{"id":"https://openalex.org/W7225756897","doi":"https://doi.org/10.3389/fimmu.2026.1921925","title":"Downregulation of PRDX3 promotes the progression of bradyarrhythmia via inducing ferroptosis and inflammatory macrophage infiltration in cardiac ganglion plexus","display_name":"Downregulation of PRDX3 promotes the progression of bradyarrhythmia via inducing ferroptosis and inflammatory macrophage infiltration in cardiac ganglion plexus","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225756897","doi":"https://doi.org/10.3389/fimmu.2026.1921925"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1921925","doi":"https://doi.org/10.3389/fimmu.2026.1921925","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1921925","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1921925/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1921925/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146612502","display_name":"Mingliang Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingliang Shao","raw_affiliation_strings":["Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044025267","display_name":"Chenhuan Yao","orcid":"https://orcid.org/0009-0004-5284-3883","observed_orcids":["https://orcid.org/0009-0004-5284-3883"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenhuan Yao","raw_affiliation_strings":["Department of Research and Teaching, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Teaching, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125474705","display_name":"Chengwei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengwei Wang","raw_affiliation_strings":["Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]},{"raw_affiliation_string":"Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161408915","display_name":"Ting Tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]},{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Tu","raw_affiliation_strings":["Bengbu Medical University","Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bengbu Medical University","institution_ids":["https://openalex.org/I169351748"]},{"raw_affiliation_string":"Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008284058","display_name":"Jia Hu","orcid":"https://orcid.org/0000-0001-7299-425X","observed_orcids":["https://orcid.org/0000-0001-7299-425X"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Hu","raw_affiliation_strings":["Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]},{"raw_affiliation_string":"Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122105370","display_name":"Zhiqiang Chen","orcid":"https://orcid.org/0000-0003-4096-0607","observed_orcids":["https://orcid.org/0000-0003-4096-0607"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]},{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Chen","raw_affiliation_strings":["Bengbu Medical University","Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bengbu Medical University","institution_ids":["https://openalex.org/I169351748"]},{"raw_affiliation_string":"Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161375232","display_name":"Xianping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianping Wang","raw_affiliation_strings":["Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161387877","display_name":"Bing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Liu","raw_affiliation_strings":["Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, The People\u2019s Hospital of Xuancheng City, The Affiliated Xuancheng Hospital of Wannan Medical University","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5125472694","display_name":"Shiwen Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiwen Liu","raw_affiliation_strings":["Department of Cardiology, Guangde Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Guangde Hospital of Traditional Chinese Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5146612502"],"corresponding_institution_ids":["https://openalex.org/I100357981"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7885000109672546},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4864000082015991},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.46799999475479126},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4027000069618225},{"id":"https://openalex.org/C2780416994","wikidata":"https://www.wikidata.org/wiki/Q419462","display_name":"Peroxiredoxin","level":4,"score":0.3939000070095062},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.39070001244544983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35989999771118164},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.34369999170303345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3305000066757202},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.32030001282691956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3163999915122986},