{"id":"https://openalex.org/W7225791623","doi":"https://doi.org/10.22207/jpam.20.4.19","title":"Diosgenin as a Potential Therapeutic Agent for Bleomycin-Induced Pulmonary Fibrosis with Anti-Inflammatory, Antifibrotic and Antibacterial Activity","display_name":"Diosgenin as a Potential Therapeutic Agent for Bleomycin-Induced Pulmonary Fibrosis with Anti-Inflammatory, Antifibrotic and Antibacterial Activity","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225791623","doi":"https://doi.org/10.22207/jpam.20.4.19"},"language":"en","primary_location":{"id":"doi:10.22207/jpam.20.4.19","doi":"https://doi.org/10.22207/jpam.20.4.19","is_oa":true,"landing_page_url":"https://doi.org/10.22207/jpam.20.4.19","pdf_url":null,"source":{"id":"https://openalex.org/S2476582842","display_name":"Journal of Pure and Applied Microbiology","issn_l":"0973-7510","issn":["0973-7510","2581-690X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4353108566","host_organization_name":"Dr. M.N. Khan","host_organization_lineage":["https://openalex.org/P4353108566"],"host_organization_lineage_names":["Dr. M.N. Khan"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pure and Applied Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.22207/jpam.20.4.19","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040090562","display_name":"Ashwini Narayan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashwini Narayan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3571-4575","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090121517","display_name":"Souparnika H. Manjunath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Souparnika H. Manjunath","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8016-0017","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714238","display_name":"Anil Kumar","orcid":"https://orcid.org/0000-0001-6813-7765","observed_orcids":["https://orcid.org/0000-0001-6813-7765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anil Kumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6813-7765","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101600234","display_name":"Priya Babu Shubha","orcid":"https://orcid.org/0000-0003-3751-3435","observed_orcids":["https://orcid.org/0000-0003-3751-3435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.S. Priya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3751-3435","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038970988","display_name":"Syed Baker","orcid":"https://orcid.org/0000-0003-0554-8764","observed_orcids":["https://orcid.org/0000-0003-0554-8764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Baker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0554-8764","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084457781","display_name":"S. Niranjan Raj","orcid":"https://orcid.org/0000-0002-9382-7634","observed_orcids":["https://orcid.org/0000-0002-9382-7634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Niranjan Raj","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3686-4746","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103265136","display_name":"Shanthappa Nanjundaswamy","orcid":"https://orcid.org/0000-0002-2893-1398","observed_orcids":["https://orcid.org/0000-0002-2893-1398"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Nanjunda Swamy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2893-1398","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6744999885559082},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.6654000282287598},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6328999996185303},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.520799994468689},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5069000124931335},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.47699999809265137},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4616999924182892},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3797000050544739},{"id":"https://openalex.org/C2778353156","wikidata":"https://www.wikidata.org/wiki/Q415739","display_name":"Cefazolin","level":3,"score":0.3702999949455261},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.33649998903274536},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.3312000036239624},{"id":"https://openalex.org/C2781047374","wikidata":"https://www.wikidata.org/wiki/Q2100012","display_name":"Pulmonary