{"id":"https://openalex.org/W7225773191","doi":"https://doi.org/10.1371/journal.pone.0361190","title":"Piloting cannabis for sleep disturbance in palliative care over 5 weeks: The pillow study protocol","display_name":"Piloting cannabis for sleep disturbance in palliative care over 5 weeks: The pillow study protocol","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225773191","doi":"https://doi.org/10.1371/journal.pone.0361190"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0361190","doi":"https://doi.org/10.1371/journal.pone.0361190","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361190","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pone.0361190","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059209523","display_name":"Alison M. Newton","orcid":"https://orcid.org/0009-0004-4659-9546","observed_orcids":["https://orcid.org/0009-0004-4659-9546"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Newton","raw_affiliation_strings":["The Ohio State University College of Medicine"],"raw_orcid":"https://orcid.org/0009-0004-4659-9546","affiliations":[{"raw_affiliation_string":"The Ohio State University College of Medicine","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031938093","display_name":"Jessica L. Krok\u2010Schoen","orcid":"https://orcid.org/0000-0003-2484-5887","observed_orcids":["https://orcid.org/0000-0003-2484-5887"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica L. Krok-Schoen","raw_affiliation_strings":["The Ohio State University College of Medicine"],"raw_orcid":"https://orcid.org/0000-0003-2484-5887","affiliations":[{"raw_affiliation_string":"The Ohio State University College of Medicine","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043199850","display_name":"Erin Stevens","orcid":"https://orcid.org/0000-0002-8876-2557","observed_orcids":["https://orcid.org/0000-0002-8876-2557"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin E. Stevens","raw_affiliation_strings":["The Ohio State University College of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-8876-2557","affiliations":[{"raw_affiliation_string":"The Ohio State University College of Medicine","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033535451","display_name":"Shanna L. Babalonis","orcid":"https://orcid.org/0000-0002-1450-2621","observed_orcids":["https://orcid.org/0000-0002-1450-2621"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanna L. Babalonis","raw_affiliation_strings":["University of Kentucky College of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-1450-2621","affiliations":[{"raw_affiliation_string":"University of Kentucky College of Medicine","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029782732","display_name":"Theodore L. Wagener","orcid":"https://orcid.org/0000-0002-9072-228X","observed_orcids":["https://orcid.org/0000-0002-9072-228X","https://orcid.org/0000-0002-4028-0081","https://orcid.org/0000-0003-3484-2794"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore L. Wagener","raw_affiliation_strings":["The Ohio State University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University College of Medicine","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091084441","display_name":"Alice M. Hinton","orcid":"https://orcid.org/0000-0003-4505-4021","observed_orcids":["https://orcid.org/0000-0003-4505-4021"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Hinton","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132931394","display_name":"Roberto Benzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Benzo","raw_affiliation_strings":["The Ohio State University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University College of Medicine","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000172773","display_name":"Theodore M. Brasky","orcid":"https://orcid.org/0000-0001-7781-609X","observed_orcids":["https://orcid.org/0000-0001-7781-609X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore M. Brasky","raw_affiliation_strings":["The Ohio State University College of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-7781-609X","affiliations":[{"raw_affiliation_string":"The Ohio State University College of Medicine","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"11","first_page":"e0361190","last_page":"e0361190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13340","display_name":"Palliative and Oncologic Care","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7752000093460083},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.7279999852180481},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.727400004863739},{"id":"https://openalex.org/C2778537899","wikidata":"https://www.wikidata.org/wiki/Q254034","display_name":"Bedtime","level":2,"score":0.6389999985694885},{"id":"https://openalex.org/C2994186709","wikidata":"https://www.wikidata.org/wiki/Q29483","display_name":"Palliative