{"id":"https://openalex.org/W7225757167","doi":"https://doi.org/10.21203/rs.3.rs-11135174/v1","title":"Etiological profile of severe-to-profound sensorineural hearing loss in children undergoing cochlear implantation: the role of brain MRI in the etiological diagnosis of congenital cytomegalovirus","display_name":"Etiological profile of severe-to-profound sensorineural hearing loss in children undergoing cochlear implantation: the role of brain MRI in the etiological diagnosis of congenital cytomegalovirus","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225757167","doi":"https://doi.org/10.21203/rs.3.rs-11135174/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11135174/v1","doi":"https://doi.org/10.21203/rs.3.rs-11135174/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11135174/v1","pdf_url":"https://www.researchsquare.com/article/rs-11135174/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11135174/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109083251","display_name":"Marco Albuquerque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"MARCO ALBUQUERQUE","raw_affiliation_strings":["Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161367029","display_name":"Marla Monteiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marla Monteiro","raw_affiliation_strings":["Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161366626","display_name":"Vitor Lopes Braga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor Lopes Braga","raw_affiliation_strings":["Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161371655","display_name":"Mariana Correggliano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana Correggliano","raw_affiliation_strings":["Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027529605","display_name":"Robinson Koji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Robinson Koji","raw_affiliation_strings":["Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062321658","display_name":"Fernando Kok","orcid":"https://orcid.org/0000-0002-7577-9122","observed_orcids":["https://orcid.org/0000-0002-7577-9122"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Kok","raw_affiliation_strings":["Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.892799973487854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8601999878883362},{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.6607000231742859},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6581000089645386},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.6345000267028809},{"id":"https://openalex.org/C2779889316","wikidata":"https://www.wikidata.org/wiki/Q642836","display_name":"Neuroradiology","level":3,"score":0.5309000015258789},{"id":"https://openalex.org/C2778882171","wikidata":"https://www.wikidata.org/wiki/Q724965","display_name":"Cochlear implant","level":2,"score":0.527999997138977},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5092999935150146},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.48170000314712524},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4498000144958496},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36309999227523804},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2948000133037567},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.2915000021457672},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.29010000824928284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11135174/v1","doi":"https://doi.org/10.21203/rs.3.rs-11135174/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11135174/v1","pdf_url":"https://www.researchsquare.com/article/rs-11135174/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11135174/v1","doi":"https://doi.org/10.21203/rs.3.rs-11135174/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11135174/v1","pdf_url":"https://www.researchsquare.com/article/rs-11135174/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225757167.pdf","grobid_xml":"https://content.openalex.org/works/W7225757167.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Congenital":[2,128,230],"cytomegalovirus":[3,129,231],"(cCMV)":[4],"is":[5],"the":[6,17,37,52,138,225,233,247,263,279],"leading":[7,234],"non-genetic":[8,114,141,235],"cause":[9,236],"of":[10,19,40,57,109,148,237,265],"pediatric":[11],"sensorineural":[12],"hearing":[13,207,258],"loss":[14],"(SNHL),":[15],"but":[16,198],"contribution":[18],"brain":[20,274,284],"magnetic":[21],"resonance":[22],"imaging":[23],"(MRI)":[24],"to":[25,35,50,250],"its":[26],"etiological":[27,38,103],"diagnosis":[28,104],"remains":[29],"insufficiently":[30],"explored.":[31],"This":[32,61],"study":[33,63],"aimed":[34],"characterize":[36],"profile":[39],"children":[41,66,203,254],"with":[42,67,95,180,195,204,255],"severe-to-profound":[43,68,238],"SNHL":[44,69,177,179,239],"undergoing":[45],"cochlear":[46,74,287],"implant":[47,75],"evaluation":[48],"and":[49,54,80,112,164,184,218,271],"investigate":[51],"clinical":[53],"neuroimaging":[55,81],"spectrum":[56,270],"cCMV":[58,187,266],"infection.":[59],"Methods:":[60],"retrospective":[62],"included":[64],"126":[65],"evaluated":[70],"at":[71],"a":[72,92,146,268],"tertiary":[73],"center.":[76],"Clinical,":[77],"etiological,":[78],"genetic,":[79],"data":[82],"were":[83,88,150,173,199,221],"reviewed.":[84],"Brain":[85,143],"MRI":[86],"examinations":[87],"systematically":[89],"reassessed":[90],"by":[91,122],"neuroradiology":[93],"team,":[94],"particular":[96],"emphasis":[97],"on":[98],"white-matter":[99,144,190],"abnormalities.":[100],"Results:":[101],"An":[102],"was":[105,131,232],"established":[106],"in":[107,125,133,152,157,161,166,202,224,240,253],"76%":[108],"cases.":[110],"Acquired":[111],"congenital":[113],"causes":[115],"accounted":[116],"for":[117,282],"56":[118],"cases":[119],"(44%),":[120],"followed":[121],"genetic":[123],"etiologies":[124],"29":[126],"(24%).":[127],"infection":[130],"identified":[132],"25":[134],"patients":[135,154,194],"(20%),":[136],"representing":[137],"most":[139],"frequent":[140],"etiology.":[142],"abnormalities,":[145,211],"hallmark":[147],"cCMV,":[149],"diffuse":[151],"17/25":[153],"(68%),":[155],"temporal":[156],"4":[158],"(16%),":[159],"periventricular":[160],"2":[162,167],"(8%),":[163],"focal":[165],"(8%).":[168],"Three":[169],"descriptive":[170],"clinical-radiological":[171],"groups":[172],"outlined:":[174],"apparently":[175,205,256],"isolated":[176,206,257],"(n=7),":[178],"neurological":[181,196],"involvement":[182],"(n=14),":[183],"classical":[185,226],"multisystem":[186,227],"(n=4).":[188],"Diffuse":[189],"abnormalities":[191,244],"predominated":[192],"among":[193],"manifestations":[197],"also":[200],"observed":[201],"loss.":[208,259],"Additional":[209],"structural":[210],"including":[212,252],"ventriculomegaly,":[213],"intracranial":[214],"calcifications,":[215],"parenchymal":[216],"cysts,":[217],"cortical":[219],"malformations,":[220],"more":[222],"common":[223],"group.":[228],"Conclusion:":[229],"this":[241],"cohort.":[242],"White-matter":[243],"frequently":[245],"represented":[246],"primary":[248],"clue":[249],"diagnosis,":[251],"These":[260],"findings":[261],"support":[262],"concept":[264],"as":[267],"clinicoradiological":[269],"reinforce":[272],"preoperative":[273],"MRI,":[275],"which":[276],"may":[277],"represent":[278],"final":[280],"opportunity":[281],"reliable":[283],"assessment":[285],"before":[286],"implantation.":[288]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
