{"id":"https://openalex.org/W7225794490","doi":"https://doi.org/10.52340/gs.2026.08.04(1).10","title":"THE ROLE OF GLUCONEOGENESIS IN EMERGENCY MEDICINE: METABOLIC ADAPTATION IN CRITICAL CONDITIONS","display_name":"THE ROLE OF GLUCONEOGENESIS IN EMERGENCY MEDICINE: METABOLIC ADAPTATION IN CRITICAL CONDITIONS","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225794490","doi":"https://doi.org/10.52340/gs.2026.08.04(1).10"},"language":"en","primary_location":{"id":"doi:10.52340/gs.2026.08.04(1).10","doi":"https://doi.org/10.52340/gs.2026.08.04(1).10","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).10","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.52340/gs.2026.08.04(1).10","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161463108","display_name":"Magda Makhatadze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Magda Makhatadze","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050315577","display_name":"Natia Gamkrelidze","orcid":"https://orcid.org/0009-0009-8057-2204","observed_orcids":["https://orcid.org/0009-0009-8057-2204"]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Natia Gamkrelidze","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I7848551"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.9433000087738037},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.6141999959945679},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6065000295639038},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5342000126838684},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.5235000252723694},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4961000084877014},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.49309998750686646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47999998927116394},{"id":"https://openalex.org/C2777949327","wikidata":"https://www.wikidata.org/wiki/Q680603","display_name":"Glycogenolysis","level":3,"score":0.4666999876499176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4498000144958496},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4494999945163727},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4456999897956848},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.43959999084472656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3815000057220459},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.3643999993801117},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.32249999046325684},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.3174000084400177},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C76923068","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Blood sugar regulation","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52340/gs.2026.08.04(1).10","doi":"https://doi.org/10.52340/gs.2026.08.04(1).10","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).10","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52340/gs.2026.08.04(1).10","doi":"https://doi.org/10.52340/gs.2026.08.04(1).10","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).10","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Critical":[1],"illness,":[2],"including":[3],"sepsis,":[4],"severe":[5,82],"trauma,":[6],"and":[7,40,49,61,76,101,110,127,138,148,155,178,223,239,262,276,287,292,310],"prolonged":[8,247],"fasting,":[9],"triggers":[10],"significant":[11],"metabolic":[12,26,159,257,288],"changes":[13],"aimed":[14],"at":[15],"maintaining":[16],"energy":[17],"supply":[18],"to":[19,72,81,135,196,206,231,242,300],"vital":[20],"organs.":[21],"Gluconeogenesis":[22,251],"is":[23,31,53,70,234,298],"an":[24],"essential":[25],"pathway":[27],"through":[28,172],"which":[29],"glucose":[30,44,64,95,146,170,185,202,278,308],"produced":[32],"from":[33],"non-carbohydrate":[34],"sources,":[35],"such":[36,211],"as":[37,188,212],"lactate,":[38],"glycerol,":[39],"amino":[41,228],"acids;":[42],"however,":[43],"homeostasis":[45,96],"in":[46,63,94,108,144,209,221,256,290,306],"critical":[47,102,165,248,260],"illness":[48,166,261],"acute":[50,98,158,213,263],"emergency":[51,222,291],"conditions":[52,210],"also":[54],"influenced":[55],"by":[56],"glycogenolysis,":[57],"peripheral":[58,179,277],"insulin":[59,180],"resistance,":[60],"alterations":[62,143,305],"utilization.":[65],"Understanding":[66,266],"these":[67],"interconnected":[68],"mechanisms":[69],"key":[71],"interpreting":[73],"glycemic":[74,285],"fluctuations":[75],"the":[77,90,116,136,153,272,302],"body\u2019s":[78],"adaptive":[79],"response":[80],"physiological":[83],"stress.":[84],"Methods:":[85],"This":[86],"narrative":[87],"review":[88],"examines":[89],"role":[91,255],"of":[92,115,141,157,274],"gluconeogenesis":[93,183,233],"during":[97,246,259],"medical":[99,264],"emergencies":[100],"illness.":[103,249],"Relevant":[104],"literature":[105],"was":[106,133],"searched":[107],"PubMed/MEDLINE":[109],"Google":[111],"Scholar":[112],"using":[113],"combinations":[114],"following":[117],"terms:":[118],"\u201cgluconeogenesis,\u201d":[119],"\u201cemergency":[120],"medicine,\u201d":[121],"\u201chypoglycemia,\u201d":[122],"\u201cstress":[123],"hyperglycemia,\u201d":[124],"\u201csepsis,\u201d":[125],"\u201ctrauma,\u201d":[126],"\u201cacute":[128],"liver":[129,214],"failure.\u201d":[130],"Particular":[131],"attention":[132],"given":[134],"hormonal":[137],"inflammatory":[139,173],"regulation":[140],"gluconeogenesis,":[142],"endogenous":[145,169,201,307],"production,":[147],"their":[149],"clinical":[150,282],"implications":[151],"for":[152],"assessment":[154,289],"management":[156],"disturbances.":[160],"Results:":[161],"Evidence":[162],"demonstrates":[163],"that":[164],"markedly":[167],"alters":[168],"production":[171,203,309],"cascades,":[174],"counterregulatory":[175],"hormone":[176],"release,":[177],"resistance.":[181],"While":[182],"sustains":[184],"availability,":[186],"particularly":[187,208],"glycogen":[189],"stores":[190],"deplete,":[191],"its":[192,267],"dysregulation":[193],"may":[194,204,240],"contribute":[195,205,241],"stress":[197],"hyperglycemia,":[198],"whereas":[199],"impaired":[200],"hypoglycemia,":[207],"failure.":[215],"These":[216],"disturbances":[217],"are":[218],"clinically":[219],"relevant":[220],"intensive":[224,293],"care":[225,294],"settings.":[226,295],"Furthermore,":[227],"acid":[229],"mobilization":[230],"support":[232],"associated":[235],"with":[236,271],"protein":[237],"catabolism":[238],"skeletal":[243],"muscle":[244],"loss":[245],"Conclusion:":[250],"plays":[252],"a":[253],"pivotal":[254],"adaptation":[258],"emergencies.":[265],"regulatory":[268],"mechanisms,":[269],"together":[270],"roles":[273],"glycogenolysis":[275],"utilization,":[279],"provides":[280],"valuable":[281],"insights":[283],"into":[284],"control":[286],"Further":[296],"research":[297],"warranted":[299],"elucidate":[301],"relationship":[303],"between":[304],"patient":[311],"outcomes.":[312]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
