{"id":"https://openalex.org/W7225794563","doi":"https://doi.org/10.64898/2026.11.09.765458","title":"Structural relationships between the SLC12 cotransporter C-terminal domain, universal stress proteins and adenylating enzymes","display_name":"Structural relationships between the SLC12 cotransporter C-terminal domain, universal stress proteins and adenylating enzymes","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225794563","doi":"https://doi.org/10.64898/2026.11.09.765458"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.765458","doi":"https://doi.org/10.64898/2026.11.09.765458","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765458","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.09.765458","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079404524","display_name":"Edina Rosta","orcid":"https://orcid.org/0000-0002-9823-4766","observed_orcids":["https://orcid.org/0000-0002-9823-4766"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Edina Rosta","raw_affiliation_strings":["University College London;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110164600","display_name":"Katharina L. D\u00fcrr","orcid":"https://orcid.org/0000-0002-3245-4088","observed_orcids":["https://orcid.org/0000-0002-3245-4088"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katharina L. D\u00fcrr","raw_affiliation_strings":["University of Oxford; Kavli Institute for Nanoscience Discovery and Department of Chemistry"],"raw_orcid":"https://orcid.org/0000-0002-3245-4088","affiliations":[{"raw_affiliation_string":"University of Oxford; Kavli Institute for Nanoscience Discovery and Department of Chemistry","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079404524"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.10140000283718109,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7077999711036682},{"id":"https://openalex.org/C160403918","wikidata":"https://www.wikidata.org/wiki/Q4682322","display_name":"Adenylylation","level":4,"score":0.6985999941825867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6638000011444092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4510999917984009},{"id":"https://openalex.org/C2776043855","wikidata":"https://www.wikidata.org/wiki/Q55506489","display_name":"Pyrophosphate","level":3,"score":0.4424999952316284},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4399999976158142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43689998984336853},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.33889999985694885},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.329800009727478},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3172999918460846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.30300000309944153},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3003000020980835},{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.298799991607666},{"id":"https://openalex.org/C2994266630","wikidata":"https://www.wikidata.org/wiki/Q424021","display_name":"Adenine nucleotide","level":4,"score":0.298799991607666},{"id":"https://openalex.org/C57711820","wikidata":"https://www.wikidata.org/wiki/Q310425","display_name":"C-terminus","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.2833000123500824},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.2596000134944916},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.257999986410141}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.765458","doi":"https://doi.org/10.64898/2026.11.09.765458","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765458","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.09.765458","doi":"https://doi.org/10.64898/2026.11.09.765458","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765458","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Several":[0],"SLC12":[1,15,139,183],"cotransporters":[2],"bind":[3],"ATP":[4,46,106,154,212],"in":[5,107,132,162],"a":[6,54,127,133,160,168,174,190],"cytoplasmic":[7],"C-terminal":[8],"domain":[9],"(CTD).":[10],"We":[11],"analysed":[12],"16,192":[13],"CTD-containing":[14],"sequences":[16],"and":[17,34,41,51,76,87,90,102,141,198],"compared":[18],"42,845":[19],"representative":[20],"structures":[21,140],"to":[22,209],"examine":[23],"the":[24,45,91,108,137,201],"relationship":[25],"between":[26,83],"this":[27,60,120],"nucleotide":[28,165,184,207],"site,":[29],"universal":[30,84],"stress":[31,85],"proteins":[32,86],"(USPs)":[33],"adenylating":[35],"enzymes.":[36],"In":[37,71,136],"phosphorylated":[38],"NKCC1,":[39],"D891":[40],"D927":[42],"lie":[43],"near":[44],"phosphate":[47],"chain,":[48],"while":[49],"R801":[50],"K889":[52],"form":[53,94],"basic":[55],"phosphate-binding":[56],"clamp.":[57],"NKCC1":[58],"retains":[59],"arrangement,":[61],"whereas":[62],"KCC":[63],"paralogs":[64],"replace":[65],"or":[66,164,167],"lose":[67],"several":[68],"corresponding":[69,109],"groups.":[70],"structural":[72,110,175],"comparisons":[73,104],"with":[74,205],"USP":[75,142],"adenylating-enzyme":[77],"references,":[78],"both":[79],"CTD":[80],"lobes":[81,93],"score":[82],"EC-annotated":[88],"domains,":[89],"two":[92],"separate":[95],"lineages":[96],"that":[97],"include":[98],"bacterial":[99],"transporters.":[100],"Lobe-specific":[101],"nucleotide-frame":[103],"place":[105],"region":[111],"used":[112],"for":[113,129,151,177],"\u03b1-phosphate":[114],"chemistry":[115],"by":[116],"catalytic":[117],"members":[118],"of":[119,195,200],"fold.":[121],"Published":[122],"work":[123],"on":[124],"UspG":[125],"provides":[126],"precedent":[128],"protein-bound":[130],"AMP":[131],"natural":[134],"USP.":[135],"examined":[138],"models,":[143],"candidate":[144],"protein":[145,163,180],"hydroxyls":[146],"lack":[147],"an":[148],"in-line":[149],"geometry":[150],"attack":[152],"at":[153,182],"P\u03b1.":[155],"Protein":[156],"adenylation":[157,181],"would":[158],"require":[159],"change":[161],"geometry,":[166],"different":[169],"acceptor.":[170],"These":[171],"results":[172],"define":[173],"basis":[176],"testing":[178],"conditional":[179],"sites.":[185],"The":[186],"required":[187],"evidence":[188],"is":[189],"covalent":[191],"protein\u2013AMP":[192],"adduct,":[193],"identification":[194],"its":[196],"acceptor":[197],"measurement":[199],"expected":[202],"pyrophosphate":[203],"coproduct,":[204],"soluble":[206],"analysis":[208],"distinguish":[210],"accompanying":[211],"reactions.":[213]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
