{"id":"https://openalex.org/W7225754750","doi":"https://doi.org/10.64898/2026.11.09.765290","title":"Identification and localization of bone marrow ILC2s using Id2/Cxcr6 dual-reporter mice","display_name":"Identification and localization of bone marrow ILC2s using Id2/Cxcr6 dual-reporter mice","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225754750","doi":"https://doi.org/10.64898/2026.11.09.765290"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.765290","doi":"https://doi.org/10.64898/2026.11.09.765290","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765290","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026872623","display_name":"Cassandra Lepetit","orcid":"https://orcid.org/0000-0003-3061-927X","observed_orcids":["https://orcid.org/0000-0003-3061-927X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154398","display_name":"Microenvironment and B-cells: Immunopathology, Cell, Differentiation and Cancer","ror":"https://ror.org/05p7fmf80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210128919","https://openalex.org/I4387154398","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cassandra Lepetit","raw_affiliation_strings":["Universite Rennes, INSERM, EFS, UMR S1236, Rennes, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite Rennes, INSERM, EFS, UMR S1236, Rennes, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154398","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148573520","display_name":"Paloma Hedde","orcid":"https://orcid.org/0009-0009-6768-9491","observed_orcids":["https://orcid.org/0009-0009-6768-9491"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paloma Hedde","raw_affiliation_strings":["Institut Pasteur, Univ. Paris Cite;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Univ. Paris Cite;","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039193577","display_name":"Godefroy Jacquemin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Godefroy Jacquemin","raw_affiliation_strings":["Institut Pasteur, Univ. Paris Cite;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Univ. Paris Cite;","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052531911","display_name":"Elisa Gomez Perdiguero","orcid":"https://orcid.org/0000-0002-7717-7897","observed_orcids":["https://orcid.org/0000-0002-7717-7897"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisa Gomez-Perdiguero","raw_affiliation_strings":["Institut Pasteur;"],"raw_orcid":"https://orcid.org/0000-0002-7717-7897","affiliations":[{"raw_affiliation_string":"Institut Pasteur;","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161416192","display_name":"Stephane JC Mancini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stephane JC Mancini","raw_affiliation_strings":["Univ Rennes, INSERM, EFS, UMR S1236, Rennes;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Rennes, INSERM, EFS, UMR S1236, Rennes;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I56067802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032944800","display_name":"Rachel Golub","orcid":"https://orcid.org/0000-0002-2306-5363","observed_orcids":["https://orcid.org/0000-0002-2306-5363"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rachel GOLUB","raw_affiliation_strings":["Institut Pasteur, Univ Paris Cite"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Univ Paris Cite","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6930999755859375},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.649399995803833},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6323999762535095},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4555000066757202},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.44999998807907104},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4350999891757965},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37130001187324524},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35830000042915344},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.35109999775886536},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.34360000491142273},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3400999903678894},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3231000006198883},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.3118000030517578},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.29280000925064087},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28349998593330383},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26089999079704285},{"id":"https://openalex.org/C34372108","wikidata":"https://www.wikidata.org/wiki/Q5756291","display_name":"High Resolution Melt","level":4,"score":0.25859999656677246},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.765290","doi":"https://doi.org/10.64898/2026.11.09.765290","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765290","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Type":[0],"2":[1],"innate":[2],"lymphoid":[3,33,130],"cells":[4,89,154,167,207],"(ILC2s)":[5],"are":[6],"present":[7],"in":[8,209],"the":[9,26,38,77,110,113,123,134,147,162,203,206,232],"bone":[10,49,163,239],"marrow,":[11],"where":[12],"their":[13,22],"identification":[14,204],"and":[15,25,47,61,90,98,115,127,132,138,195,227,234],"spatial":[16,235],"localization":[17,233],"remain":[18],"challenging":[19],"because":[20],"of":[21,28,40,67,112,125,136,184,192,205,237],"low":[23],"abundance":[24],"expression":[27,71],"shared":[29],"markers":[30,102,145],"by":[31],"other":[32],"populations.":[34],"Here,":[35],"we":[36,56],"evaluated":[37],"use":[39,135],"Id2YFP/+":[41],"Cxcr6GFP/+":[42],"dual-reporter":[43,148,221],"mice":[44],"to":[45,230],"identify":[46],"visualize":[48],"marrow":[50,164,240],"ILC2s.":[51,213,241],"Using":[52],"spectral":[53],"flow":[54,173,223],"cytometry,":[55,224],"showed":[57],"that":[58,177],"both":[59],"ST2\u207b":[60],"ST2\u207a":[62,116],"ILC2s":[63,178],"expressed":[64],"high":[65],"levels":[66],"ID2,":[68],"whereas":[69],"CXCR6":[70],"differed":[72],"between":[73],"these":[74,144,215],"subsets.":[75,117],"However,":[76],"ID2":[78],"expressing":[79,129],"compartments":[80],"also":[81],"contained":[82],"NK":[83,196],"cells,":[84,86],"NKT":[85],"conventional":[87],"T":[88,194],"ILC":[91],"progenitors.":[92],"Surface":[93],"marker":[94],"profiling":[95,226],"identified":[96],"CD25":[97],"ICOS":[99],"as":[100,140,165,211],"useful":[101],"for":[103,180,202],"enriching":[104],"ILC2":[105,158],"populations,":[106,198],"with":[107,146,156],"ST2":[108],"enabling":[109],"segregation":[111],"ST2-":[114],"Single-cell":[118],"RNA":[119],"sequencing":[120],"further":[121],"characterized":[122],"diversity":[124],"Id2":[126],"Cxcr6":[128],"populations":[131],"supported":[133],"CD5":[137],"NKp46":[139],"exclusion":[141,191],"markers.":[142],"Combining":[143],"system,":[149],"confocal":[150,228],"microscopy":[151],"revealed":[152],"YFP\u207aGFP\u207aCD5-NKp46\u207b":[153],"compatible":[155],"an":[157],"phenotype,":[159],"distributed":[160],"throughout":[161],"isolated":[166],"or":[168],"within":[169],"multicellular":[170],"clusters.":[171],"Complementary":[172],"cytometric":[174],"analyses":[175],"demonstrated":[176],"accounted":[179],"more":[181],"than":[182],"90%":[183],"a":[185,218],"phenotypically":[186],"related":[187],"reporter-positive":[188],"population":[189],"after":[190],"major":[193],"cell":[197],"providing":[199],"additional":[200],"support":[201],"visualized":[208],"situ":[210],"putative":[212,238],"Together,":[214],"findings":[216],"establish":[217],"strategy":[219],"combining":[220],"mice,":[222],"transcriptomic":[225],"imaging":[229],"investigate":[231],"organization":[236]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-11T00:00:00"}
