{"id":"https://openalex.org/W7225792232","doi":"https://doi.org/10.1113/jp289999","title":"Acute intermittent carotid body stimulations induce long\u2010term facilitation of respiratory\u2013cardiovascular coupling in rats","display_name":"Acute intermittent carotid body stimulations induce long\u2010term facilitation of respiratory\u2013cardiovascular coupling in rats","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225792232","doi":"https://doi.org/10.1113/jp289999","pmid":"https://pubmed.ncbi.nlm.nih.gov/43012411"},"language":"en","primary_location":{"id":"doi:10.1113/jp289999","doi":"https://doi.org/10.1113/jp289999","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jp289999","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1113/jp289999","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5097476428","display_name":"Ambre Linossier","orcid":"https://orcid.org/0009-0008-9641-3163","observed_orcids":["https://orcid.org/0009-0008-9641-3163"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210125028","display_name":"Institut de Neurobiologie de la M\u00e9diterran\u00e9e","ror":"https://ror.org/02jthx987","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210125028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ambre A. Linossier","raw_affiliation_strings":["INMED, INSERM Aix\u2010Marseille University  Marseille France"],"raw_orcid":"https://orcid.org/0009-0008-9641-3163","affiliations":[{"raw_affiliation_string":"INMED, INSERM Aix\u2010Marseille University  Marseille France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210125028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072251378","display_name":"Christian Gestreau","orcid":"https://orcid.org/0000-0001-5069-482X","observed_orcids":["https://orcid.org/0000-0001-5069-482X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210125028","display_name":"Institut de Neurobiologie de la M\u00e9diterran\u00e9e","ror":"https://ror.org/02jthx987","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210125028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Gestreau","raw_affiliation_strings":["INMED, INSERM Aix\u2010Marseille University  Marseille France"],"raw_orcid":"https://orcid.org/0000-0001-5069-482X","affiliations":[{"raw_affiliation_string":"INMED, INSERM Aix\u2010Marseille University  Marseille France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210125028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077077867","display_name":"Cl\u00e9ment Menuet","orcid":"https://orcid.org/0000-0002-7419-6427","observed_orcids":["https://orcid.org/0000-0002-7419-6427"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210125028","display_name":"Institut de Neurobiologie de la M\u00e9diterran\u00e9e","ror":"https://ror.org/02jthx987","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210125028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cl\u00e9ment Menuet","raw_affiliation_strings":["INMED, INSERM Aix\u2010Marseille University  Marseille France"],"raw_orcid":"https://orcid.org/0000-0002-7419-6427","affiliations":[{"raw_affiliation_string":"INMED, INSERM Aix\u2010Marseille University  Marseille France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210125028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":{"value":5400,"currency":"USD","value_usd":5400},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7648000121116638},{"id":"https://openalex.org/C2780796939","wikidata":"https://www.wikidata.org/wiki/Q25326656","display_name":"Intermittent hypoxia","level":3,"score":0.7251999974250793},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.5608999729156494},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5548999905586243},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.5037000179290771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49950000643730164},{"id":"https://openalex.org/C136511781","wikidata":"https://www.wikidata.org/wiki/Q7168702","display_name":"Peripheral