{"id":"https://openalex.org/W7225757569","doi":"https://doi.org/10.1161/hypertensionaha.126.27843","title":"Piezo1 Responsiveness in Muscle Afferents and Mechanoreflex in Diabetic Rats","display_name":"Piezo1 Responsiveness in Muscle Afferents and Mechanoreflex in Diabetic Rats","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225757569","doi":"https://doi.org/10.1161/hypertensionaha.126.27843","pmid":"https://pubmed.ncbi.nlm.nih.gov/43007059"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.126.27843","doi":"https://doi.org/10.1161/hypertensionaha.126.27843","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.126.27843","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061460941","display_name":"Rie Ishizawa","orcid":"https://orcid.org/0000-0002-2746-7132","observed_orcids":["https://orcid.org/0000-0002-2746-7132"]},"institutions":[{"id":"https://openalex.org/I30290273","display_name":"National Institute of Fitness and Sports in Kanoya","ror":"https://ror.org/04n6qtb21","country_code":"JP","type":"education","lineage":["https://openalex.org/I30290273"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Rie Ishizawa","raw_affiliation_strings":["Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","Faculty of Sports and Life Science, National Institute of Fitness and Sports in Kanoya, Japan (R.I.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Faculty of Sports and Life Science, National Institute of Fitness and Sports in Kanoya, Japan (R.I.)","institution_ids":["https://openalex.org/I30290273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038217155","display_name":"Han\u2010Kyul Kim","orcid":"https://orcid.org/0000-0003-1048-9543","observed_orcids":["https://orcid.org/0000-0003-1048-9543"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han-Kyul Kim","raw_affiliation_strings":["Departments of Internal Medicine (H.-K.K., W.V.), University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":"https://orcid.org/0000-0003-1048-9543","affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine (H.-K.K., W.V.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053441893","display_name":"Amane Hori","orcid":"https://orcid.org/0000-0001-9450-9171","observed_orcids":["https://orcid.org/0000-0001-9450-9171"]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Amane Hori","raw_affiliation_strings":["Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","Integrated Research Center for Self-Care Technology, National Institute of Advanced Industrial Science and Technology, Takamatsu, Japan (A.H.)"],"raw_orcid":"https://orcid.org/0000-0001-9450-9171","affiliations":[{"raw_affiliation_string":"Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Integrated Research Center for Self-Care Technology, National Institute of Advanced Industrial Science and Technology, Takamatsu, Japan (A.H.)","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063678885","display_name":"Norio Hotta","orcid":"https://orcid.org/0000-0002-3039-5934","observed_orcids":["https://orcid.org/0000-0002-3039-5934"]},"institutions":[{"id":"https://openalex.org/I184937672","display_name":"Chubu University","ror":"https://ror.org/02sps0775","country_code":"JP","type":"education","lineage":["https://openalex.org/I184937672"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Hotta","raw_affiliation_strings":["College of Life and Health Sciences, Chubu University, Kasugai, Japan (N.H., K.K., C.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Chubu University, Kasugai, Japan (N.H., K.K., C.K.)","institution_ids":["https://openalex.org/I184937672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016247661","display_name":"Kimiaki Katanosaka","orcid":"https://orcid.org/0000-0002-4866-6536","observed_orcids":["https://orcid.org/0000-0002-4866-6536"]},"institutions":[{"id":"https://openalex.org/I184937672","display_name":"Chubu University","ror":"https://ror.org/02sps0775","country_code":"JP","type":"education","lineage":["https://openalex.org/I184937672"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimiaki Katanosaka","raw_affiliation_strings":["College of Life and Health Sciences, Chubu University, Kasugai, Japan (N.H., K.K., C.K.)"],"raw_orcid":"https://orcid.org/0000-0002-4866-6536","affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Chubu University, Kasugai, Japan (N.H., K.K., C.K.)","institution_ids":["https://openalex.org/I184937672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002975039","display_name":"Chiaki Kihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184937672","display_name":"Chubu University","ror":"https://ror.org/02sps0775","country_code":"JP","type":"education","lineage":["https://openalex.org/I184937672"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiaki Kihara","raw_affiliation_strings":["College of Life and Health Sciences, Chubu University, Kasugai, Japan (N.H., K.K., C.