{"id":"https://openalex.org/W7225787297","doi":"https://doi.org/10.52340/gs.2026.08.04(1).05","title":"THE USE OF CARDIOVASCULAR COMPLICATION MARKERS IN THE URGENT CARE MANAGEMENT OF LONG COVID","display_name":"THE USE OF CARDIOVASCULAR COMPLICATION MARKERS IN THE URGENT CARE MANAGEMENT OF LONG COVID","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225787297","doi":"https://doi.org/10.52340/gs.2026.08.04(1).05"},"language":"en","primary_location":{"id":"doi:10.52340/gs.2026.08.04(1).05","doi":"https://doi.org/10.52340/gs.2026.08.04(1).05","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).05","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.52340/gs.2026.08.04(1).05","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072754579","display_name":"Nona Kakauridze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":true,"raw_author_name":"Nona Kakauridze","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072754579"],"corresponding_institution_ids":["https://openalex.org/I7848551"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7706000208854675},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7232999801635742},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5577999949455261},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5033000111579895},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4537999927997589},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.40450000762939453},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.3815000057220459},{"id":"https://openalex.org/C3017438360","wikidata":"https://www.wikidata.org/wiki/Q11188","display_name":"Global population","level":3,"score":0.3718000054359436},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.3476000130176544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3111000061035156},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.289000004529953},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28630000352859497},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.28519999980926514},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C2778363899","wikidata":"https://www.wikidata.org/wiki/Q23900955","display_name":"Window of opportunity","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52340/gs.2026.08.04(1).05","doi":"https://doi.org/10.52340/gs.2026.08.04(1).05","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).05","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52340/gs.2026.08.04(1).05","doi":"https://doi.org/10.52340/gs.2026.08.04(1).05","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).05","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"According":[1],"to":[2,54,72,81,298,308,351],"contemporary":[3],"epidemiological":[4],"data":[5],"from":[6],"the":[7,13,21,45,64,87,102,109,128,131,148,169,194,243,264,275,288,312,352,393,420],"Global":[8],"Burden":[9],"of":[10,16,63,68,77,89,101,105,134,152,173,287,355,392,399],"Disease":[11],"(GBD),":[12],"absolute":[14],"rate":[15],"cardiovascular":[17],"(CV)":[18],"accidents":[19],"in":[20,41,108,120,147,225,261,311,330,419],"elderly":[22,331,421],"population":[23],"(60+)":[24],"is":[25,30,50,71,154,197,223,408],"increasing":[26,326],"sharply.":[27],"This":[28,125,180,359],"dynamic":[29],"critically":[31],"accelerated":[32,145,323,371],"by":[33,168],"post-COVID-19":[34,106,135],"syndrome":[35,107],"(Long":[36],"COVID).":[37],"Diagnosing":[38],"Long":[39,363],"COVID":[40,364],"older":[42],"adults":[43],"using":[44],"American":[46],"12-point":[47],"RECOVER":[48],"index":[49],"frequently":[51],"challenging":[52],"due":[53],"an":[55,74],"atypical":[56],"clinical":[57,84,227,250,402],"presentation":[58],"and":[59,92,116,139,144,159,164,177,187,215,239,256,277,296,314,345,377,384,406,416],"overlapping":[60],"symptoms.":[61],"Aim":[62],"Study:":[65],"The":[66,150],"aim":[67],"this":[69,121,229],"paper":[70,126],"conduct":[73],"in-depth":[75],"analysis":[76],"current":[78],"scientific":[79],"literature":[80],"identify":[82],"specific":[83],"markers":[85,96,403],"against":[86],"background":[88],"established":[90],"