chemoreceptors","level":4,"score":0.48080000281333923},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4514000117778778},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.40540000796318054},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39989998936653137},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.38449999690055847},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.37619999051094055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.375},{"id":"https://openalex.org/C2778774071","wikidata":"https://www.wikidata.org/wiki/Q956224","display_name":"Carotid sinus","level":3,"score":0.37369999289512634},{"id":"https://openalex.org/C1337776","wikidata":"https://www.wikidata.org/wiki/Q1941955","display_name":"Facilitation","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.3296999931335449},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.28600001335144043},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C2777099253","wikidata":"https://www.wikidata.org/wiki/Q737313","display_name":"Phrenic nerve","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1113/jp289999","doi":"https://doi.org/10.1113/jp289999","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jp289999","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:43012411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43012411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1113/jp289999","doi":"https://doi.org/10.1113/jp289999","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jp289999","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1512074319","https://openalex.org/W1554027333","https://openalex.org/W1858094378","https://openalex.org/W1968724866","https://openalex.org/W1969051028","https://openalex.org/W1978909977","https://openalex.org/W1999340472","https://openalex.org/W2006833263","https://openalex.org/W2025872245","https://openalex.org/W2028139576","https://openalex.org/W2043624136","https://openalex.org/W2046587771","https://openalex.org/W2048900931","https://openalex.org/W2055795971","https://openalex.org/W2057174409","https://openalex.org/W2057255915","https://openalex.org/W2066562440","https://openalex.org/W2080653965","https://openalex.org/W2080805045","https://openalex.org/W2088749476","https://openalex.org/W2089742414","https://openalex.org/W2098105306","https://openalex.org/W2113191958","https://openalex.org/W2115643876","https://openalex.org/W2116030040","https://openalex.org/W2128107556","https://openalex.org/W2135469903","https://openalex.org/W2138908243","https://openalex.org/W2139899796","https://openalex.org/W2142940235","https://openalex.org/W2143237504","https://openalex.org/W2148827677","https://openalex.org/W2151385266","https://openalex.org/W2161477107","https://openalex.org/W2168420273","https://openalex.org/W2168810867","https://openalex.org/W2174445036","https://openalex.org/W2272744191","https://openalex.org/W2280140496","https://openalex.org/W2407109582","https://openalex.org/W2495628158","https://openalex.org/W2516502922","https://openalex.org/W2519480146","https://openalex.org/W2587962034","https://openalex.org/W2600107558","https://openalex.org/W2608338557","https://openalex.org/W2886625991","https://openalex.org/W2909792718","https://openalex.org/W2912635477","https://openalex.org/W2992206186","https://openalex.org/W3034035735","https://openalex.org/W3034185915","https://openalex.org/W3047264902","https://openalex.org/W3092861045","https://openalex.org/W3127166110","https://openalex.org/W3164635161","https://openalex.org/W3189619256","https://openalex.org/W4220839663","https://openalex.org/W4290805117","https://openalex.org/W4319771363","https://openalex.org/W4362716954","https://openalex.org/W4390202141","https://openalex.org/W4404124620","https://openalex.org/W4407349202","https://openalex.org/W4409190929","https://openalex.org/W4410112158","https://openalex.org/W4415349344","https://openalex.org/W4417424223","https://openalex.org/W7161683138","https://openalex.org/W7213135880"],"related_works":[],"abstract_inverted_index":{"Hypertension,":[0],"the":[1,31,47,58,63,125],"leading":[2],"modifiable":[3],"risk":[4],"factor":[5],"for":[6],"global":[7],"mortality,":[8],"is":[9