{"id":"https://openalex.org/W7225779254","doi":"https://doi.org/10.18502/acta.v64i10.23198","title":"Lean Versus Obese Nonalcoholic Fatty Liver Disease (NAFLD): Comparative Analysis of Lipid Profiles","display_name":"Lean Versus Obese Nonalcoholic Fatty Liver Disease (NAFLD): Comparative Analysis of Lipid Profiles","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225779254","doi":"https://doi.org/10.18502/acta.v64i10.23198"},"language":"en","primary_location":{"id":"doi:10.18502/acta.v64i10.23198","doi":"https://doi.org/10.18502/acta.v64i10.23198","is_oa":true,"landing_page_url":"https://doi.org/10.18502/acta.v64i10.23198","pdf_url":null,"source":{"id":"https://openalex.org/S2754060852","display_name":"ACTA MEDICA IRANICA","issn_l":"0044-6025","issn":["0044-6025","1735-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319141","host_organization_name":"Tehran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319141"],"host_organization_lineage_names":["Tehran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA MEDICA IRANICA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18502/acta.v64i10.23198","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161475474","display_name":"Vahid Heidary Majd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122832768","display_name":"Kurdistan University of Medical Sciences","ror":"https://ror.org/01ntx4j68","country_code":"IR","type":"education","lineage":["https://openalex.org/I3122832768"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Vahid Heidary Majd","raw_affiliation_strings":["Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran","institution_ids":["https://openalex.org/I3122832768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161486064","display_name":"Omid Alavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122832768","display_name":"Kurdistan University of Medical Sciences","ror":"https://ror.org/01ntx4j68","country_code":"IR","type":"education","lineage":["https://openalex.org/I3122832768"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Omid Alavi","raw_affiliation_strings":["Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran","institution_ids":["https://openalex.org/I3122832768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257306","display_name":"Farshad Sheikhesmaili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122832768","display_name":"Kurdistan University of Medical Sciences","ror":"https://ror.org/01ntx4j68","country_code":"IR","type":"education","lineage":["https://openalex.org/I3122832768"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farshad Sheikhesmaili","raw_affiliation_strings":["Liver & Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver & Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran","institution_ids":["https://openalex.org/I3122832768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161469020","display_name":"Zahra Pouya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38476204","display_name":"Urmia University","ror":"https://ror.org/032fk0x53","country_code":"IR","type":"education","lineage":["https://openalex.org/I38476204"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Pouya","raw_affiliation_strings":["Student Research Committee, Urmia University, Urmia, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Urmia University, Urmia, Iran","institution_ids":["https://openalex.org/I38476204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081494580","display_name":"Parisa Khalilzadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3122832768","display_name":"Kurdistan University of Medical Sciences","ror":"https://ror.org/01ntx4j68","country_code":"IR","type":"education","lineage":["https://openalex.org/I3122832768"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parisa Khalilzadeh","raw_affiliation_strings":["Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran","institution_ids":["https://openalex.org/I3122832768"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057161317","display_name":"Nariman Moradi","orcid":"https://orcid.org/0000-0001-7760-4804","observed_orcids":["https://orcid.org/0000-0001-7760-4804"]},"institutions":[{"id":"https://openalex.org/I3122832768","display_name":"Kurdistan University of Medical Sciences","ror":"https://ror.org/01ntx4j68","country_code":"IR","type":"education","lineage":["https://openalex.org/I3122832768"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nariman Moradi","raw_affiliation_strings":["Liver & Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver & Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran","institution_ids":["https://openalex.org/I3122832768"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.886900007724762},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.7878000140190125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7705000042915344},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6807000041007996},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.6628999710083008},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5928000211715698},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5582000017166138},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.45969998836517334},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.4422000050544739},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41029998660087585},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4074000120162964},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.3310999870300293},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3037000000476837},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2946999967098236},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.2939000129699707}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18502/acta.v64i10.23198","doi":"https://doi.org/10.18502/acta.v64i10.23198","is_oa":true,"landing_page_url":"https://doi.org/10.18502/acta.v64i10.23198","pdf_url":null,"source":{"id":"https://openalex.org/S2754060852","display_name":"ACTA MEDICA IRANICA","issn_l":"0044-6025","issn":["0044-6025","1735-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319141","host_organization_name":"Tehran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319141"],"host_organization_lineage_names":["Tehran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA MEDICA IRANICA","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18502/acta.v64i10.23198","doi":"https://doi.org/10.18502/acta.v64i10.23198","is_oa":true,"landing_page_url":"https://doi.org/10.18502/acta.v64i10.23198","pdf_url":null,"source":{"id":"https://openalex.org/S2754060852","display_name":"ACTA MEDICA IRANICA","issn_l":"0044-6025","issn":["0044-6025","1735-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319141","host_organization_name":"Tehran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319141"],"host_organization_lineage_names":["Tehran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA MEDICA IRANICA","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Non-alcoholic":[0],"fatty":[1],"liver":[2,51,117,184],"disease":[3,70],"(NAFLD)":[4],"has":[5],"become":[6],"a":[7,124],"major":[8],"global":[9],"health":[10],"concern,":[11],"closely":[12],"associated":[13],"with":[14,135,183,220,249],"obesity,":[15],"insulin":[16],"resistance,":[17],"and":[18,40,54,59,72,86,94,116,139,172,193,216,240,252],"dyslipidemia.":[19],"However,":[20],"the":[21,260],"occurrence":[22],"of":[23,263],"NAFLD":[24,61,81,218,238],"in":[25,89,151,162,203,213],"non-obese":[26],"individuals,":[27],"referred":[28],"to":[29,47,63,69,166,244,258],"as":[30,99],"lean":[31,58,100,167,215],"NAFLD,":[32],"remains":[33],"poorly":[34],"understood,":[35],"particularly":[36],"regarding":[37],"lipid":[38,49,110],"metabolism":[39],"biochemical":[41,55],"alterations.":[42],"Therefore,":[43],"this":[44],"study":[45,76],"aimed":[46],"compare":[48],"profiles,":[50],"enzyme":[52,199],"levels,":[53],"parameters":[56],"between":[57,92,154],"obese":[60,105,163,217,226],"patients":[62,82,164],"clarify":[64,259],"potential":[65],"metabolic":[66,232],"differences":[67],"contributing":[68],"pathogenesis":[71],"progression.":[73],"A":[74],"cross-sectional":[75],"was":[77,129,149,211],"conducted":[78],"on":[79],"95":[80],"diagnosed":[83],"by":[84],"ultrasound":[85],"paraclinical":[87],"evaluations":[88],"Kurdistan":[90],"provinces":[91],"2021":[93],"2024.":[95],"Participants":[96],"were":[97,121,159,201],"categorized":[98],"(BMI":[101,106],"<25":[102],"kg/m\u00b2)":[103],"or":[104],"\u226530":[107],"kg/m\u00b2).":[108],"Serum":[109],"profiles":[111],"(TC,":[112],"TG,":[113],"HDL,":[114],"LDL)":[115],"enzymes":[118],"(AST,":[119],"ALT)":[120],"analyzed":[122],"using":[123,131],"BT3500":[125],"autoanalyzer.":[126],"Statistical":[127],"analysis":[128],"performed":[130],"SPSS":[132],"version":[133],"22,":[134],"Mann\u2013Whitney":[136],"U,":[137],"Chi-square,":[138],"Spearman":[140],"correlation":[141],"tests":[142],"applied":[143],"where":[144],"appropriate.":[145],"No":[146],"significant":[147,180,207],"difference":[148],"observed":[150,212],"gender":[152],"distribution":[153],"groups":[155,205],"(P=0.115).":[156],"LDL":[157,194,222],"levels":[158,195,200,223],"significantly":[160],"higher":[161,221],"compared":[165],"counterparts":[168],"(P=0.046),":[169],"while":[170],"triglycerides":[171],"HDL":[173],"showed":[174],"no":[175],"statistical":[176],"differences.":[177],"BMI":[178],"demonstrated":[179],"positive":[181],"correlations":[182],"fat":[185],"grade":[186],"(r=0.205,":[187],"P=0.025),":[188],"total":[189],"cholesterol":[190],"(r=0.212,":[191],"P=0.02),":[192],"(r=0.229,":[196],"P=0.012).":[197],"Liver":[198],"elevated":[202],"both":[204,214],"without":[206],"intergroup":[208],"variation.":[209],"Dyslipidemia":[210],"patients,":[219],"detected":[224],"among":[225],"individuals.":[227],"These":[228],"findings":[229],"suggest":[230],"that":[231],"alterations":[233],"may":[234],"occur":[235],"across":[236],"different":[237],"phenotypes":[239],"are":[241,256],"not":[242],"limited":[243],"obesity":[245],"status.":[246],"Further":[247],"studies":[248],"larger":[250],"samples":[251],"comprehensive":[253],"analytical":[254],"adjustments":[255],"needed":[257],"clinical":[261],"implications":[262],"these":[264],"observations.":[265]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}