{"id":"https://openalex.org/W7225792996","doi":"https://doi.org/10.3389/fnmol.2026.1968273","title":"Cerebellar climbing fibers in neurodevelopmental disorders","display_name":"Cerebellar climbing fibers in neurodevelopmental disorders","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225792996","doi":"https://doi.org/10.3389/fnmol.2026.1968273"},"language":"en","primary_location":{"id":"doi:10.3389/fnmol.2026.1968273","doi":"https://doi.org/10.3389/fnmol.2026.1968273","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2026.1968273","pdf_url":null,"source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fnmol.2026.1968273","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138783538","display_name":"Presley A Pickeral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Presley A. Pickeral","raw_affiliation_strings":["Fralin Biomedical Research Institute, Virginia Tech Carilion"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fralin Biomedical Research Institute, Virginia Tech Carilion","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065080054","display_name":"Meike E. van der Heijden","orcid":"https://orcid.org/0000-0003-0801-8806","observed_orcids":["https://orcid.org/0000-0003-0801-8806"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meike E. van der Heijden","raw_affiliation_strings":["Center for Neurobiology Research, Virginia Tech Carilion","Department of Pediatrics, Virginia Tech Carilion","Fralin Biomedical Research Institute, Virginia Tech Carilion","Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech","School of Medicine, Virginia Tech Carilion","School of Neuroscience, Virginia Tech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology Research, Virginia Tech Carilion","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Pediatrics, Virginia Tech Carilion","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Fralin Biomedical Research Institute, Virginia Tech Carilion","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"School of Medicine, Virginia Tech Carilion","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"School of Neuroscience, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065080054"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.17309999465942383,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8471999764442444},{"id":"https://openalex.org/C2780393176","wikidata":"https://www.wikidata.org/wiki/Q4736445","display_name":"Climbing fiber","level":4,"score":0.8296999931335449},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.7544999718666077},{"id":"https://openalex.org/C2778472085","wikidata":"https://www.wikidata.org/wiki/Q1570272","display_name":"Purkinje cell","level":3,"score":0.6420000195503235},{"id":"https://openalex.org/C95038775","wikidata":"https://www.wikidata.org/wiki/Q22857","display_name":"Climbing","level":2,"score":0.6403999924659729},{"id":"https://openalex.org/C2778058767","wikidata":"https://www.wikidata.org/wiki/Q5064084","display_name":"Parallel fiber","level":4,"score":0.5913000106811523},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5670999884605408},{"id":"https://openalex.org/C107690735","wikidata":"https://www.wikidata.org/wiki/Q852461","display_name":"Motor learning","level":2,"score":0.5440999865531921},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.5188000202178955},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.4887000024318695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4072999954223633},{"id":"https://openalex.org/C2777318268","wikidata":"https://www.wikidata.org/wiki/Q6916721","display_name":"Mossy fiber (hippocampus)","level":4,"score":0.3797999918460846},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.3458000123500824},{"id":"https://openalex.org/C113062710","wikidata":"https://www.wikidata.org/wiki/Q2463100","display_name":"Motor coordination","level":2,"score":0.3255999982357025},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3172999918460846},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.3151000142097473},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.31130000948905945},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fnmol.2026.1968273","doi":"https://doi.org/10.3389/fnmol.2026.1968273","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2026.1968273","pdf_url":null,"source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fnmol.2026.1968273","doi":"https://doi.org/10.3389/fnmol.2026.1968273","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2026.1968273","pdf_url":null,"source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1619466689","https://openalex.org/W1788860859","https://openalex.org/W1902195748","https://openalex.org/W1936685714","https://openalex.org/W1939847411","https://openalex.org/W1966277592","https://openalex.org/W1974689666","https://openalex.org/W1975478015","https://openalex.org/W1994415148","https://openalex.org/W1995940333","https://openalex.org/W1999601172","https://openalex.org/W2008470349","https://openalex.org/W2010138104","https://openalex.org/W2012028550","https://