{"id":"https://openalex.org/W7225759543","doi":"https://doi.org/10.1007/s10103-026-05095-w","title":"Colposcopic magnified scanning-assisted CO2 laser treatment (CMSLT) for vaginal high-grade squamous intraepithelial lesion (VaHSIL): A single-center prospective cohort study","display_name":"Colposcopic magnified scanning-assisted CO2 laser treatment (CMSLT) for vaginal high-grade squamous intraepithelial lesion (VaHSIL): A single-center prospective cohort study","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225759543","doi":"https://doi.org/10.1007/s10103-026-05095-w"},"language":"en","primary_location":{"id":"doi:10.1007/s10103-026-05095-w","doi":"https://doi.org/10.1007/s10103-026-05095-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10103-026-05095-w","pdf_url":null,"source":{"id":"https://openalex.org/S124030303","display_name":"Lasers in Medical Science","issn_l":"0268-8921","issn":["0268-8921","1435-604X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s10103-026-05095-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068172355","display_name":"Annalisa Pieralli","orcid":"https://orcid.org/0000-0002-5550-9926","observed_orcids":["https://orcid.org/0000-0002-5550-9926","https://orcid.org/0000-0003-3713-6879"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Pieralli","raw_affiliation_strings":["Azienda Ospedaliero Universitaria Careggi, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliero Universitaria Careggi, Firenze, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099579316","display_name":"Raffaella Venzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaella Venzi","raw_affiliation_strings":["Azienda Ospedaliero Universitaria Careggi, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliero Universitaria Careggi, Firenze, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014096971","display_name":"Claudia Maccarrone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Maccarrone","raw_affiliation_strings":["NOA-Nuovo Ospedale Apuane, Massa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NOA-Nuovo Ospedale Apuane, Massa, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030123832","display_name":"Claudia Giglioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104099","display_name":"Nuovo Ospedale San Giovanni di Dio","ror":"https://ror.org/01c1ce922","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210104099"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Giglioni","raw_affiliation_strings":["Ospedale San Giovanni di Dio Torregalli, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ospedale San Giovanni di Dio Torregalli, Firenze, Italy","institution_ids":["https://openalex.org/I4210104099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112403390","display_name":"Claudia Bianchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Bianchi","raw_affiliation_strings":["Azienda Ospedaliero Universitaria Careggi, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliero Universitaria Careggi, Firenze, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056887484","display_name":"Giulia Fantappi\u00e8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Fantappi\u00e8","raw_affiliation_strings":["Azienda Ospedaliero Universitaria Careggi, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliero Universitaria Careggi, Firenze, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003313091","display_name":"Luca Giannoni","orcid":"https://orcid.org/0000-0001-6846-7414","observed_orcids":["https://orcid.org/0000-0001-6846-7414","https://orcid.org/0000-0002-6514-2232"]},"institutions":[{"id":"https://openalex.org/I4210090274","display_name":"El.En. Group (Italy)","ror":"https://ror.org/00aztzy37","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210090274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Giannoni","raw_affiliation_strings":["El.En. Group, Calenzano, 50041, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6514-2232","affiliations":[{"raw_affiliation_string":"El.En. Group, Calenzano, 50041, Italy","institution_ids":["https://openalex.org/I4210090274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018063262","display_name":"Irene Fusco","orcid":"https://orcid.org/0000-0001-7264-8808","observed_orcids":["https://orcid.org/0000-0001-7264-8808"]},"institutions":[{"id":"https://openalex.org/I4210090274","display_name":"El.En. Group (Italy)","ror":"https://ror.org/00aztzy37","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210090274"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Irene Fusco","raw_affiliation_strings":["El.En. Group, Calenzano, 50041, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"El.En. Group, Calenzano, 50041, Italy","institution_ids":["https://openalex.org/I4210090274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047201285","display_name":"Massimiliano Fambrini","orcid":"https://orcid.org/0000-0003-0461-6390","observed_orcids":["https://orcid.org/0000-0003-0461-6390"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimiliano Fambrini","raw_affiliation_strings":["Azienda Ospedaliero Universitaria Careggi, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliero Universitaria Careggi, Firenze, Italy","institution_ids":["https://openalex.org/I4210115393"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018063262"],"corresponding_institution_ids":["https://openalex.org/I4210090274"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9125999808311462},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6891999840736389},{"id":"https://openalex.org/C2776117191","wikidata":"https://www.wikidata.org/wiki/Q912741","display_name":"Colposcopy","level":4,"score":0.6147000193595886},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5512999892234802},{"id":"https://openalex.org/C2775924586","wikidata":"https://www.wikidata.org/wiki/Q7581955","display_name":"Squamous intraepithelial