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Chubu University, Kasugai, Japan (N.H., K.K., C.K.)","institution_ids":["https://openalex.org/I184937672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041436521","display_name":"Juan A. Estrada","orcid":"https://orcid.org/0000-0003-1252-4840","observed_orcids":["https://orcid.org/0000-0003-1252-4840"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan A. Estrada","raw_affiliation_strings":["Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":"https://orcid.org/0000-0003-1252-4840","affiliations":[{"raw_affiliation_string":"Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025568147","display_name":"Ayumi Fukazawa","orcid":"https://orcid.org/0000-0002-7322-043X","observed_orcids":["https://orcid.org/0000-0002-7322-043X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayumi Fukazawa","raw_affiliation_strings":["Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":"https://orcid.org/0000-0002-7322-043X","affiliations":[{"raw_affiliation_string":"Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022845523","display_name":"Gary A. Iwamoto","orcid":"https://orcid.org/0000-0001-5880-4843","observed_orcids":["https://orcid.org/0000-0001-5880-4843"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary A. Iwamoto","raw_affiliation_strings":["Departments of Surgery (G.A.I.), University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery (G.A.I.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085330812","display_name":"Scott A. Smith","orcid":"https://orcid.org/0000-0002-2143-2342","observed_orcids":["https://orcid.org/0000-0002-2143-2342"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Smith","raw_affiliation_strings":["Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":"https://orcid.org/0000-0002-2143-2342","affiliations":[{"raw_affiliation_string":"Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084255283","display_name":"Wanpen Vongpatanasin","orcid":"https://orcid.org/0000-0002-7531-9388","observed_orcids":["https://orcid.org/0000-0002-7531-9388"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanpen Vongpatanasin","raw_affiliation_strings":["Departments of Internal Medicine (H.-K.K., W.V.), University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":"https://orcid.org/0000-0002-7531-9388","affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine (H.-K.K., W.V.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080909826","display_name":"Masaki Mizuno","orcid":"https://orcid.org/0000-0003-4455-8084","observed_orcids":["https://orcid.org/0000-0003-4455-8084"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaki Mizuno","raw_affiliation_strings":["Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":"https://orcid.org/0000-0003-4455-8084","affiliations":[{"raw_affiliation_string":"Departments of Applied Clinical Research (R.I., A.H., J.A.E., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.24269999563694,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780785647","wikidata":"https://www.wikidata.org/wiki/Q18034667","display_name":"PIEZO1","level":5,"score":0.7233999967575073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7116000056266785},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7031000256538391},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6438000202178955},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.6414999961853027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5422999858856201},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.49790000915527344},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4627000093460083},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.46230000257492065},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.45660001039505005},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.38350000977516174},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.3434999883174896},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2797999978065491},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.2572999894618988},{"id":"https://openalex.org/C136357698","wikidata":"https://www.wikidata.org/wiki/Q3290037","display_name":"Free nerve