,30,259],"driven":[10],"in":[11,62,68,80,97,126,131,153,224,238,261,272,289,308],">50%":[12],"of":[13,27,33,182,217,226,266,354],"cases":[14],"by":[15,87,171,179,325],"neurogenic":[16,28],"mechanisms":[17,246],"linked":[18,330],"to":[19,52,146,249,331,358],"heightened":[20],"sympathetic":[21,262,310],"nerve":[22],"activity":[23],"(SNA).":[24],"A":[25],"hallmark":[26],"hypertension":[29,85,363],"exacerbation":[32],"respiratory-modulated":[34,309],"SNA":[35],"(RespSNA)":[36],"and":[37,50,71,90,117,156,163,185,194,201,215,243,264,291,318,335,339,362],"resulting":[38],"blood":[39,118,292,313,320],"pressure":[40,119,293,314],"Traube-Hering":[41],"(TH)":[42],"waves,":[43,219],"which":[44],"emerges":[45],"during":[46],"prehypertensive":[48],"period":[49],"contributes":[51],"disease":[53],"development.":[54],"Carotid":[55,255],"bodies":[56],"(CBs),":[57],"peripheral":[59],"chemoreceptors":[60],"involved":[61],"hypoxic":[64],"response,":[65],"are":[66],"hyperactive":[67],"hypertensive":[69],"patients":[70],"animal":[72],"models.":[73],"Their":[74],"chronic":[75],"intermittent":[76,108,142,209],"stimulation,":[77],"as":[78],"seen":[79],"obstructive":[81],"sleep":[82],"apnoea,":[83],"promotes":[84],"characterised":[86],"exacerbated":[88],"RespSNA":[89,159,214],"TH":[91,115,161,218],"waves.":[92],"Yet,":[93],"their":[94],"causal":[95],"role":[96,223,237,271],"initiating":[98,239,273],"these":[99,167],"changes":[100,176,288],"remains":[101,276],"unclear.":[102],"Here,":[103],"we":[104],"investigated":[105],"whether":[106,280],"acute":[107,141,208],"CB":[109,135,210,283,348],"stimulations":[110,136,284,303],"could":[111,285],"directly":[112],"enhance":[113],"RespSNA,":[114],"waves":[116,162],"from":[120,295],"a":[121,148,180,235,296,305],"physiological":[122,297,360],"baseline,":[123],"using":[124],"situ":[127],"working":[128],"heart-brainstem":[129],"preparation":[130],"rats.":[132],"Four":[133],"brief":[134],"with":[137,166],"sodium":[138],"cyanide,":[139],"mimicking":[140],"hypoxia,":[143],"were":[144,177,329],"sufficient":[145],"induce":[147,351],"prolonged":[149],"(>20":[150],"min)":[151],"increase":[152,307],"both":[154,359],"inspiratory":[155],"late":[157],"expiratory":[158],"bursts,":[160],"perfusion":[164],"pressure,":[165],"effects":[168],"being":[169],"prevented":[170,324],"carotid":[172,326],"sinus":[173,327],"denervation.":[174],"These":[175,322],"accompanied":[178],"reconfiguration":[181],"central":[183,245],"respiratory":[184,190,196],"cardiovascular":[186],"control,":[187],"including":[188],"elevated":[189],"heart":[191],"rate":[192],"variability":[193],"enhanced":[195,332],"drive":[197],"targeting":[198],"upper":[199,337],"airway":[200,338],"abdominal":[202,340],"muscles.":[203],"Our":[204,228,343],"findings":[205,344],"demonstrate":[206],"that":[207,232,244,346],"activation":[211,349],"triggers":[212],"sustained":[213],"elevation":[216],"supporting":[220],"its":[221,250,269],"potential":[222],"development":[225,265],"hypertension.":[227],"data":[229],"also":[230],"suggest":[231],"CBs":[233],"play":[234],"key":[236],"this":[240],"respiratory-cardiovascular":[241,274,333,355],"plasticity":[242],"might":[247],"contribute":[248],"long-term":[251,352],"maintenance.":[252],"KEY":[253],"POINTS:":[254],"body":[256],"(CB)":[257],"overactivity":[258],"implicated":[260],"excitation":[263],"hypertension,":[267],"but":[268],"direct":[270],"dysfunction":[275],"unresolved.":[277],"We":[278],"tested":[279],"brief,":[281],"repeated":[282],"trigger":[286],"lasting":[287],"breathing":[290],"control":[294],"baseline.":[298],"In":[299],"rats,":[300],"only":[301],"four":[302],"induced":[304],"persistent":[306],"activity,":[311],"elevating":[312],"fluctuations":[315],"(Traube-Hering":[316],"waves)":[317],"mean":[319],"pressure.":[321],"effects,":[323],"denervation,":[328],"coupling":[334],"altered":[336],"motor":[341],"control.":[342],"reveal":[345],"short-term":[347],"can":[350],"facilitation":[353],"coupling,":[356],"relevant":[357],"adaptations":[361],"pathogenesis.":[364]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}