lesion","level":5,"score":0.49059998989105225},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.48249998688697815},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.45590001344680786},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.4341999888420105},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4120999872684479},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.38519999384880066},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3698999881744385},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3481000065803528},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.3043999969959259},{"id":"https://openalex.org/C3020576462","wikidata":"https://www.wikidata.org/wiki/Q1088163","display_name":"Precancerous lesion","level":3,"score":0.29030001163482666},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.27160000801086426},{"id":"https://openalex.org/C138055712","wikidata":"https://www.wikidata.org/wiki/Q924466","display_name":"Koilocyte","level":5,"score":0.25690001249313354},{"id":"https://openalex.org/C2778842199","wikidata":"https://www.wikidata.org/wiki/Q1563560","display_name":"Electrosurgery","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s10103-026-05095-w","doi":"https://doi.org/10.1007/s10103-026-05095-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10103-026-05095-w","pdf_url":null,"source":{"id":"https://openalex.org/S124030303","display_name":"Lasers in Medical Science","issn_l":"0268-8921","issn":["0268-8921","1435-604X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Medical Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s10103-026-05095-w","doi":"https://doi.org/10.1007/s10103-026-05095-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10103-026-05095-w","pdf_url":null,"source":{"id":"https://openalex.org/S124030303","display_name":"Lasers in Medical Science","issn_l":"0268-8921","issn":["0268-8921","1435-604X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W981105054","https://openalex.org/W2053408740","https://openalex.org/W2067928118","https://openalex.org/W2079048781","https://openalex.org/W2084256942","https://openalex.org/W2395982254","https://openalex.org/W2431494813","https://openalex.org/W2900292982","https://openalex.org/W2999393293","https://openalex.org/W3036341973","https://openalex.org/W3090300247","https://openalex.org/W3175774851","https://openalex.org/W3197750940","https://openalex.org/W4206149336","https://openalex.org/W4214809844","https://openalex.org/W4360612108","https://openalex.org/W4388463450","https://openalex.org/W4391924460","https://openalex.org/W4392111945","https://openalex.org/W4396893144","https://openalex.org/W4401233363","https://openalex.org/W4404921109","https://openalex.org/W4407056871","https://openalex.org/W4410958265"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"To":[1],"evaluate":[2],"the":[3,72,75,108,118,126,184,188,212,270,277],"feasibility":[4],"of":[5,74,219,269,279],"Colposcopic":[6],"Magnified":[7],"Scanning":[8],"Laser":[9],"Treatments":[10],"(CMSLT),":[11],"divided":[12],"into":[13,64],"laser":[14,25,138],"excision":[15],"(CMSLE)":[16],"and":[17,71,81,96,157,262,276,286],"vaporization":[18],"(CMSLV),":[19],"using":[20],"a":[21,27,49,59,137,142,164,192,216,236],"scanner-assisted":[22,145,271],"CO":[23],"2":[24],"as":[26],"singular":[28],"outpatient":[29,134],"therapeutic":[30],"modality":[31],"for":[32,62,174,284],"patients":[33,101,113],"affected":[34],"by":[35],"vaginal":[36,42],"high-grade":[37,43],"squamous":[38,44],"intraepithelial":[39,45],"lesion":[40,46],"(vaHSIL).":[41],"(vaHSIL)":[47],"is":[48],"rare":[50],"condition":[51],"associated":[52,263],"with":[53,102,141,153,163,178,239,264],"persistent":[54],"high-risk":[55],"HPV":[56,154],"infection,":[57],"carrying":[58],"concrete":[60],"potential":[61],"progression":[63,202],"invasive":[65,205],"carcinoma.":[66],"Due":[67],"to":[68,116,168,204,258],"diagnostic":[69],"complexities":[70],"rarity":[73],"disease,":[76],"its":[77],"optimal":[78],"clinical":[79],"management":[80],"treatment":[82],"standardization":[83],"remain":[84],"controversial.":[85],"This":[86],"prospective":[87],"non-randomized":[88],"cohort":[89],"study":[90],"was":[91,161,176,207],"conducted":[92],"between":[93,183],"January":[94],"2022":[95],"June":[97],"2024":[98],"on":[99,107],"63":[100],"histologically":[103],"confirmed":[104],"vaHSIL.":[105],"Based":[106],"2011":[109],"IFCPC":[110],"colposcopic":[111,225],"terminology,":[112],"were":[114],"assigned":[115],"either":[117],"CMSLV":[119],"group":[120,128,190],"(":[121,129],"n":[122,130],"=":[123,131],"22)":[124],"or":[125,243,247],"CMSLE":[127,189,213],"41).":[132],"The":[133,147,170,201,267],"protocol":[135],"utilized":[136],"system":[139],"implemented":[140],"computerized":[143],"surgical":[144],"micromanipulator.":[146],"two-year":[148],"follow-up":[149],"included":[150],"semi-annual":[151],"screenings":[152],"testing,":[155],"cytology,":[156],"colposcopy.":[158],"Follow-up":[159],"adherence":[160],"high,":[162],"dropout":[165],"rate":[166,197,203,218],"limited":[167],"11.3%.":[169],"cumulative":[171],"recurrence":[172],"risk":[173,278],"vaHSIL":[175],"14.5%,":[177],"no":[179,240],"statistically":[180],"significant":[181],"difference":[182],"two":[185],"modalities,":[186],"although":[187],"showed":[191],"higher":[193],"2-year":[194],"disease-free":[195],"survival":[196],"(70%":[198],"vs.":[199],"57%).":[200],"carcinoma":[206],"1.6%":[208,234],"1":[209],"cases":[210],"in":[211,235],"cohort),":[214],"revealing":[215],"2.4%":[217],"occult":[220,281],"cancer":[221],"missed":[222],"at":[223],"initial":[224],"assignment.":[226],"Only":[227],"one":[228],"major":[229],"complication":[230],"occurred":[231],"(vaginal":[232],"perforation,":[233],"post-hysterectomy":[237],"patient),":[238],"minor":[241],"complications":[242],"long-term":[244],"sequelae":[245],"(dyspareunia":[246],"pain)":[248],"reported.":[249],"CMSLT":[250],"may":[251],"represent":[252],"feasible":[253],"approach":[254],"since":[255],"it":[256],"happened":[257],"be":[259],"safe,":[260],"effective":[261],"patient":[265],"compliance.":[266],"precision":[268],"technology":[272],"minimizes":[273],"thermal":[274],"damage":[275],"undertreating":[280],"cancer,":[282],"allowing":[283],"tailored":[285],"efficient":[287],"therapy.":[288]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}