{"id":"https://openalex.org/W7225758862","doi":"https://doi.org/10.3390/livers6060117","title":"Changes in von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Acute Decompensation and Subsequent Stabilization","display_name":"Changes in von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Acute Decompensation and Subsequent Stabilization","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225758862","doi":"https://doi.org/10.3390/livers6060117"},"language":"en","primary_location":{"id":"doi:10.3390/livers6060117","doi":"https://doi.org/10.3390/livers6060117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/livers6060117","pdf_url":null,"source":{"id":"https://openalex.org/S4210233479","display_name":"Livers","issn_l":"2673-4389","issn":["2673-4389"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Livers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/livers6060117","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052704930","display_name":"Zsuzsa Bianka \u00c9lthes","orcid":"https://orcid.org/0009-0004-9664-7673","observed_orcids":["https://orcid.org/0009-0004-9664-7673"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Zsuzsa Bianka Elthes","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","Doctoral School of Dental Sciences, University of Debrecen, 4032 Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]},{"raw_affiliation_string":"Doctoral School of Dental Sciences, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084103594","display_name":"Zsuzsanna Vit\u00e1lis","orcid":"https://orcid.org/0000-0001-8198-5312","observed_orcids":["https://orcid.org/0000-0001-8198-5312"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsanna Vitalis","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003196609","display_name":"Tam\u00e1s Tornai","orcid":"https://orcid.org/0000-0003-4793-9974","observed_orcids":["https://orcid.org/0000-0003-4793-9974"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tamas Tornai","raw_affiliation_strings":["Institute for Pancreatic Disorders, Semmelweis University, 1083 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0003-4793-9974","affiliations":[{"raw_affiliation_string":"Institute for Pancreatic Disorders, Semmelweis University, 1083 Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030524789","display_name":"D\u00e1vid Tornai","orcid":"https://orcid.org/0000-0002-1335-5498","observed_orcids":["https://orcid.org/0000-0002-1335-5498"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"David Tornai","raw_affiliation_strings":["Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-1335-5498","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061533135","display_name":"Jol\u00e1n H\u00e1rsfalvi","orcid":"https://orcid.org/0000-0001-9940-4846","observed_orcids":["https://orcid.org/0000-0001-9940-4846"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Jolan Harsfalvi","raw_affiliation_strings":["Department of Biophysics and Radiation Biology, Semmelweis University, 1428 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics and Radiation Biology, Semmelweis University, 1428 Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083822804","display_name":"M\u00e1ria Papp","orcid":"https://orcid.org/0000-0003-3662-4010","observed_orcids":["https://orcid.org/0000-0003-3662-4010"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"M\u00e1ria Papp","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"],"raw_orcid":"https://orcid.org/0000-0003-3662-4010","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084179438","display_name":"Istv\u00e1n Tornai","orcid":"https://orcid.org/0000-0002-8163-101X","observed_orcids":["https://orcid.org/0000-0002-8163-101X"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Istvan Tornai","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","Doctoral School of Dental Sciences, University of Debrecen, 4032 Debrecen, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-8163-101X","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]},{"raw_affiliation_string":"Doctoral School of Dental Sciences, University of Debrecen, 4032 Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052704930","https://openalex.org/A5084179438"],"corresponding_institution_ids":["https://openalex.org/I132735039"],"apc_list":{"value":1000,"currency":"CHF","value_usd":1207},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1207},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"6","first_page":"117","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8529999852180481},{"id":"https://openalex.org/C2778721985","wikidata":"https://www.wikidata.org/wiki/Q1183680","display_name":"Decompensation","level":2,"score":0.7883999943733215},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6722999811172485},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6431000232696533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6380000114440918},{"id":"https://openalex.org/C2780921031","wikidata":"https://www.wikidata.org/wiki/Q14873945","display_name":"ADAMTS13","level":4,"score":0.6107000112533569},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5776000022888184},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.5249000191688538},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4307999908924103},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.4180000126361847},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.37700000405311584},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C2994427840","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Liver