{"id":"https://openalex.org/W7225779293","doi":"https://doi.org/10.1016/j.dscb.2026.100334","title":"Protective and Therapeutic Effects of Artemisia judaica Extract Against Sodium Fluoride-Induced Neurotoxicity in Rats: Behavioral, Biochemical, and Histopathological Evidence","display_name":"Protective and Therapeutic Effects of Artemisia judaica Extract Against Sodium Fluoride-Induced Neurotoxicity in Rats: Behavioral, Biochemical, and Histopathological Evidence","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225779293","doi":"https://doi.org/10.1016/j.dscb.2026.100334"},"language":"en","primary_location":{"id":"doi:10.1016/j.dscb.2026.100334","doi":"https://doi.org/10.1016/j.dscb.2026.100334","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dscb.2026.100334","pdf_url":null,"source":{"id":"https://openalex.org/S4210215057","display_name":"Brain Disorders","issn_l":"2666-4593","issn":["2666-4593"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.dscb.2026.100334","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018748074","display_name":"Mohamed Gaber Shalan","orcid":"https://orcid.org/0000-0003-1671-7172","observed_orcids":["https://orcid.org/0000-0003-1671-7172"]},"institutions":[{"id":"https://openalex.org/I4210122761","display_name":"Arish University","ror":"https://ror.org/02nzd5081","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210122761"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mohamed Shalan","raw_affiliation_strings":["Zoology Department, Faculty of Science, Arish University, North Sinai, Arish, 45511, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-1671-7172","affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Arish University, North Sinai, Arish, 45511, Egypt","institution_ids":["https://openalex.org/I4210122761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018748074"],"corresponding_institution_ids":["https://openalex.org/I4210122761"],"apc_list":{"value":1810,"currency":"USD","value_usd":1810},"apc_paid":{"value":1810,"currency":"USD","value_usd":1810},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"100334","last_page":"100334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11969","display_name":"Fluoride Effects and Removal","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11969","display_name":"Fluoride Effects and Removal","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.11140000075101852,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8891000151634216},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.64410001039505},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.5109999775886536},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5022000074386597},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4903999865055084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.421999990940094},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.39629998803138733},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.3846000134944916},{"id":"https://openalex.org/C2776461903","wikidata":"https://www.wikidata.org/wiki/Q237800","display_name":"Carassius","level":3,"score":0.3409999907016754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34049999713897705},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C79410662","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose\u2013response relationship","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.dscb.2026.100334","doi":"https://doi.org/10.1016/j.dscb.2026.100334","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dscb.2026.100334","pdf_url":null,"source":{"id":"https://openalex.org/S4210215057","display_name":"Brain Disorders","issn_l":"2666-4593","issn":["2666-4593"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Disorders","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.dscb.2026.100334","doi":"https://doi.org/10.1016/j.dscb.2026.100334","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dscb.2026.100334","pdf_url":null,"source":{"id":"https://openalex.org/S4210215057","display_name":"Brain