ending","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.25450000166893005}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1161/hypertensionaha.126.27843","doi":"https://doi.org/10.1161/hypertensionaha.126.27843","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.126.27843","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:43007059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43007059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1508052749","https://openalex.org/W1511198581","https://openalex.org/W1545516547","https://openalex.org/W1837386705","https://openalex.org/W1938572211","https://openalex.org/W1964609862","https://openalex.org/W1972305562","https://openalex.org/W1973170673","https://openalex.org/W1979839680","https://openalex.org/W1983831716","https://openalex.org/W1985954324","https://openalex.org/W1990969710","https://openalex.org/W1999720993","https://openalex.org/W2012788801","https://openalex.org/W2018247592","https://openalex.org/W2029387172","https://openalex.org/W2034721936","https://openalex.org/W2036198864","https://openalex.org/W2048244595","https://openalex.org/W2054608908","https://openalex.org/W2084833342","https://openalex.org/W2095971269","https://openalex.org/W2099955260","https://openalex.org/W2100810368","https://openalex.org/W2103447688","https://openalex.org/W2110880731","https://openalex.org/W2125605921","https://openalex.org/W2131536322","https://openalex.org/W2135466550","https://openalex.org/W2139426841","https://openalex.org/W2154069424","https://openalex.org/W2160258136","https://openalex.org/W2164687363","https://openalex.org/W2176489849","https://openalex.org/W2176907467","https://openalex.org/W2180851509","https://openalex.org/W2388122187","https://openalex.org/W2542750476","https://openalex.org/W2560341035","https://openalex.org/W2747918806","https://openalex.org/W2748155559","https://openalex.org/W2898266525","https://openalex.org/W2914680588","https://openalex.org/W2946606555","https://openalex.org/W2954153234","https://openalex.org/W3008716270","https://openalex.org/W3024012344","https://openalex.org/W3030159217","https://openalex.org/W3130939396","https://openalex.org/W3135150292","https://openalex.org/W3166797325","https://openalex.org/W4366083707","https://openalex.org/W4402480413"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Abnormal":[1],"mechanoreflex":[2,84,121,218],"function":[3],"from":[4,42],"skeletal":[5],"muscle":[6,47,83,88,128,206,217],"significantly":[7,140,158,170],"contributes":[8],"to":[9,120,131,200,216],"the":[10,22,30,97,135,175,195],"heightened":[11],"circulatory":[12,214],"response":[13],"during":[14],"exercise":[15],"in":[16,34,59,69,96,105,142,174,220],"type":[17],"2":[18],"diabetes":[19],"(T2DM).":[20],"However,":[21],"underlying":[23],"mechanisms":[24],"remain":[25],"unclear.":[26],"We":[27],"hypothesized":[28],"that":[29,192],"abnormal":[31],"cardiovascular":[32],"responses":[33,119,215],"T2DM":[35,50,143],"are":[36],"mediated":[37],"by":[38,102,160,181],"mechanoreflex-induced":[39],"exaggerations":[40],"resulting":[41],"enhanced":[43,201],"Piezo1-mediated":[44,91],"mechanosensitivity":[45,86],"of":[46,65,87,162,194,203],"afferents.":[48],"METHODS:":[49],"rats":[51],"(Sprague-Dawley":[52],"rats)":[53],"were":[54,100,139,157],"given":[55],"a":[56,62,164,182],"high-fat":[57],"diet":[58],"combination":[60],"with":[61,212],"low":[63],"dose":[64],"streptozotocin.":[66],"Using":[67],"an":[68,75],"vivo":[70,77],"decerebrated":[71],"rat":[72],"model":[73],"and":[74,90,115,134,152,208],"ex":[76],"single-fiber":[78],"recording":[79],"preparation,":[80],"we":[81],"measured":[82],"responses,":[85],"afferents,":[89],"responses.":[92],"Piezo1":[93,136,147,172],"protein":[94,173],"levels":[95],"membrane":[98],"fraction":[99],"detected":[101],"Western":[103],"blotting":[104],"human":[106],"embryonic":[107],"kidney":[108],"293":[109],"(HEK293)":[110],"cells.":[111],"RESULTS:":[112],"Blood":[113],"pressure":[114,150],"sympathetic":[116],"nerve":[117],"activity":[118],"activation,":[122],"as":[123,125],"well":[124],"group":[126,153,204],"IV":[127,154,205],"afferent":[129,155],"firing":[130,156],"mechanical":[132],"stimulation":[133],"agonist":[137],"(Yoda1),":[138],"greater":[141],"rats.":[144],"More":[145],"importantly,":[146],"agonist-induced":[148],"blood":[149],"changes":[151],"potentiated":[159],"administration":[161],"lipopolysaccharide,":[163],"gut-derived":[165],"inflammatory":[166],"endotoxin.":[167],"Furthermore,":[168],"lipopolysaccharide":[169],"increased":[171],"cell":[176],"membrane,":[177],"which":[178],"was":[179],"attenuated":[180],"PKA":[183],"(protein":[184],"kinase":[185],"A)":[186],"inhibitor.":[187],"CONCLUSIONS:":[188],"These":[189],"findings":[190],"suggest":[191],"activation":[193,219],"lipopolysaccharide-Piezo1":[196],"pathway":[197],"may":[198,209],"contribute":[199],"responsiveness":[202],"afferents":[207],"be":[210],"associated":[211],"exaggerated":[213],"T2DM.":[221]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
