{"id":"https://openalex.org/W7225786158","doi":"https://doi.org/10.1186/s12951-026-05216-1","title":"Lactobacillus reuteri extracellular vesicles alleviate septic liver injury via cGAS-STING-dependent macrophage reprogramming","display_name":"Lactobacillus reuteri extracellular vesicles alleviate septic liver injury via cGAS-STING-dependent macrophage reprogramming","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225786158","doi":"https://doi.org/10.1186/s12951-026-05216-1"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-026-05216-1","doi":"https://doi.org/10.1186/s12951-026-05216-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05216-1","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12951-026-05216-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161487253","display_name":"Yihao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107780","display_name":"Xi'an Medical University","ror":"https://ror.org/01fmc2233","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210107780"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yihao Zhang","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","Xi\u2019an Medical University, Xi\u2019an, 710021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Xi\u2019an Medical University, Xi\u2019an, 710021, China","institution_ids":["https://openalex.org/I4210107780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161429991","display_name":"Peng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Wang","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","The 903rd Hospital of the Joint Logistic Support Force, Hangzhou, 310013, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]},{"raw_affiliation_string":"The 903rd Hospital of the Joint Logistic Support Force, Hangzhou, 310013, Zhejiang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034049094","display_name":"Lai Wei","orcid":"https://orcid.org/0000-0003-1000-7559","observed_orcids":["https://orcid.org/0000-0003-1000-7559"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lai Wei","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028869562","display_name":"Yixuan Yuan","orcid":"https://orcid.org/0009-0007-7432-3813","observed_orcids":["https://orcid.org/0009-0007-7432-3813"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixuan Yuan","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146674266","display_name":"Mengyang Li","orcid":"https://orcid.org/0009-0009-8701-6219","observed_orcids":["https://orcid.org/0009-0009-8701-6219"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyang Li","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113131307","display_name":"Linbin Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linbin Yi","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444915","display_name":"Dongliang Zhang","orcid":"https://orcid.org/0000-0001-9231-2658","observed_orcids":["https://orcid.org/0000-0001-9231-2658"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongliang Zhang","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143758635","display_name":"Zhi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Zhang","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161448249","display_name":"Shaojun Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaojun Yang","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161455986","display_name":"Wenbo Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Yang","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136312843","display_name":"Jinwang Zheng","orcid":"https://orcid.org/0009-0007-8144-2677","observed_orcids":["https://orcid.org/0009-0007-8144-2677"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinwang Zheng","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152097214","display_name":"Danna Yao","orcid":"https://orcid.org/0009-0003-6182-8346","observed_orcids":["https://orcid.org/0009-0003-6182-8346"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danna Yao","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161430231","display_name":"Panpan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Sun","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153624877","display_name":"Luyang Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyang Zhao","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161470968","display_name":"Xudong Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xudong Zhang","raw_affiliation_strings":["The 903rd Hospital of the Joint Logistic Support Force, Hangzhou, 310013, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 903rd Hospital of the Joint Logistic Support Force, Hangzhou, 310013, Zhejiang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161477833","display_name":"Zeyang Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107780","display_name":"Xi'an Medical University","ror":"https://ror.org/01fmc2233","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210107780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeyang Zheng","raw_affiliation_strings":["Xi\u2019an Medical University, Xi\u2019an, 710021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Medical University, Xi\u2019an, 