{"id":"https://openalex.org/W7225778688","doi":"https://doi.org/10.1038/s42003-026-11304-7","title":"Oral absorption, bioavailability, and uptake routes of omega-3 polyunsaturated fatty acid derived 17(S)-HDHA, 15(S)-HEPE, RvD1 and RvE1 in healthy rats","display_name":"Oral absorption, bioavailability, and uptake routes of omega-3 polyunsaturated fatty acid derived 17(S)-HDHA, 15(S)-HEPE, RvD1 and RvE1 in healthy rats","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225778688","doi":"https://doi.org/10.1038/s42003-026-11304-7"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-026-11304-7","doi":"https://doi.org/10.1038/s42003-026-11304-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11304-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s42003-026-11304-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013903786","display_name":"Aidan D Tyrrell","orcid":"https://orcid.org/0000-0002-0882-7737","observed_orcids":["https://orcid.org/0000-0002-0882-7737"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aidan D. Tyrrell","raw_affiliation_strings":["Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0882-7737","affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040539181","display_name":"Chuck T. Chen","orcid":"https://orcid.org/0000-0002-1099-4198","observed_orcids":["https://orcid.org/0000-0002-1099-4198"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chuck T. Chen","raw_affiliation_strings":["Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1099-4198","affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121427804","display_name":"Yan Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yan Fu","raw_affiliation_strings":["Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046131098","display_name":"Prasad P. Devarshi","orcid":"https://orcid.org/0000-0003-3117-1681","observed_orcids":["https://orcid.org/0000-0003-3117-1681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prasad P. Devarshi","raw_affiliation_strings":["Science & Technology, Pharmavite LLC, West Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science & Technology, Pharmavite LLC, West Hills, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043530089","display_name":"Ryan W. Grant","orcid":"https://orcid.org/0000-0002-8940-4196","observed_orcids":["https://orcid.org/0000-0002-8940-4196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan W. Grant","raw_affiliation_strings":["Science & Technology, Pharmavite LLC, West Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science & Technology, Pharmavite LLC, West Hills, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015038886","display_name":"Ann C. Skulas\u2010Ray","orcid":"https://orcid.org/0000-0003-2914-9055","observed_orcids":["https://orcid.org/0000-0003-2914-9055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann C. Skulas-Ray","raw_affiliation_strings":["Science & Technology, Pharmavite LLC, West Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science & Technology, Pharmavite LLC, West Hills, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161480464","display_name":"Qian Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Ye","raw_affiliation_strings":["Science & Technology, Pharmavite LLC, West Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science & Technology, Pharmavite LLC, West Hills, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050185774","display_name":"Susan Hazels Mitmesser","orcid":"https://orcid.org/0000-0001-6353-1763","observed_orcids":["https://orcid.org/0000-0001-6353-1763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan H. Mitmesser","raw_affiliation_strings":["Science & Technology, Pharmavite LLC, West Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science & Technology, Pharmavite LLC, West Hills, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027965558","display_name":"Richard Paul Bazinet","orcid":"https://orcid.org/0000-0002-5013-5144","observed_orcids":["https://orcid.org/0000-0002-5013-5144"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Richard P. Bazinet","raw_affiliation_strings":["Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027965558"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8373000025749207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6931999921798706},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.6815999746322632},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.6323999762535095},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.6194000244140625},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.6029999852180481},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5728999972343445},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5601000189781189},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5163000226020813},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.49799999594688416},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.46959999203681946},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.45179998874664307},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4154999852180481},{"id":"https://openalex.org/C11772777","wikidata":"https://www.wikidata.org/wiki/Q423126","display_name":"Chylomicron","level":5,"score":0.387800008058548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37929999828338623},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.36230000853538513},{"id":"https://openalex.org/C3019361228","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral dose","level":3,"score":0.3531000018119812},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.32440000772476196},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.31360000371932983},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.3059000074863434},{"id":"https://openalex.org/C2779604457","wikidata":"https://www.wikidata.org/wiki/Q1340349","display_name":"Enterocyte","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28349998593330383},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42003-026-11304-7","doi":"https://doi.org/10.1038/s42003-026-11304-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11304-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s42003-026-11304-7","doi":"https://doi.org/10.1038/s42003-026-11304-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-026-11304-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Lipid":[1],"mediators":[2,20,52,115,147],"derived":[3],"from":[4],"omega-3":[5],"polyunsaturated":[6],"fatty":[7],"acids":[8],"(n-3":[9],"PUFA),":[10],"eicosapentaenoic":[11],"acid":[12,16],"(EPA)":[13],"and":[14,27,41,50,60,66,79,112,126],"docosahexaenoic":[15],"(DHA),":[17],"are":[18,148],"critical":[19],"of":[21,31,44,101,109,124],"inflammation.":[22],"In":[23],"contrast":[24],"to":[25,55,95],"EPA":[26],"DHA,":[28],"the":[29,85],"bioavailability":[30,100],"their":[32,57],"lipid":[33,51,114,146],"mediator":[34],"derivatives":[35],"remains":[36],"unstudied.":[37],"Oral,":[38],"intravenous":[39],"(IV),":[40],"intraduodenal":[42],"administration":[43,104],"stable":[45],"isotope":[46],"labeled":[47],"n-3":[48,110,144],"PUFA,":[49],"was":[53],"used":[54],"establish":[56],"bioavailability,":[58],"half-lives,":[59],"absorption":[61,135],"routes":[62],"in":[63,134],"rats.":[64],"Blood":[65],"lymph":[67],"were":[68,81],"analyzed":[69],"by":[70],"liquid":[71],"chromatography\u2013tandem":[72],"mass":[73],"spectrometry.":[74],"Orally":[75],"administered":[76,113],"17(S)-HDHA-d5,":[77],"15(S)-HEPE-d5,":[78],"RvD1-d5":[80],"rapidly":[82],"absorbed":[83,149],"into":[84],"unesterified":[86],"plasma":[87,107,122],"pool,":[88],"reaching":[89],"peak":[90],"concentrations":[91],"within":[92],"15":[93],"min":[94],"1":[96],"h,":[97],"with":[98],"a":[99,154],"3\u20136%.":[102],"IV":[103],"revealed":[105],"rapid":[106],"clearance":[108],"PUFA":[111],"(half-life":[116],"~30":[117],"s).":[118],"Lymph":[119],"cannulation":[120],"reduced":[121],"appearance":[123],"17(S)-HDHA-d5":[125],"15(S)-HEPE-d5":[127],"but":[128],"not":[129],"RvD1-d5,":[130],"indicating":[131],"structure-dependent":[132],"changes":[133],"via":[136],"lymphatic":[137],"or":[138],"portal":[139],"routes.":[140],"These":[141],"findings":[142],"demonstrate":[143],"PUFA-derived":[145],"following":[150],"oral":[151,157],"intake,":[152],"providing":[153],"foundation":[155],"for":[156],"delivery.":[158]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}