{"id":"https://openalex.org/W7225776972","doi":"https://doi.org/10.1002/pro.70854","title":"Synthesis and evaluation of novel triazole\u2013Schiff base derivatives bearing a morpholine moiety as potent urease inhibitors: Molecular docking and molecular dynamics studies","display_name":"Synthesis and evaluation of novel triazole\u2013Schiff base derivatives bearing a morpholine moiety as potent urease inhibitors: Molecular docking and molecular dynamics studies","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225776972","doi":"https://doi.org/10.1002/pro.70854","pmid":"https://pubmed.ncbi.nlm.nih.gov/43010862"},"language":"en","primary_location":{"id":"doi:10.1002/pro.70854","doi":"https://doi.org/10.1002/pro.70854","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pro.70854","pdf_url":null,"source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050792944","display_name":"Yonca Y\u0131lmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135987583","display_name":"Kafkas University","ror":"https://ror.org/04v302n28","country_code":"TR","type":"education","lineage":["https://openalex.org/I135987583"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yonca Y\u0131lmaz","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences Kafkas University  Kars T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences Kafkas University  Kars T\u00fcrkiye","institution_ids":["https://openalex.org/I135987583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030666306","display_name":"Hilal Medetalibeyo\u011flu","orcid":"https://orcid.org/0000-0002-1310-6811","observed_orcids":["https://orcid.org/0000-0002-1310-6811"]},"institutions":[{"id":"https://openalex.org/I135987583","display_name":"Kafkas University","ror":"https://ror.org/04v302n28","country_code":"TR","type":"education","lineage":["https://openalex.org/I135987583"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hilal Medetalibeyo\u011flu","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences Kafkas University  Kars T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-1310-6811","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences Kafkas University  Kars T\u00fcrkiye","institution_ids":["https://openalex.org/I135987583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036175645","display_name":"\u00d6zlem BAKIR","orcid":"https://orcid.org/0000-0002-1964-3271","observed_orcids":["https://orcid.org/0000-0002-1964-3271"]},"institutions":[{"id":"https://openalex.org/I64134780","display_name":"Atat\u00fcrk University","ror":"https://ror.org/03je5c526","country_code":"TR","type":"education","lineage":["https://openalex.org/I64134780"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6zlem Bak\u0131r Bo\u011fa","raw_affiliation_strings":["Department of Biology, Faculty of Science Ataturk University  Erzurum T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-1964-3271","affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science Ataturk University  Erzurum T\u00fcrkiye","institution_ids":["https://openalex.org/I64134780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025459628","display_name":"Haydar Y\u00fcksek","orcid":"https://orcid.org/0000-0003-1289-1800","observed_orcids":["https://orcid.org/0000-0003-1289-1800"]},"institutions":[{"id":"https://openalex.org/I135987583","display_name":"Kafkas University","ror":"https://ror.org/04v302n28","country_code":"TR","type":"education","lineage":["https://openalex.org/I135987583"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Haydar Y\u00fcksek","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences Kafkas University  Kars T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences Kafkas University  Kars T\u00fcrkiye","institution_ids":["https://openalex.org/I135987583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010110985","display_name":"Esab\u0131 Ba\u015faran Kurbano\u011flu","orcid":"https://orcid.org/0000-0002-7434-6309","observed_orcids":["https://orcid.org/0000-0002-7434-6309"]},"institutions":[{"id":"https://openalex.org/I64134780","display_name":"Atat\u00fcrk University","ror":"https://ror.org/03je5c526","country_code":"TR","type":"education","lineage":["https://openalex.org/I64134780"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esabi Ba\u015faran Kurbano\u011flu","raw_affiliation_strings":["Department of Biology, Faculty of Science Ataturk University  Erzurum T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science Ataturk University  Erzurum T\u00fcrkiye","institution_ids":["https://openalex.org/I64134780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074363699","display_name":"Abdurrahman