{"id":"https://openalex.org/W7225786308","doi":"https://doi.org/10.1021/acs.est.6c10253","title":"Organoid-Based Strategy for Exploration of Cancer-Related Early Signatures of Low-Dose Methylmercury Exposure","display_name":"Organoid-Based Strategy for Exploration of Cancer-Related Early Signatures of Low-Dose Methylmercury Exposure","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225786308","doi":"https://doi.org/10.1021/acs.est.6c10253"},"language":"en","primary_location":{"id":"doi:10.1021/acs.est.6c10253","doi":"https://doi.org/10.1021/acs.est.6c10253","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.est.6c10253","pdf_url":null,"source":{"id":"https://openalex.org/S13479253","display_name":"Environmental Science & Technology","issn_l":"0013-936X","issn":["0013-936X","1520-5851"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","fnege-4","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science & Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041262499","display_name":"Senyan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Senyan Wang","raw_affiliation_strings":["The First Affiliated Hospital of Zhengzhou University , , , ,","Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103407763","display_name":"Li Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Li","raw_affiliation_strings":["Chinese Academy of Sciences , , ,","University of Chinese Academy of Sciences , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences , , ,","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , , ,","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453194","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-3835-8361","observed_orcids":["https://orcid.org/0000-0002-3835-8361"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["The First Affiliated Hospital of Zhengzhou University , , , ,","Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161423489","display_name":"Leilei Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leilei Ding","raw_affiliation_strings":["Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148867486","display_name":"Xinze Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinze Li","raw_affiliation_strings":["Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161485791","display_name":"Yifan Ouyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Ouyang","raw_affiliation_strings":["Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037787060","display_name":"Xiaoyan Sun","orcid":"https://orcid.org/0000-0001-8423-4952","observed_orcids":["https://orcid.org/0000-0001-8423-4952"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Sun","raw_affiliation_strings":["Zhengzhou University , , , ,","Zhengzhou University Affiliated Cancer Hospital , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"Zhengzhou University Affiliated Cancer Hospital , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129491181","display_name":"Danyang Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danyang Lu","raw_affiliation_strings":["Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161477704","display_name":"Huihui Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Gu","raw_affiliation_strings":["Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005574583","display_name":"Ligang Hu","orcid":"https://orcid.org/0000-0002-6213-4720","observed_orcids":["https://orcid.org/0000-0002-6213-4720"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ligang Hu","raw_affiliation_strings":["Chinese Academy of Sciences , , ,","University of Chinese Academy of Sciences , , ,"],"raw_orcid":"https://orcid.org/0000-0002-6213-4720","affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences , , ,","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , , ,","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161476530","display_name":"Xiaofang Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofang Zhao","raw_affiliation_strings":["Zhengzhou University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University , , , ,","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780373914","wikidata":"https://www.wikidata.org/wiki/Q414075","display_name":"Methylmercury","level":3,"score":0.8709999918937683},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6644999980926514},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.5076000094413757},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.49540001153945923},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46540001034736633},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.462799996137619},{"id":"https://openalex.org/C2993769243","wikidata":"https://www.wikidata.org/wiki/Q484652","display_name":"International agency","level":3,"score":0.41679999232292175},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4124000072479248},{"id":"https://openalex.org/C41157215","wikidata":"https://www.wikidata.org/wiki/Q3995923","display_name":"Environmental toxicology","level":3,"score":0.41179999709129333},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.39309999346733093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39259999990463257},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.37299999594688416},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.36820000410079956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.353300005197525},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.31209999322891235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3041999936103821},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2980000078678131},{"id":"https://openalex.org/C3020576462","wikidata":"https://www.wikidata.org/wiki/Q1088163","display_name":"Precancerous