{"id":"https://openalex.org/W7225759001","doi":"https://doi.org/10.54254/2753-8818/2026.hz38824","title":"Surgical Resection and Remodeling of the Tumor Microenvironment in Colorectal Cancer","display_name":"Surgical Resection and Remodeling of the Tumor Microenvironment in Colorectal Cancer","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225759001","doi":"https://doi.org/10.54254/2753-8818/2026.hz38824"},"language":"en","primary_location":{"id":"doi:10.54254/2753-8818/2026.hz38824","doi":"https://doi.org/10.54254/2753-8818/2026.hz38824","is_oa":true,"landing_page_url":"https://doi.org/10.54254/2753-8818/2026.hz38824","pdf_url":null,"source":{"id":"https://openalex.org/S4387283303","display_name":"Theoretical and Natural Science","issn_l":"2753-8818","issn":["2753-8818","2753-8826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theoretical and Natural Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.54254/2753-8818/2026.hz38824","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161394531","display_name":"Minke Xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Minke Xin","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161394531"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"191","issue":"1","first_page":"None","last_page":"None"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7433000206947327},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7360000014305115},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.713100016117096},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6880999803543091},{"id":"https://openalex.org/C2776098842","wikidata":"https://www.wikidata.org/wiki/Q17152720","display_name":"Surgical stress","level":2,"score":0.621399998664856},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6108999848365784},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.59170001745224},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5228999853134155},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4309000074863434},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.4108999967575073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3547999858856201},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.33889999985694885},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33079999685287476},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3301999866962433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.328000009059906},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C523026621","wikidata":"https://www.wikidata.org/wiki/Q1413084","display_name":"Colorectal surgery","level":3,"score":0.30399999022483826},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2964000105857849},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.27469998598098755},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C3020304732","wikidata":"https://www.wikidata.org/wiki/Q1671866","display_name":"Surgical wound","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.54254/2753-8818/2026.hz38824","doi":"https://doi.org/10.54254/2753-8818/2026.hz38824","is_oa":true,"landing_page_url":"https://doi.org/10.54254/2753-8818/2026.hz38824","pdf_url":null,"source":{"id":"https://openalex.org/S4387283303","display_name":"Theoretical and Natural Science","issn_l":"2753-8818","issn":["2753-8818","2753-8826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theoretical and Natural Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.54254/2753-8818/2026.hz38824","doi":"https://doi.org/10.54254/2753-8818/2026.hz38824","is_oa":true,"landing_page_url":"https://doi.org/10.54254/2753-8818/2026.hz38824","pdf_url":null,"source":{"id":"https://openalex.org/S4387283303","display_name":"Theoretical and Natural Science","issn_l":"2753-8818","issn":["2753-8818","2753-8826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theoretical and Natural Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Surgery":[0],"is":[1],"an":[2],"important":[3],"treatment":[4],"for":[5,133,221],"solid":[6],"tumors":[7,14],"at":[8],"present,":[9],"but":[10,168],"surgical":[11,196],"removal":[12],"of":[13,19,49,85,92,104,119,130,181,192],"also":[15],"causes":[16],"a":[17,27,164,170,218],"series":[18],"complex":[20,171],"biological":[21,172],"changes.":[22],"Surgical":[23],"trauma":[24],"can":[25,99,175],"trigger":[26],"systemic":[28],"inflammatory":[29,66],"response,":[30],"accompanied":[31],"by":[32],"functional":[33],"alterations":[34],"in":[35,204],"natural":[36],"killer":[37],"cells,":[38,43],"monocytes":[39],"and":[40,68,89,116,138,146,149,155,184,202,216],"other":[41],"immune":[42,179,198],"as":[44,46,163,169],"well":[45],"the":[47,56,65,69,73,80,83,90,102,111,117,125,128,143,178,182,185,193,212],"release":[48],"damage-associated":[50],"molecular":[51],"patterns":[52],"(DAMPs).":[53],"For":[54],"example,":[55],"high":[57],"mobility":[58],"group":[59],"box-1":[60],"protein":[61],"(HMGB1)":[62],"could":[63],"affect":[64,110,142],"response":[67,137],"tumor":[70,105,113,144,166,187,214],"microenvironment":[71,145],"through":[72],"Toll-like":[74],"receptor":[75],"(TLR)-related":[76],"signaling":[77],"pathway.":[78],"At":[79],"same":[81],"time,":[82],"activation":[84],"cancer-associated":[86],"fibroblasts":[87],"(CAFs)":[88],"remodeling":[91],"extracellular":[93],"matrix":[94],"(ECM)":[95],"during":[96],"wound":[97],"healing":[98],"further":[100,109,210],"change":[101],"structure":[103],"tissue,":[106],"which":[107],"may":[108,141,150],"subsequent":[112],"cells'":[114],"survival":[115],"development":[118],"peri-metastatic":[120],"lesions.":[121],"In":[122],"addition":[123],"to":[124,209],"resection":[126],"itself,":[127],"choice":[129],"anesthetic":[131],"agent":[132],"surgery,":[134],"perioperative":[135,213,223],"stress":[136],"continued":[139],"changes":[140],"human":[147],"immunity":[148],"interact":[151],"with":[152],"surgery-induced":[153],"inflammation":[154],"immunosuppression.":[156],"Therefore,":[157],"surgery":[158],"should":[159],"not":[160],"be":[161],"regarded":[162],"simple":[165],"resection,":[167],"event":[173],"that":[174],"simultaneously":[176],"reshape":[177],"status":[180],"body":[183],"local":[186],"microenvironment.":[188],"An":[189],"in-depth":[190],"understanding":[191],"interplay":[194],"between":[195],"trauma,":[197],"regulation,":[199],"tissue":[200],"remodeling,":[201],"anesthesia":[203],"colorectal":[205],"cancer":[206],"will":[207],"help":[208],"understand":[211],"biology":[215],"provide":[217],"theoretical":[219],"basis":[220],"potential":[222],"intervention":[224],"strategies.":[225]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