Atalay","orcid":"https://orcid.org/0000-0002-9018-7264","observed_orcids":["https://orcid.org/0000-0002-9018-7264","https://orcid.org/0000-0001-8404-1528"]},"institutions":[{"id":"https://openalex.org/I1329879541","display_name":"Avrasya University","ror":"https://ror.org/00pv8s374","country_code":"TR","type":"education","lineage":["https://openalex.org/I1329879541"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abdurrahman Atalay","raw_affiliation_strings":["Department of Nutrition and Dietetics, Faculty of Health Science Avrasya University  Trabzon T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-9018-7264","affiliations":[{"raw_affiliation_string":"Department of Nutrition and Dietetics, Faculty of Health Science Avrasya University  Trabzon T\u00fcrkiye","institution_ids":["https://openalex.org/I1329879541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105141047","display_name":"Ahmet Bu\u011fra Ortaakarsu","orcid":"https://orcid.org/0000-0003-3317-9505","observed_orcids":["https://orcid.org/0000-0003-3317-9505"]},"institutions":[{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ahmet Bu\u011fra Ortaakarsu","raw_affiliation_strings":["Aurealcraft Incorporated  Newark Delaware USA","Department of Chemistry, Faculty of Science Gazi University  Ankara T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-3317-9505","affiliations":[{"raw_affiliation_string":"Aurealcraft Incorporated  Newark Delaware USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Faculty of Science Gazi University  Ankara T\u00fcrkiye","institution_ids":["https://openalex.org/I95634034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5105141047"],"corresponding_institution_ids":["https://openalex.org/I95634034"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8978000283241272},{"id":"https://openalex.org/C2781056017","wikidata":"https://www.wikidata.org/wiki/Q410243","display_name":"Morpholine","level":2,"score":0.7784000039100647},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.6929000020027161},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6757000088691711},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6625999808311462},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6486999988555908},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5813999772071838},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4381999969482422},{"id":"https://openalex.org/C3020299119","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Binding pocket","level":3,"score":0.3935000002384186},{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.382099986076355},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.37450000643730164},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C25057246","wikidata":"https://www.wikidata.org/wiki/Q1344441","display_name":"Molecular mechanics","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C2780538656","wikidata":"https://www.wikidata.org/wiki/Q528995","display_name":"Thiourea","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.2996000051498413},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.2646999955177307}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012545","descriptor_name":"Schiff Bases","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012545","descriptor_name":"Schiff Bases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014510","descriptor_name":"Urease","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014510","descriptor_name":"Urease","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/pro.70854","doi":"https://doi.org/10.1002/pro.70854","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pro.70854","pdf_url":null,"source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmid:43010862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43010862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1972758026","https://openalex.org/W1978733464","https://openalex.org/W1987327282","https://openalex.org/W2072793080","https://openalex.org/W2112154906","https://openalex.org/W2151319145","https://openalex.org/W2151320149","https://openalex.org/W2158123709","https://openalex.org/W2609522315","https://openalex.org/W2801139006","https://openalex.org/W2805248373","https://openalex.org/W2923582143","https://openalex.org/W3012250480","https://openalex.org/W3044294667","https://openalex.org/W3109170131","https://openalex.org/W3111226494","https://openalex.org/W3162032752","https://openalex.org/W3167019654","https://openalex.org/W3177545261","https://openalex.org/W3202731616","https://openalex.org/W4205191469","https://openalex.org/W4210673469","https://openalex.org/W4224323341","https://openalex.org/W4281720921","https://openalex.org/W4307272925","https://openalex.org/W4308286898","https://openalex.org/W4366598306","https://openalex.org/W4383058878","https://openalex