{"id":"https://openalex.org/W7225792774","doi":"https://doi.org/10.64898/2026.11.09.765451","title":"Combined pharmacotherapy suppress ferroptosis and inflammation after neonatal intraventricular hemorrhage","display_name":"Combined pharmacotherapy suppress ferroptosis and inflammation after neonatal intraventricular hemorrhage","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225792774","doi":"https://doi.org/10.64898/2026.11.09.765451"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.765451","doi":"https://doi.org/10.64898/2026.11.09.765451","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765451","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161447508","display_name":"Michelle Zigelstein","orcid":"https://orcid.org/0009-0000-5049-6057","observed_orcids":["https://orcid.org/0009-0000-5049-6057"]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Zigelstein","raw_affiliation_strings":["Westchester Medical Center;"],"raw_orcid":"https://orcid.org/0009-0000-5049-6057","affiliations":[{"raw_affiliation_string":"Westchester Medical Center;","institution_ids":["https://openalex.org/I1321686444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126194141","display_name":"Vanessa Castro Diaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa Castro Diaz","raw_affiliation_strings":["Westchester Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westchester Medical Center;","institution_ids":["https://openalex.org/I1321686444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082507798","display_name":"Christina La Gamma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1286207013","display_name":"George Washington University Hospital","ror":"https://ror.org/00fwdyt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286207013"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina La Gamma","raw_affiliation_strings":["George Washington University Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University Hospital;","institution_ids":["https://openalex.org/I1286207013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113606438","display_name":"Furong Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Furong Hu","raw_affiliation_strings":["New York Medical College;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College;","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161461141","display_name":"Sansar C Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sansar C Sharma","raw_affiliation_strings":["New York Medical College;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College;","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072211764","display_name":"Selvakumar Subbian","orcid":"https://orcid.org/0000-0003-2021-8632","observed_orcids":["https://orcid.org/0000-0003-2021-8632"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selvakumar Subbian","raw_affiliation_strings":["Rutgers University"],"raw_orcid":"https://orcid.org/0000-0003-2021-8632","affiliations":[{"raw_affiliation_string":"Rutgers University","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050395217","display_name":"Libor Vel\u00ed\u0161ek","orcid":"https://orcid.org/0000-0003-2805-349X","observed_orcids":["https://orcid.org/0000-0003-2805-349X"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Libor Velisek","raw_affiliation_strings":["New York Medical College;"],"raw_orcid":"https://orcid.org/0000-0003-2805-349X","affiliations":[{"raw_affiliation_string":"New York Medical College;","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072970088","display_name":"Jana Vel\u00ed\u0161kov\u00e1","orcid":"https://orcid.org/0000-0001-6094-7210","observed_orcids":["https://orcid.org/0000-0001-6094-7210"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jana Veliskova","raw_affiliation_strings":["New York Medical College;"],"raw_orcid":"https://orcid.org/0000-0001-6094-7210","affiliations":[{"raw_affiliation_string":"New York Medical College;","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088604691","display_name":"Ravi Sachidanandam","orcid":"https://orcid.org/0000-0001-9844-4459","observed_orcids":["https://orcid.org/0000-0001-9844-4459"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Sacchidanandam","raw_affiliation_strings":["New York Medical College;"],"raw_orcid":"https://orcid.org/0000-0001-9844-4459","affiliations":[{"raw_affiliation_string":"New York Medical College;","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000655221","display_name":"Govindaiah Vinukonda","orcid":"https://orcid.org/0000-0002-6065-3092","observed_orcids":["https://orcid.org/0000-0002-6065-3092"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Govindaiah Vinukonda","raw_affiliation_strings":["New York Medical College;"],"raw_orcid":"https://orcid.org/0000-0002-6065-3092","affiliations":[{"raw_affiliation_string":"New York Medical College;","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013592135","display_name":"Edmund F. LaGamma","orcid":"https://orcid.org/0000-0001-9720-1949","observed_orcids":["https://orcid.org/0000-0001-9720-1949"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmund F LaGamma","raw_affiliation_strings":["New York Medical College;"],"raw_orcid":"https://orcid.org/0000-0001-9720-1949","affiliations":[{"raw_affiliation_string":"New York Medical College;","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000655221"],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.8611000180244446},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.746999979019165},{"id":"https://openalex.org/C2779252433","wikidata":"https://www.wikidata.org/wiki/Q6058597","display_name":"Intraventricular hemorrhage","level":4,"score":0.6596999764442444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6322000026702881},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47929999232292175},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4526999890804291},{"id":"https://openalex.org/C2780123866","wikidata":"https://www.wikidata.org/wiki/Q469490","display_name":"Periventricular