lesion","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C71572567","wikidata":"https://www.wikidata.org/wiki/Q864231","display_name":"Bioaccumulation","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2935999929904938}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.est.6c10253","doi":"https://doi.org/10.1021/acs.est.6c10253","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.est.6c10253","pdf_url":null,"source":{"id":"https://openalex.org/S13479253","display_name":"Environmental Science & Technology","issn_l":"0013-936X","issn":["0013-936X","1520-5851"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","fnege-4","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science & Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1970644508","https://openalex.org/W2056116706","https://openalex.org/W2078758579","https://openalex.org/W2086715138","https://openalex.org/W2128822546","https://openalex.org/W2132988519","https://openalex.org/W2147849590","https://openalex.org/W2180792845","https://openalex.org/W2782718389","https://openalex.org/W2887269283","https://openalex.org/W2965791769","https://openalex.org/W3005029215","https://openalex.org/W3152719213","https://openalex.org/W3171613464","https://openalex.org/W3206919339","https://openalex.org/W3208026624","https://openalex.org/W4214721577","https://openalex.org/W4220924628","https://openalex.org/W4224220192","https://openalex.org/W4256565045","https://openalex.org/W4293777876","https://openalex.org/W4294613035","https://openalex.org/W4296218969","https://openalex.org/W4306407471","https://openalex.org/W4310952187","https://openalex.org/W4385346921","https://openalex.org/W4389476920","https://openalex.org/W4390661922","https://openalex.org/W4391090816","https://openalex.org/W4393253999","https://openalex.org/W4400321618","https://openalex.org/W4401945434","https://openalex.org/W4402973284","https://openalex.org/W4405816933","https://openalex.org/W4408217927","https://openalex.org/W4412520913","https://openalex.org/W4413415021","https://openalex.org/W4414250615","https://openalex.org/W4415615658","https://openalex.org/W4416850308","https://openalex.org/W7125646234","https://openalex.org/W7148655694","https://openalex.org/W7220747709"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Methylmercury":[1],"(MeHg)":[2],"compounds":[3],"are":[4],"classified":[5],"as":[6,24,173],"Group":[7,25],"2B":[8],"agents,":[9],"possibly":[10],"carcinogenic":[11,40],"to":[12,56,65,127,161],"humans":[13],"by":[14,30],"the":[15,31,39,58],"International":[16],"Agency":[17,35],"for":[18,95,177,195],"Research":[19],"on":[20],"Cancer":[21],"(IARC),":[22],"and":[23,71,114,145,189],"C":[26],"possible":[27],"human":[28],"carcinogens":[29],"U.S.":[32],"Environmental":[33],"Protection":[34],"(U.S.":[36],"EPA),":[37],"but":[38,110],"implications":[41],"of":[42,60,80,200],"environmentally":[43],"relevant":[44],"low-dose":[45,61,102,124,152,201],"exposure":[46,63,126,154,180],"remain":[47],"unclear.":[48],"Here,":[49],"we":[50],"established":[51],"a":[52,174,191],"population-informed":[53],"organoid-based":[54],"strategy":[55,176],"explore":[57],"potential":[59],"MeHg":[62,82,103,125,153,187],"leading":[64],"cancer":[66,85,90],"incidence.":[67],"A":[68],"National":[69],"Health":[70],"Nutrition":[72],"Examination":[73],"Survey":[74],"(NHANES)-based":[75],"analysis":[76,121],"revealed":[77],"nonlinear":[78],"associations":[79],"blood":[81],"with":[83,87,182],"overall":[84],"history":[86],"increased":[88],"predicted":[89],"probability":[91],"around":[92],"5.39":[93],"\u03bcg/L":[94],"MeHg.":[96],"Liver":[97],"organoid":[98,171],"experiments":[99],"showed":[100],"that":[101,151],"did":[104],"not":[105],"cause":[106],"overt":[107],"short-term":[108],"cytotoxicity":[109,166],"induced":[111],"DNA":[112,141],"damage":[113],"stress-response":[115],"signatures":[116],"after":[117],"prolonged":[118],"exposure.":[119],"Transcriptomic":[120],"further":[122],"linked":[123],"cancer-related":[128],"stress":[129],"pathways,":[130],"including":[131],"reactive":[132],"oxygen":[133],"species":[134],"(ROS)":[135],"associated":[136],"chemical":[137],"carcinogenesis,":[138],"p53":[139],"signaling,":[140],"repair,":[142],"mitochondrial":[143],"stress,":[144],"cell-cycle":[146],"regulation.":[147],"These":[148],"results":[149],"indicate":[150],"could":[155],"trigger":[156],"early":[157],"biological":[158],"responses":[159],"related":[160],"cancer-associated":[162],"processes":[163],"before":[164],"apparent":[165],"occurs.":[167],"This":[168],"study":[169],"supports":[170],"models":[172],"human-relevant":[175],"linking":[178],"population":[179],"signals":[181],"tissue-level":[183],"toxicological":[184],"evidence":[185],"in":[186],"research":[188],"provides":[190],"potentially":[192],"adaptable":[193],"framework":[194],"evaluating":[196],"subtle":[197],"health":[198],"effects":[199],"environmental":[202],"pollutants.":[203]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}