{"id":"https://openalex.org/W7225760481","doi":"https://doi.org/10.6084/m9.figshare.34969056","title":"Current landscape of small molecule MGMT expression inhibitors as potential resistance reversers for glioblastoma","display_name":"Current landscape of small molecule MGMT expression inhibitors as potential resistance reversers for glioblastoma","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225760481","doi":"https://doi.org/10.6084/m9.figshare.34969056"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.34969056","doi":"https://doi.org/10.6084/m9.figshare.34969056","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34969056","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.34969056","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161402326","display_name":"Qikang Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qikang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161402272","display_name":"Yutian Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutian Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161375900","display_name":"Lijiao Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijiao Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077485181","display_name":"Rugang Zhong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rugang Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161402163","display_name":"Peng Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161405005","display_name":"Geng Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geng Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161387884","display_name":"Guohui Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guohui Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.902999997138977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6541000008583069},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5533000230789185},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5442000031471252},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5214999914169312},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5008999705314636},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4163999855518341},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3950999975204468},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.36890000104904175},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.3675999939441681},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.36230000853538513},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.35269999504089355},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3402000069618225},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.3345000147819519},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.3208000063896179},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3077999949455261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29980000853538513},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28940001130104065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28349998593330383},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.2565000057220459},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.34969056","doi":"https://doi.org/10.6084/m9.figshare.34969056","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34969056","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.34969056.v1","doi":"https://doi.org/10.6084/m9.figshare.34969056.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34969056.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.34969056","doi":"https://doi.org/10.6084/m9.figshare.34969056","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34969056","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Primary":[0],"or":[1,314,357],"acquired":[2],"temozolomide":[3,206],"(TMZ)":[4],"resistance":[5,216],"in":[6,60,170,335],"glioblastoma":[7],"(GBM)":[8,189],"critically":[9],"limits":[10],"clinical":[11,164],"efficacy,":[12],"with":[13,195],"O6\u2011methylguanine\u2011DNA":[14],"methyltransferase":[15],"(MGMT)":[16],"serving":[17],"as":[18,34,71],"the":[19,93,203,237,243,246,253,256,259,304,308,317,371,379],"key":[20],"repair":[21],"protein":[22,144,222,319],"that":[23,102,284,310,389],"directly":[24],"reverses":[25],"TMZ-induced":[26],"O6-methylguanine":[27],"(O6-MG)":[28],"lesions.":[29],"Classical":[30],"MGMT":[31,43,59,81,104,137,241,254,267,274,297,305,318,334,384],"inactivators":[32],"such":[33,70],"O6\u2011benzylguanine":