{"id":"https://openalex.org/W7225788441","doi":"https://doi.org/10.3389/fonc.2026.1833435","title":"Case Report: Giant vulvar aggressive angiomyxoma in a postmenopausal woman with a decade-long history","display_name":"Case Report: Giant vulvar aggressive angiomyxoma in a postmenopausal woman with a decade-long history","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225788441","doi":"https://doi.org/10.3389/fonc.2026.1833435"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1833435","doi":"https://doi.org/10.3389/fonc.2026.1833435","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1833435","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1833435/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1833435/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048234312","display_name":"Nengyuan Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nengyuan Lv","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University)","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161480544","display_name":"Kaiping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiping Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University)","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008688961","display_name":"Haizhen Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HaiZhen Zheng","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University)","institution_ids":["https://openalex.org/I192209268","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074386199","display_name":"Jinyi Tong","orcid":"https://orcid.org/0000-0003-2576-8764","observed_orcids":["https://orcid.org/0000-0003-2576-8764"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinyi Tong","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University of Medicine","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074386199"],"corresponding_institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8845999836921692},{"id":"https://openalex.org/C2779709535","wikidata":"https://www.wikidata.org/wiki/Q3617384","display_name":"Aggressive angiomyxoma","level":3,"score":0.8148000240325928},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7531999945640564},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6136999726295471},{"id":"https://openalex.org/C2776316342","wikidata":"https://www.wikidata.org/wiki/Q2192288","display_name":"Vulva","level":2,"score":0.5605000257492065},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.5583000183105469},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5206999778747559},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4690000116825104},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.43529999256134033},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.428600013256073},{"id":"https://openalex.org/C2908754239","wikidata":"https://www.wikidata.org/wiki/Q1908194","display_name":"Vulvar neoplasm","level":3,"score":0.4083999991416931},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39480000734329224},{"id":"https://openalex.org/C2910938049","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferation index","level":3,"score":0.37529999017715454},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.3578999936580658},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.3488999903202057},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3240000009536743},{"id":"https://openalex.org/C2779904257","wikidata":"https://www.wikidata.org/wiki/Q1428130","display_name":"Curettage","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C2910900425","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchymal Tumor","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.29420000314712524},{"id":"https://openalex.org/C206179267","wikidata":"https://www.wikidata.org/wiki/Q188952","display_name":"Medical history","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C2776085573","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferative index","level":3,"score":0.2913999855518341},{"id":"https://openalex.org/C2910822663","wikidata":"https://www.wikidata.org/wiki/Q1417240","display_name":"Benign neoplasms","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C2780505380","wikidata":"https://www.wikidata.org/wiki/Q7142931","display_name":"Past medical history","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2808000147342682},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C3019796121","wikidata":"https://www.wikidata.org/wiki/Q5048356","display_name":"Case presentation","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C3018711458","wikidata":"https://www.wikidata.org/wiki/Q208373","display_name":"Female circumcision","level":2,"score":0.258899986743927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fonc.2026.1833435","doi":"https://doi.org/10.3389/fonc.2026.1833435","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1833435","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1833435/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1833435","doi":"https://doi.org/10.3389/fonc.2026.1833435","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1833435","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1833435/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225788441.pdf","grobid_xml":"https://content.openalex.org/works/W7225788441.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1966447835","https://openalex.org/W2020214957","https://openalex.org/W2027972881","https://openalex.org/W2028257398","https://openalex.org/W2034344372","https://openalex.org/W2073666824","https://openalex.org/W2131034370","https://openalex.org/W2134870794","https://openalex.org/W2616169972","https://openalex.org/W2773244851","https://openalex.org/W2805586868","https://openalex.org/W2901272770","https://openalex.org/W2936543279","https://openalex.org/W2970890637","https://openalex.org/W3028028488","https://openalex.org/W3129001332","https://openalex.org/W3189297593","https://openalex.org/W4223910773","https://openalex.org/W4296367586","https://openalex.org/W4309667656","https://openalex.org/W4321498000","https://openalex.org/W4366224707","https://openalex.org/W4395044779","https://openalex.org/W4408883136","https://openalex.org/W4412019379","https://openalex.org/W4413782080","https://openalex.org/W4414167807","https://openalex.org/W7160443416"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Aggressive":[1],"angiomyxoma":[2],"(AAM)":[3],"is":[4,26,182],"a":[5,42,45,50,54,67,106,138,146,153,194],"rare,":[6],"locally":[7],"infiltrative":[8],"mesenchymal":[9],"tumor":[10],"that":[11,125],"typically":[12],"arises":[13],"in":[14,23,113,133],"the":[15,76,88,159,165],"pelvic-perineal":[16],"region":[17],"of":[18,44,53,90,110,162,168,180],"reproductive-aged":[19],"women.":[20],"Its":[21],"occurrence":[22],"postmenopausal":[24,47,134],"women":[25],"uncommon":[27],"and":[28,75,105,152,173],"may":[29],"present":[30],"diagnostic":[31],"challenges":[32],"due":[33],"to":[34],"its":[35],"indolent":[36,148],"nature.":[37],"Case":[38],"presentation":[39],"We":[40],"report":[41,199],"case":[43,123,196],"63-year-old":[46],"woman":[48],"with":[49,92,187],"10-year":[51],"history":[52],"gradually":[55],"enlarging,":[56],"asymptomatic":[57,140],"right":[58],"vulvar":[59,185],"mass.":[60,70,141],"Pelvic":[61],"Magnetic":[62],"Resonance":[63],"Imaging":[64],"(MRI)":[65],"revealed":[66],"well-circumscribed,":[68],"lobulated":[69],"Surgical":[71],"excision":[72],"was":[73],"performed,":[74],"gross":[77],"specimen":[78],"measured":[79],"15":[80],"\u00d7":[81,83],"8":[82],"6":[84],"cm.":[85],"Histopathology":[86],"confirmed":[87],"diagnosis":[89],"AAM,":[91],"an":[93],"immunohistochemical":[94],"profile":[95],"showing":[96],"Estrogen":[97],"Receptor":[98,102],"(ER)":[99],"(+),":[100],"Progesterone":[101],"(PR)":[103],"(\u2013),":[104],"Ki-67":[107,156],"proliferation":[108],"index":[109,179],"approximately":[111],"10%":[112],"hotspot":[114],"areas.":[115],"All":[116],"surgical":[117],"margins":[118],"were":[119],"negative.":[120],"Conclusion":[121],"This":[122],"demonstrates":[124],"AAM":[126],"can":[127],"grow":[128],"insidiously":[129],"over":[130],"many":[131],"years":[132],"women,":[135],"presenting":[136],"as":[137],"large,":[139],"The":[142],"atypical":[143],"features,":[144],"including":[145],"decade-long":[147],"history,":[149],"PR":[150],"negativity":[151],"relatively":[154],"elevated":[155],"index,":[157],"highlight":[158],"biological":[160],"variability":[161],"AAM.":[163],"However,":[164],"prognostic":[166],"significance":[167],"these":[169],"findings":[170],"remains":[171],"uncertain":[172],"requires":[174],"further":[175],"investigation.":[176],"A":[177],"high":[178],"suspicion":[181],"necessary":[183],"for":[184],"masses":[186],"prolonged":[188],"histories,":[189],"even":[190],"after":[191],"menopause.":[192],"As":[193],"single":[195],"report,":[197],"this":[198],"has":[200],"limited":[201],"representativeness.":[202]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
