{"id":"https://openalex.org/W7225756784","doi":"https://doi.org/10.1681/asn.2026r9rfv6m9","title":"Pretreatment Antinephrin Antibody Titers Stratify Nephrotic Syndrome in Pediatric Patients and Predict Steroid Response, Independent of Genetic Risk Alleles","display_name":"Pretreatment Antinephrin Antibody Titers Stratify Nephrotic Syndrome in Pediatric Patients and Predict Steroid Response, Independent of Genetic Risk Alleles","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7225756784","doi":"https://doi.org/10.1681/asn.2026r9rfv6m9"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2026r9rfv6m9","doi":"https://doi.org/10.1681/asn.2026r9rfv6m9","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2026r9rfv6m9","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088334278","display_name":"Tomoko Horinouchi","orcid":"https://orcid.org/0000-0003-1655-6030","observed_orcids":["https://orcid.org/0000-0003-1655-6030"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Horinouchi","raw_affiliation_strings":["Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159551619","display_name":"Masaya Muto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaya Muto","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024306261","display_name":"China Nagano","orcid":"https://orcid.org/0000-0003-4946-1345","observed_orcids":["https://orcid.org/0000-0003-4946-1345"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"China Nagano","raw_affiliation_strings":["Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069163214","display_name":"Takaya Ozeki","orcid":"https://orcid.org/0000-0002-1839-1180","observed_orcids":["https://orcid.org/0000-0002-1839-1180"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaya Ozeki","raw_affiliation_strings":["Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044516599","display_name":"Yuta Inoki","orcid":"https://orcid.org/0009-0005-8645-5464","observed_orcids":["https://orcid.org/0009-0005-8645-5464"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Inoki","raw_affiliation_strings":["Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039848734","display_name":"Yuta Ichikawa","orcid":"https://orcid.org/0000-0001-5926-1203","observed_orcids":["https://orcid.org/0000-0001-5926-1203"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Ichikawa","raw_affiliation_strings":["Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075446830","display_name":"Eri Morita Yamamoto","orcid":"https://orcid.org/0000-0002-1074-9045","observed_orcids":["https://orcid.org/0000-0002-1074-9045"]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Morita Yamamoto","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090555589","display_name":"Koichi Kamei","orcid":"https://orcid.org/0000-0003-3528-6961","observed_orcids":["https://orcid.org/0000-0003-3528-6961"]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Kamei","raw_affiliation_strings":["Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan;","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011346273","display_name":"Riku Hamada","orcid":"https://orcid.org/0000-0002-7151-459X","observed_orcids":["https://orcid.org/0000-0002-7151-459X"]},"institutions":[{"id":"https://openalex.org/I4210144200","display_name":"Tokyo Metropolitan Children's Medical Center","ror":"https://ror.org/04hj57858","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210144200"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Riku Hamada","raw_affiliation_strings":["Tokyo Metropolitan Children's Medical Center, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Metropolitan Children's Medical Center, Tokyo, Japan;","institution_ids":["https://openalex.org/I4210144200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014966690","display_name":"Yoshitaka Isaka","orcid":"https://orcid.org/0000-0002-0820-7167","observed_orcids":["https://orcid.org/0000-0002-0820-7167","https://orcid.org/0009-0003-6787-655X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Isaka","raw_affiliation_strings":["Department of Nephrology, The University of Osaka, Osaka, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The University of Osaka, Osaka, Japan;","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135778007","display_name":"Shoichi Maruyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoichi Maruyama","raw_affiliation_strings":["Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084675851","display_name":"Kenji Ishikura","orcid":"https://orcid.org/0000-0003-2692-6437","observed_orcids":["https://orcid.org/0000-0003-2692-6437"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Ishikura","raw_affiliation_strings":["Department of Pediatrics, Kitasato University School of Medicine, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kitasato University School of Medicine, Tokyo, Japan;","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028804627","display_name":"Amane Harada","orcid":"https://orcid.org/0000-0002-6455-9765","observed_orcids":["https://orcid.org/0000-0002-6455-9765"]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Amane Harada","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007720060","display_name":"Kandai Nozu","orcid":"https://orcid.org/0000-0002-0290-3137","observed_orcids":["https://orcid.org/0000-0002-0290-3137"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kandai Nozu","raw_affiliation_strings":["Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036822255","display_name":"Kazumoto Iijima","orcid":"https://orcid.org/0000-0003-0378-8174","observed_orcids":["https://orcid.org/0000-0003-0378-8174"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumoto Iijima","raw_affiliation_strings":["Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan;","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7590000033378601},{"id":"https://openalex.org/keywords/steroid-response-prediction","display_name":"steroid response prediction","score":0.4819999933242798},{"id":"https://openalex.org/keywords/risk-alleles","display_name":"risk alleles","score":0.8880000114440918},{"id":"https://openalex.org/keywords/disease-stratification","display_name":"disease stratification","score":0.597000002861023},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8256000280380249},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.6707000136375427},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5764999985694885},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5745000243186951},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4941999912261963},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.4099000096321106},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4041999876499176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40299999713897705},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.3449000120162964},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.3330000042915344},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2793999910354614}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.2026r9rfv6m9","doi":"https://doi.org/10.1681/asn.2026r9rfv6m9","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2026r9rfv6m9","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385289018","https://openalex.org/W4407753626","https://openalex.org/W7225710063","https://openalex.org/W7225731976","https://openalex.org/W7223690927","https://openalex.org/W4415311178","https://openalex.org/W7225741305","https://openalex.org/W4247204978","https://openalex.org/W4417357329","https://openalex.org/W4407901567"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-11T00:00:00"}