{"id":"https://openalex.org/W7225790155","doi":"https://doi.org/10.3389/fcell.2026.1956452","title":"Ubiquitin-specific peptidase 33 as a potential therapeutic target for homeostatic dysregulation","display_name":"Ubiquitin-specific peptidase 33 as a potential therapeutic target for homeostatic dysregulation","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225790155","doi":"https://doi.org/10.3389/fcell.2026.1956452"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1956452","doi":"https://doi.org/10.3389/fcell.2026.1956452","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1956452","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2026.1956452","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135543485","display_name":"Yuhong Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhong Wen","raw_affiliation_strings":["Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","Institute of Urology, China Three Gorges University","Yichang Central People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Institute of Urology, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161424925","display_name":"Yiwen Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Wan","raw_affiliation_strings":["Department of Operating Theatre, The First College of Clinical Medical Science, China Three Gorges University and Yichang Central People\u2019s Hospital","Yichang Central People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Operating Theatre, The First College of Clinical Medical Science, China Three Gorges University and Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I161350542","https://openalex.org/I4210152080"]},{"raw_affiliation_string":"Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135547508","display_name":"Bisheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bisheng Li","raw_affiliation_strings":["Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","Institute of Urology, China Three Gorges University","Yichang Central People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Institute of Urology, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135593641","display_name":"Rubin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rubin Wang","raw_affiliation_strings":["Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","Institute of Urology, China Three Gorges University","Yichang Central People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Institute of Urology, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135557206","display_name":"Jianhua Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhua Xiao","raw_affiliation_strings":["Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","Institute of Urology, China Three Gorges University","Yichang Central People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Institute of Urology, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100875514","display_name":"Yuan Honggang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Honggang Yuan","raw_affiliation_strings":["Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","Institute of Urology, China Three Gorges University","Yichang Central People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Institute of Urology, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152080"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022384177","display_name":"Yihao Liao","orcid":"https://orcid.org/0000-0003-2337-4868","observed_orcids":["https://orcid.org/0000-0003-2337-4868"]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yihao Liao","raw_affiliation_strings":["Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","Institute of Urology, China Three Gorges University","Yichang Central People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Central People\u2019s Hospital, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Institute of Urology, China Three Gorges University","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Yichang Central People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152080"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022384177","https://openalex.org/A5100875514"],"corresponding_institution_ids":["https://openalex.org/I161350542","https://openalex.org/I4210152080"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.623199999332428},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5422999858856201},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4821000099182129},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4115999937057495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40959998965263367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40869998931884766},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.38359999656677246},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3409000039100647},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3336000144481659},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.33219999074935913},{"id":"https://openalex.org/C158980903","wikidata":"https://www.wikidata.org/wiki/Q7899329","display_name":"Upstream and downstream (DNA)","level":3,"score":0.32269999384880066},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.301800012588501},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.26930001378059387},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25699999928474426},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.2538999915122986},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcell.2026.1956452","doi":"https://doi.org/10.3389/fcell.2026.1956452","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1956452","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1956452","doi":"https://doi.org/10.3389/fcell.2026.1956452","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1956452","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1976041483","https://openalex.org/W1985783625","https://openalex.org/W1991930213","https://openalex.org/W2005737394","https://openalex.org/W2015788406","https://openalex.org/W2017794722","https://openalex.org/W2022520132","https://openalex.org/W2027832797","https://openalex.org/W2034361893","https://openalex.org/W2129805026","https://openalex.org/W2139073905","https://openalex.org/W2150123812","https://openalex.org/W2159351792","https://openalex.org/W2166091870","https://openalex.org/W2168722578","https://openalex.org/W2310322011","https://openalex.org/W2552433701","https://openalex.org/W2613182354","https://openalex.org/W2757682641","https://openalex.org/W2789622129","https://openalex.org/W2803114144","https://openalex.org/W2803210216","https://openalex.org/W2806864054","https://openalex.org/W2914591999","https://openalex.org/W2925323710","https://openalex.org/W2969723332","https://openalex.org/W2979410128","https://openalex.org/W2995927738","https://openalex.org/W3009473049","https://openalex.org/W3080215956","https://openalex.org/W3081212724","https://openalex.org/W3087940658","https://openalex.org/W3091696541","https://openalex.org/W3132705981","https://openalex.org/W3133661441","https://openalex.org/W3153512175","https://openalex.org/W3197841936","https://openalex.org/W4212816453","https://openalex.org/W4212835316","https://openalex.org/W4225364558","https://openalex.org/W4366463344","https://openalex.org/W4378189500","https://openalex.org/W4378781982","https://openalex.org/W4380786119","https://openalex.org/W4382364144","https://openalex.org/W4388464266","https://openalex.org/W4393935425","https://openalex.org/W4402399351","https://openalex.org/W4402661006","https://openalex.org/W4402824671","https://openalex.org/W4404723887","https://openalex.org/W4405034119","https://openalex.org/W4405531138","https://openalex.org/W4409593536","https://openalex.org/W4411200856","https://openalex.org/W4411342361","https://openalex.org/W4412551028","https://openalex.org/W4413113597","https://openalex.org/W4413274563","https://openalex.org/W4414408776","https://openalex.org/W4415318080","https://openalex.org/W4415723186","https://openalex.org/W7117338276","https://openalex.org/W7128380194","https://openalex.org/W7161154948","https://openalex.org/W7161378786","https://openalex.org/W7162878694","https://openalex.org/W7164000484","https://openalex.org/W7172299491"],"related_works":[],"abstract_inverted_index":{"Ubiquitination":[0],"and":[1,7,24,32,46,51,61,67,82,85,98,118],"deubiquitination":[2],"regulate":[3],"protein":[4],"turnover,":[5],"localization":[6],"signaling.":[8],"Ubiquitin-specific":[9],"pep-tidase":[10],"33":[11],"(USP33)":[12],"participates":[13],"in":[14,20,49,135],"these":[15],"processes":[16],"through":[17],"substrates":[18],"involved":[19],"proliferation,":[21],"apoptosis,":[22],"migration":[23],"treatment":[25],"response.":[26],"Its":[27],"effects":[28],"differ":[29],"across":[30,55],"malignancies":[31],"can":[33,128],"diverge":[34],"within":[35],"the":[36,71,124],"same":[37],"tissue.":[38],"This":[39],"review":[40],"examines":[41],"USP33":[42,75,126],"structure,":[43],"upstream":[44],"regulation":[45],"substrate-dependent":[47],"functions":[48,134],"cancer":[50],"other":[52,136],"diseases.":[53],"Comparisons":[54],"studies":[56],"indicate":[57],"that":[58,123],"substrate":[59],"identity":[60],"recruitment,":[62],"TP53":[63],"status,":[64],"post-translational":[65],"modifi-cations":[66],"cellular":[68],"environment":[69],"influence":[70],"biological":[72],"outcome":[73],"of":[74],"activity.":[76],"We":[77],"compare":[78],"biochemical,":[79],"cellular,":[80],"animal":[81],"patient-associated":[83],"findings":[84],"discuss":[86],"their":[87],"implications":[88],"for":[89],"inhibitor":[90,106],"development,":[91],"selectivity":[92],"relative":[93],"to":[94],"USP20,":[95],"targeted":[96],"degradation":[97],"patient":[99],"selection.":[100],"No":[101],"established":[102],"clinically":[103],"validated":[104],"USP33-selective":[105],"is":[107],"available.":[108],"Therapeutic":[109],"development":[110],"therefore":[111],"requires":[112],"compounds":[113],"with":[114,121],"demonstrated":[115],"target":[116],"engagement":[117],"selectivity,":[119],"together":[120],"evidence":[122],"relevant":[125],"pathway":[127],"be":[129],"inhibited":[130],"without":[131],"disrupting":[132],"protective":[133],"tissues.":[137]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}