{"id":"https://openalex.org/W7225790453","doi":"https://doi.org/10.3389/fvets.2026.1986705","title":"Cross-species horse-to-dog fecal microbiota transplantation as a novel nature-inspired therapy for non-responsive chronic enteropathy in dogs","display_name":"Cross-species horse-to-dog fecal microbiota transplantation as a novel nature-inspired therapy for non-responsive chronic enteropathy in dogs","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225790453","doi":"https://doi.org/10.3389/fvets.2026.1986705"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2026.1986705","doi":"https://doi.org/10.3389/fvets.2026.1986705","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1986705","pdf_url":null,"source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fvets.2026.1986705","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028712874","display_name":"Daniel Scicchitano","orcid":"https://orcid.org/0000-0002-1583-7239","observed_orcids":["https://orcid.org/0000-0002-1583-7239"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniel Scicchitano","raw_affiliation_strings":["Microbiome Analytics Srl","Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Analytics Srl","institution_ids":[]},{"raw_affiliation_string":"Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086872365","display_name":"Giorgia Palladino","orcid":"https://orcid.org/0000-0002-5432-919X","observed_orcids":["https://orcid.org/0000-0002-5432-919X"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgia Palladino","raw_affiliation_strings":["Microbiome Analytics Srl","Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Analytics Srl","institution_ids":[]},{"raw_affiliation_string":"Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065599706","display_name":"Federica D\u2019Amico","orcid":"https://orcid.org/0000-0002-2136-9558","observed_orcids":["https://orcid.org/0000-0002-2136-9558"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica D\u2019Amico","raw_affiliation_strings":["Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052399561","display_name":"Silvia Turroni","orcid":"https://orcid.org/0000-0003-2345-9482","observed_orcids":["https://orcid.org/0000-0003-2345-9482"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Turroni","raw_affiliation_strings":["Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001489063","display_name":"Massimo Vignoli","orcid":"https://orcid.org/0000-0002-4981-4051","observed_orcids":["https://orcid.org/0000-0002-4981-4051"]},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Vignoli","raw_affiliation_strings":["Dipartimento di Medicina Veterinaria, Universit\u00e0 di Teramo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Veterinaria, Universit\u00e0 di Teramo","institution_ids":["https://openalex.org/I124326101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058916582","display_name":"Simone Rampelli","orcid":"https://orcid.org/0000-0002-5655-6695","observed_orcids":["https://orcid.org/0000-0002-5655-6695"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Rampelli","raw_affiliation_strings":["Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002378349","display_name":"Rossella Terragni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rossella Terragni","raw_affiliation_strings":["Clinica Veterinaria Pet Care"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Veterinaria Pet Care","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086792856","display_name":"Marco Candela","orcid":"https://orcid.org/0000-0001-7420-790X","observed_orcids":["https://orcid.org/0000-0001-7420-790X"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Candela","raw_affiliation_strings":["Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Science and Biotechnology Unit, Dipartimento di Farmacia e Biotecnologie, Universit\u00e0 di Bologna","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086792856"],"corresponding_institution_ids":["https://openalex.org/I9360294"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778426112","wikidata":"https://www.wikidata.org/wiki/Q3055380","display_name":"Enteropathy","level":3,"score":0.769599974155426},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.6970999836921692},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6963000297546387},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5184000134468079},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47909998893737793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47189998626708984},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4260999858379364},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3788999915122986},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.3605000078678131},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3546999990940094},{"id":"https://openalex.org/C137923570","wikidata":"https://www.wikidata.org/wiki/Q2121103","display_name":"Fecal bacteriotherapy","level":4,"score":0.34940001368522644},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.3492000102996826},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.2948000133037567},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2619999945163727},{"id":"https://openalex.org/C189539697","wikidata":"https://www.wikidata.org/wiki/Q1125312","display_name":"Microbiological