47],"preparations,":[48],"effervescent":[50],"tablet":[51],"using":[53,78,116,168],"microscale":[55],"sample":[56],"preparation":[57],"strategy.":[58],"Method":[59],"was":[61,71,107],"conducted":[62],"accordance":[64],"with":[65,81],"ICH":[67],"Q2(R2)":[68],"guideline.":[69],"Separation":[70],"achieved":[72],"on":[73],"C18":[75],"chromatographic":[76],"column":[77],"gradient":[79],"elution":[80],"0.015":[82],"M":[83],"potassium":[84],"dihydrogen":[85],"phosphate":[86],"buffer":[87],"(pH":[88],"3.0)":[89],"methanol":[91],"as":[92],"mobile":[94],"phase":[95],"components.":[96],"A":[97],"variable":[98],"flow":[99],"program":[100],"ranging":[101],"from":[102,155],"1.0":[103],"to":[104],"1.2":[105],"mL/min":[106],"applied,":[108],"analytes":[110,154],"were":[111],"monitored":[112],"at":[113,122],"245":[114],"nm":[115],"diode":[118],"array":[119],"detector":[120],"maintained":[121],"25":[123],"\u00b1":[124],"2":[125],"\u00b0C.":[126],"showed":[129],"excellent":[130],"linearity":[131],"within":[132],"concentration":[133],"ranges":[134],"3.2\u201329.3":[136],"\u00b5g/mL":[137,143],"5.5\u201348.5":[142],"paracetamol.":[145],"Forced":[146],"degradation":[147,156],"studies":[148],"demonstrated":[149],"effective":[150],"separation":[151],"both":[153],"products,":[157],"confirming":[158],"nature":[161],"method.":[164],"Green":[165],"analytical":[166],"assessment":[167],"AES,":[169],"AGREE,":[170],"MoGAPI,":[171],"BAGI,":[172],"RGB12":[174],"yielded":[175],"scores":[176],"78,":[178],"0.60,":[179],"74,":[180],"80,":[181],"96.7%,":[183],"respectively.":[184]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
