{"id":"https://openalex.org/W7225759528","doi":"https://doi.org/10.3390/ijms272210057","title":"Proteomic Landscapes of Aging and Disease: Multi-Omics Integration, Machine Learning, and Translational Opportunities","display_name":"Proteomic Landscapes of Aging and Disease: Multi-Omics Integration, Machine Learning, and Translational Opportunities","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225759528","doi":"https://doi.org/10.3390/ijms272210057"},"language":"en","primary_location":{"id":"doi:10.3390/ijms272210057","doi":"https://doi.org/10.3390/ijms272210057","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210057","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms272210057","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161410658","display_name":"Xudong Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudong Jin","raw_affiliation_strings":["Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100587943","display_name":"Xu Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Duan","raw_affiliation_strings":["Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129401944","display_name":"Jinghao Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinghao Ma","raw_affiliation_strings":["Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161368439","display_name":"Zhaoze Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoze Wang","raw_affiliation_strings":["Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161363328","display_name":"Weijie Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijie Chen","raw_affiliation_strings":["Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129480672","display_name":"Huan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Xu","raw_affiliation_strings":["Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161398203","display_name":"Fujun Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fujun Yang","raw_affiliation_strings":["Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161379130","display_name":"Jian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Chen","raw_affiliation_strings":["Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 507 Zhengmin Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5161379130","https://openalex.org/A5161398203"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"22","first_page":"10057","last_page":"10057"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.09939999878406525,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6735000014305115},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.617900013923645},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5623000264167786},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.48179998993873596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.476500004529953},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.47209998965263367},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4410000145435333},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.4205000102519989},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4016000032424927},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39989998936653137},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.38600000739097595},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3847000002861023},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.36660000681877136},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35830000042915344},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.29409998655319214},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.2842999994754791},{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2538999915122986},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms272210057","doi":"https://doi.org/10.3390/ijms272210057","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210057","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms272210057","doi":"https://doi.org/10.3390/ijms272210057","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms272210057","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1944789189","https://openalex.org/W1968569587","https://openalex.org/W1982281628","https://openalex.org/W2010084870","https://openalex.org/W2013867688","https://openalex.org/W2036272929","https://openalex.org/W2043978015","https://openalex.org/W2044286001","https://openalex.org/W2048966030","https://openalex.org/W2082425146","https://openalex.org/W2086699218","https://openalex.org/W2112299930","https://openalex.org/W2115852450","https://openalex.org/W2128551987","https://openalex.org/W2128807350","https://openalex.org/W2136597136","https://openalex.org/W2152386173","https://openalex.org/W2161485411","https://openalex.org/W2163236262","https://openalex.org/W2166415858","https://openalex.org/W2168953601","https://openalex.org/W2592588133","https://openalex.org/W2611138580","https