{"id":"https://openalex.org/W7225754771","doi":"https://doi.org/10.3389/fonc.2026.1899149","title":"Multimodal imaging features and symptom-directed management of primary prostatic granular cell tumor: a case report with 36-month follow-up","display_name":"Multimodal imaging features and symptom-directed management of primary prostatic granular cell tumor: a case report with 36-month follow-up","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225754771","doi":"https://doi.org/10.3389/fonc.2026.1899149"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1899149","doi":"https://doi.org/10.3389/fonc.2026.1899149","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1899149","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fonc.2026.1899149","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158314191","display_name":"Shanshan Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanshan Chen","raw_affiliation_strings":["Department of Ultrasound, Leshan People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Leshan People\u2019s Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161394053","display_name":"Zhenhua Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhenhua Xu","raw_affiliation_strings":["Department of Ultrasound, Leshan People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Leshan People\u2019s Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110688714","display_name":"Bin Ding","orcid":"https://orcid.org/0009-0001-4120-5219","observed_orcids":["https://orcid.org/0009-0001-4120-5219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Ding","raw_affiliation_strings":["Department of Ultrasound, Leshan People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Leshan People\u2019s Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161408897","display_name":"Yingjie Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yingjie Li","raw_affiliation_strings":["Department of Ultrasound, Leshan People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Leshan People\u2019s Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161370534","display_name":"Yunhao Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunhao Luo","raw_affiliation_strings":["Department of Ultrasound, West China Hospital of Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, West China Hospital of Sichuan University","institution_ids":["https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5161370534"],"corresponding_institution_ids":["https://openalex.org/I2800091995","https://openalex.org/I4210089761"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13383","display_name":"Tumors and Oncological Cases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13383","display_name":"Tumors and Oncological Cases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8259999752044678},{"id":"https://openalex.org/C2776845205","wikidata":"https://www.wikidata.org/wiki/Q1269399","display_name":"Dysuria","level":3,"score":0.7727000117301941},{"id":"https://openalex.org/C2781100745","wikidata":"https://www.wikidata.org/wiki/Q1977435","display_name":"Debulking","level":4,"score":0.6628000140190125},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6413000226020813},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.5863999724388123},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5491999983787537},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.5414000153541565},{"id":"https://openalex.org/C2776394215","wikidata":"https://www.wikidata.org/wiki/Q940874","display_name":"Granular cell tumor","level":3,"score":0.5152999758720398},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4876999855041504},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.48069998621940613},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4415000081062317},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4390000104904175},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C2779091618","wikidata":"https://www.wikidata.org/wiki/Q1366695","display_name":"Urinary retention","level":2,"score":0.3801000118255615},{"id":"https://openalex.org/C2908973413","wikidata":"https://www.wikidata.org/wiki/Q1977435","display_name":"Tumor Debulking","level":3,"score":0.35429999232292175},{"id":"https://openalex.org/C3020547009","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathological examination","level":2,"score":0.32260000705718994},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.31139999628067017},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.30489999055862427},{"id":"https://openalex.org/C2780070792","wikidata":"https://www.wikidata.org/wiki/Q4923668","display_name":"Bladder outlet obstruction","level":4,"score":0.2935999929904938},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.28540000319480896},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C2777957205","wikidata":"https://www.wikidata.org/wiki/Q4006435","display_name":"Prostatic