{"id":"https://openalex.org/W7225758918","doi":"https://doi.org/10.3389/fcimb.2026.1968174","title":"Independent predictors of time from symptom onset to discharge among patients with severe fever with thrombocytopenia syndrome: a retrospective cohort study","display_name":"Independent predictors of time from symptom onset to discharge among patients with severe fever with thrombocytopenia syndrome: a retrospective cohort study","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225758918","doi":"https://doi.org/10.3389/fcimb.2026.1968174"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.1968174","doi":"https://doi.org/10.3389/fcimb.2026.1968174","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1968174","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1968174/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1968174/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136352061","display_name":"Lingfang Zhou","orcid":"https://orcid.org/0009-0000-4924-9577","observed_orcids":["https://orcid.org/0009-0000-4924-9577"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210158774","display_name":"Zhejiang Taizhou Hospital","ror":"https://ror.org/05m0wv206","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158774","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingfang Zhou","raw_affiliation_strings":["Department of Geriatric Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210158774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161397871","display_name":"Cunguo Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210158774","display_name":"Zhejiang Taizhou Hospital","ror":"https://ror.org/05m0wv206","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158774","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cunguo Chen","raw_affiliation_strings":["Department of Geriatric Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210158774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053957083","display_name":"Danping Cui","orcid":"https://orcid.org/0000-0002-2093-0200","observed_orcids":["https://orcid.org/0000-0002-2093-0200"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210158774","display_name":"Zhejiang Taizhou Hospital","ror":"https://ror.org/05m0wv206","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158774","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danping Cui","raw_affiliation_strings":["Department of Geriatric Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210158774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5136352061"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210158774"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8263000249862671},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7419000267982483},{"id":"https://openalex.org/C170964787","wikidata":"https://www.wikidata.org/wiki/Q7611170","display_name":"Stepwise regression","level":2,"score":0.5309000015258789},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.512499988079071},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4932999908924103},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4846000075340271},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4805999994277954},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.4758000075817108},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.43790000677108765},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.39649999141693115},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.3776000142097473},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3644999861717224},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.35850000381469727},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.35749998688697815},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.3343999981880188},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.31349998712539673},{"id":"https://openalex.org/C138528620","wikidata":"https://www.wikidata.org/wiki/Q2510752","display_name":"Explained variation","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C152732102","wikidata":"https://www.wikidata.org/wiki/Q13434396","display_name":"Variance inflation factor","level":4,"score":0.2685999870300293},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C189285262","wikidata":"https://www.wikidata.org/wiki/Q1332350","display_name":"Multicollinearity","level":3,"score":0.26330000162124634}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcimb.2026.1968174","doi":"https://doi.org/10.3389/fcimb.2026.1968174","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1968174","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1968174/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.1968174","doi":"https://doi.org/10.3389/fcimb.2026.1968174","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1968174","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1968174/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225758918.pdf","grobid_xml":"https://content.openalex.org/works/W7225758918.