leukomalacia","level":4,"score":0.44760000705718994},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.426800012588501},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41670000553131104},{"id":"https://openalex.org/C2776663378","wikidata":"https://www.wikidata.org/wiki/Q1134467","display_name":"Ependyma","level":3,"score":0.37209999561309814},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3513000011444092},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.328000009059906},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.32260000705718994},{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.3203999996185303},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.31439998745918274},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.301800012588501},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3003999888896942},{"id":"https://openalex.org/C2779662492","wikidata":"https://www.wikidata.org/wiki/Q468787","display_name":"Hematoma","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.27459999918937683},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2703999876976013},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.265500009059906},{"id":"https://openalex.org/C2993827019","wikidata":"https://www.wikidata.org/wiki/Q105402","display_name":"Cerebral ventricle","level":2,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.765451","doi":"https://doi.org/10.64898/2026.11.09.765451","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765451","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Neonatal":[0],"intraventricular":[1],"hemorrhage":[2],"(IVH)":[3],"is":[4,81,231],"a":[5,52,187,204,258],"common":[6],"complication":[7],"of":[8,33,87,99,109,164,279,303,308,331],"extremely":[9],"premature":[10],"newborns,":[11],"and":[12,22,27,43,68,96,120,123,134,140,148,161,174,238,265,286,311],"results":[13,248,275],"in":[14,71,143,178,215,267,335],"reduced":[15,129],"neurogenesis,":[16],"white":[17],"matter":[18],"injury,":[19],"cortical":[20],"atrophy,":[21],"subsequent":[23],"cerebral":[24],"palsy,":[25],"learning":[26,44],"memory":[28,42],"disabilities.":[29],"However,":[30],"the":[31,36,72,84,88,91,97,100,144,165,179,232,268,336],"impact":[32],"IVH":[34,222],"on":[35],"hippocampus,":[37],"an":[38,107,126],"area":[39],"critical":[40],"for":[41,261],"capabilities":[45],"throughout":[46],"life,":[47],"remains":[48],"relatively":[49],"unexplored.":[50],"Using":[51],"preterm":[53],"rabbit":[54],"pup":[55],"model":[56],"that":[57,299,305,318],"structurally":[58],"resembles":[59],"human":[60],"perinatal":[61],"brain":[62,270],"development,":[63],"we":[64,201],"report,":[65],"widespread":[66],"hematoma":[67,237],"iron":[69,127,130,239,263],"accumulation":[70,80,240],"hippocampal":[73,216,236,253],"dentate":[74,102],"gyrus":[75,103],"(DG)":[76],"following":[77,244],"IVH.":[78,246,315],"This":[79,183],"facilitated":[82],"by":[83],"anatomical":[85],"positioning":[86],"hippocampus":[89],"within":[90],"unidirectional":[92],"CSF":[93],"flow":[94],"pathway":[95],"vulnerability":[98],"immature":[101],"vasculature.":[104],"Sulforaphane":[105],"(SFN;":[106],"activator":[108],"nuclear":[110],"factor":[111,115,119],"erythroid":[112],"2":[113,116],"related":[114],"[Nrf2]":[117],"transcriptional":[118],"anti-inflammatory":[121],"pathways)":[122],"deferoxamine":[124],"(DFN;":[125],"chelator)":[128],"deposition,":[131],"free":[132],"hemoglobin,":[133],"activated":[135],"glial":[136],"cells":[137],"(sp.":[138],"astrocytes":[139],"microglia),":[141],"particularly":[142],"DG":[145],"molecular":[146],"layer":[147],"hilar":[149],"regions.":[150],"The":[151,247,293],"attenuated":[152],"inflammatory":[153],"responses":[154],"correlate":[155],"with":[156,170,186,226],"decreased":[157],"ferroptosis-mediated":[158],"neuronal":[159,175],"death,":[160],"substantial":[162],"restoration":[163],"dysregulated":[166],"gene":[167,188],"pathways":[168],"associated":[169,185,241],"inflammation,":[171],"immune":[172],"activation,":[173],"cell":[176,192,326],"death":[177,193],"developing":[180,269],"hippocampal/DG":[181,309],"region.":[182],"was":[184,213],"profile":[189],"favoring":[190],"ferroptotic":[191],"rather":[194],"than":[195],"apoptosis":[196],"or":[197,223],"autophagy":[198],"pathways.":[199],"Moreover,":[200],"also":[202],"identified":[203],"regional":[205],"specificity":[206],"to":[207,218,234,271,282,289],"certain":[208],"effects":[209,321],"as":[210,255,257],"no":[211],"astrogliosis":[212],"observed":[214],"CA1":[217],"CA4":[219],"regions":[220],"after":[221,313],"when":[224],"compared":[225],"healthy":[227],"controls.":[228],"Our":[229],"study":[230,294],"first":[233],"demonstrate":[235],"pathologic":[242],"mechanisms":[243],"neonatal":[245,314],"provide":[249],"mechanistic":[250],"insights":[251],"into":[252],"injury":[254,280,304],"well":[256],"therapeutic":[259,291,297],"proof-of-concept":[260],"targeting":[262],"toxicity":[264],"inflammation":[266],"mitigate":[272],"injury.":[273],"These":[274],"justify":[276],"extending":[277],"analyses":[278],"reversal":[281],"long-term":[283],"postnatal":[284],"ages":[285],"behavior":[287],"studies":[288],"assess":[290],"potential.":[292],"illustrates":[295],"novel":[296],"interventions":[298],"attenuate":[300],"early":[301],"mediators":[302],"improves":[306],"recovery":[307],"formation/maturation":[310],"neuroprotection":[312],"We":[316],"speculate":[317],"these":[319],"protective":[320],"may":[322],"prolong":[323],"donor":[324],"stem":[325],"survival":[327],"thus,":[328],"potentiating":[329],"benefits":[330],"living":[332],"cellular":[333],"therapy":[334],"future.":[337]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}