[35],"(O6\u2011BG)":[36],"and":[37,45,67,108,119,142,179,327],"O6\u2011(4\u2011bromothenyl)guanine":[38],"(O6\u20114\u2011BTG,":[39],"lomeguatrib)":[40],"effectively":[41],"deplete":[42],"activity":[44],"sensitize":[46],"tumor":[47,56,171,336],"cells":[48],"to":[49,161,183,213,265,295,332,342,349,354,374,385,391,395],"alkylating":[50],"agents.":[51],"However,":[52],"their":[53,286],"lack":[54],"of":[55,115],"selectivity":[57],"depletes":[58],"normal":[61],"hematopoietic":[62,73],"tissues,":[63],"inducing":[64],"dose-limiting":[65],"myelotoxicity":[66],"necessitating":[68],"counterstrategies":[69],"MGMT-tolerant":[72],"stem":[74],"cell":[75,247],"protection.":[76],"To":[77],"overcome":[78,375],"this":[79],"bottleneck,":[80],"intervention":[82],"strategies":[83,373],"have":[84,262,329],"expanded":[85],"from":[86,275,381],"direct":[87],"enzymatic":[88],"inhibition":[89],"toward":[90],"regulation":[91],"at":[92,293],"expression":[94,105],"level.":[95],"This":[96,215,368],"review":[97,369],"focuses":[98],"on":[99],"small":[100],"molecules":[101,352],"downregulate":[103],"through":[106,146],"transcriptional":[107],"epigenetic":[109],"regulation,":[110],"CNS-active":[111],"drug":[112,205],"interventions,":[113],"modulation":[114],"MGMT-related":[116,376],"signaling":[117],"pathways,":[118],"naturally":[120],"derived":[121],"bioactive":[122],"compounds.":[123],"It":[124],"also":[125,272],"summarizes":[126,370],"emerging":[127],"technological":[128],"approaches":[129,346],"including":[130,324],"tumor-targeted":[131],"conjugation,":[132],"blood\u2013brain":[133],"barrier-penetrating":[134],"delivery":[135],"systems,":[136],"gene":[138],"silencing":[139,303],"via":[140],"siRNA,":[141],"induced":[143],"degradation":[145],"ubiquitin-proteasome":[147],"modulation.":[148],"The":[149,199,251],"expression-regulation":[150],"strategy":[151],"offers":[152],"a":[153,196,221,228,339],"broader":[154],"therapeutic":[155],"window":[156],"for":[157],"restoring":[158],"GBM":[159,393],"sensitivity":[160],"TMZ.":[162],"Nevertheless,":[163],"translation":[165],"still":[166],"requires":[167],"further":[168],"optimization":[169],"selectivity,":[172],"effective":[173,258],"brain":[174,193,355],"exposure,":[175],"rational":[176],"combination":[177],"timing,":[178],"robust":[180],"pharmacodynamic":[181],"validation":[182],"establish":[184],"meaningful":[185],"patient":[186],"benefit.":[187],"Glioblastoma":[188],"is":[190,217],"an":[191],"aggressive":[192],"cancer":[194,232,238],"poor":[197],"outlook.":[198],"standard":[200],"treatment":[201,396],"includes":[202],"chemotherapy":[204,364],"(TMZ),":[207],"but":[208,269],"many":[209],"tumors":[210],"become":[211],"resistant":[212],"it.":[214],"largely":[218],"driven":[219],"by":[220,302],"called":[223],"MGMT,":[224],"which":[225],"acts":[226],"like":[227],"\u201crepair":[229],"worker\u201d":[230],"inside":[231],"cells.":[233],"When":[234],"TMZ":[235],"damages":[236],"cell\u2019s":[239],"DNA,":[240],"fixes":[242],"damage":[244],"before":[245],"can":[248,365],"be":[249,366],"killed.":[250],"higher":[252],"levels,":[255],"less":[257],"chemotherapy.":[260],"Researchers":[261],"developed":[263],"drugs":[264,271],"block":[266],"directly,":[268],"these":[270],"remove":[273],"healthy":[276,359,400],"bone":[277,360],"marrow":[278,361],"cells,":[279,337],"causing":[280],"serious":[281],"side":[282],"effects":[283],"limit":[285],"use.":[287],"Therefore,":[288],"scientists":[289],"are":[290],"now":[291],"looking":[292],"ways":[294],"lower":[296],"levels":[298],"more":[299,386],"selectively":[300],"\u2013":[301],"gene,":[306],"disrupting":[307],"signals":[309],"turn":[311],"it":[312],"on,":[313],"breaking":[315],"down":[316],"itself.":[320],"Some":[321],"existing":[322],"drugs,":[323],"anti-seizure":[325],"medications":[326],"antidepressants,":[328],"been":[330],"found":[331],"reduce":[333],"offering":[338],"potential":[340],"shortcut":[341],"new":[343],"treatments.":[344],"Other":[345],"use":[347],"nanoparticles":[348],"deliver":[350],"MGMT-blocking":[351],"specifically":[353],"tumors,":[356],"protect":[358],"so":[362],"stronger":[363],"given.":[367],"latest":[372],"resistance,":[377],"highlighting":[378],"shift":[380],"simply":[382],"blocking":[383],"sophisticated":[387],"methods":[388],"aim":[390],"make":[392],"vulnerable":[394],"again":[397],"while":[398],"sparing":[399],"tissues.":[401]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