Disorders","issn_l":"2666-4593","issn":["2666-4593"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Disorders","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W87827613","https://openalex.org/W2065349183","https://openalex.org/W2156674541","https://openalex.org/W2181184271","https://openalex.org/W2405968564","https://openalex.org/W2512475249","https://openalex.org/W2545964760","https://openalex.org/W2562320276","https://openalex.org/W2605741827","https://openalex.org/W2724998383","https://openalex.org/W2773070642","https://openalex.org/W2790778233","https://openalex.org/W2800742941","https://openalex.org/W2806339508","https://openalex.org/W2875881146","https://openalex.org/W2885699756","https://openalex.org/W2903380994","https://openalex.org/W2923187757","https://openalex.org/W2936784817","https://openalex.org/W2973191177","https://openalex.org/W3010640420","https://openalex.org/W3025182139","https://openalex.org/W3037955882","https://openalex.org/W3090361865","https://openalex.org/W3093466389","https://openalex.org/W3110258185","https://openalex.org/W3174482405","https://openalex.org/W3174966881","https://openalex.org/W3185936507","https://openalex.org/W3193560081","https://openalex.org/W3196196399","https://openalex.org/W3197959919","https://openalex.org/W3210100449","https://openalex.org/W3212028579","https://openalex.org/W4200342573","https://openalex.org/W4224307174","https://openalex.org/W4283219606","https://openalex.org/W4297877979","https://openalex.org/W4300862154","https://openalex.org/W4310211651","https://openalex.org/W4313898815","https://openalex.org/W4315798203","https://openalex.org/W4367547642","https://openalex.org/W4385382683","https://openalex.org/W4386142394","https://openalex.org/W4393190624","https://openalex.org/W4399686270","https://openalex.org/W4403411515","https://openalex.org/W4406904495","https://openalex.org/W4407058177","https://openalex.org/W4412600220","https://openalex.org/W4412674057","https://openalex.org/W4413895462","https://openalex.org/W4414904832","https://openalex.org/W4415026819","https://openalex.org/W4416087161","https://openalex.org/W4416987412","https://openalex.org/W7131273849","https://openalex.org/W7147227818","https://openalex.org/W7154830224"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Sodium":[1],"fluoride":[2],"(NaF)":[3],"is":[4],"a":[5,197],"widely":[6],"used":[7],"compound":[8],"that,":[9],"at":[10],"toxic":[11],"exposure":[12,73],"levels,":[13],"induces":[14],"oxidative":[15,75],"stress-driven":[16],"neurotoxicity":[17,43,191],"accompanied":[18,94],"by":[19,78,95],"hepatorenal":[20,55],"dysfunction;":[21],"yet":[22],"effective":[23],"preventive":[24,185],"strategies":[25],"remain":[26],"limited.":[27],"This":[28],"study":[29],"investigated":[30],"the":[31,151],"protective":[32],"and":[33,44,49,68,81,85,89,98,113,129,136,142,145,157,167,192],"therapeutic":[34,187],"efficacy":[35,188],"of":[36,87],"Artemisia":[37,181],"judaica":[38,182],"extract":[39],"(AJE)":[40],"against":[41,189],"NaF-induced":[42,190],"neurobehavioral":[45],"deficits":[46],"in":[47,150],"rats,":[48],"evaluated":[50],"its":[51,194],"effects":[52],"on":[53],"associated":[54],"injury.":[56],"Male":[57],"Wistar":[58],"rats":[59],"were":[60,93],"assigned":[61],"to":[62],"control,":[63],"AJE,":[64],"NaF,":[65],"post-treatment":[66,171],"(NaF\u2192AJE),":[67],"co-treatment":[69],"(NaF+AJE)":[70],"groups.":[71],"NaF":[72,124],"induced":[74],"stress,":[76],"evidenced":[77],"increased":[79,102],"malondialdehyde":[80],"nitric":[82],"oxide":[83],"levels":[84],"depletion":[86],"glutathione":[88],"catalase.":[90],"These":[91],"changes":[92],"elevated":[96],"hepatic":[97],"renal":[99],"dysfunction":[100],"biomarkers,":[101],"cyclooxygenase-2":[103],"(COX-2),":[104],"transforming":[105],"growth":[106],"factor-\u03b2":[107],"(TGF-\u03b2),":[108],"myelin":[109],"basic":[110],"protein":[111],"(MBP),":[112],"neurofilament":[114],"light":[115],"chain":[116],"(NEFL),":[117],"together":[118],"with":[119,160],"reduced":[120,139],"B-cell":[121],"lymphoma-2":[122],"(Bcl-2).":[123],"also":[125],"altered":[126],"exploratory":[127],"behavior":[128],"impaired":[130],"spatial":[131,137],"learning":[132],"performance,":[133],"recognition":[134],"memory,":[135],"memory;":[138],"body":[140],"weight":[141],"food":[143],"intake;":[144],"caused":[146],"marked":[147],"histopathological":[148,168],"alterations":[149],"cerebral":[152],"cortex,":[153],"spinal":[154],"cord,":[155],"liver,":[156],"kidneys.":[158],"Co-treatment":[159],"AJE":[161],"markedly":[162],"attenuated":[163],"these":[164,177],"biochemical,":[165],"behavioral,":[166],"abnormalities,":[169],"whereas":[170],"produced":[172],"only":[173],"partial":[174],"recovery.":[175],"Collectively,":[176],"findings":[178],"demonstrate":[179],"that":[180],"provides":[183],"greater":[184],"than":[186],"highlights":[193],"potential":[195],"as":[196],"natural":[198],"dietary":[199],"intervention.":[200]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}