toxicity","level":3,"score":0.32010000944137573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3199999928474426},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.30329999327659607},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.30230000615119934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3003999888896942},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C2778974779","wikidata":"https://www.wikidata.org/wiki/Q1758380","display_name":"Tobramycin","level":4,"score":0.2727999985218048},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2547000050544739},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22207/jpam.20.4.19","doi":"https://doi.org/10.22207/jpam.20.4.19","is_oa":true,"landing_page_url":"https://doi.org/10.22207/jpam.20.4.19","pdf_url":null,"source":{"id":"https://openalex.org/S2476582842","display_name":"Journal of Pure and Applied Microbiology","issn_l":"0973-7510","issn":["0973-7510","2581-690X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4353108566","host_organization_name":"Dr. M.N. Khan","host_organization_lineage":["https://openalex.org/P4353108566"],"host_organization_lineage_names":["Dr. M.N. Khan"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pure and Applied Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22207/jpam.20.4.19","doi":"https://doi.org/10.22207/jpam.20.4.19","is_oa":true,"landing_page_url":"https://doi.org/10.22207/jpam.20.4.19","pdf_url":null,"source":{"id":"https://openalex.org/S2476582842","display_name":"Journal of Pure and Applied Microbiology","issn_l":"0973-7510","issn":["0973-7510","2581-690X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4353108566","host_organization_name":"Dr. M.N. Khan","host_organization_lineage":["https://openalex.org/P4353108566"],"host_organization_lineage_names":["Dr. M.N. Khan"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pure and Applied Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Idiopathic":[0],"pulmonary":[1,34,230],"fibrosis":[2,35,39,231],"(IPF)":[3],"is":[4],"a":[5,61,215],"severe":[6,57],"long":[7],"disease":[8],"characterized":[9],"by":[10,42,47,72,78,93,110],"excessive":[11],"extracellular":[12,102],"matrix":[13],"deposition,":[14],"chronic":[15],"inflammation,":[16],"and":[17,28,49,80,85,112,124,173,185,193,201,223,232],"irreversible":[18],"lung":[19,58,150],"remodeling.":[20],"The":[21],"study":[22],"conducted":[23],"in":[24,36,65,82,137],"vivo":[25],"anti-inflammatory,":[26,221],"antifibrotic":[27],"antibacterial":[29,207,224],"activity":[30,167],"against":[31,178],"bleomycin":[32,44],"induced":[33,41],"mice.":[37],"Pulmonary":[38,74],"was":[40,69,76,141,168],"intratracheal":[43],"administration,":[45],"followed":[46],"prophylactic":[48,84],"therapeutic":[50,86,218],"treatment":[51,228],"with":[52,60,220],"diosgenin.":[53,73],"Histopathological":[54],"analysis":[55,147],"revealed":[56],"injury":[59],"3.3":[62],"fold":[63],"increase":[64],"fibrotic":[66],"burden,":[67],"which":[68],"significantly":[70,113,189],"attenuated":[71],"inflammation":[75],"reduced":[77],"39%":[79],"33%":[81],"the":[83,227],"groups,":[87],"respectively,":[88,204],"while":[89],"collagen":[90,120],"deposition":[91],"decreased":[92],"80%,":[94],"comparable":[95],"to":[96],"nintedanib":[97],"(84%).":[98],"Diosgenin":[99,188],"suppressed":[100],"neutrophil":[101],"trap":[103],"formation,":[104],"reducing":[105],"citrullinated":[106],"histone":[107],"H3":[108],"(CitH3)":[109],"30%-40%,":[111],"downregulated":[114],"fibronectin,":[115],"\u03b1-smooth":[116],"muscle":[117],"actin":[118],"(\u03b1-SMA),":[119],"type":[121],"I":[122],"(Col1),":[123],"monocyte":[125],"chemoattractant":[126],"protein-1":[127],"(MCP1).":[128],"Although":[129],"TGF-\u03b2":[130,138],"mRNA":[131],"expression":[132],"increased,":[133],"no":[134],"corresponding":[135],"reduction":[136],"protein":[139],"levels":[140],"observed,":[142],"suggesting":[143],"post-transcriptional":[144],"regulation.":[145],"Pharmacokinetic":[146],"demonstrated":[148],"preferential":[149],"accumulation":[151],"at":[152,160],"10":[153],"mg/kg,":[154],"whereas":[155],"higher":[156],"systemic":[157],"exposure":[158],"occurred":[159],"30":[161],"mg":[162],"per":[163],"kg":[164],"(mg/kg).":[165],"Antibacterial":[166],"evaluated":[169],"using":[170],"broth":[171],"dilution":[172],"agar":[174],"well":[175],"diffusion":[176],"assays":[177],"Escherichia":[179],"coli,":[180],"Bacillus":[181,183],"subtilis,":[182],"cereus,":[184],"Salmonella":[186],"typhi.":[187],"inhibited":[190],"bacterial":[191,234],"growth":[192],"produced":[194],"inhibition":[195],"zones":[196],"of":[197,229],"23,":[198],"22,":[199],"20,":[200],"19":[202],"mm,":[203],"demonstrating":[205],"broad-spectrum":[206],"activity.":[208],"Collectively,":[209],"these":[210],"findings":[211],"identify":[212],"diosgenin":[213],"as":[214],"promising":[216],"multi-target":[217],"candidate":[219],"antifibrotic,":[222],"properties":[225],"for":[226],"associated":[233],"infections.":[235]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