culture","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fvets.2026.1986705","doi":"https://doi.org/10.3389/fvets.2026.1986705","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1986705","pdf_url":null,"source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2026.1986705","doi":"https://doi.org/10.3389/fvets.2026.1986705","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1986705","pdf_url":null,"source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1984290997","https://openalex.org/W2115701239","https://openalex.org/W2124351063","https://openalex.org/W2132548846","https://openalex.org/W2133856765","https://openalex.org/W2143423915","https://openalex.org/W2401404581","https://openalex.org/W2513506562","https://openalex.org/W2771856369","https://openalex.org/W2783366090","https://openalex.org/W2905330024","https://openalex.org/W2939772042","https://openalex.org/W2963276645","https://openalex.org/W2992182084","https://openalex.org/W3003639447","https://openalex.org/W3014589784","https://openalex.org/W3017885772","https://openalex.org/W3039960006","https://openalex.org/W3096109224","https://openalex.org/W3097741772","https://openalex.org/W4200465838","https://openalex.org/W4205445450","https://openalex.org/W4244129975","https://openalex.org/W4289529396","https://openalex.org/W4296097456","https://openalex.org/W4296739068","https://openalex.org/W4309985404","https://openalex.org/W4311974347","https://openalex.org/W4362583597","https://openalex.org/W4390764874","https://openalex.org/W4391035352","https://openalex.org/W4392296275","https://openalex.org/W4398761949","https://openalex.org/W4402132004","https://openalex.org/W4403844713","https://openalex.org/W4405073788","https://openalex.org/W4409240435","https://openalex.org/W4409285342","https://openalex.org/W4411875872","https://openalex.org/W4412654246","https://openalex.org/W4416308764","https://openalex.org/W4417366629","https://openalex.org/W7131068782"],"related_works":[],"abstract_inverted_index":{"Introduction":[0],"Canine":[1,53],"chronic":[2],"enteropathy":[3],"(CE)":[4],"is":[5],"frequently":[6],"associated":[7,246],"with":[8,45,81,93,144,185,247],"gut":[9,33,277],"microbiota":[10,14,34,70,187],"dysbiosis,":[11],"and":[12,32,63,79,85,115,119,136,204,210,230,243,267],"fecal":[13],"transplantation":[15],"(FMT)":[16],"has":[17],"emerged":[18],"as":[19,141,232,260],"a":[20,37,129,170,261,269],"potential":[21],"microbiota-modulating":[22],"therapeutic":[23,262],"approach.":[24],"Methods":[25],"This":[26],"study":[27],"evaluated":[28],"the":[29,52,86,116,176,275],"clinical":[30,131,148,237],"outcomes":[31],"effects":[35],"of":[36,106,111,121,172,194,208,217,235,256],"novel":[38],"cross-species":[39,257],"horse-to-dog":[40,258],"FMT":[41,259],"in":[42,160,220],"20":[43],"dogs":[44,84,92,126],"CE.":[46],"Clinical":[47,56],"response":[48,132],"was":[49,72],"assessed":[50],"using":[51],"Chronic":[54],"Enteropathy":[55],"Activity":[57],"Index":[58],"(CCECAI)":[59],"at":[60,133,150],"30":[61,134,154],"days":[62,135],"approximately":[64],"1":[65,151],"year":[66],"after":[67],"treatment.":[68],"Gut":[69],"composition":[71],"characterized":[73],"by":[74,181],"16S":[75],"rRNA":[76],"gene":[77],"sequencing":[78],"compared":[80],"healthy":[82,103,177],"reference":[83,178],"equine":[87],"donor.":[88],"Results":[89],"At":[90,153],"baseline,":[91],"CE":[94,266],"displayed":[95],"reduced":[96],"microbial":[97],"diversity,":[98],"marked":[99],"compositional":[100],"differences":[101],"from":[102],"dogs,":[104],"depletion":[105],"health-associated":[107],"taxa,":[108],"including":[109,189,197],"members":[110],"Oscillospirales,":[112],"Limosilactobacillus,":[113],"Collinsella,":[114],"Peptoclostridium":[117],"complex,":[118],"enrichment":[120,207],"Escherichia-Shigella.":[122],"Following":[123],"FMT,":[124],"13/20":[125,145],"(65%)":[127,146],"showed":[128],"positive":[130],"16/20":[137],"(80%)":[138],"were":[139,165,245],"classified":[140],"long-term":[142],"responders,":[143],"achieving":[147],"remission":[149],"year.":[152],"days,":[155],"no":[156],"significant":[157],"global":[158],"changes":[159,183],"alpha":[161],"or":[162],"beta":[163],"diversity":[164],"detected;":[166],"however,":[167],"ordination":[168],"suggested":[169],"shift":[171],"post-FMT":[173],"profiles":[174],"toward":[175,206],"configuration,":[179],"accompanied":[180],"taxonomic":[182],"consistent":[184],"partial":[186],"restoration,":[188],"an":[190],"increased":[191],"relative":[192],"abundance":[193],"Peptoclostridium-associated":[195],"ASVs,":[196],"those":[198],"putatively":[199],"assigned":[200],"to":[201],"Peptoacetobacter":[202],"hiranonis,":[203],"trends":[205],"Holdemanella":[209,229],"Turicibacter.":[211],"ASV-sharing":[212],"analysis":[213,226],"revealed":[214],"minimal":[215],"persistence":[216],"horse-derived":[218],"microorganisms":[219],"recipient":[221],"dogs.":[222],"A":[223],"multilayer":[224],"predictive":[225],"identified":[227],"baseline":[228],"Parabacteroides":[231],"candidate":[233],"markers":[234],"favorable":[236],"response,":[238],"whereas":[239],"Clostridium,":[240],"Corynebacterium,":[241],"Enterococcus,":[242],"Romboutsia":[244],"poorer":[248],"outcomes.":[249],"Discussion":[250],"These":[251],"findings":[252],"support":[253],"further":[254],"evaluation":[255],"strategy":[263],"for":[264],"canine":[265],"suggest":[268],"predominantly":[270],"biostimulatory":[271],"mechanism":[272],"acting":[273],"on":[274],"resident":[276],"microbiota.":[278]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}