{"id":"https://openalex.org/W7225774108","doi":"https://doi.org/10.3390/ijms272210099","title":"GPCR and Insulin Signaling: Friends or Foes in Insulin Resistance?","display_name":"GPCR and Insulin Signaling: Friends or Foes in Insulin Resistance?","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225774108","doi":"https://doi.org/10.3390/ijms272210099"},"language":"en","primary_location":{"id":"doi:10.3390/ijms272210099","doi":"https://doi.org/10.3390/ijms272210099","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210099","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms272210099","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011805055","display_name":"Ang\u00e9lica Rueda","orcid":"https://orcid.org/0000-0001-8749-8494","observed_orcids":["https://orcid.org/0000-0001-8749-8494"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ang\u00e9lica Rueda","raw_affiliation_strings":["Laboratory of Biochemistry and Cardiovascular Physiology, Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-8749-8494","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Cardiovascular Physiology, Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015645943","display_name":"Jos\u00e9\u2010Antonio Arias\u2010Monta\u00f1o","orcid":"https://orcid.org/0000-0002-0791-8397","observed_orcids":["https://orcid.org/0000-0002-0791-8397"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9-Antonio Arias-Monta\u00f1o","raw_affiliation_strings":["Laboratory of Cellular and Molecular Neuropharmacology, Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Mexico City 07360, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Neuropharmacology, Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013104039","display_name":"Jes\u00fas Alberto Olivares-Reyes","orcid":"https://orcid.org/0000-0001-8389-9274","observed_orcids":["https://orcid.org/0000-0001-8389-9274"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Jes\u00fas Alberto Olivares-Reyes","raw_affiliation_strings":["Laboratory of Signal Transduction, Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Mexico City 07360, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-8389-9274","affiliations":[{"raw_affiliation_string":"Laboratory of Signal Transduction, Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute, Mexico City 07360, Mexico","institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013104039"],"corresponding_institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"22","first_page":"10099","last_page":"10099"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8202999830245972},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7871000170707703},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.7178000211715698},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6611999869346619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.516700029373169},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.505299985408783},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4546999931335449},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.450300008058548},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44859999418258667},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44290000200271606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4092000126838684},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.3785000145435333},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.37689998745918274},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.367900013923645},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.35359999537467957},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3513999879360199},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34529998898506165},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C197902417","wikidata":"https://www.wikidata.org/wiki/Q18033191","display_name":"IRS2","level":5,"score":0.27730000019073486},{"id":"https://openalex.org/C42221972","wikidata":"https://www.wikidata.org/wiki/Q7321217","display_name":"Rhodopsin-like receptors","level":5,"score":0.2685999870300293},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26440000534057617},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26010000705718994},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.25839999318122864}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms272210099","doi":"https://doi.org/10.3390/ijms272210099","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210099","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms272210099","doi":"https://doi.org/10.3390/ijms272210099","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210099","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"G":[0],"protein-coupled":[1],"receptors":[2,11,35],"(GPCRs)":[3],"are":[4,29,41],"a":[5],"diverse":[6],"family":[7],"of":[8,26,96,126,146,170],"cell":[9,50,54],"surface":[10],"that":[12],"transmit":[13],"signals":[14],"from":[15,119],"external":[16],"molecules,":[17],"such":[18,81,108],"as":[19,82,109],"hormones":[20],"and":[21,28,57,73,78,90,106,115,135,144,159,162],"neurotransmitters,":[22],"to":[23,44,123,152,167],"the":[24,30,49,100,131,142,154,168],"interior":[25],"cells":[27],"most":[31],"widely":[32],"distributed":[33],"membrane":[34],"in":[36,48,69,141],"living":[37],"beings.":[38],"Their":[39],"actions":[40,72,105],"not":[42],"limited":[43],"mediating":[45],"rapid":[46],"effects":[47],"but":[51],"also":[52,62],"regulate":[53],"proliferation,":[55],"differentiation,":[56],"gene":[58],"expression.":[59],"GPCRs":[60,134,158],"have":[61,98],"been":[63],"recognized":[64],"for":[65,111],"their":[66,74,164],"important":[67],"role":[68],"regulating":[70],"metabolic":[71,79,88],"association":[75],"with":[76],"diseases":[77],"disorders,":[80],"type":[83],"2":[84],"diabetes":[85],"mellitus":[86],"(T2DM),":[87],"syndrome,":[89],"insulin":[91,104,127,136,147,160,171],"resistance.":[92,172],"A":[93],"significant":[94],"number":[95],"reports":[97],"demonstrated":[99],"strong":[101],"relationship":[102],"between":[103,157],"GPCRs,":[107],"those":[110],"adrenaline/noradrenaline,":[112],"angiotensin,":[113],"vasopressin,":[114],"corticotropin-releasing":[116],"factor,":[117],"ranging":[118],"sensitization":[120],"(positive":[121],"actions)":[122],"negative":[124],"regulation":[125],"actions.":[128],"This":[129,149],"raises":[130],"question:":[132],"Are":[133],"signaling":[137,161],"friends":[138],"or":[139],"foes":[140],"development":[143,169],"progression":[145],"resistance?":[148],"review":[150],"aims":[151],"explore":[153],"complex":[155],"interplay":[156],"how":[163],"interactions":[165],"contribute":[166]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
