{"id":"https://openalex.org/W7225786908","doi":"https://doi.org/10.64898/2026.11.09.765492","title":"Neuropathological assessment of cerebrovascular integrity in Chronic Traumatic Encephalopathy","display_name":"Neuropathological assessment of cerebrovascular integrity in Chronic Traumatic Encephalopathy","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225786908","doi":"https://doi.org/10.64898/2026.11.09.765492"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.765492","doi":"https://doi.org/10.64898/2026.11.09.765492","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765492","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.09.765492","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057572954","display_name":"Adam D. Martinac","orcid":"https://orcid.org/0009-0008-5264-4090","observed_orcids":["https://orcid.org/0009-0008-5264-4090"]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adam E Martinac","raw_affiliation_strings":["NeuRA;"],"raw_orcid":"https://orcid.org/0009-0008-5264-4090","affiliations":[{"raw_affiliation_string":"NeuRA;","institution_ids":["https://openalex.org/I83657090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161478603","display_name":"Anthony DeLorenzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony DeLorenzo","raw_affiliation_strings":["Neuroscience Research Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Australia;","institution_ids":["https://openalex.org/I83657090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116590090","display_name":"Derya Dik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Derya Dik","raw_affiliation_strings":["Neuroscience Research Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Australia;","institution_ids":["https://openalex.org/I83657090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161479510","display_name":"Liana Pasas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Liana Pasas","raw_affiliation_strings":["Neuroscience Research Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Australia;","institution_ids":["https://openalex.org/I83657090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070086635","display_name":"Lynne E. Bilston","orcid":"https://orcid.org/0000-0001-8250-9019","observed_orcids":["https://orcid.org/0000-0001-8250-9019"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lynne E Bilston","raw_affiliation_strings":["University of New South Wales"],"raw_orcid":"https://orcid.org/0000-0001-8250-9019","affiliations":[{"raw_affiliation_string":"University of New South Wales","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008905184","display_name":"Claire E. Shepherd","orcid":"https://orcid.org/0000-0002-0399-3218","observed_orcids":["https://orcid.org/0000-0002-0399-3218"]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Claire E Shepherd","raw_affiliation_strings":["Neuroscience Research Australia;"],"raw_orcid":"https://orcid.org/0000-0002-0399-3218","affiliations":[{"raw_affiliation_string":"Neuroscience Research Australia;","institution_ids":["https://openalex.org/I83657090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.07509999722242355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776407475","wikidata":"https://www.wikidata.org/wiki/Q1981783","display_name":"Pathognomonic","level":3,"score":0.8815000057220459},{"id":"https://openalex.org/C2780427682","wikidata":"https://www.wikidata.org/wiki/Q500446","display_name":"Pericyte","level":4,"score":0.6847000122070312},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.652899980545044},{"id":"https://openalex.org/C2777799939","wikidata":"https://www.wikidata.org/wiki/Q1711381","display_name":"Perivascular space","level":2,"score":0.635200023651123},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5936999917030334},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5652999877929688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5623999834060669},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.546999990940094},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.4140999913215637},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.4016000032424927},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.34450000524520874},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.3292999863624573},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C2779265215","wikidata":"https://www.wikidata.org/wiki/Q1647118","display_name":"Pia mater","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C2779205420","wikidata":"https://www.wikidata.org/wiki/Q2915951","display_name":"Vasa vasorum","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.257999986410141},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.765492","doi":"https://doi.org/10.64898/2026.11.09.765492","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765492","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.09.765492","doi":"https://doi.org/10.64898/2026.11.09.765492","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765492","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Chronic":[0],"traumatic":[1],"encephalopathy":[2],"neuropathological":[3],"change":[4],"(CTE-NC)":[5],"is":[6,25,209],"defined":[7],"by":[8],"perivascular":[9,31,206,239],"deposits":[10],"of":[11,174],"phosphorylated":[12],"tau,":[13],"with":[14,27,68,212],"lesions":[15,59],"preferentially":[16],"located":[17],"at":[18,191,233],"sulcal":[19],"depths.":[20],"We":[21,63,169],"investigated":[22],"whether":[23],"CTE-NC":[24,44,55,190],"associated":[26,211],"structural":[28],"changes":[29,232],"to":[30,83],"spaces":[32],"(PVSs)":[33],"or":[34,162,184,230],"microvascular":[35,146],"degeneration.":[36],"Post-mortem":[37],"middle":[38],"frontal":[39],"gyrus":[40],"tissue":[41],"from":[42],"11":[43,47],"cases":[45,56],"and":[46,71,79,194,241],"age-matched":[48],"controls":[49],"was":[50],"examined":[51],"using":[52],"immunohistochemistry.":[53],"All":[54],"exhibited":[57],"pathognomonic":[58,205],"in":[60,97,144,189,219],"this":[61],"region.":[62],"quantified":[64],"PVS":[65,72,88,110,176],"width":[66,89],"along":[67],"vessel":[69,75,152,216],"lumen":[70,178],"area,":[73],"string":[74,151],"burden,":[76],"pericyte":[77,157,182],"density,":[78],"aquaporin-4":[80],"(AQP4)":[81],"polarisation":[82],"the":[84,95,192,204,234,238],"astrocytic":[85],"endfoot.":[86],"Total":[87],"did":[90],"not":[91,210,224],"differ":[92],"significantly":[93],"between":[94,236],"groups":[96],"grey":[98],"matter":[99,105],"(P":[100,106],"=":[101,107,115,120,129,134,149,155,160,167],"0.543)":[102],"nor":[103,122],"white":[104],"0.468).":[108],"Neither":[109],"area":[111,124],"(sulcal":[112,126],"depth,":[113,127],"P":[114,119,128,133],"0.097;":[116],"gyral":[117,131],"crest,":[118,132],"0.645)":[121],"PVS-to-lumen":[123],"ratio":[125],"0.454;":[130],"0.307)":[135],"differed":[136],"significantly.":[137],"Similarly,":[138],"there":[139],"were":[140],"no":[141,172],"significant":[142],"differences":[143],"total":[145],"length":[147],"(p":[148,154,159,166],"0.693),":[150],"burden":[153],"0.128),":[156],"density":[158],"0.589),":[161],"AQP4":[163,186],"endfoot":[164,187],"enrichment":[165,188],"0.538).":[168],"therefore":[170],"found":[171],"evidence":[173],"large-scale":[175],"enlargement,":[177],"narrowing,":[179],"capillary":[180],"degeneration,":[181],"loss,":[183],"altered":[185],"locations":[193],"spatial":[195],"scales":[196],"investigated.":[197],"Taken":[198],"together,":[199],"these":[200],"findings":[201],"suggest":[202],"that":[203,222],"tau":[207],"lesion":[208],"a":[213],"classical":[214],"small":[215],"degenerative":[217],"phenotype":[218],"CTE-NC.":[220],"However,":[221],"does":[223],"exclude":[225],"more":[226],"subtle":[227],"molecular,":[228],"functional,":[229],"ultrastructural":[231],"interface":[235],"vessels,":[237],"space,":[240],"surrounding":[242],"brain":[243],"tissue.":[244]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