.org/W4385387001","https://openalex.org/W4386781103","https://openalex.org/W4387661517","https://openalex.org/W4392794003","https://openalex.org/W4396623857","https://openalex.org/W4396902863","https://openalex.org/W4398174521","https://openalex.org/W4399782631","https://openalex.org/W4400672373","https://openalex.org/W4402701438","https://openalex.org/W4403065930","https://openalex.org/W4403463885","https://openalex.org/W4404431323","https://openalex.org/W4405287506","https://openalex.org/W4408384006","https://openalex.org/W4409191894","https://openalex.org/W4411969426","https://openalex.org/W4412021829","https://openalex.org/W4412420911","https://openalex.org/W4412457425","https://openalex.org/W4413431727","https://openalex.org/W4414162989","https://openalex.org/W4416958915","https://openalex.org/W7082443477","https://openalex.org/W7124591155"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Urease,":[1],"a":[2,13,151,165,228],"binuclear":[3,126],"nickel":[4],"metalloenzyme":[5],"central":[6],"to":[7],"microbial":[8],"survival":[9],"and":[10,39,42,51,98,129,136,161,188,203,243,252,268],"pathogenicity,":[11],"is":[12,107],"key":[14],"protein":[15],"target":[16],"for":[17,168],"mechanism\u2010guided":[18],"inhibitor":[19,82],"design.":[20],"In":[21,54],"this":[22],"study,":[23],"nine":[24],"morpholine\u2010containing":[25],"1,2,4\u2010triazole\u2010based":[26],"N":[27],"\u2010Mannich":[28],"derivatives":[29],"(":[30],"mb1\u20139":[31],")":[32],"were":[33,143],"synthesized":[34],"through":[35],"sequential":[36],"Schiff\u2010base":[37],"formation":[38],"Mannich":[40],"functionalization":[41],"structurally":[43],"characterized":[44],"by":[45,74,95],"FT\u2010IR,":[46],"1":[47],"H/":[48],"13":[49],"C\u2010NMR,":[50],"HRMS":[52],"analyses.":[53],"vitro":[55],"urease\u2010inhibition":[56],"assays":[57],"revealed":[58],"marked":[59],"structure\u2010dependent":[60],"activity,":[61],"with":[62,109,196,262],"mb4":[63,149,184,222,272],"exhibiting":[64],"the":[65,80,113,116,121,125,133,139,147,178,212,274,282],"highest":[66],"potency":[67],"(IC":[68,84],"50":[69,85],"=":[70,86],"5.55":[71],"\u03bcM),":[72,77],"followed":[73],"mb7":[75,189],"(12.92":[76],"both":[78],"outperforming":[79],"reference":[81],"thiourea":[83],"20.84":[87],"\u03bcM).":[88],"The":[89,256],"experimental":[90,171,259],"activity":[91],"profile":[92],"was":[93],"rationalized":[94],"molecular":[96,99],"docking":[97,141],"dynamics":[100],"simulations,":[101],"which":[102],"demonstrated":[103],"that":[104,156,177],"productive":[105],"inhibition":[106,260],"associated":[108],"persistent":[110,235],"accommodation":[111],"of":[112,120,221,258],"ligands":[114],"within":[115,211,281],"catalytic":[117],"pocket,":[118],"coordination":[119],"morpholine":[122],"oxygen":[123],"toward":[124],"Ni":[127],"center,":[128],"additional":[130],"stabilization":[131],"involving":[132],"triazole":[134],"carbonyl":[135],"Cys321.":[137],"Although":[138],"calculated":[140],"scores":[142],"relatively":[144],"close":[145],"across":[146],"series,":[148],"adopted":[150],"particularly":[152,183],"favorable":[153,219,253],"binding":[154,194,220],"geometry":[155],"simultaneously":[157],"preserved":[158],"metal\u2010centered":[159],"interactions":[160],"active\u2010site":[162,213,265],"stabilization,":[163],"providing":[164],"structural":[166,198],"basis":[167],"its":[169],"superior":[170],"potency.":[172],"Consistently,":[173],"MD":[174],"simulations":[175,242],"showed":[176],"more":[179,204],"active":[180,202],"aromatic":[181],"derivatives,":[182],",":[185,187,190,223],"mb5":[186],"maintained":[191],"comparatively":[192],"stable":[193],"conformations":[195],"limited":[197],"fluctuations,":[199],"whereas":[200],"less":[201],"conformationally":[205],"flexible":[206],"analogs":[207],"exhibited":[208],"greater":[209],"mobility":[210],"environment.":[214],"MM/GBSA":[215],"analysis":[216,226],"further":[217],"supported":[218,278],"while":[224],"diffusion\u2010map":[225],"identified":[227],"dominant,":[229],"well\u2010defined":[230],"low\u2010energy":[231],"conformational":[232],"basin,":[233],"indicating":[234],"ligand":[236],"retention":[237],"under":[238],"dynamic":[239,269],"conditions.":[240],"Membrane\u2010permeation":[241],"ADME":[244],"predictions":[245],"additionally":[246],"suggested":[247],"physiologically":[248],"compatible":[249],"passive":[250],"diffusion":[251],"drug\u2010like":[254],"properties.":[255],"convergence":[257],"data":[261],"metal":[263],"coordination,":[264],"interaction":[266],"patterns,":[267],"stability":[270],"identifies":[271],"as":[273],"most":[275],"promising":[276],"mechanistically":[277],"urease\u2010inhibitory":[279],"scaffold":[280],"series.":[283]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}