failure","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2563000023365021}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/livers6060117","doi":"https://doi.org/10.3390/livers6060117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/livers6060117","pdf_url":null,"source":{"id":"https://openalex.org/S4210233479","display_name":"Livers","issn_l":"2673-4389","issn":["2673-4389"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Livers","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/livers6060117","doi":"https://doi.org/10.3390/livers6060117","is_oa":true,"landing_page_url":"https://doi.org/10.3390/livers6060117","pdf_url":null,"source":{"id":"https://openalex.org/S4210233479","display_name":"Livers","issn_l":"2673-4389","issn":["2673-4389"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Livers","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1489226586","https://openalex.org/W1978346666","https://openalex.org/W1984935226","https://openalex.org/W1993340951","https://openalex.org/W2007670274","https://openalex.org/W2042800921","https://openalex.org/W2090387429","https://openalex.org/W2097279639","https://openalex.org/W2154205460","https://openalex.org/W2156786460","https://openalex.org/W2330386487","https://openalex.org/W2791921015","https://openalex.org/W2792370912","https://openalex.org/W2811480666","https://openalex.org/W2885835966","https://openalex.org/W2911180111","https://openalex.org/W2959081801","https://openalex.org/W2973122913","https://openalex.org/W2990140100","https://openalex.org/W3043538464","https://openalex.org/W3146809376","https://openalex.org/W3148443221","https://openalex.org/W3149553378","https://openalex.org/W3160282231","https://openalex.org/W3216623253","https://openalex.org/W4200093827","https://openalex.org/W4200449992","https://openalex.org/W4220680851","https://openalex.org/W4224295504","https://openalex.org/W4280645451","https://openalex.org/W4283711619","https://openalex.org/W4294991796","https://openalex.org/W4360804301","https://openalex.org/W4379162629","https://openalex.org/W4382931764","https://openalex.org/W4386022201","https://openalex.org/W4386795974","https://openalex.org/W4386855705","https://openalex.org/W4392287353","https://openalex.org/W4392355144","https://openalex.org/W4400879537","https://openalex.org/W4401031140","https://openalex.org/W4402050286","https://openalex.org/W4404861693","https://openalex.org/W4410484241","https://openalex.org/W4412595217","https://openalex.org/W4413883737","https://openalex.org/W4414161688","https://openalex.org/W4415489595","https://openalex.org/W4416187870"],"related_works":[],"abstract_inverted_index":{"Background":[0],"and":[1,31,56,79,90,105,119,125,244],"aims:":[2],"Acute":[3],"decompensation":[4],"(AD)":[5],"of":[6,40,248],"cirrhosis":[7,21,238],"is":[8,239],"a":[9,240],"critical":[10],"clinical":[11],"event":[12],"with":[13,72,139],"heterogeneous":[14],"outcomes,":[15],"ranging":[16],"from":[17,200],"stable":[18],"decompensated":[19],"(SD)":[20,160],"to":[22,45,202],"acute-on-chronic":[23],"liver":[24],"failure":[25,134],"(ACLF).":[26],"Disturbances":[27],"in":[28,37,48,59,136,213,221,237,255],"the":[29,38,94,234,245],"primary":[30,49],"secondary":[32],"hemostasis":[33],"have":[34],"been":[35],"implicated":[36],"progression":[39],"cirrhosis.":[41,256],"This":[42],"study":[43],"aimed":[44],"evaluate":[46],"changes":[47],"hemostasis,":[50],"i.e.,":[51],"VWF":[52,103,120,168,180,188,208],"parameters,":[53],"multimer":[54,121],"distribution":[55,122],"ADAMTS13":[57,114,197,226],"activity":[58,115,181,198,227],"patients":[60,70,141,215],"who":[61],"could":[62],"clinically":[63],"improve":[64],"after":[65],"AD.":[66],"Methods:":[67],"Thirty-five":[68],"cirrhotic":[69],"hospitalized":[71],"AD":[73,217,251],"were":[74,97,109,211,219],"prospectively":[75],"assessed":[76],"at":[77,80,99,130,154,157],"baseline":[78],"3-month":[81],"follow-up":[82],"when":[83],"they":[84],"reached":[85],"an":[86],"SD":[87,223],"state.":[88],"Clinical":[89],"laboratory":[91],"characteristics,":[92],"including":[93],"MELD":[95,148],"score,":[96],"evaluated":[98],"both":[100],"time":[101],"points.":[102],"level":[104],"its":[106],"different":[107],"activities":[108],"measured":[110],"using":[111,123],"automated":[112],"immunoassays,":[113],"by":[116],"chemiluminescent":[117],"assay,":[118],"electrophoresis":[124],"densitometry.":[126],"Results:":[127],"At":[128],"AD,":[129,155],"least":[131],"one":[132],"organ":[133],"occurred":[135],"13":[137],"patients,":[138],"4":[140],"identified":[142],"as":[143],"ACLF":[144],"grade":[145],"1.":[146],"The":[147],"score":[149],"was":[150,162],"22":[151],"(IQR":[152],"18\u201325)":[153],"while":[156,196,225],"3":[158],"months":[159],"it":[161],"17":[163],"(12\u201320)":[164],"(p":[165,177,185,193,204],"<":[166,205],"0.001).":[167,206],"parameters":[169],"similarly":[170],"decreased":[171],"[VWF":[172],"antigen":[173],"530%":[174],"vs.":[175,183,191],"409%":[176],"=":[178,186,194],"0.009),":[179],"332%":[182],"301%":[184],"0.038),":[187],"collagen-binding":[189],"399%":[190],"308%":[192],"0.017)],":[195],"increased":[199],"55%":[201],"84%":[203],"Ultra-large":[207],"multimers":[209],"(ULMWM)":[210],"detected":[212],"six":[214],"during":[216,250],"but":[218],"absent":[220],"all":[222],"samples,":[224],"normalized.":[228],"Conclusions:":[229],"Our":[230],"findings":[231],"demonstrate":[232],"that":[233],"VWF\u2013ADAMTS13":[235],"axis":[236],"dynamically":[241],"changing":[242],"marker,":[243],"temporary":[246],"appearance":[247],"ULMWM":[249],"exposes":[252],"thrombogenic":[253],"potential":[254]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