openalex.org/W2016441731","https://openalex.org/W2029563691","https://openalex.org/W2031133527","https://openalex.org/W2045308400","https://openalex.org/W2063699514","https://openalex.org/W2073650605","https://openalex.org/W2075346916","https://openalex.org/W2079590167","https://openalex.org/W2080255931","https://openalex.org/W2090336587","https://openalex.org/W2093621557","https://openalex.org/W2104321133","https://openalex.org/W2112227347","https://openalex.org/W2126888533","https://openalex.org/W2128332414","https://openalex.org/W2144696231","https://openalex.org/W2148160463","https://openalex.org/W2155051950","https://openalex.org/W2160906323","https://openalex.org/W2168445735","https://openalex.org/W2171136974","https://openalex.org/W2171357033","https://openalex.org/W2228196161","https://openalex.org/W2254741440","https://openalex.org/W2554550778","https://openalex.org/W2605002006","https://openalex.org/W2747564569","https://openalex.org/W2757506735","https://openalex.org/W2767871845","https://openalex.org/W2859077248","https://openalex.org/W2883082006","https://openalex.org/W2886989735","https://openalex.org/W2898208307","https://openalex.org/W2923061357","https://openalex.org/W2948368019","https://openalex.org/W2981304003","https://openalex.org/W2982484335","https://openalex.org/W2998823168","https://openalex.org/W3045023537","https://openalex.org/W3102260669","https://openalex.org/W3121240969","https://openalex.org/W3152448303","https://openalex.org/W3174801515","https://openalex.org/W3191965259","https://openalex.org/W3203959760","https://openalex.org/W4210691315","https://openalex.org/W4220845729","https://openalex.org/W4224257264","https://openalex.org/W4235246253","https://openalex.org/W4280600229","https://openalex.org/W4293379163","https://openalex.org/W4384922405","https://openalex.org/W4384933796","https://openalex.org/W4385298737","https://openalex.org/W4385879177","https://openalex.org/W4386574266","https://openalex.org/W4386944653","https://openalex.org/W4388486753","https://openalex.org/W4389484740","https://openalex.org/W4389636500","https://openalex.org/W4395448125","https://openalex.org/W4398242172","https://openalex.org/W4400323659","https://openalex.org/W4403217639","https://openalex.org/W4404214031","https://openalex.org/W4405248584","https://openalex.org/W4406899721","https://openalex.org/W4407915954","https://openalex.org/W4407948722","https://openalex.org/W4409460551","https://openalex.org/W4410024924","https://openalex.org/W4413397412","https://openalex.org/W4415001574","https://openalex.org/W4416535901","https://openalex.org/W7139118013","https://openalex.org/W7165014060"],"related_works":[],"abstract_inverted_index":{"The":[0,42],"cerebellum":[1,43],"is":[2,183],"increasingly":[3],"recognized":[4],"for":[5,39],"its":[6],"involvement":[7],"in":[8,14,26,35,111,130,186],"various":[9,36],"neurodevelopmental":[10,131,187],"disorders":[11],"with":[12,61],"deficits":[13],"motor":[15],"and":[16,57,99,132,142,149,156,179],"cognitive":[17],"functioning.":[18],"In":[19],"this":[20],"review,":[21],"we":[22],"highlight":[23],"recent":[24],"advances":[25],"our":[27],"understanding":[28],"of":[29,67,175],"abnormal":[30],"olivocerebellar":[31,169],"climbing":[32,50,79,105,127,153],"fiber":[33,106,128,154],"development":[34,129,155,178],"preclinical":[37],"models":[38],"these":[40],"disorders.":[41,188],"undergoes":[44],"extensive":[45],"postnatal":[46],"development,":[47,107],"during":[48],"which":[49],"fibers":[51],"from":[52,77,103],"the":[53,64,68,147,168],"inferior":[54],"olive":[55],"establish":[56],"refine":[58],"synaptic":[59,116,118],"connections":[60],"Purkinje":[62,73],"cells,":[63],"principal":[65],"neurons":[66],"cerebellar":[69,96],"cortex.":[70],"Initially,":[71],"each":[72],"cell":[74],"receives":[75],"input":[76],"multiple":[78],"fibers,":[80],"but":[81],"developmental":[82],"synapse":[83,112],"elimination":[84],"ultimately":[85],"produces":[86],"a":[87,172],"precise":[88],"one-to-one":[89],"connection.":[90],"Increasing":[91],"evidence":[92],"indicates":[93],"that":[94,182],"faulty":[95],"circuit":[97,170],"formation":[98],"function":[100,181],"can":[101],"arise":[102],"aberrant":[104,126],"such":[108],"as":[109,171],"defects":[110],"elimination,":[113],"dendritic":[114],"translocation,":[115],"structure,":[117],"number,":[119],"or":[120],"neurotransmission.":[121],"Multiple":[122],"studies":[123],"have":[124],"identified":[125],"neurological":[133,180],"disorders,":[134],"including":[135],"autism":[136],"spectrum":[137],"disorder,":[138],"schizophrenia,":[139],"ataxia,":[140],"dystonia,":[141],"essential":[143],"tremor.":[144],"We":[145],"summarize":[146],"cellular":[148],"molecular":[150],"mechanisms":[151],"governing":[152],"examine":[157],"how":[158],"their":[159],"disruption":[160],"contributes":[161],"to":[162],"disease":[163],"pathogenesis.":[164],"This":[165],"work":[166],"highlights":[167],"critical":[173],"determinant":[174],"typical":[176],"brain":[177],"often":[184],"disrupted":[185]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}