pathomechanisms":[91],"biomarkers.":[93],"Identifying":[94],"these":[95,400],"will":[97],"enable":[98],"early":[99,417],"detection":[100],"negative":[103],"impact":[104],"elderly,":[110],"thereby":[111],"preventing":[112,411],"subsequent":[113],"cardio-cerebral":[114],"catastrophes":[115],"reducing":[117],"mortality":[118,418],"rates":[119],"vulnerable":[122],"population.":[123,422],"Pathophysiology:":[124],"reviews":[127],"link":[129],"between":[130],"molecular":[132,341],"cascade":[133],"systemic":[136,395],"thromboinflammation,":[137],"macro-":[138],"microvascular":[140,309,382],"dysfunction":[141,200],"(ANOCA/INOCA),":[142],"neurodegeneration,":[143],"senescence":[146],"elderly.":[149],"pathophysiology":[151],"COVID-19":[153],"conceptualized":[155],"as":[156,246,283,339,366],"a":[157,284,340,367],"biphasic\u2014slowly":[158],"rapidly":[160],"progressing\u2014connective":[161],"tissue,":[162],"immune,":[163],"thromboinflammatory":[165],"condition":[166],"driven":[167],"prolonged":[170],"tissue":[171],"persistence":[172,181],"viral":[174],"antigens":[175],"(spike":[176],"nucleocapsid":[178],"proteins).":[179],"induces":[182],"premature":[183,210,412],"lymphocyte":[184],"aging":[185],"(immunosenescence)":[186],"telomere":[188,375],"decondensation,":[189],"undermining":[190],"cellular":[191],"regeneration.":[192],"Because":[193],"endothelial":[195,305],"response":[196],"systemic,":[198],"CV":[199],"occurs":[201],"synchronously":[202],"with":[203],"cerebral":[204,240],"small":[205],"vessel":[206],"disease":[207],"(CSVD),":[208],"programming":[209],"biological":[211,368],"aging.":[212],"Key":[213],"Molecular":[214],"Clinical":[216],"Markers:":[217],"Since":[218],"identifying":[219],"every":[220],"single":[221],"marker":[222],"impractical":[224],"routine":[226],"practice,":[228],"study":[230,360],"focuses":[231],"on":[232],"core":[233],"biomarkers":[234],"that":[235,362],"simultaneously":[236],"reflect":[237],"myocardial":[238],"injury":[241,387],"at":[242],"micro-level,":[244],"serving":[245],"essential":[247],"tools":[248],"for":[249,370,410],"monitoring:":[251],"Apolipoprotein":[252],"A1":[253],"(ApoA-1)":[254],"Decline":[255],"Elevated":[257,302],"Homocysteine:":[258],"A":[259],"decrease":[260],"ApoA-1":[262],"dismantles":[263],"natural":[265],"anti-inflammatory":[266],"shield,":[267],"triggering":[268,343],"lipid":[269],"peroxidation.":[270],"Concurrently,":[271],"hyperhomocysteinemia":[272],"directly":[273],"damages":[274],"endothelium":[276],"exacerbates":[278],"atherothrombotic":[279],"processes.":[280],"IL-18:":[281],"Functions":[282],"master":[285],"mediator":[286],"pro-inflammatory":[289],"cascade,":[290],"activating":[291,346],"inflammasome,":[292],"amplifying":[293],"vascular":[294],"inflammation,":[295],"contributing":[297],"atherosclerotic":[299],"plaque":[300],"instability.":[301],"P-Selectin:":[303],"Drives":[304],"adhesion,":[306],"leading":[307,350],"ischemia":[310],"heart":[313],"blood-brain":[315],"barrier":[316],"disruption.":[317],"Chronic":[318],"D-Dimer":[319],"Elevation:":[320],"Confirms":[321],"ongoing,":[322],"microthrombosis,":[324],"significantly":[325],"ischemic":[327],"stroke":[328],"risks":[329],"individuals.":[332],"Nuclear":[333],"Factor":[334],"kappa":[335],"B":[336],"(NF-\u03baB):":[337],"Acts":[338],"switch":[342],"neuroinflammation":[344],"tau":[347],"protein":[348],"hyperphosphorylation,":[349],"pathological":[353],"assembly":[354],"neurofibrillary":[356],"tangles.":[357],"Conclusion:":[358],"confirms":[361],"acts":[365],"catalyst":[369],"senescence,":[372],"manifested":[373],"through":[374],"decondensation":[376],"immune":[378],"cell":[379],"exhaustion.":[380],"Coronary":[381],"pathology":[383],"neurodegenerative":[385],"brain":[386],"represent":[388],"two":[389],"distinct":[390],"manifestations":[391],"same":[394],"endotheliitis.":[396],"Early":[397],"monitoring":[398],"dual-action":[401],"(including":[404],"Homocysteine":[405],"IL-18)":[407],"vital":[409],"dementia,":[413],"fatal":[414],"strokes,":[415]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