710021, China","institution_ids":["https://openalex.org/I4210107780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161455955","display_name":"Dan Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dan Xiao","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161472938","display_name":"Kuo Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kuo Shen","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161482443","display_name":"Dahai Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dahai Hu","raw_affiliation_strings":["Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, 710032, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5161455955","https://openalex.org/A5161472938","https://openalex.org/A5161482443"],"corresponding_institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2775898472","wikidata":"https://www.wikidata.org/wiki/Q597078","display_name":"Lactobacillus reuteri","level":4,"score":0.9480000138282776},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6409000158309937},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5342000126838684},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47510001063346863},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.44440001249313354},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4440000057220459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41359999775886536},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4097000062465668},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.37790000438690186},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.37130001187324524},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.349700003862381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32989999651908875},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.28600001335144043},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.25839999318122864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12951-026-05216-1","doi":"https://doi.org/10.1186/s12951-026-05216-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05216-1","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12951-026-05216-1","doi":"https://doi.org/10.1186/s12951-026-05216-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05216-1","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Sepsis-associated":[0],"liver":[1,192],"injury":[2,193],"(SALI)":[3],"is":[4],"highly":[5,172],"lethal":[6],"and":[7,16,38,79,126,174,180,214],"primarily":[8],"driven":[9],"by":[10,57,194],"dysregulated":[11],"macrophage":[12,140],"responses,":[13],"yet":[14],"safe":[15],"targeted":[17,175],"interventions":[18],"remain":[19,41],"limited.":[20],"Probiotic-derived":[21],"bacterial":[22,166],"extracellular":[23],"vesicles":[24],"(BEVs)":[25],"offer":[26],"a":[27,62,66,102,169],"promising":[28],"naturally-derived,":[29],"cell-free":[30],"nanotherapeutic":[31,176],"alternative,":[32],"but":[33],"their":[34],"precise":[35],"immunomodulatory":[36],"mechanisms":[37],"intracellular":[39],"targets":[40],"undefined.":[42],"Here,":[43],"we":[44,121],"demonstrate":[45],"that":[46,105,123],"Lactobacillus":[47],"reuteri-derived":[48],"BEVs":[49],"(BEV":[50],"L.":[51,73,132,144,187,202],"reuteri":[52,74,133,145,188,203],")":[53],"effectively":[54],"mitigate":[55],"SALI":[56],"reprogramming":[58],"hepatic":[59,216],"macrophages":[60],"from":[61],"pro-inflammatory":[63],"M1":[64],"toward":[65],"reparative":[67],"M2":[68],"state.":[69],"Mechanistically,":[70],"internalized":[71],"BEV":[72,131,143,186,201],"preserve":[75],"mitochondrial":[76,85,205],"structural":[77],"integrity":[78],"prevent":[80,204],"the":[81,93,96,107,124,137,148,160,196,210],"cytosolic":[82],"leakage":[83],"of":[84,95,130,139,162],"DNA":[86,206],"(mtDNA).":[87],"This":[88],"upstream":[89],"protection":[90],"significantly":[91],"restricts":[92],"activation":[94],"mtDNA-cGAS-STING-NF-\u03baB":[97],"inflammatory":[98,184,212],"cascade,":[99],"serving":[100],"as":[101,168],"crucial":[103],"blockade":[104],"drives":[106],"macrophages\u2019":[108],"anti-inflammatory":[109],"phenotypic":[110],"switch.":[111],"Furthermore,":[112],"utilizing":[113,163],"systemically":[114],"administered":[115],"myeloid-specific":[116],"STING":[117,141],"conditional":[118],"knockout":[119],"mice,":[120],"confirm":[122],"hepatoprotective":[125],"systemic":[127,155],"therapeutic":[128],"effects":[129],"strictly":[134],"depend":[135],"on":[136],"suppression":[138],"signaling.":[142],"fundamentally":[146],"intercept":[147],"pathogenic":[149],"mitochondria-STING":[150],"crosstalk":[151],"to":[152],"resolve":[153],"macrophage-driven":[154],"inflammation.":[156],"These":[157],"findings":[158],"highlight":[159],"potential":[161],"specific":[164],"Gram-positive":[165],"nanovesicles":[167],"biologically":[170],"safe,":[171],"biocompatible,":[173],"strategy":[177],"for":[178],"sepsis":[179],"related":[181],"severe":[182],"acute":[183],"disorders.":[185],"protects":[189],"against":[190],"sepsis-induced":[191],"targeting":[195],"cGAS-STING":[197],"signaling":[198],"pathway.":[199],"Internalized":[200],"leakage,":[207],"thereby":[208],"silencing":[209],"STING/NF-\u03baB":[211],"cascade":[213],"restoring":[215],"homeostasis":[217]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
