{"id":"https://openalex.org/W7225792967","doi":"https://doi.org/10.1186/s13048-026-02279-4","title":"KELIM and post-chemotherapy CA-125 for assessing chemosensitivity in high-grade serous carcinoma","display_name":"KELIM and post-chemotherapy CA-125 for assessing chemosensitivity in high-grade serous carcinoma","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225792967","doi":"https://doi.org/10.1186/s13048-026-02279-4"},"language":"en","primary_location":{"id":"doi:10.1186/s13048-026-02279-4","doi":"https://doi.org/10.1186/s13048-026-02279-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13048-026-02279-4","pdf_url":null,"source":{"id":"https://openalex.org/S15947008","display_name":"Journal of Ovarian Research","issn_l":"1757-2215","issn":["1757-2215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ovarian Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13048-026-02279-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000158452","display_name":"Mara Santarelli","orcid":"https://orcid.org/0009-0000-5414-3726","observed_orcids":["https://orcid.org/0009-0000-5414-3726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mara Santarelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015719076","display_name":"Veli\u2010Matti Isoviita","orcid":"https://orcid.org/0000-0001-7329-8934","observed_orcids":["https://orcid.org/0000-0001-7329-8934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veli-Matti Isoviita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161453929","display_name":"Yilin Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yilin Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040561209","display_name":"Carola Doerr","orcid":"https://orcid.org/0000-0002-4981-3227","observed_orcids":["https://orcid.org/0000-0002-4981-3227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carola Doerr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161019868","display_name":"Sampsa Hautaniemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sampsa Hautaniemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091615132","display_name":"Titta Joutsiniemi","orcid":"https://orcid.org/0000-0003-2169-9933","observed_orcids":["https://orcid.org/0000-0003-2169-9933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Titta Joutsiniemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044104350","display_name":"Johanna Hynninen","orcid":"https://orcid.org/0000-0002-0854-7225","observed_orcids":["https://orcid.org/0000-0002-0854-7225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna Hynninen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159586665","display_name":"Sakari Hietanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sakari Hietanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059640936","display_name":"Benno Schwikowski","orcid":"https://orcid.org/0000-0001-5127-5619","observed_orcids":["https://orcid.org/0000-0001-5127-5619"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benno Schwikowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2781100745","wikidata":"https://www.wikidata.org/wiki/Q1977435","display_name":"Debulking","level":4,"score":0.9593999981880188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8945000171661377},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6097999811172485},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.5845000147819519},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5710999965667725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5415999889373779},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4032999873161316},{"id":"https://openalex.org/C2777632260","wikidata":"https://www.wikidata.org/wiki/Q19000698","display_name":"Serous carcinoma","level":4,"score":0.3684999942779541},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.36239999532699585},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.3411000072956085},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.3377000093460083},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.30559998750686646},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3043000102043152},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.2685999870300293},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.26739999651908875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13048-026-02279-4","doi":"https://doi.org/10.1186/s13048-026-02279-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13048-026-02279-4","pdf_url":null,"source":{"id":"https://openalex.org/S15947008","display_name":"Journal