{"id":"https://openalex.org/W7225780477","doi":"https://doi.org/10.1523/jneurosci.1263-25.2026","title":"Levodopa boosts hippocampal activity and strengthens generalizable rule representations in prefrontal cortex during the inference of meaning","display_name":"Levodopa boosts hippocampal activity and strengthens generalizable rule representations in prefrontal cortex during the inference of meaning","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225780477","doi":"https://doi.org/10.1523/jneurosci.1263-25.2026"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1263-25.2026","doi":"https://doi.org/10.1523/jneurosci.1263-25.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1263-25.2026","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1523/jneurosci.1263-25.2026","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095957176","display_name":"Elena Mainetto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Mainetto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069951807","display_name":"Xiaochen Zheng","orcid":"https://orcid.org/0000-0002-3697-3395","observed_orcids":["https://orcid.org/0000-0002-3697-3395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaochen Y. Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134893534","display_name":"Upasana Shah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Upasana Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120190328","display_name":"Katar\u00edna Labancov\u00e1","orcid":"https://orcid.org/0009-0001-4304-8579","observed_orcids":["https://orcid.org/0009-0001-4304-8579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katar\u00edna Labancov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113916490","display_name":"Robbert\u2010Jan Verkes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robbert-Jan Verkes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090502534","display_name":"Mona M. Garvert","orcid":"https://orcid.org/0000-0002-8678-5536","observed_orcids":["https://orcid.org/0000-0002-8678-5536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mona M. Garvert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091066494","display_name":"Hanneke E.M. den Ouden","orcid":"https://orcid.org/0000-0001-7039-5130","observed_orcids":["https://orcid.org/0000-0001-7039-5130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanneke E. M. den Ouden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072571980","display_name":"Roshan Cools","orcid":"https://orcid.org/0000-0001-8994-5534","observed_orcids":["https://orcid.org/0000-0001-8994-5534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roshan Cools","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e1263252026","last_page":"e1263252026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10465","display_name":"Neurobiology of Language and Bilingualism","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10465","display_name":"Neurobiology of Language and Bilingualism","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.664900004863739},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6455000042915344},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5838000178337097},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5748000144958496},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.517799973487854},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.47690001130104065},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.40709999203681946},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3824999928474426},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37229999899864197},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3652999997138977},{"id":"https://openalex.org/C2780876879","wikidata":"https://www.wikidata.org/wiki/Q3054749","display_name":"Meaning (existential)","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C49790547","wikidata":"https://www.wikidata.org/wiki/Q943817","display_name":"Levels-of-processing effect","level":3,"score":0.3028999865055084},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2709999978542328},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1523/jneurosci.1263-25.2026","doi":"https://doi.org/10.1523/jneurosci.1263-25.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1263-25.2026","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1263-25.2026","doi":"https://doi.org/10.1523/jneurosci.1263-25.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1263-25.2026","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Dopamine":[0,170],"has":[1,171],"long":[2,172],"been":[3,173],"implicated":[4,174],"in":[5,133,142,175],"a":[6,64,176],"variety":[7,177],"of":[8,34,51,58,100,161,178,203,216],"higher-order":[9,179],"cognitive":[10,180],"functions,":[11,181],"including":[12,182],"language":[13,25,183,193],"processing.":[14,184],"However,":[15,185],"the":[16,97,102,107,114,134,143,150,186],"neural":[17,49,98,187],"processes":[18,188],"and":[19,48,79,157,212],"representations":[20,50,118,141,160,215],"by":[21,77,189],"which":[22,190],"dopamine":[23,153,191],"influences":[24],"processing":[26,47,194],"remain":[27],"unclear.":[28,197],"Here":[29,198],"we":[30,199],"show":[31,200],"that":[32,68,119,152,201],"administration":[33,202],"levodopa":[35,204],"to":[36,71,95,205],"young":[37,206],"healthy":[38,207],"volunteers":[39,208],"(n":[40],"=":[41],"70,":[42],"47":[43],"females)":[44],"boosts":[45,154,192],"hippocampal":[46,135,155,210],"generalizable":[52,217],"abstract":[53,81,103,125,139,162,218],"rules":[54,104,163,219],"for":[55,106],"successful":[56],"inference":[57,109],"novel":[59,65,115,166,222],"word":[60,75,116,223],"meaning.":[61,167],"We":[62],"used":[63],"experimental":[66],"paradigm":[67],"required":[69,105],"participants":[70],"build":[72],"new":[73],"artificial":[74],"meanings":[76],"inferring":[78],"applying":[80],"affixation":[82],"rules.":[83,126],"A":[84],"repetition":[85],"suppression":[86],"procedure":[87],"was":[88],"combined":[89],"with":[90],"multivariate":[91],"representational":[92],"similarity":[93],"analyses":[94],"isolate":[96],"locus":[99],"both":[101],"compositional":[108],"process,":[110],"as":[111,113],"well":[112],"meaning":[117],"were":[120],"composed":[121],"based":[122],"on":[123],"these":[124],"Levodopa":[127],"modulated":[128],"not":[129],"only":[130],"inference-related":[131],"signals":[132],"formation,":[136],"but":[137],"also":[138],"rule":[140],"medial":[144],"frontal":[145],"cortex.":[146],"These":[147],"results":[148],"support":[149],"hypothesis":[151],"activity":[156,211],"strengthens":[158,213],"prefrontal":[159,214],"when":[164,220],"building":[165,221],"Significance":[168],"statement":[169],"have":[195],"remained":[196],"enhances":[209],"meanings.":[224]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