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.3149000108242035},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30230000615119934},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.29580000042915344},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27889999747276306},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2596000134944916}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fimmu.2026.1921925","doi":"https://doi.org/10.3389/fimmu.2026.1921925","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1921925","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1921925/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1921925","doi":"https://doi.org/10.3389/fimmu.2026.1921925","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1921925","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1921925/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225756897.pdf","grobid_xml":"https://content.openalex.org/works/W7225756897.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W265000889","https://openalex.org/W1973085272","https://openalex.org/W2007662985","https://openalex.org/W2015098273","https://openalex.org/W2297250216","https://openalex.org/W2499148376","https://openalex.org/W2588989924","https://openalex.org/W2603383085","https://openalex.org/W2747001701","https://openalex.org/W2962423504","https://openalex.org/W2980020667","https://openalex.org/W3115840934","https://openalex.org/W3123922203","https://openalex.org/W3207615849","https://openalex.org/W4220801154","https://openalex.org/W4284889683","https://openalex.org/W4294921564","https://openalex.org/W4321496428","https://openalex.org/W4379384673","https://openalex.org/W4387784011","https://openalex.org/W4388801054","https://openalex.org/W4392350483","https://openalex.org/W4400220813","https://openalex.org/W4404597675","https://openalex.org/W4407393513","https://openalex.org/W4410722070","https://openalex.org/W4412901673","https://openalex.org/W4412957034","https://openalex.org/W4412998279","https://openalex.org/W4414002778","https://openalex.org/W4417539244","https://openalex.org/W7164333602"],"related_works":[],"abstract_inverted_index":{"Aim":[0],"Bradyarrhythmia":[1],"is":[2],"a":[3,29,80,198],"prevalent":[4],"cardiac":[5,87,168],"disorder":[6],"often":[7],"necessitating":[8],"lifelong":[9],"pacemaker":[10],"implantation,":[11],"yet":[12],"the":[13,23,34,70,86,127,158],"underlying":[14],"molecular":[15],"mechanisms":[16],"remain":[17],"poorly":[18],"defined.":[19],"This":[20],"study":[21],"investigated":[22],"role":[24,200],"of":[25,36,42,73,83,103,140,201],"Peroxiredoxin":[26],"3":[27],"(PRDX3),":[28],"mitochondrial":[30,111,119],"antioxidant":[31],"enzyme,":[32],"in":[33,75,85,91,96,143,203],"pathogenesis":[35],"bradyarrhythmia.":[37,76,204],"Methods":[38],"A":[39],"rat":[40],"model":[41],"bradyarrhythmia":[43,92,187],"was":[44],"constructed.":[45],"In":[46],"vivo":[47,144],"telemetric":[48],"ECG":[49],"recording,":[50],"transcriptome":[51],"RNA-sequencing,":[52],"flow":[53],"cytometry,":[54],"western":[55],"blot,":[56],"reverse":[57],"transcription-quantitative":[58],"PCR":[59],"and":[60,110,148,153,166,174,192],"enzyme-linked":[61],"immunosorbent":[62],"assay":[63,65],"(ELISA)":[64],"were":[66],"performed":[67],"to":[68,117],"evaluate":[69],"potential":[71],"function":[72,169],"PRDX3":[74,84,94,114,141,162,184,202],"Results":[77],"We":[78],"observed":[79],"significant":[81],"downregulation":[82,185],"ganglion":[88],"plexus":[89],"(CGP)":[90],"rats.":[93],"knockdown":[95],"primary":[97],"CGP":[98],"cells":[99],"exhibited":[100],"hallmark":[101],"features":[102],"ferroptosis,":[104],"including":[105],"iron":[106],"accumulation,":[107,124],"lipid":[108],"peroxidation":[109],"dysfunction.":[112],"Mechanistically,":[113],"deficiency":[115],"led":[116],"excessive":[118],"reactive":[120],"oxygen":[121],"species":[122],"(ROS)":[123],"which":[125],"inactivated":[126],"glutathione":[128],"peroxidase":[129],"4":[130],"(GPX4)":[131],"signaling":[132],"pathway,":[133],"thereby":[134],"driving":[135],"ferroptotic":[136],"cell":[137],"death.":[138],"Restoration":[139],"expression":[142],"significantly":[145],"ameliorated":[146],"bradyarrhythmia,":[147],"suppressed":[149],"inflammatory":[150,193],"cytokines":[151],"production":[152],"M1":[154,194],"macrophage":[155,195],"infiltration":[156],"within":[157],"sinoatrial":[159],"node.":[160],"Furthermore,":[161],"restoration":[163],"alleviated":[164],"ferroptosis":[165,191],"improved":[167],"by":[170],"stabilizing":[171],"heart":[172],"rates":[173],"reducing":[175],"R-R":[176],"interval":[177],"variability.":[178],"Conclusion":[179],"Our":[180],"findings":[181],"demonstrate":[182],"that":[183],"promotes":[186],"progression":[188],"via":[189],"inducing":[190],"infiltration,":[196],"revealing":[197],"novel":[199]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}