urethra","level":4,"score":0.26089999079704285},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fonc.2026.1899149","doi":"https://doi.org/10.3389/fonc.2026.1899149","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1899149","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1899149","doi":"https://doi.org/10.3389/fonc.2026.1899149","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1899149","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1965577110","https://openalex.org/W1971730986","https://openalex.org/W2009052747","https://openalex.org/W2079385178","https://openalex.org/W2079530594","https://openalex.org/W2167248110","https://openalex.org/W2185281146","https://openalex.org/W2415938085","https://openalex.org/W2570770554","https://openalex.org/W2736190390","https://openalex.org/W2781702144","https://openalex.org/W2808560259","https://openalex.org/W2889034373","https://openalex.org/W2922071185","https://openalex.org/W2961181884","https://openalex.org/W2983172199","https://openalex.org/W3005462027","https://openalex.org/W3005955148","https://openalex.org/W3041830995","https://openalex.org/W4220775315","https://openalex.org/W4285810908","https://openalex.org/W4298087078","https://openalex.org/W4327703901","https://openalex.org/W4386799791","https://openalex.org/W4391482273","https://openalex.org/W4402739985","https://openalex.org/W4408507566"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Granular":[1],"cell":[2,163],"tumor":[3,112,121],"(GCT)":[4],"is":[5,16,27],"a":[6,58,92,99,146,180,234,253],"rare":[7],"neoplasm":[8],"with":[9,20,60,70,88,114,133,150,200],"characteristic":[10],"abundant":[11,115],"eosinophilic":[12,116],"cytoplasmic":[13],"granules":[14],"and":[15,30,40,54,73,77,98,128,140,153,204,212,230],"most":[17],"commonly":[18],"associated":[19],"Schwannian":[21],"differentiation.":[22],"Primary":[23],"prostatic":[24,62,161],"GCT":[25],"(GCT-P)":[26],"exceptionally":[28],"rare,":[29],"published":[31],"reports":[32],"provide":[33],"limited":[34],"information":[35],"on":[36,227],"its":[37],"imaging":[38,48,80,207,236,259],"appearance":[39],"longitudinal":[41],"clinical":[42],"course.":[43],"We":[44],"describe":[45],"the":[46,86,120,151,157,174,189,274],"multimodal":[47],"findings,":[49,155],"pathological":[50,143],"confirmation,":[51],"symptom-directed":[52,181,254],"treatment,":[53],"36-month":[55],"follow-up":[56],"of":[57,85,102,106,159,166,173,187,193,245,266,278],"patient":[59,190,251],"primary":[61,160],"GCT.":[63],"Case":[64],"report":[65],"A":[66],"46-year-old":[67],"man":[68],"presented":[69],"progressive":[71],"dysuria":[72],"urinary":[74,198,202],"retention.":[75],"Ultrasound":[76],"magnetic":[78],"resonance":[79],"(MRI)":[81],"revealed":[82],"diffuse":[83],"enlargement":[84],"prostate,":[87],"heterogeneous":[89],"T2":[90],"hyperintensity,":[91],"T2-weighted":[93,222],"\u201cstripe":[94,223],"sign\u201d":[95,224],"restricted":[96],"diffusion,":[97],"PI-RADS":[100],"score":[101],"5.":[103],"Histopathological":[104,210],"examination":[105,211],"transperineal":[107],"prostate":[108,175],"biopsy":[109],"specimens":[110],"showed":[111],"cells":[113,122],"granular":[117,162],"cytoplasm.":[118],"Immunohistochemically,":[119],"were":[123,214],"strongly":[124],"positive":[125,130],"for":[126,131,137,216,280],"CD68":[127],"weakly":[129],"S-100,":[132],"additional":[134],"supportive":[135],"positivity":[136],"SOX10,":[138],"NSE,":[139],"PAS-D.":[141],"Expert":[142],"review":[144],"at":[145],"higher-level":[147],"hospital,":[148],"together":[149],"histopathological":[152],"immunohistochemical":[154],"supported":[156],"diagnosis":[158,217],"tumor.":[164],"Because":[165],"severe":[167],"bladder":[168,246],"outlet":[169,247],"obstruction,":[170],"photoselective":[171],"vaporization":[172],"(PVP)":[176],"was":[177,225,261],"performed":[178],"as":[179,252],"debulking":[182,255],"procedure.":[183,256],"During":[184],"36":[185,264],"months":[186,265],"follow-up,":[188,267],"remained":[191],"free":[192],"recurrent":[194],"obstructive":[195],"or":[196],"residual":[197],"symptoms,":[199],"improved":[201],"function":[203],"no":[205],"definite":[206,258],"progression.":[208],"Conclusions":[209],"immunohistochemistry":[213],"essential":[215],"in":[218,249],"this":[219,250],"case.":[220],"The":[221],"observed":[226,262],"multiple":[228],"sections":[229],"planes":[231],"but":[232],"remains":[233],"preliminary":[235],"observation":[237],"requiring":[238],"further":[239],"validation.":[240],"PVP":[241,279],"provided":[242],"substantial":[243],"relief":[244],"obstruction":[248],"No":[257],"progression":[260],"during":[263],"although":[268],"these":[269],"findings":[270],"do":[271],"not":[272],"establish":[273],"long-term":[275],"oncological":[276],"efficacy":[277],"GCT-P.":[281]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}