{"id":"https://openalex.org/W7225757887","doi":"https://doi.org/10.21203/rs.3.rs-11437313/v1","title":"Early Outcomes of Spongiosum-guided Topographic Anatomical Reassembly Compared with Tubularized Incised Plate Repair for Distal Hypospadias: A Single-Center Pilot Randomized Trial","display_name":"Early Outcomes of Spongiosum-guided Topographic Anatomical Reassembly Compared with Tubularized Incised Plate Repair for Distal Hypospadias: A Single-Center Pilot Randomized Trial","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225757887","doi":"https://doi.org/10.21203/rs.3.rs-11437313/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11437313/v1","doi":"https://doi.org/10.21203/rs.3.rs-11437313/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11437313/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-11437313/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050264439","display_name":"Amr K. Salama","orcid":"https://orcid.org/0000-0003-4107-2919","observed_orcids":["https://orcid.org/0000-0003-4107-2919"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amr K. Salama","raw_affiliation_strings":["Alexandria University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexandria University","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161404195","display_name":"Aly El Tabib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aly El Tabib","raw_affiliation_strings":["Alexandria University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexandria University","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022077281","display_name":"Waleed A. Dawood","orcid":"https://orcid.org/0000-0003-0001-3349","observed_orcids":["https://orcid.org/0000-0003-0001-3349"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Waleed Dawood","raw_affiliation_strings":["Alexandria University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexandria University","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040774881","display_name":"Mohamed Elsaid Youssif","orcid":"https://orcid.org/0000-0002-3231-6777","observed_orcids":["https://orcid.org/0000-0002-3231-6777"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Youssif","raw_affiliation_strings":["Alexandria University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexandria University","institution_ids":["https://openalex.org/I84524832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84524832"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11174","display_name":"Pediatric Urology and Nephrology Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12716","display_name":"Congenital Anomalies and Fetal Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8944000005722046},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6960999965667725},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6780999898910522},{"id":"https://openalex.org/C2777990738","wikidata":"https://www.wikidata.org/wiki/Q1132108","display_name":"Hypospadias","level":2,"score":0.6172000169754028},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.4544999897480011},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.38769999146461487},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.34040001034736633},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C2777085111","wikidata":"https://www.wikidata.org/wiki/Q9386","display_name":"Urethra","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11437313/v1","doi":"https://doi.org/10.21203/rs.3.rs-11437313/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11437313/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11437313/v1","doi":"https://doi.org/10.21203/rs.3.rs-11437313/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11437313/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Spongiosum-tissue-guided":[2],"anatomical":[3],"reassembly":[4],"(STAR)":[5],"is":[6,188],"a":[7,31,47],"newerapproach":[8],"to":[9,61,68,140,150],"distal":[10,43],"hypospadias":[11,44],"repair":[12,29],"that":[13,185],"emphasizes":[14],"spongioplasty":[15],"and":[16,25,53,75,117],"limitsglanular":[17],"dissection.":[18],"We":[19],"compared":[20],"early":[21],"outcomes":[22,195],"after":[23,92,170],"STAR":[24,73,115,168],"tubularized":[26],"incisedplate":[27],"(TIP)":[28],"in":[30,71,77,113,121,129,206],"pilot":[32,159],"randomized":[33],"trial.":[34],"Methods:":[35],"Boys":[36],"younger":[37],"than":[38,169],"16":[39],"years":[40],"with":[41],"primary":[42,83],"wererandomized":[45],"at":[46,98],"single":[48],"center":[49],"between":[50],"January":[51,207],"2024":[52,208],"August":[54],"2025.":[55],"Of":[56],"104participants,":[57],"52":[58],"were":[59,66,101,125],"allocated":[60],"each":[62],"group.":[63],"Three":[64],"participants":[65,111],"lost":[67],"follow-up,leaving":[69],"51":[70,110],"the":[72,78,82,114,122,161,173],"group":[74,80,116,124],"50":[76],"TIP":[79,123],"for":[81],"analysis.":[84],"Theprimary":[85],"outcome":[86],"was":[87,133,147,165,175],"complication-free":[88,163],"status":[89,97],"3":[90,106],"months":[91,100],"surgery.":[93],"HOSE":[94],"scoresand":[95],"complication":[96],"12":[99],"secondary":[102],"outcomes.":[103],"Results:":[104],"At":[105],"months,":[107],"42":[108],"of":[109,119],"(82.4%)":[112],"45":[118],"50(90.0%)":[120],"complication-free.":[126],"The":[127,145,177],"difference":[128,182],"rates":[130],"(STAR":[131],"minusTIP)":[132],"\u22127.6":[134],"percentage":[135],"points":[136],"(95%":[137],"CI,":[138],"\u221221.5":[139],"6.3;":[141],"p":[142],"=":[143],"0.266).":[144],"trial":[146],"notlarge":[148],"enough":[149],"establish":[151,184],"superiority,":[152],"non-inferiority,":[153],"or":[154,183],"equivalence.":[155],"Conclusion:":[156],"In":[157],"this":[158],"trial,":[160],"3-month":[162],"rate":[164],"numerically":[166],"lowerafter":[167],"TIP,":[171],"but":[172],"estimate":[174],"imprecise.":[176],"findings":[178],"do":[179],"not":[180],"explainthe":[181],"either":[186],"procedure":[187],"superior.":[189],"Larger":[190],"trials":[191],"are":[192],"needed":[193],"tocompare":[194],"reliably.":[196],"Trial":[197],"registration:":[198],"ClinicalTrials.gov,":[199],"NCT07832760;":[200],"registered":[201],"September":[202],"2026,":[203],"afterenrollment":[204],"began":[205],"following":[209],"IRB":[210],"approval.":[211]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}