{"id":"https://openalex.org/W7225792339","doi":"https://doi.org/10.1128/aac.00963-26","title":"Rosmarinic acid exerts anti-CVB3 effects by inducing HO-1 via the SIRT1/AMPK\u03b1/Nrf2 pathway","display_name":"Rosmarinic acid exerts anti-CVB3 effects by inducing HO-1 via the SIRT1/AMPK\u03b1/Nrf2 pathway","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225792339","doi":"https://doi.org/10.1128/aac.00963-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/43012511"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00963-26","doi":"https://doi.org/10.1128/aac.00963-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00963-26","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/aac.00963-26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100938236","display_name":"Junbo Huang","orcid":"https://orcid.org/0009-0005-8882-0998","observed_orcids":["https://orcid.org/0009-0005-8882-0998"]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junbo Huang","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":"https://orcid.org/0009-0005-8882-0998","affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657187","display_name":"Qing Song","orcid":"https://orcid.org/0000-0003-2716-6492","observed_orcids":["https://orcid.org/0000-0003-2716-6492"]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Song","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138750139","display_name":"Yanjun Di","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Di","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161492261","display_name":"Zhiyun Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyun Cheng","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161491756","display_name":"Haowei Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haowei Lin","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123338264","display_name":"Haoyi Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyi Zhan","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161474371","display_name":"Yanhui Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhui Chen","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161451307","display_name":"Yachen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yachen Wang","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102110752","display_name":"Lijuan Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Xie","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161474749","display_name":"Fucai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fucai Wang","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050133817","display_name":"Lei Tong","orcid":"https://orcid.org/0000-0003-2389-8928","observed_orcids":["https://orcid.org/0000-0003-2389-8928"]},"institutions":[{"id":"https://openalex.org/I119045251","display_name":"Huaqiao University","ror":"https://ror.org/03frdh605","country_code":"CN","type":"education","lineage":["https://openalex.org/I119045251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Tong","raw_affiliation_strings":["School of Medicine, Huaqiao University"],"raw_orcid":"https://orcid.org/0000-0003-2389-8928","affiliations":[{"raw_affiliation_string":"School of Medicine, Huaqiao University","institution_ids":["https://openalex.org/I119045251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I119045251"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e0096326","last_page":"e0096326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778771215","wikidata":"https://www.wikidata.org/wiki/Q50380051","display_name":"Rosmarinic acid","level":3,"score":0.8695999979972839},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.628000020980835},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5309000015258789},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5157999992370605},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.47679999470710754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.444599986076355},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.42480000853538513},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.37940001487731934},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.36800000071525574},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3353999853134155},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.32839998602867126},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3237999975681305},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31610000133514404},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.3122999966144562},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.31049999594688416},{"id":"https://openalex.org/C2780209191","wikidata":"https://www.wikidata.org/wiki/Q14914339","display_name":"IRF3","level":4,"score":0.30239999294281006},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C96529984","wikidata":"https://www