care","level":2,"score":0.6326000094413757},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.525600016117096},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5157999992370605},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5001000165939331},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4731000065803528},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.45680001378059387},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.40470001101493835},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.39340001344680786},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3880000114440918},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.38499999046325684},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3668999969959259},{"id":"https://openalex.org/C2778996325","wikidata":"https://www.wikidata.org/wiki/Q422201","display_name":"Actigraphy","level":3,"score":0.32739999890327454},{"id":"https://openalex.org/C188394188","wikidata":"https://www.wikidata.org/wiki/Q744029","display_name":"Sleep medicine","level":4,"score":0.31839999556541443},{"id":"https://openalex.org/C2777601987","wikidata":"https://www.wikidata.org/wiki/Q5283581","display_name":"Disturbance (geology)","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1371/journal.pone.0361190","doi":"https://doi.org/10.1371/journal.pone.0361190","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361190","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0361190","doi":"https://doi.org/10.1371/journal.pone.0361190","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361190","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1858551680","https://openalex.org/W2006503897","https://openalex.org/W2012183525","https://openalex.org/W2036547523","https://openalex.org/W2113421289","https://openalex.org/W2114486723","https://openalex.org/W2130553178","https://openalex.org/W2147927085","https://openalex.org/W2165855160","https://openalex.org/W2399987572","https://openalex.org/W2546643588","https://openalex.org/W2612426134","https://openalex.org/W2616653812","https://openalex.org/W2756282134","https://openalex.org/W2914189407","https://openalex.org/W2980259131","https://openalex.org/W3008075220","https://openalex.org/W3082036175","https://openalex.org/W3133662323","https://openalex.org/W4225116982","https://openalex.org/W4383032823","https://openalex.org/W4385607379","https://openalex.org/W4385829789"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Sleep":[1,26,43],"disturbance":[2,27,98,224],"affects":[3],"60%":[4],"of":[5,10,40,86],"cancer":[6,229],"patients,":[7],"3-fold":[8],"that":[9],"the":[11,45,82,113,130,186],"general":[12],"population,":[13],"and":[14,23,28,84,90,99,135,148,167,190,202,211,225],"is":[15,44],"frequently":[16],"driven":[17],"by":[18,146],"clinical":[19,58,106],"characteristics,":[20],"physical":[21],"symptoms,":[22],"psychological":[24],"distress.":[25],"other":[29],"symptoms":[30,192],"often":[31],"exacerbate":[32],"one":[33],"another,":[34],"leading":[35],"to":[36,80,91,129,151,215],"reduced":[37],"health-related":[38],"quality":[39],"life":[41],"(HRQOL).":[42],"most":[46],"commonly":[47],"reported":[48],"reason":[49],"for":[50,63,74,96,177],"cannabis":[51,160],"use":[52,62],"among":[53],"adults":[54],"with":[55],"cancer,":[56],"yet":[57],"evidence":[59],"supporting":[60],"its":[61,93],"symptom":[64,226],"management":[65],"remains":[66],"limited.":[67],"Objectives":[68],"This":[69,102],"report":[70,136],"describes":[71],"a":[72,75,87,157,217],"protocol":[73],"pilot":[76,103],"randomized":[77,105,145],"trial":[78,107,221],"designed":[79],"evaluate":[81],"safety":[83],"feasibility":[85],"cannabis-based":[88],"intervention":[89],"explore":[92],"preliminary":[94,212],"efficacy":[95,213],"sleep":[97,140,223],"HRQOL.":[100],"Methods":[101],"parallel-arm":[104],"will":[108,126,143,182,193,206],"enroll":[109],"50":[110],"patients":[111],"from":[112],"Ohio":[114],"State":[115],"University":[116],"Comprehensive":[117],"Cancer":[118],"Center":[119],"(OSUCCC;":[120],"anticipated":[121],"Fall":[122],"2026).":[123],"Eligible":[124],"participants":[125],"be":[127,144,183,194],"new":[128],"OSUCCC\u2019s":[131],"Palliative":[132],"Care":[133],"clinic":[134],"at":[137],"least":[138],"moderate":[139],"disturbance.":[141],"Participants":[142],"sex":[147],"race":[149],"strata":[150],"receive":[152],"either":[153],"usual":[154],"care":[155],"or":[156],"nightly":[158],"oral":[159],"gummy":[161],"containing":[162],"5":[163,168],"mg":[164,169],"\u0394-9-tetrahydrocannabinol":[165],"(THC)":[166],"cannabidiol":[170],"(CBD),":[171],"taken":[172],"1":[173],"hour":[174],"before":[175],"bedtime":[176],"30":[178],"days.":[179],"Adverse":[180],"events":[181],"monitored":[184],"throughout":[185],"study.":[187],"Sleep,":[188],"HRQOL,":[189],"related":[191],"assessed":[195],"using":[196],"self-reported":[197],"questionnaires,":[198],"ecological":[199],"momentary":[200],"assessments,":[201],"actigraphy.":[203],"Conclusions":[204],"Findings":[205],"provide":[207],"critical":[208],"safety,":[209],"feasibility,":[210],"data":[214],"support":[216],"future":[218],"large-scale,":[219],"multisite":[220],"targeting":[222],"palliation":[227],"in":[228],"care.":[230]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}