://openalex.org/W2625907748","https://openalex.org/W2739317540","https://openalex.org/W2739492614","https://openalex.org/W2754229266","https://openalex.org/W2773867130","https://openalex.org/W2795906582","https://openalex.org/W2796559433","https://openalex.org/W2801170851","https://openalex.org/W2805712258","https://openalex.org/W2808845633","https://openalex.org/W2815133411","https://openalex.org/W2884910505","https://openalex.org/W2906721882","https://openalex.org/W2911642321","https://openalex.org/W2913940235","https://openalex.org/W2953064750","https://openalex.org/W2955177623","https://openalex.org/W2959728234","https://openalex.org/W2974643180","https://openalex.org/W2981995922","https://openalex.org/W2991106430","https://openalex.org/W2994160326","https://openalex.org/W3000364256","https://openalex.org/W3008786370","https://openalex.org/W3015916968","https://openalex.org/W3023701177","https://openalex.org/W3087329093","https://openalex.org/W3109793670","https://openalex.org/W3119309452","https://openalex.org/W3155873411","https://openalex.org/W3161350353","https://openalex.org/W3212074568","https://openalex.org/W4210803359","https://openalex.org/W4280598306","https://openalex.org/W4289884271","https://openalex.org/W4291149804","https://openalex.org/W4292370349","https://openalex.org/W4313531093","https://openalex.org/W4324149058","https://openalex.org/W4387344289","https://openalex.org/W4388488098","https://openalex.org/W4396508150","https://openalex.org/W4401427258","https://openalex.org/W4401585036","https://openalex.org/W4403375090","https://openalex.org/W4404595397","https://openalex.org/W4405661535","https://openalex.org/W4406537335","https://openalex.org/W4409661761","https://openalex.org/W4409974660","https://openalex.org/W4409984842","https://openalex.org/W4412150939","https://openalex.org/W4412707869","https://openalex.org/W4414594146","https://openalex.org/W4414962071","https://openalex.org/W4416688116","https://openalex.org/W4417457874","https://openalex.org/W7140094449","https://openalex.org/W7161796026","https://openalex.org/W7161846230","https://openalex.org/W7166520422","https://openalex.org/W7168144478","https://openalex.org/W7171985819","https://openalex.org/W7203896217"],"related_works":[],"abstract_inverted_index":{"Aging":[0],"is":[1],"accompanied":[2],"by":[3,34,79,91],"progressive":[4],"changes":[5,17],"in":[6],"molecular,":[7],"cellular,":[8],"and":[9,23,30,37,46,59,68,102,116,128,135,143,146,155,169,175],"systemic":[10],"homeostasis.":[11],"At":[12],"the":[13],"protein":[14,24,106,123],"level,":[15],"these":[16],"involve":[18],"altered":[19],"proteostasis,":[20],"post-translational":[21],"regulation,":[22],"interaction":[25],"networks,":[26],"but":[27,88],"their":[28,109],"direction":[29],"functional":[31],"significance":[32],"vary":[33],"tissue,":[35],"age,":[36],"disease":[38],"context.":[39],"Mass":[40],"spectrometry,":[41],"affinity-based":[42],"assays,":[43],"spatial":[44],"proteomics,":[45],"emerging":[47,140],"single-cell":[48],"methods":[49,96,137],"now":[50],"support":[51,97],"complementary":[52],"views":[53],"of":[54,152,157],"proteins":[55],"across":[56],"tissues,":[57],"biofluids,":[58],"cell":[60],"populations.":[61],"Integrating":[62],"proteomics":[63],"with":[64,126],"genomic,":[65],"transcriptomic,":[66],"epigenomic,":[67],"metabolomic":[69],"data":[70],"can":[71],"identify":[72],"regulatory":[73],"relationships":[74],"that":[75],"are":[76,160],"not":[77,90],"resolved":[78],"a":[80],"single":[81],"molecular":[82],"layer;":[83],"such":[84],"integration":[85],"prioritizes":[86],"mechanisms":[87],"does":[89],"itself":[92],"establish":[93],"causality.":[94],"Machine-learning":[95],"spectral":[98],"prediction,":[99,150],"multi-omics":[100,134],"integration,":[101],"prediction":[103,156],"from":[104],"high-dimensional":[105],"profiles,":[107],"although":[108],"performance":[110],"depends":[111],"on":[112],"study":[113],"design,":[114],"calibration,":[115],"independent":[117],"validation.":[118],"This":[119],"narrative":[120],"review":[121],"synthesizes":[122],"alterations":[124],"associated":[125],"aging":[127],"major":[129],"age-related":[130],"diseases,":[131],"describes":[132],"what":[133],"computational":[136],"add,":[138],"compares":[139],"measurement":[141],"technologies,":[142],"evaluates":[144],"biomarker":[145],"therapeutic":[147,177],"opportunities.":[148],"Chronological-age":[149],"estimation":[151],"biological":[153],"aging,":[154],"clinical":[158,173],"outcomes":[159],"treated":[161],"as":[162],"distinct":[163],"objectives.":[164],"Current":[165],"evidence":[166],"supports":[167],"discovery":[168],"candidate":[170],"prioritization;":[171],"prospective":[172],"utility":[174],"causal":[176],"benefit":[178],"remain":[179],"to":[180],"be":[181],"established.":[182]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}