{"id":"https://openalex.org/W7225779082","doi":"https://doi.org/10.1038/s41467-026-78755-8","title":"Topographical mismatch sustains open microchannels in living soft tissue for non-destructive protein biopsy","display_name":"Topographical mismatch sustains open microchannels in living soft tissue for non-destructive protein biopsy","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225779082","doi":"https://doi.org/10.1038/s41467-026-78755-8"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-78755-8","doi":"https://doi.org/10.1038/s41467-026-78755-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78755-8","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41467-026-78755-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043348890","display_name":"Phuong Thao Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Phuong Thao Le","raw_affiliation_strings":["Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea"],"raw_orcid":"https://orcid.org/0009-0007-3390-5278","affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047089898","display_name":"Gaeun Yun","orcid":"https://orcid.org/0009-0002-1396-7563","observed_orcids":["https://orcid.org/0009-0002-1396-7563"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gaeun Yun","raw_affiliation_strings":["Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161482646","display_name":"Tae Sik Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4389425440","display_name":"Samsung Changwon Hospital","ror":"https://ror.org/04wdz4v71","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4389425440"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Sik Hwang","raw_affiliation_strings":["Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea","institution_ids":["https://openalex.org/I4389425440","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161448172","display_name":"Hyoun Wook Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4389425440","display_name":"Samsung Changwon Hospital","ror":"https://ror.org/04wdz4v71","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4389425440"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyoun Wook Lee","raw_affiliation_strings":["Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea","institution_ids":["https://openalex.org/I4389425440","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061422971","display_name":"HyeokJin Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeokjin Cho","raw_affiliation_strings":["Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083239857","display_name":"Jungho Lee","orcid":"https://orcid.org/0000-0003-3040-8800","observed_orcids":["https://orcid.org/0000-0003-3040-8800"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jungho Lee","raw_affiliation_strings":["Cellknit Inc., Pohang, South Korea","Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea"],"raw_orcid":"https://orcid.org/0000-0003-3040-8800","affiliations":[{"raw_affiliation_string":"Cellknit Inc., Pohang, South Korea","institution_ids":[]},{"raw_affiliation_string":"Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018500712","display_name":"Geunbae Lim","orcid":"https://orcid.org/0000-0002-7062-3575","observed_orcids":["https://orcid.org/0000-0002-7062-3575"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Geunbae Lim","raw_affiliation_strings":["Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea","Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea","SNTEL Co., Ltd., Pohang, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-7062-3575","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"SNTEL Co., Ltd., Pohang, South Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018500712","https://openalex.org/A5083239857"],"corresponding_institution_ids":["https://openalex.org/I123900574"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6775000095367432},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.6704000234603882},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.6031000018119812},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.49149999022483826},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.42980000376701355},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42719998955726624},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3452000021934509},{"id":"https://openalex.org/C204366326","wikidata":"https://www.wikidata.org/wiki/Q3027650","display_name":"Deformation (meteorology)","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33889999985694885},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C3020090656","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Arterial wall","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C150489694","wikidata":"https://www.wikidata.org/wiki/Q6057172","display_name":"Interstitial space","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25870001316070557},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.257999986410141},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C2908754555","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Tissue fluid","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41467-026-78755-8","doi":"https://doi.org/10.1038/s41467-026-78755-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78755-8","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-78755-8","doi":"https://doi.org/10.1038/s41467-026-78755-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78755-8","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Sustaining":[0],"open":[1,185],"microchannels":[2],"within":[3,31],"living":[4,83,164],"soft":[5,161],"tissue":[6],"has":[7],"remained":[8],"a":[9,122,152,177],"problem":[10],"of":[11,62,72,97,109,121],"mechanics:":[12],"implants":[13,23],"rigid":[14],"enough":[15,25],"to":[16,26,57,99,146],"maintain":[17],"patent":[18],"channels":[19],"inflict":[20],"inflammation,":[21],"while":[22],"compliant":[24],"avoid":[27],"it":[28],"are":[29],"sealed":[30],"minutes":[32],"by":[33,139],"viscoelastic":[34],"recoil.":[35],"Here,":[36,173],"we":[37],"resolve":[38],"this":[39,114],"conflict":[40],"through":[41,102],"topographical":[42],"mismatch\u2014a":[43],"deliberate":[44],"geometric":[45],"non-conformity":[46],"between":[47,160],"an":[48],"ultrathin":[49],"multi-lobed":[50,178],"implant":[51],"and":[52,76,94,137,163],"the":[53,59,87,105,174],"surrounding":[54],"tissue.":[55,165],"Engineered":[56],"exceed":[58],"conformability":[60],"limit":[61],"skin,":[63],"these":[64],"conduits":[65,184],"sustain":[66],"patency":[67],"for":[68,77,156,186],"over":[69],"42":[70],"hours":[71,136],"sustained":[73],"physiological":[74],"deformation":[75],"at":[78,130,134],"least":[79],"7":[80],"days":[81],"in":[82],"skin":[84],"without":[85],"triggering":[86],"mechanotransductive":[88],"signalling":[89],"that":[90,117,181],"initiates":[91],"fibrotic":[92],"encapsulation,":[93],"transmit":[95],"macromolecules":[96],"up":[98],"70":[100],"kilodaltons":[101],"intact":[103],"skin\u2014surpassing":[104],"molecular":[106],"weight":[107],"ceiling":[108],"transdermal":[110],"iontophoresis.":[111],"In":[112],"vivo,":[113],"access":[115],"reveals":[116],"interstitial":[118,194],"fluid":[119,195],"concentration":[120],"model":[123],"protein":[124,191],"peaks":[125],"4.7-fold":[126],"higher":[127],"than":[128],"serum":[129],"2":[131],"hours,":[132,141],"inverts":[133],"8":[135],"rebounds":[138],"24":[140],"uncovering":[142],"tissue-level":[143],"pharmacokinetics":[144],"inaccessible":[145],"blood":[147],"sampling.":[148],"Topographical":[149],"mismatch":[150],"establishes":[151],"generalisable":[153],"design":[154],"principle":[155],"sustained,":[157],"biocompatible":[158],"interfaces":[159],"devices":[162,167],"Skin-attached":[166],"can":[168],"easily":[169],"inflame":[170],"or":[171],"collapse.":[172],"authors":[175],"show":[176],"microneedle":[179],"device":[180],"holds":[182],"micron-scale":[183],"seven":[187],"days,":[188],"allowing":[189],"repeated":[190],"sampling":[192],"from":[193]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