of Ovarian Research","issn_l":"1757-2215","issn":["1757-2215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ovarian Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13048-026-02279-4","doi":"https://doi.org/10.1186/s13048-026-02279-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13048-026-02279-4","pdf_url":null,"source":{"id":"https://openalex.org/S15947008","display_name":"Journal of Ovarian Research","issn_l":"1757-2215","issn":["1757-2215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ovarian Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Accurate":[2],"assessment":[3],"of":[4,29,50,172,217,257,301],"platinum":[5],"chemosensitivity":[6,218],"is":[7],"important":[8],"for":[9,136,204],"treatment":[10,266],"planning":[11],"and":[12,57,85,104,117,126,239,279],"translational":[13],"research":[14],"in":[15,60,70,79,219,227,276,304],"ovarian":[16],"high-grade":[17,220],"serous":[18,221],"carcinoma.":[19,222],"CA-125":[20,91,259],"kinetics":[21],"has":[22],"been":[23,38],"proposed":[24],"as":[25,236,285],"a":[26,237],"surrogate":[27],"marker":[28],"chemosensitivity,":[30],"but":[31,197],"different":[32,255],"CA-125-based":[33,52,208,252],"scoring":[34],"strategies":[35],"have":[36],"rarely":[37],"compared":[39],"within":[40],"the":[41,71,112,133,147,155,180,188,280,305],"same":[42],"patient":[43],"cohort.":[44,74,307],"We":[45],"performed":[46],"an":[47,297],"exploratory":[48],"comparison":[49],"seven":[51],"measures":[53,130,161,209,253],"representing":[54],"model-based,":[55],"multi-timepoint,":[56],"single-timepoint":[58],"approaches":[59],"patients":[61,80,95,228,302],"treated":[62,81,100,106],"with":[63,82,101,107,123,144,166,184,213,261],"neoadjuvant":[64,83,102,113,230],"chemotherapy":[65,84,103,114],"or":[66],"primary":[67,86,108,156,245],"debulking":[68,87,109,142,157,246],"surgery":[69,158],"prospective":[72],"DECIDER":[73,306],"Measures":[75],"were":[76,96,120,195,198],"analyzed":[77],"separately":[78],"surgery.":[88,110,247],"Results":[89],"Longitudinal":[90],"values":[92,149],"from":[93],"96":[94],"analyzed,":[97],"including":[98],"55":[99],"41":[105],"In":[111,154],"group,":[115,159],"KELIM":[116,223],"Percentage":[118],"Reduction":[119],"significantly":[121],"associated":[122],"platinum-free":[124],"interval":[125,141],"progression-free":[127],"survival.":[128],"Reduction-based":[129],"also":[131],"showed":[132,162,179,210],"highest":[134],"accuracy":[135],"predicting":[137],"complete":[138],"cytoreduction":[139],"after":[140,170,202,244],"surgery,":[143],"area":[145],"under":[146],"curve":[148],"up":[150],"to":[151,272],"approximately":[152],"0.75.":[153],"reduction-based":[160],"weaker":[163],"associations,":[164],"consistent":[165,182],"reduced":[167],"dynamic":[168],"range":[169],"removal":[171],"bulk":[173],"tumor":[174],"before":[175],"chemotherapy.":[176],"Post-Chemotherapy":[177,233],"Level":[178,234],"most":[181,225],"association":[183],"overall":[185],"survival":[186],"among":[187],"evaluated":[189],"measures.":[190],"Homologous":[191],"recombination":[192],"deficiency-associated":[193],"trends":[194],"observed":[196],"not":[199],"statistically":[200],"significant":[201],"correction":[203],"multiple":[205],"testing.":[206],"Conclusions":[207],"treatment-context-specific":[211],"associations":[212,262],"clinically":[214],"relevant":[215],"indicators":[216],"was":[224,270],"informative":[226],"receiving":[229],"chemotherapy,":[231],"whereas":[232],"emerged":[235],"simple":[238],"broadly":[240],"applicable":[241],"marker,":[242],"particularly":[243],"These":[248],"findings":[249],"show":[250],"that":[251,263],"capture":[254],"aspects":[256],"treatment-associated":[258],"dynamics,":[260],"depend":[264],"on":[265],"strategy.":[267],"However,":[268],"discrimination":[269],"insufficient":[271],"support":[273],"clinical":[274],"decision-making":[275],"this":[277],"cohort,":[278],"results":[281],"should":[282],"be":[283],"interpreted":[284],"exploratory.":[286],"Trial":[287],"registration":[288],"ClinicalTrials.gov,":[289],"NCT04846933.":[290],"Registered":[291],"2021-04-12.":[292],"The":[293],"present":[294],"manuscript":[295],"reports":[296],"observational":[298],"secondary":[299],"analysis":[300],"enrolled":[303],"Retrospectively":[308],"registered.":[309]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
