{"id":"https://openalex.org/W7225793312","doi":"https://doi.org/10.3390/metabo16110880","title":"Metabolomics in Cancer Drug-Response Prediction and Target Discovery: From Experimental Models to Clinical Translation","display_name":"Metabolomics in Cancer Drug-Response Prediction and Target Discovery: From Experimental Models to Clinical Translation","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225793312","doi":"https://doi.org/10.3390/metabo16110880"},"language":"en","primary_location":{"id":"doi:10.3390/metabo16110880","doi":"https://doi.org/10.3390/metabo16110880","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16110880","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/metabo16110880","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161427412","display_name":"Zhaomin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaomin Liu","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","National Institute of Health Data Science of China, Shandong University, Jinan 250012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Institute of Health Data Science of China, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022109280","display_name":"Yiji Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijie Chen","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","National Institute of Health Data Science of China, Shandong University, Jinan 250012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Institute of Health Data Science of China, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114858490","display_name":"Lantao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lantao Wang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","National Institute of Health Data Science of China, Shandong University, Jinan 250012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Institute of Health Data Science of China, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161439837","display_name":"Wenyan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyan Yang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","National Institute of Health Data Science of China, Shandong University, Jinan 250012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Institute of Health Data Science of China, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161453815","display_name":"Yang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","National Institute of Health Data Science of China, Shandong University, Jinan 250012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Institute of Health Data Science of China, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161435045","display_name":"Zhe Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhe Wang","raw_affiliation_strings":["Shandong Provincial Key Laboratory of Precision Oncology, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan 250117, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Precision Oncology, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan 250117, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114860228","display_name":"Cheng Wang","orcid":"https://orcid.org/0000-0001-8135-4473","observed_orcids":["https://orcid.org/0000-0001-8135-4473"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Wang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","National Institute of Health Data Science of China, Shandong University, Jinan 250012, China"],"raw_orcid":"https://orcid.org/0000-0001-8135-4473","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Institute of Health Data Science of China, Shandong University, Jinan 250012, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5114860228","https://openalex.org/A5161435045"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210100830","https://openalex.org/I4210163399"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"880","last_page":"880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8133000135421753},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6697999835014343},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5453000068664551},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4528999924659729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44110000133514404},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3901999890804291},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.373199999332428},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.36739999055862427},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3619999885559082},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.35519999265670776},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.3504999876022339},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.3407999873161316},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30709999799728394},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.28349998593330383},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27390000224113464},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.2703000009059906},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.26510000228881836},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2517000138759613},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/metabo16110880","doi":"https://doi.org/10.3390/metabo16110880","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16110880","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/metabo16110880","doi":"https://doi.org/10.3390/metabo16110880","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16110880","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Drug":[0],"response":[1],"in":[2,100],"cancer":[3,67,91],"often":[4],"remains":[5],"heterogeneous":[6],"even":[7],"among":[8],"tumors":[9],"sharing":[10],"the":[11,23,38,84],"same":[12],"genomic":[13],"driver,":[14],"indicating":[15],"that":[16],"genotype":[17],"alone":[18],"does":[19,54],"not":[20,55],"fully":[21],"capture":[22],"metabolic":[24,79,96,105,138],"state":[25,35],"underlying":[26],"therapeutic":[27],"sensitivity.":[28],"Metabolomics":[29],"provides":[30],"a":[31,188,194],"window":[32],"into":[33],"this":[34,61],"by":[36],"measuring":[37],"biochemical":[39],"consequences":[40],"of":[41],"oncogenic":[42],"signaling,":[43],"nutrient":[44],"availability,":[45],"microenvironmental":[46],"stress,":[47],"and":[48,78,99,107,110,116,125,130,161,175,198],"drug":[49],"perturbation,":[50],"although":[51],"metabolite":[52],"abundance":[53],"directly":[56],"quantify":[57],"pathway":[58,171],"flux.":[59],"In":[60],"narrative":[62],"review,":[63],"we":[64],"examine":[65,121],"how":[66],"pharmacometabolomics":[68],"is":[69],"evolving":[70],"from":[71,167],"descriptive":[72],"biomarker":[73],"profiling":[74],"toward":[75],"drug-response":[76],"prediction":[77],"target":[80,182],"discovery.":[81],"We":[82,119,140],"organize":[83],"evidence":[85,144,166],"across":[86],"three":[87],"translational":[88],"settings:":[89],"high-throughput":[90],"models":[92],"for":[93,103,113,136],"identifying":[94],"response-associated":[95],"states,":[97],"patient-derived":[98],"vivo":[101],"systems":[102],"testing":[104],"dependencies":[106],"resistance":[108],"mechanisms,":[109],"clinical":[111,163,199],"cohorts":[112],"treatment":[114],"stratification":[115],"longitudinal":[117],"monitoring.":[118],"further":[120],"isotope":[122],"tracing,":[123],"spatial":[124],"single-cell":[126],"metabolomics,":[127],"multi-omics":[128],"modeling,":[129,169],"causal":[131],"inference":[132],"as":[133],"complementary":[134],"approaches":[135],"interpreting":[137],"changes.":[139],"propose":[141],"five":[142],"non-cumulative":[143],"checkpoints":[145,186],"(E1\u2013E5)":[146],"spanning":[147],"treatment-linked":[148],"association":[149],"or":[150,157,177],"prediction,":[151],"internal":[152],"evaluation,":[153],"independent":[154,203],"corroboration,":[155,174],"source/pathway":[156],"target-specific":[158],"perturbation":[159,179],"evidence,":[160],"prospective":[162],"utility.":[164],"Convergent":[165],"predictive":[168],"tracer-informed":[170],"analysis,":[172],"cross-model":[173],"genetic":[176],"pharmacological":[178],"can":[180],"strengthen":[181],"hypotheses.":[183],"The":[184],"proposed":[185],"provide":[187],"qualitative":[189],"appraisal":[190],"framework":[191],"rather":[192],"than":[193],"formally":[195],"validated":[196],"score,":[197],"signatures":[200],"still":[201],"require":[202],"evaluation":[204],"before":[205],"routine":[206],"use.":[207]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