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2033470575","https://openalex.org/W3001564493","https://openalex.org/W4206140425","https://openalex.org/W4210854228","https://openalex.org/W4327560460","https://openalex.org/W4380373492","https://openalex.org/W4388515769","https://openalex.org/W4390263301","https://openalex.org/W4394955269","https://openalex.org/W4405466396","https://openalex.org/W4414482311","https://openalex.org/W4415039935","https://openalex.org/W4415222843","https://openalex.org/W7125826746"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Severe":[1],"fever":[2],"with":[3,12,51],"thrombocytopenia":[4],"syndrome":[5],"(SFTS)":[6],"is":[7],"a":[8,70],"tick-borne":[9],"bunyaviral":[10],"infection":[11],"heterogeneous":[13],"recovery":[14,35,168,251],"trajectories":[15],"and":[16,46,64,93,120,184,201,228,269,289,301,308],"high":[17],"case":[18],"fatality.":[19],"Most":[20],"prior":[21],"studies":[22],"use":[23],"in-hospital":[24],"mortality":[25],"as":[26],"the":[27],"primary":[28,104],"endpoint;":[29],"few":[30],"quantify":[31],"independent":[32,135,213],"predictors":[33,136],"of":[34,74,84,152,203,244,248,286],"duration":[36,169,190,217,279],"among":[37,280],"surviving":[38],"patients.":[39,315],"This":[40],"study":[41],"aimed":[42],"to":[43,57,60,113,133,232],"identify":[44,134],"clinical":[45],"laboratory":[47,91],"factors":[48],"independently":[49,276],"associated":[50],"total":[52,107,167],"time":[53,183],"from":[54,81,99,109,230],"symptom":[55,111,197,274],"onset":[56,112,198,231,275],"hospital":[58,194,271,296],"discharge":[59,116,182],"guide":[61],"risk":[62,293],"stratification":[63],"targeted":[65,298],"intervention.":[66],"Methods":[67],"We":[68],"performed":[69],"retrospective":[71],"cohort":[72],"analysis":[73,176],"43":[75],"consecutive":[76],"laboratory-confirmed":[77],"SFTS":[78,282,314],"survivors":[79],"discharged":[80,281],"Taizhou":[82],"Hospital":[83],"Zhejiang":[85],"Province":[86],"(July":[87],"2019\u2013April":[88],"2025).":[89],"Demographics,":[90],"values,":[92],"organ":[94,267],"involvement":[95,205,223],"data":[96],"were":[97,161],"extracted":[98],"electronic":[100],"medical":[101,310],"records.":[102],"The":[103,165,236],"outcome":[105],"was":[106,131,147,170],"days":[108,229],"initial":[110],"meeting":[114],"standardized":[115],"criteria.":[117],"Univariate":[118,175],"correlation":[119],"group":[121],"comparisons":[122],"screened":[123],"candidate":[124],"variables;":[125],"backward":[126],"stepwise":[127],"multiple":[128],"linear":[129],"regression":[130,210],"applied":[132],"after":[137,196,273],"multicollinearity":[138],"diagnosis":[139],"via":[140],"variance":[141,249],"inflation":[142],"factor":[143],"(VIF).":[144],"Model":[145],"performance":[146],"assessed":[148],"using":[149],"adjusted":[150,241],"coefficient":[151],"determination":[153],"(adjusted":[154],"R":[155,242],"2":[156,243],").":[157],"All":[158],"statistical":[159],"tests":[160],"two-sided":[162],"(\u03b1=0.05).":[163],"Results":[164],"mean":[166],"16.58":[171],"\u00b1":[172],"7.86":[173],"days.":[174],"demonstrated":[177],"significant":[178],"correlations":[179],"between":[180],"longer":[181],"three":[185,212],"variables:":[186],"prolonged":[187],"platelet":[188,215,263,287,299],"decline":[189,216,264],"(r=0.6577,":[191],"P<0.0001),":[192,200],"delayed":[193,270],"admission":[195,272],"(r=0.7441,":[199],"presence":[202],"cardiac/circulatory":[204,222],"(P":[206],"=":[207,220,226],"0.0002).":[208],"Multivariate":[209],"confirmed":[211],"predictors:":[214],"(\u03b2=0.63,":[218],"P":[219,225],"0.0001),":[221],"(\u03b2=5.33,":[224],"0.0003),":[227],"hospitalization":[233,278],"(\u03b2=1.41,":[234],"P<0.001).":[235],"final":[237],"model":[238],"had":[239,256],"an":[240],"0.7762,":[245],"explaining":[246],"77.62%":[247],"in":[250],"time;":[252],"all":[253],"included":[254],"variables":[255],"VIF<2.5":[257],"without":[258],"severe":[259],"multicollinearity.":[260],"Conclusions":[261],"Prolonged":[262],"duration,":[265],"cardiovascular":[266,290],"injury,":[268],"prolong":[277],"survivors.":[283],"Dynamic":[284],"monitoring":[285],"counts":[288],"biomarkers":[291],"enables":[292],"stratification.":[294],"Early":[295],"presentation,":[297],"support,":[300],"cardioprotective":[302],"management":[303],"may":[304],"shorten":[305],"disease":[306],"courses":[307],"optimize":[309],"resource":[311],"utilization":[312],"for":[313]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}