.wikidata.org/wiki/Q286136","display_name":"EC50","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.259799987077713},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25049999356269836}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1128/aac.00963-26","doi":"https://doi.org/10.1128/aac.00963-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00963-26","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:43012511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43012511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/aac.00963-26","doi":"https://doi.org/10.1128/aac.00963-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00963-26","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1743171475","https://openalex.org/W2005257517","https://openalex.org/W2134967712","https://openalex.org/W2566198415","https://openalex.org/W2783737543","https://openalex.org/W2792033012","https://openalex.org/W2803422725","https://openalex.org/W2936373618","https://openalex.org/W2949829593","https://openalex.org/W2966018070","https://openalex.org/W2971816091","https://openalex.org/W2998243830","https://openalex.org/W3007272556","https://openalex.org/W3015590570","https://openalex.org/W3048480647","https://openalex.org/W3086543504","https://openalex.org/W3168436232","https://openalex.org/W4280493659","https://openalex.org/W4280601414","https://openalex.org/W4280651588","https://openalex.org/W4283394826","https://openalex.org/W4285098415","https://openalex.org/W4286224999","https://openalex.org/W4295900646","https://openalex.org/W4311420631","https://openalex.org/W4324044586","https://openalex.org/W4368361933","https://openalex.org/W4387002167","https://openalex.org/W4387043486","https://openalex.org/W4387497697","https://openalex.org/W4392968433","https://openalex.org/W4396545601","https://openalex.org/W4399391745","https://openalex.org/W4400798933","https://openalex.org/W4402313279","https://openalex.org/W4402786261","https://openalex.org/W4403821271","https://openalex.org/W4404032730","https://openalex.org/W4404704290","https://openalex.org/W4407580250","https://openalex.org/W4408499528","https://openalex.org/W4413971228","https://openalex.org/W4414482078","https://openalex.org/W7139102759","https://openalex.org/W7161488005"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Coxsackievirus":[1],"B3":[2],"(CVB3)":[3],"is":[4,14],"the":[5,37,48,90,133,141,183],"primary":[6],"pathogen":[7],"of":[8,40,68,75,104,124,179,182,189],"viral":[9,62],"myocarditis":[10],"(VMC),":[11],"and":[12,23,30,45,47,55,71,111,121,149,162,172,177,187],"there":[13],"no":[15],"specific":[16],"therapy.":[17],"Rosmarinic":[18],"acid":[19],"(RA)":[20],"has":[21],"anti-inflammatory":[22,122],"antioxidant":[24],"properties,":[25],"but":[26],"its":[27,108],"anti-CVB3":[28],"activity":[29],"mechanism":[31],"remain":[32],"unclear.":[33],"This":[34],"study":[35],"examined":[36],"inhibitory":[38],"effect":[39],"RA":[41,60,87,95,125,131,156,168],"on":[42],"CVB3":[43,170],"replication":[44,63,92,171],"VMC,":[46],"underlying":[49],"mechanism.":[50],"In":[51,153,166],"CVB3-infected":[52],"HeLa":[53],"cells":[54],"a":[56,72,137],"mouse":[57],"VMC":[58,173],"model,":[59],"blocked":[61],"dose-dependently,":[64],"with":[65,89,101],"an":[66,102],"EC50":[67],"26.49":[69],"\u03bcM":[70],"selectivity":[73],"index":[74],"21.72,":[76],"which":[77],"was":[78],"more":[79],"effective":[80],"than":[81],"ribavirin.":[82],"Time-of-addition":[83],"experiments":[84],"showed":[85],"that":[86],"interfered":[88],"post-entry":[91],"stage.":[93],"Mechanistically,":[94],"directly":[96],"bound":[97],"sirtuin":[98],"1":[99],"(SIRT1),":[100],"affinity":[103],"\u221210.2":[105],"kcal/mol,":[106],"increasing":[107],"conformational":[109],"stability":[110],"inhibiting":[112],"ubiquitin-proteasome":[113],"degradation,":[114],"thereby":[115],"reversing":[116],"CVB3-induced":[117,159],"SIRT1":[118,129],"downregulation.":[119],"Antiviral":[120],"effects":[123],"were":[126],"abolished":[127],"by":[128],"knockdown.":[130],"activated":[132],"AMPK/Nrf2/HO-1":[134],"cascade":[135],"in":[136],"SIRT1-dependent":[138],"manner.":[139],"Notably,":[140],"HO-1":[142],"metabolite":[143],"biliverdin":[144],"(BV)":[145],"stimulated":[146],"STAT1/2":[147],"phosphorylation":[148],"interferon-stimulated":[150],"gene":[151],"expression.":[152,165],"vivo":[154],",":[155],"effectively":[157],"ameliorated":[158],"myocardial":[160],"injury":[161],"restored":[163],"SIRT1/AMPK/Nrf2/HO-1":[164],"conclusion,":[167],"prevents":[169],"via":[174],"direct":[175],"binding":[176],"stabilization":[178],"SIRT1,":[180],"activation":[181],"SIRT1/AMPK/Nrf2/HO-1/BV":[184],"signaling":[185],"pathway,":[186],"stimulation":[188],"interferon":[190],"response":[191],"through":[192],"STAT1/2.":[193]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
