{"id":"https://openalex.org/W7225761462","doi":"https://doi.org/10.1021/acschembio.6c00725","title":"Editing the C2 Position of Glycolipid Ligands Reveals Ligand-Dependent Recognition by Mincle","display_name":"Editing the C2 Position of Glycolipid Ligands Reveals Ligand-Dependent Recognition by Mincle","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225761462","doi":"https://doi.org/10.1021/acschembio.6c00725","pmid":"https://pubmed.ncbi.nlm.nih.gov/43006791"},"language":"en","primary_location":{"id":"doi:10.1021/acschembio.6c00725","doi":"https://doi.org/10.1021/acschembio.6c00725","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.6c00725","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050636429","display_name":"Hiroto Tamashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroto Tamashima","raw_affiliation_strings":["Kyushu University , , Maidashi, Higashi-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University , , Maidashi, Higashi-ku , ,","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048748635","display_name":"Haruka Oishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Oishi","raw_affiliation_strings":["The University of Osaka , , Yamadaoka , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Osaka , , Yamadaoka , , ,","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101888762","display_name":"Eri Ishikawa","orcid":"https://orcid.org/0000-0002-4922-6751","observed_orcids":["https://orcid.org/0000-0002-4922-6751"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Ishikawa","raw_affiliation_strings":["The University of Osaka , , Yamadaoka , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Osaka , , Yamadaoka , , ,","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089948047","display_name":"Takahiro Ikazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Ikazaki","raw_affiliation_strings":["Kyushu University , , Maidashi, Higashi-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University , , Maidashi, Higashi-ku , ,","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065936845","display_name":"Makoto Yoritate","orcid":"https://orcid.org/0000-0003-2182-3914","observed_orcids":["https://orcid.org/0000-0003-2182-3914"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Yoritate","raw_affiliation_strings":["Kyushu University , , Maidashi, Higashi-ku , ,"],"raw_orcid":"https://orcid.org/0000-0003-2182-3914","affiliations":[{"raw_affiliation_string":"Kyushu University , , Maidashi, Higashi-ku , ,","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007250393","display_name":"Hiroaki Matoba","orcid":"https://orcid.org/0000-0002-7063-9403","observed_orcids":["https://orcid.org/0000-0002-7063-9403"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Matoba","raw_affiliation_strings":["Kyushu University , , Maidashi, Higashi-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University , , Maidashi, Higashi-ku , ,","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112473850","display_name":"Sho Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Yamasaki","raw_affiliation_strings":["The University of Osaka , , Yamadaoka , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Osaka , , Yamadaoka , , ,","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062498976","display_name":"Go Hirai","orcid":"https://orcid.org/0000-0003-3420-555X","observed_orcids":["https://orcid.org/0000-0003-3420-555X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Go Hirai","raw_affiliation_strings":["Kyushu University , , Maidashi, Higashi-ku , ,"],"raw_orcid":"https://orcid.org/0000-0003-3420-555X","affiliations":[{"raw_affiliation_string":"Kyushu University , , Maidashi, Higashi-ku , ,","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062498976"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0925000011920929,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C22222904","wikidata":"https://www.wikidata.org/wiki/Q422882","display_name":"Glycolipid","level":2,"score":0.8241000175476074},{"id":"https://openalex.org/C2778452849","wikidata":"https://www.wikidata.org/wiki/Q421773","display_name":"Trehalose","level":2,"score":0.7293999791145325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5842000246047974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5640000104904175},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5436999797821045},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4034999907016754},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38960000872612},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3292999863624573},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3188000023365021},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.2912999987602234},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.25940001010894775},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acschembio.6c00725","doi":"https://doi.org/10.1021/acschembio.6c00725","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.6c00725","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:43006791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43006791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1735091417","https://openalex.org/W1978338761","https://openalex.org/W2006091616","https://openalex.org/W2027562913","https://openalex.org/W2036260143","https://openalex.org/W2037400650","https://openalex.org/W2043173265","https://openalex.org/W2049833046","https://openalex.org/W2061551128","https://openalex.org/W2065429310","https://openalex.org/W2075099807","https://openalex.org/W2075385714","https://openalex.org/W2087608197","https://openalex.org/W2092586460","https://openalex.org/W2135221251","https://openalex.org/W2239399748","https://openalex.org/W2332423443","https://openalex.org/W2412069337","https://openalex.org/W2471386371","https://openalex.org/W2512919990","https://openalex.org/W2560674140","https://openalex.org/W2590209386","https://openalex.org/W2595584585","https://openalex.org/W2604816124","https://openalex.org/W2611953884","https://openalex.org/W2738544723","https://openalex.org/W2772467665","https://openalex.org/W2780659543","https://openalex.org/W2800181679","https://openalex.org/W2803434802","https://openalex.org/W2899440123","https://openalex.org/W2920090843","https://openalex.org/W2993050524","https://openalex.org/W2994998810","https://openalex.org/W3029832814","https://openalex.org/W3135538617","https://openalex.org/W3210541081","https://openalex.org/W4306711895","https://openalex.org/W4315434974","https://openalex.org/W4317437933","https://openalex.org/W4362506160","https://openalex.org/W4384069376"],"related_works":[],"abstract_inverted_index":{"Macrophage-inducible":[0],"C-type":[1],"lectin":[2],"(Mincle)":[3],"induces":[4],"immune":[5],"responses":[6],"in":[7,64,113],"the":[8,29,40,45,58,71,123,136,154],"presence":[9],"of":[10,31,44,48,57,62,74,108,126,138,156],"pathogen-":[11],"and":[12,23,132,134],"damage-associated":[13],"molecular":[14],"patterns,":[15],"including":[16],"glycolipids":[17],"such":[18],"as":[19],"trehalose":[20,63,130],"dimycolate":[21],"(TDM),":[22],"is":[24],"a":[25,96,105,120,139,143],"potential":[26],"target":[27],"for":[28,122,160],"development":[30],"vaccine":[32],"adjuvants.":[33],"While":[34],"previous":[35],"research":[36],"has":[37],"extensively":[38],"explored":[39],"structure-activity":[41],"relationship":[42],"(SAR)":[43],"lipid":[46],"component":[47],"Mincle":[49,83,114,149],"ligands,":[50],"here":[51,90],"we":[52,88],"focus":[53],"on":[54,129,163],"structural":[55],"modification":[56],"C-2":[59,110],"hydroxy":[60,111],"group":[61,73,79,112],"TDM.":[65],"We":[66],"previously":[67],"reported":[68],"that":[69,91],"replacing":[70],"2-hydroxy":[72],"\u03b1-glucosylceramide":[75,133],"with":[76],"an":[77],"exomethylene":[78],"significantly":[80],"enhances":[81],"its":[82],"activation":[84],"potential.":[85],"In":[86],"contrast,":[87],"found":[89],"2-C-substituted":[92],"pseudo-TDMs,":[93],"synthesized":[94],"through":[95],"sequential":[97],"Tsuji-Trost-type":[98],"reaction,":[99],"only":[100],"weakly":[101],"activate":[102],"Mincle,":[103],"suggesting":[104],"major":[106],"role":[107],"TDM's":[109],"activation.":[115,150],"Molecular":[116],"modeling":[117],"studies":[118],"provided":[119],"rationale":[121],"contrasting":[124],"effects":[125],"C2-exomethylene":[127],"substitution":[128],"esters":[131],"guided":[135],"design":[137],"2-exomethylene":[140],"pseudo-\u03b1-GlcCer":[141],"bearing":[142],"6-behenate":[144],"moiety,":[145],"which":[146],"showed":[147],"enhanced":[148],"Our":[151],"results":[152],"suggest":[153],"existence":[155],"multiple":[157],"binding":[158],"modes":[159],"\u03b1-glucosylceramide-type":[161],"ligands":[162],"Mincle.":[164]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
